EKS-ORL-00016
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORL-00016
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph474.57.4E-143598856259
StatusUnreviewed
Ensembl ProteinENSORLP00000015533
UniProt AccessionH2MAH9;
Protein Name
Protein Synonyms/Alias
Gene NameEPHA8
Gene Synonyms/Alias EPHA8;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSORLG00000012405ENSORLP00000015533ENSORLT00000015534
OrganismOryzias latipes
Functional Description
Protein Length965
Protein Sequence
(FASTA)
SQWDAINEMD EYFTPIHTYQ VCNVMSPSQN NWLVTGWIPR EGARRIYIEV KFTLRDCNSM 60
PGVLGTCKET FNLYYYESDR AVGSAIRENQ FNKIDTIAAD ESFTGVDLGV RRLKLNTEVR 120
GVGPLTRRGF YLAFQDIGAC IALTSVRVYY KRCVGVSRNL AVFTDVVTGA DSSSLVEVRG 180
QCVDHAEERD TPKMYCSAEG EWLVPIGRCV CSAGFEEHRD SCVGCRSCEV GYYKPVAGDG 240
PCGKCPQHSH SETRAAISCP CDSNYYRAAD DPPAAPCSRP PSAPVNVISS VNGTSVNLEW 300
DRPLDTGGRS DLQYSVLCLK CSREGPCEDC SASVKFVPRR NGLTEPWVTV LNLVAHTNYS 360
FRIVATNAVT HLSSERPPYA SVNITTNQAA PSEVLAIRQE NASQNSVTLL WHEPDQPNGV 420
ILEYDIKYHE KDNEEQTYST LKSKNTSARV SGLKPGTKYI FQIRARTSAG CGRFSQNVEI 480
QTGKAGQQSS VQIRDELLIN YCPSAKTFLI RTMVLALFCI HPRHCGYSKA FQDSDEEKMH 540
YQNGHGTFSS FPPICDQMLM LFILVSFPDA RFYIDPHTYE DPCQALHEFA REIEASRIKI 600
EKIIGSGEFG EVCYGRMRLP GKRDIPVALK TLKAGYTEKQ KRDFLAEASI MAQFDHPNVI 660
HLEGVVTHSK PAMIITEYME NGSLDSFLRV CDLEICTIQL VGLLRGIAAG MTYLSDLGYI 720
HRDLAARNIL VNSNLVCKVS DFGLSRVLED DPDAAYTTSN GGGKIPIRWT APEAIAYRKF 780
SSSSDVWSYG VVMWEVMSYG ERPYWNLTNR DVIKSVEEGY RLPAPMGCPA ALHTLMLDCW 840
QKDRNERPRF CQIVTILDKL IRNPENLKSV DKLCSLNSPP LTERAIPDFS SCNSVDEWLD 900
TIKMGRYKEH FAAGGYYTLG HVISMKQGDI QRLGVTLMGH QKKIMTSVQL MRAQVLNKSV 960
PSVHV 965
Nucleotide Sequence
(FASTA)
TCTCAGTGGG ACGCCATTAA CGAGATGGAC GAGTACTTCA CCCCGATCCA CACGTACCAG 60
GTCTGCAACG TGATGAGCCC CAGCCAAAAC AACTGGCTGG TGACGGGCTG GATTCCCCGA 120
GAGGGAGCCA GAAGGATCTA CATCGAGGTT AAGTTCACCC TGAGAGACTG CAACAGCATG 180
CCCGGAGTGC TGGGAACCTG CAAGGAAACC TTCAACTTGT ACTATTATGA GTCTGACAGA 240
GCCGTGGGCT CAGCCATCCG GGAGAACCAG TTCAATAAAA TTGACACCAT AGCTGCTGAT 300
GAGAGCTTCA CCGGCGTTGA CCTCGGAGTC CGAAGACTTA AACTCAACAC AGAGGTGCGA 360
GGCGTGGGCC CCCTGACGCG GCGAGGCTTC TACCTGGCCT TCCAGGACAT CGGGGCCTGC 420
ATCGCTCTCA CCTCCGTGCG GGTGTACTAC AAACGCTGCG TGGGGGTGAG CCGTAACCTA 480
GCTGTCTTCA CCGACGTGGT GACAGGGGCC GACTCGTCCT CCCTGGTGGA GGTCAGGGGT 540
CAGTGTGTGG ACCACGCGGA GGAGAGAGAC ACACCAAAGA TGTACTGCAG CGCTGAGGGG 600
GAGTGGCTGG TGCCAATTGG GAGGTGCGTG TGCTCGGCTG GATTTGAGGA GCACAGAGAC 660
TCCTGCGTTG GTTGCAGGTC CTGTGAGGTG GGTTATTACA AACCGGTGGC AGGGGATGGC 720
CCGTGTGGCA AATGTCCACA GCACAGCCAC TCAGAGACCA GAGCTGCCAT CTCCTGTCCA 780
TGTGACTCCA ACTACTATCG AGCGGCAGAC GACCCCCCAG CAGCCCCATG CTCCCGCCCT 840
CCATCTGCTC CTGTGAACGT CATCTCCTCC GTCAACGGGA CCTCTGTGAA TTTAGAGTGG 900
GATCGTCCTC TGGACACCGG GGGTCGCAGC GACCTGCAGT ACAGCGTGTT GTGTCTGAAG 960
TGCTCCAGGG AAGGACCCTG CGAGGACTGC TCCGCAAGCG TGAAGTTTGT TCCTCGGCGG 1020
AACGGCCTTA CAGAACCTTG GGTGACGGTG CTCAACCTGG TGGCTCACAC CAACTACTCC 1080
TTCCGCATCG TGGCCACAAA TGCAGTGACT CACCTGAGCA GTGAGCGCCC TCCGTACGCA 1140
TCGGTAAACA TCACAACAAA CCAGGCAGCA CCTTCTGAGG TGTTAGCGAT CCGCCAGGAG 1200
AATGCCAGTC AGAACAGTGT GACCCTGCTG TGGCACGAAC CGGACCAGCC CAACGGAGTA 1260
ATCCTGGAGT ACGACATCAA ATACCACGAG AAGGATAATG AAGAGCAGAC TTATTCCACT 1320
CTAAAGTCTA AAAACACCAG CGCTCGGGTG TCCGGACTGA AGCCAGGAAC CAAGTACATT 1380
TTCCAAATCC GAGCCAGAAC TTCTGCAGGG TGTGGACGCT TCAGCCAGAA TGTGGAGATT 1440
CAGACAGGCA AAGCAGGCCA ACAGTCCAGC GTACAAATCA GAGATGAACT TCTAATTAAC 1500
TACTGCCCCT CTGCAAAAAC TTTTCTAATA AGAACAATGG TTCTTGCTCT GTTCTGTATT 1560
CATCCCAGAC ACTGTGGTTA CAGCAAAGCC TTCCAAGACT CCGATGAGGA GAAGATGCAT 1620
TACCAGAACG GTCATGGTAC GTTTAGCTCA TTTCCTCCAA TATGTGACCA AATGCTAATG 1680
TTGTTTATCT TAGTGTCATT CCCCGATGCG AGGTTCTATA TCGACCCGCA CACATACGAG 1740
GACCCCTGCC AGGCGCTCCA CGAGTTCGCC CGAGAAATTG AAGCTTCCAG GATCAAAATC 1800
GAGAAAATTA TTGGCTCAGG GGAGTTTGGG GAGGTGTGTT ATGGAAGGAT GAGGCTCCCG 1860
GGAAAAAGGG ACATCCCAGT GGCGCTGAAG ACTCTGAAGG CAGGATACAC AGAGAAGCAG 1920
AAGAGGGACT TCCTGGCTGA GGCATCCATA ATGGCCCAGT TTGACCACCC GAATGTCATC 1980
CACCTGGAGG GAGTCGTAAC TCACAGCAAA CCAGCGATGA TCATCACAGA GTACATGGAG 2040
AACGGCTCTC TGGACTCCTT TCTAAGGGTC TGTGATCTGG AGATCTGCAC CATCCAGCTG 2100
GTTGGGTTGC TGCGTGGCAT TGCGGCAGGC ATGACCTACC TGTCTGACCT GGGCTACATC 2160
CACCGCGACC TGGCCGCCCG CAACATCCTG GTCAACAGCA ACCTGGTGTG TAAGGTGTCT 2220
GACTTTGGCC TGTCCAGAGT CCTGGAGGAT GACCCCGATG CTGCATACAC CACCAGTAAT 2280
GGAGGTGGGA AAATCCCAAT CCGCTGGACG GCCCCCGAGG CCATTGCATA TAGAAAGTTC 2340
TCCTCGTCGA GCGACGTGTG GAGCTACGGC GTGGTCATGT GGGAGGTGAT GTCCTACGGA 2400
GAGCGACCAT ACTGGAACCT CACCAACAGA GATGTGATCA AGTCTGTGGA AGAGGGCTAC 2460
AGGCTGCCTG CTCCAATGGG CTGCCCTGCT GCTTTACACA CACTCATGCT GGACTGCTGG 2520
CAGAAGGATC GCAACGAGAG GCCGCGCTTT TGCCAGATAG TCACTATTCT TGACAAGCTA 2580
ATCCGCAACC CGGAGAACCT GAAGTCTGTG GACAAGCTCT GCAGTTTAAA CAGTCCTCCG 2640
CTGACGGAGA GAGCTATCCC TGACTTCAGT AGCTGTAACT CAGTAGACGA GTGGCTGGAC 2700
ACCATAAAGA TGGGTCGCTA CAAGGAACAC TTTGCAGCGG GGGGCTACTA CACTCTGGGA 2760
CATGTCATAA GCATGAAGCA AGGGGATATT CAGAGGCTCG GGGTGACGCT GATGGGCCAT 2820
CAGAAGAAAA TTATGACCAG TGTCCAGCTA ATGAGGGCAC AAGTCCTCAA CAAGAGCGTC 2880
CCATCAGTGC ACGTATAA 2898
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         +kiek+iG+GefGevc Gr++lpgkr+i+va+ktlkag+tekq+rdfl+easi+ qfdhp
Q: 598   IKIEKIIGSGEFGEVCYGRMRLPGKRDIPVALKTLKAGYTEKQKRDFLAEASIMAQFDHP  657
         79**********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         n+i+leGvvt+skp mi+teymeng+ldsflr  d ++ +iqlvg+lrGia+gm ylsd+
Q: 658   NVIHLEGVVTHSKPAMIITEYMENGSLDSFLRVCDLEICTIQLVGLLRGIAAGMTYLSDL  717
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaaytts..ggkipirwtapeaiay  178
         gy+hrdlaarnilvnsnlvckvsdfGlsrvledd++aaytts  ggkipirwtapeaiay
Q: 718   GYIHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPDAAYTTSngGGKIPIRWTAPEAIAY  777
         ****************************************998899**************
S: 179   rkftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlml  238
         rkf+s+sdvwsyG+v+wev+syGerpyw+++n+dvik++eegyrlp+pm+cpaal+ lml
Q: 778   RKFSSSSDVWSYGVVMWEVMSYGERPYWNLTNRDVIKSVEEGYRLPAPMGCPAALHTLML  837
         ************************************************************
S: 239   dcwqkdraerpkfeqivsi  257
         dcwqkdr+erp+f qiv+i
Q: 838   DCWQKDRNERPRFCQIVTI  856
         ****************987
Domain Sequence
(FASTA)
IKIEKIIGSG EFGEVCYGRM RLPGKRDIPV ALKTLKAGYT EKQKRDFLAE ASIMAQFDHP 60
NVIHLEGVVT HSKPAMIITE YMENGSLDSF LRVCDLEICT IQLVGLLRGI AAGMTYLSDL 120
GYIHRDLAAR NILVNSNLVC KVSDFGLSRV LEDDPDAAYT TSNGGGKIPI RWTAPEAIAY 180
RKFSSSSDVW SYGVVMWEVM SYGERPYWNL TNRDVIKSVE EGYRLPAPMG CPAALHTLML 240
DCWQKDRNER PRFCQIVTI 259
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00010
EKS-ANC-00008
EKS-BOT-00009
EKS-CAJ-00010
EKS-CAF-00011
EKS-CAP-00008
EKS-DAR-00014
EKS-EQC-00011
EKS-FEC-00008
EKS-GAG-00009
EKS-GAA-00013
EKS-GOG-00010
EKS-HOS-00010
EKS-ICT-00010
EKS-LOA-00011
EKS-MAM-00008
EKS-MEG-00008
EKS-MOD-00010
EKS-MUM-00011
EKS-MUP-00011
EKS-NOL-00010
EKS-OCP-00001
EKS-ORN-00013
EKS-ORC-00010
EKS-OTG-00011
EKS-RAN-00010
EKS-SUS-00008
EKS-TAG-00007
EKS-TAR-00021
EKS-TEN-00009
EKS-XIM-00014
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005004; F:GPI-linked ephrin receptor activity
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR020691; EphrinA_rcpt8.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013