EKS-ORL-00450

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00450

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	319.5	2.0E-95	163	398	236

Status

Unreviewed

Ensembl Protein

ENSORLP00000016089

UniProt Accession

H2MC11;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K12 (2 of 2)

Gene Synonyms/Alias

MAP3K12 (2 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000012844	ENSORLP00000016089	ENSORLT00000016090

Organism

Oryzias latipes

Functional Description

Protein Length

914

Protein Sequence
(FASTA)

TCIHEPRAPS PSLSGFSTPI SEPPYRRLDG DTPACTPETD LTPTQCVLRN VLSIDTGGQG 60

APCGSSPTPS DGPSAQFDNS VLKLHEHEAC HCGGAEADHS PEAGAVRSQS ESIRLQSGSG 120

GFLEGLFGCL KPVWTMIGKA YSTEHKHNHE ESWEVPFEEI SDLQWVGSGA QGAVFLGKFH 180

GEEVAVKKVR DIKETEIKHL RKLKHPNIIT FKGVCTQAPC YCILMEYCAQ GQLYEVLRAG 240

RKITPSLLVD WSMGIAGGMN YLHLHKIIHR DLKSPNMLIT HDDLVKISDF GTSKELSDKS 300

TKMSFAGTVA WMAPEVIRNE PVSEKVDIWS FGVVLWEMLT GEIPYKDVDS SAIIWGVGNN 360

SLQLPIPESC PDGFKILLRQ CWNCKPRNRP SFRQILLHLD IASADVLSTP QETYFKSQAE 420

WREEVKQHFE KIKSEGTCLH RLDEELINRR REELRHALDI REHYERKLER ANNLYMELSA 480

VMLQLELKEK ELQRREQSLD KKYPGLFKHH SSRQGSSSNT MDKIIKKRNV PQKLPSGKRP 540

DIPKSELIIP KMDSSVMQVT FPTCPNRGST SPSRSRRVKT RHRKPGKGSS GDLAGLKANQ 600

PSPNRDTTVQ TNSSTNNTSN QLLEPSAALR GLGHEQQQRQ LSSSSPDLIC NTLEADGQGK 660

KGGAAGLDDL TETPPRSDTP SEDAASFPFS SSPDSPCGKG AAAGRGSLGS PRLPHDGEDK 720

EDGAGAVRLP RGASGGIGSQ HLTPSAILYR AAITRKQRRG VSSEEEEGEV DSEFELPRRR 780

RPTSITKCQS VSTFSSENLS VSDGEEGHTT DHSHSGTPDV VSTNTDDKLD DRSDDLLSQG 840

SEIPVDNTDP AQTSDGLSER DGGLGQAKAQ LEAGQNSNES RALCDDSDCD SAELDQSGSG 900

EPSRPPSAGA WVSP 914

Nucleotide Sequence
(FASTA)

ACCTGTATCC ATGAGCCCCG TGCCCCTTCC CCCTCCCTGT CAGGCTTCAG CACACCCATC 60

TCTGAACCCC CATATCGACG ACTCGATGGA GACACCCCTG CTTGCACCCC TGAAACGGAC 120

CTGACCCCCA CACAGTGTGT TCTCCGTAAC GTGCTGTCCA TTGACACCGG TGGACAAGGG 180

GCACCCTGCG GCAGCAGCCC CACTCCCAGT GATGGACCCT CAGCTCAGTT TGACAACAGC 240

GTGCTAAAAT TACATGAACA TGAGGCCTGC CACTGCGGCG GAGCCGAAGC AGACCACAGT 300

CCGGAGGCTG GAGCCGTCCG GAGCCAGTCT GAGAGCATTC GGCTACAGTC GGGAAGCGGA 360

GGGTTTTTGG AGGGATTGTT TGGCTGCCTA AAACCAGTCT GGACAATGAT CGGAAAAGCC 420

TACTCTACTG AACACAAACA TAACCATGAA GAATCATGGG AAGTTCCTTT TGAAGAAATC 480

TCTGACCTGC AATGGGTGGG CAGTGGCGCT CAGGGGGCTG TCTTCCTCGG GAAGTTTCAC 540

GGAGAGGAGG TGGCCGTGAA AAAAGTGCGG GACATCAAAG AGACGGAGAT CAAACACCTG 600

CGCAAACTCA AGCATCCTAA CATCATTACC TTCAAGGGTG TGTGCACCCA GGCTCCCTGC 660

TACTGTATCT TGATGGAATA TTGTGCTCAA GGCCAGCTGT ATGAGGTGCT CAGGGCAGGC 720

CGTAAAATCA CTCCCTCCCT CCTGGTTGAC TGGTCCATGG GCATTGCGGG TGGCATGAAC 780

TACCTACACC TCCACAAAAT CATCCACAGA GACCTCAAGT CCCCAAATAT GCTAATCACA 840

CACGATGATC TGGTGAAGAT CTCTGACTTT GGCACCTCAA AGGAGCTCAG TGACAAGAGC 900

ACTAAGATGT CGTTCGCTGG CACTGTTGCC TGGATGGCTC CTGAAGTCAT TCGGAATGAG 960

CCAGTGTCAG AAAAAGTGGA TATCTGGTCT TTTGGAGTTG TGCTATGGGA GATGCTAACT 1020

GGAGAGATCC CATATAAAGA CGTGGACTCT TCTGCCATTA TCTGGGGTGT GGGAAACAAC 1080

AGCCTACAGC TACCAATTCC AGAGAGCTGC CCAGATGGCT TCAAGATCCT CCTCAGACAG 1140

TGCTGGAACT GTAAGCCCCG AAATAGACCT TCTTTTCGTC AGATTCTTCT TCATCTGGAT 1200

ATAGCCTCAG CTGATGTACT ATCAACCCCA CAGGAAACCT ACTTTAAGTC TCAGGCTGAA 1260

TGGCGAGAGG AGGTGAAACA GCACTTTGAG AAGATTAAAT CCGAGGGCAC TTGTCTCCAC 1320

CGACTCGATG AGGAACTGAT CAACCGACGC AGAGAGGAGC TCAGGCATGC TTTGGACATT 1380

CGTGAACACT ATGAGAGGAA ACTGGAGAGG GCTAACAACC TTTACATGGA GCTAAGTGCC 1440

GTCATGCTGC AGTTGGAGCT CAAAGAGAAG GAGTTGCAGA GGCGAGAACA GTCTTTGGAT 1500

AAAAAATATC CGGGATTGTT TAAGCACCAC AGCTCCAGAC AGGGTAGCTC CTCTAACACC 1560

ATGGACAAAA TCATCAAGAA GAGGAATGTC CCACAGAAAC TGCCCTCTGG AAAGAGGCCG 1620

GATATCCCTA AGTCTGAATT AATCATTCCT AAAATGGATT CCTCCGTCAT GCAAGTCACT 1680

TTCCCAACCT GTCCCAACAG AGGCTCCACT TCTCCCAGCC GGTCTAGGAG AGTGAAGACT 1740

CGCCATCGTA AGCCTGGCAA GGGCAGCAGT GGGGATCTAG CTGGACTGAA AGCAAATCAG 1800

CCTTCCCCTA ACAGGGACAC AACTGTCCAG ACTAACAGTT CAACCAACAA CACCTCGAAT 1860

CAGCTCCTGG AGCCCTCTGC AGCCCTGCGA GGCCTGGGGC ATGAGCAGCA GCAGAGGCAG 1920

CTGTCCTCCT CCAGCCCTGA CCTCATCTGC AACACGCTGG AGGCGGACGG CCAGGGGAAA 1980

AAAGGAGGAG CAGCTGGTCT GGACGATCTC ACAGAAACCC CTCCAAGAAG TGACACCCCC 2040

AGTGAGGATG CTGCGTCATT TCCTTTCTCC AGCAGTCCAG ACTCACCATG CGGAAAGGGA 2100

GCAGCAGCAG GGAGAGGATC CCTGGGATCT CCTCGTCTGC CCCATGATGG GGAGGACAAG 2160

GAAGATGGAG CCGGTGCTGT GAGGCTACCT CGGGGGGCAT CGGGGGGAAT TGGAAGCCAA 2220

CACCTGACAC CTTCAGCCAT CTTGTATAGG GCAGCTATCA CACGCAAACA GAGGCGTGGA 2280

GTGTCATCGG AAGAGGAGGA AGGTGAAGTT GACAGTGAGT TTGAGTTGCC ACGGAGACGA 2340

CGCCCGACCA GCATTACCAA GTGCCAGTCG GTGTCCACGT TCAGCTCTGA GAACCTGTCA 2400

GTGTCAGACG GTGAGGAGGG TCACACCACA GACCATTCTC ACAGCGGCAC CCCAGACGTG 2460

GTCAGCACTA ACACTGACGA CAAGCTGGAC GACCGCAGTG ACGACCTCCT CTCTCAGGGA 2520

TCCGAGATCC CTGTGGACAA CACTGATCCT GCGCAGACCT CTGACGGCCT GTCCGAGAGA 2580

GACGGCGGTT TAGGGCAGGC CAAAGCCCAG CTCGAAGCCG GGCAGAATTC TAATGAAAGC 2640

CGGGCTCTGT GTGACGACTC TGACTGTGAC AGTGCTGAGC TGGATCAGTC CGGGAGCGGG 2700

GAGCCGAGCC GTCCTCCCAG CGCTGGAGCG TGGGTGTCCC CG 2742

Domain Profile

S: 4     eeligsgafgkvykakwrkkevavKklreeaeekekleklereakllsklshpniiellG  63

          +++gsga+g+v+ +k++++evavKk+r+ +e+         e+k+l+kl+hpnii+++G

Q: 163   LQWVGSGAQGAVFLGKFHGEEVAVKKVRDIKET---------EIKHLRKLKHPNIITFKG  213

         689**************************9999.........******************

S: 64    vcleepnlllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseapkkii  123

         vc++ p+++++mey+++g+L++vl++   r+i+++ lv+w++ iA Gm+YLh +   kii

Q: 214   VCTQAPCYCILMEYCAQGQLYEVLRA--GRKITPSLLVDWSMGIAGGMNYLHLH---KII  268

         **************************..99************************...9**

S: 124   hrdLksknvLlseekktlkicdFGtarelsk.stkmsaagtlawmaPEvlkeekvseksD  182

         hrdLks+n+L+ ++++ +ki+dFGt++els+ stkms+agt+awmaPEv+++e+vsek+D

Q: 269   HRDLKSPNMLI-THDDLVKISDFGTSKELSDkSTKMSFAGTVAWMAPEVIRNEPVSEKVD  327

         ***********.99999*************99****************************

S: 183   vwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLmkecwnedpe  242

         +wS+gvvLWe+lt+e+Pykd+++ ai+++v++++l+lpip+scp+ +k L+++cwn +p+

Q: 328   IWSFGVVLWEMLTGEIPYKDVDSSAIIWGVGNNSLQLPIPESCPDGFKILLRQCWNCKPR  387

         ************************************************************

S: 243   kRpsfseivks  253

         +Rpsf++i+ +

Q: 388   NRPSFRQILLH  398

         ********876

Domain Sequence
(FASTA)

LQWVGSGAQG AVFLGKFHGE EVAVKKVRDI KETEIKHLRK LKHPNIITFK GVCTQAPCYC 60

ILMEYCAQGQ LYEVLRAGRK ITPSLLVDWS MGIAGGMNYL HLHKIIHRDL KSPNMLITHD 120

DLVKISDFGT SKELSDKSTK MSFAGTVAWM APEVIRNEPV SEKVDIWSFG VVLWEMLTGE 180

IPYKDVDSSA IIWGVGNNSL QLPIPESCPD GFKILLRQCW NCKPRNRPSF RQILLH 236

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Gasterosteus aculeatus"; ?>Oreochromis niloticus"; ?>Petromyzon marinus"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004709	; F:MAP kinase kinase kinase activity
GO:0000186	; P:activation of MAPKK activity
GO:0000165	; P:MAPK cascade
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR017419	; MAP3K12_MAP3K13.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013