EKS-ORL-00170

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00170

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	551.8	2.6E-166	413	689	277

Status

Unreviewed

Ensembl Protein

ENSORLP00000016639

UniProt Accession

H2MDJ2;

Protein Name

Fibroblast growth factor receptor

Protein Synonyms/Alias

Gene Name

FGFR2

Gene Synonyms/Alias

FGFR2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000013277	ENSORLP00000016637	ENSORLT00000016638
ENSORLG00000013277	ENSORLP00000016639	ENSORLT00000016640

Organism

Oryzias latipes

Functional Description

Protein Length

753

Protein Sequence
(FASTA)

GEALRLSCPL PATGTITWTK DGSSLGTNNH TVIEQDVLQI RDATPKDSGL YACTSVGKDT 60

VFFIVNVTDA ISSGDDEDDT ERSEDTGLDG VQSRPPYWTS PAKMEKRLHA VPAANTVKFR 120

CAAGGNPRPS LRWLKNQKPF RQEDRMGGYK VRSQHWTLLM ESVVPSDKGN YTCVVENELG 180

SINHTYTLDV VERSPHRPIL QAGLPANTTV HVGEDARFVC KVYSDAQPHI QWLKHITQNG 240

SRLGPDGHPY VRVLKTAGVN TTDKEIEVLH LPNVTFEDAG EYTCLAGNSI GISYHTATLT 300

VLPALPLLSD SDYVEIAIYC AGVFLILCMV VIVVVCRMRT TAKKPDFNGQ PAVHKLTKQL 360

PLRRQVSSDS SSSMNSNTPL VRITTRRSSA HDLPIPEYDL PEDPRWEFSR DRLTLGKPLG 420

EGCFGQVVMA EALGIDKDKP KEAATVAVKM LKDDATEKDL SDLVSEMEMM KMMGKHKNII 480

NLLGACTQDG PLYVIVEYAS KGNLREYLRA RRPPGMEYSY DIARVSDEQL TFKDLVSCTY 540

QVARGMEYLA SKKCIHRDLA ARNVLVTESN VMKIADFGLA RDVHNIDYYK KTTNGRLPVK 600

WMAPEALFDR VYTHQSDVWS FGVLMWEIFT LGGSPYPGIP VEELFKLLKE GHRMDKPGNC 660

TNELYMMMKD CWHAISSQRP TFKQLVEDLD RILSLSTNEE YLDLCAPTEQ YSPSFPDTRS 720

SCSSGDDSVF SHDPLPDEPC LPKYQHINGN VKR 753

Nucleotide Sequence
(FASTA)

GGGGAGGCGC TGAGGCTGAG CTGCCCTCTG CCCGCGACGG GGACTATCAC ATGGACCAAA 60

GATGGCAGCT CTCTGGGCAC CAACAACCAC ACAGTGATAG AGCAGGACGT GCTGCAGATC 120

CGTGATGCCA CGCCCAAGGA TTCAGGCCTG TACGCCTGCA CCAGCGTAGG CAAAGACACG 180

GTCTTCTTCA TAGTCAATGT CACAGATGCC ATCTCCTCGG GGGATGATGA GGACGACACA 240

GAGCGGTCAG AGGACACTGG CTTGGATGGA GTTCAGTCAA GGCCTCCATA CTGGACCTCG 300

CCGGCAAAGA TGGAGAAGCG TCTGCACGCG GTGCCTGCTG CCAACACGGT CAAGTTCCGC 360

TGTGCTGCAG GAGGCAACCC GAGGCCCAGT CTGCGCTGGC TGAAGAACCA AAAGCCTTTC 420

CGCCAAGAGG ACCGCATGGG AGGGTACAAG GTGCGTTCCC AGCACTGGAC TCTGCTCATG 480

GAGAGCGTGG TGCCGTCCGA CAAGGGCAAC TACACCTGTG TGGTGGAGAA CGAGTTGGGA 540

TCCATAAACC ACACCTACAC CCTGGATGTA GTGGAGCGGT CTCCTCACCG TCCAATTCTC 600

CAGGCTGGTC TTCCCGCTAA CACCACTGTG CACGTTGGTG AAGACGCCCG CTTTGTGTGC 660

AAAGTTTACA GCGATGCTCA ACCTCACATC CAGTGGCTGA AGCACATCAC CCAGAACGGC 720

AGTCGCTTGG GTCCTGATGG CCACCCCTAC GTCAGAGTGC TAAAGACAGC CGGTGTTAAC 780

ACCACAGATA AGGAGATAGA AGTTCTCCAC TTGCCCAATG TAACATTTGA GGATGCTGGG 840

GAGTACACGT GCTTGGCGGG TAATTCTATT GGGATCTCCT ATCACACTGC TACTTTGACG 900

GTGCTTCCAG CTTTGCCACT GCTTTCAGAT TCAGACTACG TGGAGATTGC AATCTACTGT 960

GCGGGCGTCT TCCTGATCCT GTGCATGGTG GTCATCGTGG TGGTGTGCCG AATGAGGACC 1020

ACCGCAAAAA AGCCTGACTT CAACGGACAG CCAGCAGTCC ACAAACTGAC CAAACAGCTT 1080

CCTCTGCGCC GCCAGGTGTC ATCGGATTCA AGCTCTTCCA TGAACTCAAA CACTCCCCTG 1140

GTTCGGATCA CGACCCGGCG AAGTTCTGCC CACGATCTGC CCATCCCGGA ATATGACCTT 1200

CCAGAGGATC CGCGATGGGA GTTTTCCCGA GACAGGTTGA CCCTGGGCAA ACCTCTGGGT 1260

GAGGGCTGCT TCGGCCAAGT TGTAATGGCA GAAGCCCTTG GCATCGACAA GGACAAACCC 1320

AAGGAGGCTG CTACTGTCGC AGTCAAGATG CTGAAAGACG ATGCCACTGA AAAAGACCTG 1380

TCTGACCTCG TGTCAGAAAT GGAAATGATG AAGATGATGG GCAAACACAA GAACATCATC 1440

AACCTTTTGG GTGCTTGCAC ACAAGACGGT CCTCTCTATG TGATAGTAGA ATATGCCTCC 1500

AAAGGCAACC TGAGGGAATA CCTCAGAGCC CGACGGCCAC CCGGCATGGA GTACTCCTAT 1560

GACATTGCTC GTGTCTCAGA CGAACAACTG ACCTTTAAGG ATCTGGTGTC CTGCACTTAT 1620

CAGGTGGCAC GAGGCATGGA GTACCTAGCA TCAAAGAAGT GTATACACAG AGACCTGGCA 1680

GCCAGGAACG TCCTGGTTAC GGAGAGCAAC GTCATGAAGA TTGCTGATTT TGGGCTGGCC 1740

AGGGACGTCC ACAACATCGA CTACTATAAA AAGACCACAA ATGGTCGACT CCCGGTGAAA 1800

TGGATGGCTC CAGAGGCTCT CTTTGACCGG GTCTACACAC ACCAGAGTGA TGTCTGGTCG 1860

TTTGGGGTGC TGATGTGGGA GATCTTCACC CTAGGGGGTT CGCCCTACCC TGGCATTCCT 1920

GTGGAAGAGC TTTTTAAGTT GCTCAAAGAG GGCCATCGCA TGGACAAGCC TGGAAACTGC 1980

ACCAACGAGC TGTACATGAT GATGAAAGAC TGTTGGCACG CCATCTCATC TCAAAGACCC 2040

ACTTTCAAGC AGCTTGTGGA GGATCTGGAT CGGATCCTCA GCCTCAGCAC CAACGAGGAG 2100

TATCTCGATC TGTGTGCCCC GACAGAGCAG TATTCCCCCA GCTTCCCCGA CACCAGGAGC 2160

TCCTGTTCCT CCGGTGACGA CTCCGTATTT TCCCACGACC CTTTACCGGA CGAGCCCTGC 2220

CTCCCCAAGT ACCAGCACAT TAACGGGAAC GTCAAAAGAT GA 2262

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         l+lgk+lGeG+fGqvv+aea+g+dkdk+k+++tvavkmlk+dat+kdl+dlvseme++k+

Q: 413   LTLGKPLGEGCFGQVVMAEALGIDKDKPKEAATVAVKMLKDDATEKDLSDLVSEMEMMKM  472

         79**********************************************************

S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120

         +GkhkniinllGactq+Gplyviveya+kGnlre+lrarrp+g+e+s+d +++s+eqlt+

Q: 473   MGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDIARVSDEQLTF  532

         ************************************************************

S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180

         kdlvs++yqvarGmeylaskkcihrdlaarnvlvte nv+kiadfGlardvh+idyykkt

Q: 533   KDLVSCTYQVARGMEYLASKKCIHRDLAARNVLVTESNVMKIADFGLARDVHNIDYYKKT  592

         ************************************************************

S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240

         tnGrlpvkwmapealfdrvyt+qsdvwsfGvl+wei+tlGgspypgi+veelfkllkeGh

Q: 593   TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH  652

         ************************************************************

S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         rm+kp +ct+ely++m++cwha +s+rptfkqlvedl

Q: 653   RMDKPGNCTNELYMMMKDCWHAISSQRPTFKQLVEDL  689

         ***********************************97

Domain Sequence
(FASTA)

LTLGKPLGEG CFGQVVMAEA LGIDKDKPKE AATVAVKMLK DDATEKDLSD LVSEMEMMKM 60

MGKHKNIINL LGACTQDGPL YVIVEYASKG NLREYLRARR PPGMEYSYDI ARVSDEQLTF 120

KDLVSCTYQV ARGMEYLASK KCIHRDLAAR NVLVTESNVM KIADFGLARD VHNIDYYKKT 180

TNGRLPVKWM APEALFDRVY THQSDVWSFG VLMWEIFTLG GSPYPGIPVE ELFKLLKEGH 240

RMDKPGNCTN ELYMMMKDCW HAISSQRPTF KQLVEDL 277

Keyword

ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0008284	; P:positive regulation of cell proliferation

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR013151	; Immunoglobulin.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 2.
PF00047	; ig; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 3.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013