EKS-ORL-00439

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00439

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	433.9	2.1E-130	243	493	251

Status

Unreviewed

Ensembl Protein

ENSORLP00000015923

UniProt Accession

H2MBJ8;

Protein Name

Protein Synonyms/Alias

Gene Name

LYN

Gene Synonyms/Alias

LYN;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000012708	ENSORLP00000015921	ENSORLT00000015922
ENSORLG00000012708	ENSORLP00000015923	ENSORLT00000015924

Organism

Oryzias latipes

Functional Description

Protein Length

508

Protein Sequence
(FASTA)

MGCIKSILIG ELTNGVEEKG SQQAAQTDQA HYVRDPTSTS KSTRVCGKRQ SLCSTEENKS 60

YKIVIGLYPY EAVHSDDLGF KKGEKMKVLE ERGEWWKARS LTTNKEGFIP CNYVAQANTM 120

ETEEWFFKDL TRKDAERQLM APANKPGSYL IRESETSKGS YSLSIRDRDN QGMDLVKHYK 180

IRKLDNGGFF ISPKISFNDI GSMVKHYHSK ADGLCRKLES PCVKPKAQKP WAKDAWEISK 240

DSIKMVKKLG AGQFGEVWMA YYNNTTKVAV KTLKPGTMTV EAFLEEANIM KTLQHERLVR 300

LYAVVTKTEP IYIITEYMAN GSLLDFLKSE VGGKLQLPKL IDFSAQIAEG MSFIEKRNYI 360

HRDLRAANVL VSESLLCKIA DFGLARVIED DEYSAREGAK FPIKWTAPEA INYGSFTIKS 420

DMWSFGVLLY EIITFGKIPY PGMTKGEVVS SIQRGYRMPR PENCPTQLYE IMTSCWKFRP 480

EDRPTFEYMQ SVLDDFYTAT EDQYQHQP 508

Nucleotide Sequence
(FASTA)

ATGGGCTGTA TTAAATCCAT ACTGATAGGA GAACTGACGA ATGGGGTGGA GGAGAAGGGC 60

AGCCAGCAGG CTGCACAGAC TGACCAAGCG CACTATGTGA GGGACCCAAC CTCTACTTCA 120

AAGAGCACCA GGGTGTGTGG CAAAAGACAG TCCCTTTGCT CAACAGAAGA AAACAAATCA 180

TACAAAATAG TGATTGGCCT TTACCCGTAT GAAGCCGTCC ATTCTGATGA CCTGGGCTTC 240

AAGAAAGGAG AGAAGATGAA GGTCTTGGAG GAACGCGGAG AATGGTGGAA AGCAAGATCT 300

CTGACCACCA ACAAAGAAGG ATTCATCCCG TGCAATTATG TCGCCCAAGC TAACACCATG 360

GAAACAGAGG AGTGGTTTTT CAAAGACCTC ACACGGAAGG ATGCTGAGAG ACAGCTGATG 420

GCGCCAGCAA ACAAACCGGG TTCTTATCTC ATCAGAGAGA GCGAAACATC AAAAGGGAGT 480

TACTCGCTGT CGATAAGAGA CAGGGACAAC CAAGGCATGG ACTTAGTAAA ACATTACAAG 540

ATCCGGAAGC TAGATAACGG GGGCTTCTTC ATTTCTCCTA AAATCTCCTT CAACGACATT 600

GGCAGCATGG TCAAACACTA CCACAGCAAA GCGGATGGCC TGTGCCGAAA GCTGGAATCC 660

CCTTGTGTGA AACCCAAAGC GCAGAAGCCA TGGGCTAAAG ATGCCTGGGA GATTTCCAAA 720

GATTCAATAA AAATGGTGAA GAAGCTGGGA GCCGGGCAGT TTGGAGAAGT CTGGATGGCA 780

TACTACAACA ATACAACCAA AGTCGCTGTG AAGACGCTGA AGCCGGGCAC CATGACAGTG 840

GAAGCTTTCC TGGAGGAAGC CAACATCATG AAGACCCTCC AGCACGAGCG GCTGGTGCGC 900

CTCTATGCTG TGGTCACCAA GACGGAGCCC ATCTACATCA TCACAGAATA CATGGCAAAC 960

GGAAGTCTTT TAGACTTTTT AAAGAGCGAG GTGGGCGGCA AACTGCAACT ACCGAAACTT 1020

ATCGATTTCT CAGCACAGAT TGCAGAAGGG ATGTCGTTTA TTGAAAAGAG GAACTACATC 1080

CACAGAGACC TGAGGGCGGC GAACGTACTG GTCTCTGAGA GTCTGCTGTG CAAAATCGCA 1140

GATTTTGGTT TGGCTAGAGT CATAGAGGAT GATGAGTACT CAGCCAGGGA GGGAGCCAAG 1200

TTCCCCATCA AATGGACGGC TCCCGAGGCC ATCAACTATG GAAGCTTCAC CATCAAATCA 1260

GACATGTGGT CGTTTGGAGT CCTGCTCTAT GAGATCATCA CCTTCGGGAA GATTCCGTAC 1320

CCGGGAATGA CTAAAGGAGA GGTGGTGTCG TCGATTCAGC GAGGCTACAG GATGCCCCGC 1380

CCCGAAAACT GCCCCACTCA GCTGTACGAA ATCATGACGT CCTGCTGGAA GTTCCGACCC 1440

GAAGACCGAC CCACCTTTGA ATACATGCAG AGCGTCCTGG ATGACTTTTA CACAGCCACG 1500

GAGGACCAGT ACCAGCACCA ACCATAG 1527

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         +k+vkklG+GqfGevw++++++++kvavktlk+gt++ eafleea+i+k+l+he+lv+ly

Q: 243   IKMVKKLGAGQFGEVWMAYYNNTTKVAVKTLKPGTMTVEAFLEEANIMKTLQHERLVRLY  302

         689*********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avv++ ePiyi+te+ma+Gslldflk+e g kl+lpkl+d++aq+aeGm+++e++n+ihr

Q: 303   AVVTKTEPIYIITEYMANGSLLDFLKSEVGGKLQLPKLIDFSAQIAEGMSFIEKRNYIHR  362

         ************************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+nvlv+esl++k+adfGlar+ieddey+a+egak+PikWtaPeai++g+ftiksd+

Q: 363   DLRAANVLVSESLLCKIADFGLARVIEDDEYSAREGAKFPIKWTAPEAINYGSFTIKSDM  422

         ************************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfG+ll+ei+t Gk+PypGmt+ ev+++++rgyr+prpe+cp++lye++++cwk +pe+

Q: 423   WSFGVLLYEIITFGKIPYPGMTKGEVVSSIQRGYRMPRPENCPTQLYEIMTSCWKFRPED  482

         ************************************************************

S: 241   rPtfetlqevl  251

         rPtfe++q+vl

Q: 483   RPTFEYMQSVL  493

         *******9976

Domain Sequence
(FASTA)

IKMVKKLGAG QFGEVWMAYY NNTTKVAVKT LKPGTMTVEA FLEEANIMKT LQHERLVRLY 60

AVVTKTEPIY IITEYMANGS LLDFLKSEVG GKLQLPKLID FSAQIAEGMS FIEKRNYIHR 120

DLRAANVLVS ESLLCKIADF GLARVIEDDE YSAREGAKFP IKWTAPEAIN YGSFTIKSDM 180

WSFGVLLYEI ITFGKIPYPG MTKGEVVSSI QRGYRMPRPE NCPTQLYEIM TSCWKFRPED 240

RPTFEYMQSV L 251

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013