EKS-ORL-00512
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORL-00512
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/DMPK442.46.6E-13378340263
StatusUnreviewed
Ensembl ProteinENSORLP00000015950
UniProt AccessionH2MBM6;
Protein Name
Protein Synonyms/Alias
Gene NameROCK2 (2 of 2)
Gene Synonyms/Alias ROCK2 (2 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSORLG00000012731ENSORLP00000015950ENSORLT00000015951
OrganismOryzias latipes
Functional Description
Protein Length1387
Protein Sequence
(FASTA)
IMPGAESRVE GRLKKLESLM RNPQSALNLE TLLDSMEALA HDLNYPVLRK NKNIEAFLNR 60
YEKVVSQLQE LQVKLDDFEK VKLIGRGAFG EVQLVRHKTS QKVYAMKKLS KFEMIKRSDS 120
AFFWEERNIM AFSNSPWIVQ LCCAFQDRRH LYMVMEFMPG GDLVTLTMNY DLPEKWACFY 180
TAEVVLALDA IHSMGFIHRD VKPDNMLLDH LGHLKLADFG TCMKMDSSGM VHCDTAVGTP 240
DYISPEVLQS QGGEGHYGRE CDWWSVGVFI YEMFVGETPF YAESLVGTYG KIMNHQNTLV 300
FPDDVEMSQE AKDLICAFLS DREVRLGRTG VDEIKRHPFF KNEQWTFDNI RDTVAPVVPE 360
LNSDIDTTNF DDIEEDKGHA ETFPPPKAFV GNQLPFIGFT YFKENQLLSK SSSISEEELK 420
DCKDKKDKVL EQLKKKLDQL EEQLDHEMQA KDELEQKLFK IKLKVPLRLS MIILKTDERT 480
TKQHRATSPL AVNHHGKAQM QHKKGGACPH THPSVKHTCQ LQKRPPVDMH TKQTVPTRIP 540
MPQNQPVRNI KINRIKFSQL KEANAMLKAE KEAVAQLKKS QTEAQKHAQS LEISLRETKE 600
QNSQLENNKV ELENQLRGMQ TELEEEKRDC RLGTETIADL QGRISSLEEK LSELKASLTQ 660
VQTEKMELQK KLNCLEKEKS NQDINLTFKI KSLQQSLELE EAEHKATKAK LADKSTIYKS 720
IEEEKSQALK ELESTLKEER SLKQQMEGKL LQLEKDYSML DCDYKQAQLK LEDMHGQKEI 780
LSEEVKQLTL RLEQETQKRN LMQNDLKMQN QQVSALRSSE KQFKQDLNHL KDMKQILDKQ 840
NQELRREKQE TDGQLRELKD HLEAEQQFTT LYKTQIHELK EECNEKNKAY KALQQRVAEY 900
IEERDSLAKQ LESSLTNADT ERLARSVAEE QFSQLQKEKI MKELEIEDML AKHKQELGDK 960
EATISLLEES NRTLTEDVAK LASEKEELNN QLIETQHKLM EAKELEKEIE TMKASFDKQL 1020
KTEITLKNQA VSKLTEVMNR KEKGRGGHRG IDTQILKKEK ENRMLQLQLR AEKEKLNTTI 1080
YKYQKDLNDM QALIAEENQA RLELKLALDS KDCDIERLRS QITSLSIHSL DTTSIGSGND 1140
LETADGYPDS RLEGWVSLLL KNSKRFAWDK KYVVVSSKNI LFYNSEQDKD QHLAYMSLDI 1200
SKLFHVRSVT QTDVYRADPK EIPKIFQILY DNEGESKREQ EATVETTSNI DRNNLISHKG 1260
HEFVVTLYHF PTNCETCNKP LWHVFKPPPA IECRRCHFKF HKDHLDKKEE VFAPCKVNYD 1320
MSTARDLLVL TSSKEEQQHW VSHLLKRIPK KNPTKSPQSS ALTSPTEPQL QPPSRPSPRL 1380
SPRNSPQ 1387
Nucleotide Sequence
(FASTA)
ATCATGCCGG GAGCGGAGAG CAGAGTGGAA GGCCGGCTGA AGAAGCTGGA GTCCCTCATG 60
AGGAACCCAC AGTCGGCCCT GAACTTGGAG ACTCTGCTGG ACTCTATGGA AGCGTTGGCT 120
CATGATCTGA ACTACCCTGT CCTGAGAAAA AACAAAAACA TAGAGGCCTT CCTCAACAGA 180
TATGAAAAGG TGGTGAGTCA GCTGCAAGAG CTCCAGGTGA AGCTTGACGA CTTTGAAAAG 240
GTGAAATTGA TTGGAAGAGG AGCATTTGGA GAAGTACAGC TGGTTCGACA CAAAACCTCC 300
CAGAAGGTTT ACGCCATGAA GAAGCTCAGC AAGTTTGAGA TGATCAAGCG GTCAGATTCA 360
GCTTTTTTCT GGGAGGAGAG AAACATCATG GCCTTTTCCA ACAGTCCCTG GATTGTCCAG 420
CTTTGCTGCG CCTTTCAAGA TCGTCGACAC CTCTACATGG TAATGGAGTT CATGCCCGGG 480
GGAGACCTGG TCACCCTCAC CATGAACTAT GACCTCCCTG AGAAGTGGGC TTGCTTCTAC 540
ACGGCGGAAG TGGTGCTCGC CCTGGACGCC ATCCACTCCA TGGGCTTCAT CCACCGGGAC 600
GTCAAACCCG ACAACATGCT GCTGGACCAC CTCGGACACC TGAAGCTGGC CGACTTCGGC 660
ACATGCATGA AGATGGACTC TTCAGGAATG GTGCATTGTG ACACAGCGGT GGGCACACCA 720
GACTATATCT CTCCTGAGGT GCTCCAGTCT CAAGGTGGTG AAGGTCATTA CGGCCGTGAA 780
TGCGACTGGT GGTCGGTTGG AGTTTTCATC TATGAAATGT TTGTTGGTGA AACTCCCTTC 840
TACGCAGAGT CTCTCGTTGG AACGTACGGG AAGATCATGA ATCATCAGAA CACCCTCGTC 900
TTCCCAGATG ACGTAGAAAT GTCTCAAGAG GCGAAAGATC TAATCTGCGC CTTTCTTTCC 960
GACAGGGAAG TTCGTCTGGG TCGCACTGGA GTGGATGAGA TCAAACGCCA CCCCTTCTTC 1020
AAAAATGAAC AGTGGACCTT TGACAACATC CGTGACACTG TGGCTCCAGT TGTGCCAGAG 1080
CTGAACAGCG ACATAGACAC CACCAACTTT GATGACATAG AGGAAGATAA AGGCCATGCT 1140
GAGACGTTTC CTCCACCCAA AGCCTTTGTG GGCAACCAGC TACCATTTAT TGGCTTCACA 1200
TATTTCAAGG AGAATCAGTT GTTGAGTAAA AGCAGCAGCA TTTCTGAGGA AGAATTGAAG 1260
GACTGCAAGG ATAAAAAGGA TAAAGTCTTG GAACAGCTTA AAAAGAAACT TGATCAGCTG 1320
GAGGAACAGC TTGACCATGA GATGCAAGCT AAAGATGAGC TGGAGCAAAA GTTATTCAAG 1380
ATTAAACTTA AAGTCCCACT CCGATTATCT ATGATTATTT TGAAAACAGA TGAGAGGACC 1440
ACGAAGCAGC ACAGAGCAAC AAGTCCACTG GCCGTTAATC ACCACGGCAA GGCCCAAATG 1500
CAGCACAAAA AGGGCGGAGC CTGTCCACAC ACACACCCAA GTGTCAAACA CACCTGCCAG 1560
TTGCAAAAAC GTCCACCTGT CGACATGCAC ACAAAACAGA CAGTGCCCAC ACGCATACCT 1620
ATGCCCCAAA ACCAACCAGT GCGAAACATT AAAATTAATA GAATAAAATT TTCACAGCTT 1680
AAAGAAGCGA ATGCCATGCT AAAGGCGGAA AAAGAGGCCG TGGCCCAGCT GAAGAAGAGT 1740
CAGACTGAGG CTCAGAAACA TGCACAGAGC CTGGAGATCA GCCTCAGAGA AACAAAAGAA 1800
CAAAACAGCC AACTGGAGAA CAACAAGGTG GAGTTGGAGA ACCAGCTCAG AGGAATGCAG 1860
ACAGAGCTGG AGGAGGAAAA GAGGGACTGC CGTCTTGGGA CAGAAACCAT TGCTGACCTG 1920
CAGGGACGAA TCTCTAGTTT GGAAGAAAAG CTGAGCGAGC TGAAGGCGTC TCTCACCCAG 1980
GTCCAAACGG AGAAGATGGA GCTACAGAAG AAACTTAACT GTCTTGAAAA GGAAAAAAGC 2040
AACCAGGACA TCAATCTGAC ATTTAAGATC AAGTCGCTCC AGCAGAGTTT GGAGCTGGAG 2100
GAGGCGGAAC ACAAGGCCAC AAAAGCCAAA CTTGCTGATA AGAGCACGAT TTATAAGTCC 2160
ATAGAGGAGG AGAAGTCTCA GGCTTTAAAA GAGTTGGAGA GCACCTTGAA GGAGGAGCGC 2220
AGCTTGAAGC AGCAGATGGA GGGGAAGCTG CTGCAGCTGG AGAAGGACTA CTCCATGCTG 2280
GACTGCGATT ACAAGCAGGC ACAGCTCAAG CTGGAGGACA TGCATGGGCA GAAGGAAATA 2340
CTGTCTGAAG AGGTCAAGCA GCTGACCTTG CGTTTGGAGC AGGAGACACA GAAACGGAAT 2400
TTGATGCAGA ATGATCTGAA GATGCAGAAC CAACAGGTGT CTGCACTTCG CTCATCAGAG 2460
AAGCAGTTTA AGCAGGATCT CAACCATCTG AAGGACATGA AGCAGATCCT AGACAAGCAG 2520
AATCAGGAGC TACGCAGGGA AAAACAAGAG ACTGATGGCC AGTTGAGGGA ACTGAAGGAC 2580
CACCTGGAGG CAGAGCAACA ATTCACAACG CTTTACAAAA CACAGATCCA TGAGCTGAAG 2640
GAGGAGTGCA ACGAGAAGAA TAAGGCGTAC AAAGCGTTGC AGCAGCGAGT CGCAGAATAC 2700
ATAGAGGAAA GGGATTCTCT GGCAAAACAG CTGGAATCCA GTTTAACCAA TGCCGATACA 2760
GAGCGCCTGG CCCGCTCCGT TGCCGAGGAG CAGTTCTCCC AACTGCAGAA GGAGAAGATC 2820
ATGAAAGAGC TGGAGATTGA AGACATGCTG GCCAAACACA AGCAGGAGCT CGGTGACAAG 2880
GAGGCCACCA TTAGCTTGCT GGAGGAGTCC AATCGCACCC TGACTGAGGA TGTGGCTAAG 2940
CTGGCCAGTG AAAAGGAAGA ACTCAACAAC CAACTGATAG AAACACAACA CAAGCTCATG 3000
GAAGCCAAGG AGTTGGAGAA AGAGATAGAG ACAATGAAGG CGTCTTTTGA CAAGCAGCTA 3060
AAGACTGAAA TCACCCTCAA GAATCAGGCT GTGAGCAAAC TGACTGAGGT GATGAACAGA 3120
AAGGAGAAGG GACGGGGAGG CCATCGAGGC ATCGATACAC AGATACTCAA GAAGGAAAAG 3180
GAGAATAGGA TGCTGCAGCT TCAGCTGAGG GCAGAAAAGG AGAAACTCAA CACCACCATA 3240
TACAAATACC AGAAGGATCT GAACGACATG CAGGCGCTGA TAGCAGAAGA GAACCAGGCC 3300
CGTTTGGAGC TTAAGCTGGC GCTGGACAGC AAAGACTGTG ACATCGAGCG ACTCCGGTCC 3360
CAGATCACCT CCCTCAGCAT CCATTCTCTA GACACCACCA GCATCGGCAG TGGAAACGAC 3420
CTGGAAACGG CTGATGGATA TCCAGACTCC AGGCTGGAGG GTTGGGTTTC GCTTCTTCTC 3480
AAGAATTCAA AGCGATTTGC CTGGGACAAA AAATATGTGG TTGTAAGCAG TAAGAATATA 3540
TTGTTCTACA ACAGCGAGCA GGACAAAGAT CAACATCTCG CTTACATGAG TTTGGACATC 3600
AGTAAGCTGT TCCACGTTCG CTCCGTCACT CAAACAGACG TGTACCGTGC AGATCCCAAA 3660
GAAATTCCAA AGATATTTCA GATCCTCTAC GACAACGAAG GCGAGAGCAA ACGAGAGCAG 3720
GAAGCCACAG TGGAAACCAC TTCCAACATC GACCGGAACA ATCTCATCAG CCACAAAGGC 3780
CACGAGTTTG TTGTCACTCT CTATCACTTC CCCACCAACT GTGAGACTTG CAACAAGCCC 3840
CTGTGGCACG TCTTCAAGCC CCCGCCGGCC ATCGAGTGCC GCCGCTGTCA CTTCAAGTTC 3900
CACAAGGACC ATTTGGACAA AAAAGAAGAA GTTTTTGCTC CCTGCAAAGT GAACTATGAC 3960
ATGTCCACTG CCAGAGACCT GCTGGTGCTA ACCAGCTCCA AAGAGGAACA GCAGCACTGG 4020
GTCAGCCACC TCCTCAAGCG CATCCCAAAG AAAAACCCGA CAAAGAGTCC TCAGTCTTCA 4080
GCGCTGACCA GCCCCACGGA ACCACAGTTG CAGCCTCCTT CCCGACCCTC CCCGCGCCTT 4140
TCACCAAGAA ATTCTCCTCA G 4161
Domain Profile
S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60
         fe +k+iGrGafgev++vr+k+++kvyamk+l+k+e++kr++saff+eer+++++++s+w
Q: 78    FEKVKLIGRGAFGEVQLVRHKTSQKVYAMKKLSKFEMIKRSDSAFFWEERNIMAFSNSPW  137
         7899********************************************************
S: 61    ivqlqyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelg  120
         ivql +afqd ++ly+vme+++GGdl+tl  +y+  lpe++a fy+ae+vlald++h++g
Q: 138   IVQLCCAFQDRRHLYMVMEFMPGGDLVTLTMNYD--LPEKWACFYTAEVVLALDAIHSMG  195
         **********************************..************************
S: 121   yvhrdikpdnilldksGhikladfGsclklnedgtvkssvavGtpdyispevlkaleegk  180
         ++hrd+kpdn+lld+ Gh+kladfG+c+k+++ g+v++++avGtpdyispevl++++ g+
Q: 196   FIHRDVKPDNMLLDHLGHLKLADFGTCMKMDSSGMVHCDTAVGTPDYISPEVLQSQG-GE  254
         ********************************************************9.9*
S: 181   geygkecdwwslGvilyellvgetpfyaeslvetyskilnhkeslkfpedekvseeakdl  240
         g+yg+ecdwws+Gv++ye++vgetpfyaeslv ty+ki+nh+++l fp+d+++s+eakdl
Q: 255   GHYGRECDWWSVGVFIYEMFVGETPFYAESLVGTYGKIMNHQNTLVFPDDVEMSQEAKDL  314
         ************************************************************
S: 241   ikklltsreerlgregiedlkkhpff  266
         i+++l++re rlgr g++++k+hpff
Q: 315   ICAFLSDREVRLGRTGVDEIKRHPFF  340
         *************************9
Domain Sequence
(FASTA)
FEKVKLIGRG AFGEVQLVRH KTSQKVYAMK KLSKFEMIKR SDSAFFWEER NIMAFSNSPW 60
IVQLCCAFQD RRHLYMVMEF MPGGDLVTLT MNYDLPEKWA CFYTAEVVLA LDAIHSMGFI 120
HRDVKPDNML LDHLGHLKLA DFGTCMKMDS SGMVHCDTAV GTPDYISPEV LQSQGGEGHY 180
GRECDWWSVG VFIYEMFVGE TPFYAESLVG TYGKIMNHQN TLVFPDDVEM SQEAKDLICA 240
FLSDREVRLG RTGVDEIKRH PFF 263
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Sequence SourceEnsembl
Orthology
Ortholog group
Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>
EKS-TAR-00553
EKS-TEN-00557
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0046872; F:metal ion binding
GO:0005543; F:phospholipid binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0000910; P:cytokinesis
GO:0035556; P:intracellular signal transduction
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR017892; Pkinase_C.
IPR001849; Pleckstrin_homology.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR020684; Rho-assoc_coiled-coil_kin.
IPR015008; Rho-bd.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
PF08912; Rho_Binding; 1.
SMARTs
SM00109; C1; 1.
SM00233; PH; 1.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS50081; ZF_DAG_PE_2; 1.
Prints
Created Date20-Feb-2013