EKS-ORL-00538

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00538

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	364.4	4.4E-109	14	307	294

Status

Unreviewed

Ensembl Protein

ENSORLP00000015813

UniProt Accession

H2MB92;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK15

Gene Synonyms/Alias

MAPK15;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000012626	ENSORLP00000015813	ENSORLT00000015814

Organism

Oryzias latipes

Functional Description

Protein Length

587

Protein Sequence
(FASTA)

ANVSEMEEHI FHKYDIKKRL GKGAYGIVWK GVDRKTGETV AVKKIFDAFR NSTDAQRTFR 60

EIMFLQEFGD HPNIVKLINV LRAENDKDIY LIFEYMDTDL HTVIKKGSLL KDIHKRYVMY 120

QLFKAIKYLH SGNVIHRDQK PSNVLLDTDC VVKLCDFGLA RSLNQVQEDS VNPALTEYVA 180

TRWYRAPEIL LGSTSQRYTK GVDMWSLGCV LGEMLLGKAL FPGTSTINQI EKIMSAIPHP 240

SPDDMFAIKS EYGSSVIQRM LLKPQVPLED LLPPSVPHDA LNLVKSLLVF NPEKRLTAEQ 300

ALQHPYVARF HNPAKEPSLN YDVVLPVDDD VQLSVVQYRN KLYEMMLEWK SKNAMLKLPQ 360

AVGCVSSPGK PNAKSERGEK KPVTAKSHRD GDREAKPACK QADQEKHVHL NADVTNAEAA 420

NVKSTLGKTS PITRPGFRKP SYNPITHTGI EIVSRKQPGQ TTNETTATLP AEGPNISASM 480

DQILQRGRSA PVAHNHSFSS TLIQTQKNSL VRKEDKSLSA GLHITSTQLV WTQSSNSRVR 540

EAPPPHRPSK KVFQNNCNVL AAGDPRAKLG SYSQAYGTIN KTELDSL 587

Nucleotide Sequence
(FASTA)

GCAAATGTCT CAGAGATGGA GGAGCACATT TTCCACAAAT ATGACATCAA GAAGAGGCTC 60

GGTAAAGGGG CATATGGGAT TGTATGGAAA GGTGTTGACA GAAAGACAGG GGAGACTGTG 120

GCGGTGAAAA AGATATTTGA TGCCTTCAGA AACAGCACAG ACGCCCAGAG AACGTTCAGA 180

GAAATAATGT TTCTTCAGGA GTTTGGAGAT CACCCCAACA TCGTGAAACT CATAAACGTC 240

CTCCGTGCAG AAAATGACAA AGACATTTAC CTCATCTTTG AGTATATGGA TACTGACTTG 300

CACACTGTTA TAAAGAAAGG CTCCCTCTTG AAGGACATCC ATAAGCGTTA TGTGATGTAC 360

CAACTCTTCA AAGCCATTAA ATACCTCCAT TCAGGAAATG TTATTCACAG AGACCAAAAG 420

CCTTCTAATG TGCTGCTGGA CACTGACTGT GTGGTCAAGT TGTGTGATTT TGGATTGGCT 480

CGATCACTCA ACCAGGTGCA AGAAGACAGT GTGAATCCAG CACTGACAGA GTACGTGGCC 540

ACTCGCTGGT ATCGAGCTCC TGAAATCCTG CTAGGATCCA CAAGTCAAAG GTACACTAAG 600

GGAGTGGACA TGTGGAGCCT TGGCTGTGTC CTGGGAGAGA TGCTGCTGGG GAAAGCCCTT 660

TTTCCCGGAA CATCCACCAT CAACCAAATA GAGAAGATCA TGAGTGCCAT CCCTCACCCC 720

AGCCCAGATG ATATGTTTGC TATCAAATCA GAATACGGGT CGTCTGTCAT TCAGAGAATG 780

CTGTTAAAAC CACAGGTGCC TTTGGAGGAT CTTCTTCCAC CGTCTGTGCC TCATGATGCT 840

CTCAACCTCG TGAAAAGTTT ACTAGTTTTT AACCCAGAGA AGCGGCTGAC TGCAGAACAA 900

GCCCTCCAGC ATCCATATGT AGCCAGGTTT CACAATCCAG CTAAAGAGCC CAGTCTCAAC 960

TATGATGTTG TTCTGCCAGT GGATGATGAT GTACAGTTAT CAGTGGTTCA ATACCGCAAC 1020

AAACTTTATG AGATGATGCT GGAGTGGAAG AGCAAAAACG CAATGCTGAA GTTGCCACAG 1080

GCTGTAGGCT GTGTCAGCAG TCCGGGGAAG CCGAATGCCA AGAGTGAACG AGGAGAGAAG 1140

AAGCCGGTGA CAGCGAAAAG CCACAGAGAT GGTGACCGGG AGGCGAAACC AGCATGCAAG 1200

CAGGCCGACC AGGAAAAGCA TGTGCATTTA AACGCCGATG TTACTAACGC TGAAGCAGCA 1260

AACGTCAAAT CTACTTTAGG GAAGACAAGC CCAATAACTC GCCCTGGTTT CAGAAAACCA 1320

TCATATAATC CAATCACTCA TACAGGTATA GAAATAGTCA GCAGGAAGCA ACCGGGACAA 1380

ACTACTAATG AAACCACAGC AACACTACCA GCAGAGGGAC CCAATATTAG TGCATCCATG 1440

GATCAGATTC TGCAGCGTGG TCGCTCAGCC CCTGTGGCCC ACAACCACTC CTTCTCCTCC 1500

ACCCTAATCC AAACACAGAA AAACTCTTTA GTGCGCAAAG AGGACAAGTC TTTATCTGCT 1560

GGCCTGCACA TCACATCAAC CCAGCTAGTG TGGACCCAGA GCTCAAACTC TCGTGTTCGT 1620

GAGGCTCCGC CGCCGCACCG TCCCAGCAAA AAGGTCTTCC AGAATAACTG CAATGTGTTG 1680

GCTGCTGGTG ACCCACGAGC CAAACTCGGC AGCTACTCCC AAGCCTATGG TACTATCAAC 1740

AAGACAGAAC TTGACAGTCT C 1761

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkel.kheN  59

         y+ +k+lg+Gayg+v++ vd++t+e+va+kk++++f+++t+a+rt+RE+++l+e+ +h+N

Q: 14    YDIKKRLGKGAYGIVWKGVDRKTGETVAVKKIFDAFRNSTDAQRTFREIMFLQEFgDHPN  73

         677899******************************************************

S: 60    iiklldvftpeeeleelkdvYlvtelmetdLkkviksq.klsdehiklllyqilrglkyl  118

         i+kl++v+++e+     kd+Yl++e+m+tdL++vik+   l+d h ++++yq+++++kyl

Q: 74    IVKLINVLRAEN----DKDIYLIFEYMDTDLHTVIKKGsLLKDIHKRYVMYQLFKAIKYL  129

         *********999....9********************9899*******************

S: 119   HsanviHrDlKPsNllvnedcelkildFGlarsadkekekk....lteyvatrwYraPei  174

         Hs nviHrD+KPsN+l+++dc +k++dFGlars ++ +e +    lteyvatrwYraPei

Q: 130   HSGNVIHRDQKPSNVLLDTDCVVKLCDFGLARSLNQVQEDSvnpaLTEYVATRWYRAPEI  189

         *********************************777766556789***************

S: 175   ll..slkeytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkie  232

         ll  ++++ytk vD+Ws+GC+l+E+l gk lfpg+++i+q+eki++ +++ps +++ +i+

Q: 190   LLgsTSQRYTKGVDMWSLGCVLGEMLLGKALFPGTSTINQIEKIMSAIPHPSPDDMFAIK  249

         **87789*****************************************************

S: 233   seearnyikslpkkkkkdfeelfpk.aseealdLleklLvldpdkRisveeaLehpYl  289

         se  +++i+++  k++ ++e+l+p    ++al+L+++lLv++p+kR+++e+aL+hpY+

Q: 250   SEYGSSVIQRMLLKPQVPLEDLLPPsVPHDALNLVKSLLVFNPEKRLTAEQALQHPYV  307

         ***********************9857899***************************7

Domain Sequence
(FASTA)

YDIKKRLGKG AYGIVWKGVD RKTGETVAVK KIFDAFRNST DAQRTFREIM FLQEFGDHPN 60

IVKLINVLRA ENDKDIYLIF EYMDTDLHTV IKKGSLLKDI HKRYVMYQLF KAIKYLHSGN 120

VIHRDQKPSN VLLDTDCVVK LCDFGLARSL NQVQEDSVNP ALTEYVATRW YRAPEILLGS 180

TSQRYTKGVD MWSLGCVLGE MLLGKALFPG TSTINQIEKI MSAIPHPSPD DMFAIKSEYG 240

SSVIQRMLLK PQVPLEDLLP PSVPHDALNL VKSLLVFNPE KRLTAEQALQ HPYV 294

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013