EKS-ORL-00199
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORL-00199
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKC473.03.2E-142266523258
StatusUnreviewed
Ensembl ProteinENSORLP00000017353
UniProt AccessionH2MFH9;
Protein Name
Protein Synonyms/Alias
Gene NamePRKCA (1 of 2)
Gene Synonyms/Alias PRKCA (1 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSORLG00000013842ENSORLP00000017353ENSORLT00000017354
OrganismOryzias latipes
Functional Description
Protein Length544
Protein Sequence
(FASTA)
QKCHSEVHRS FRGLSRGKPD YDPRTKHKFK IHTFGSPTFC DHCGSLLYGL IHQGMKCDSC 60
DMNVHKQCVM NVPSLCGMDH TEKRGRLLLR CEVSGDKLKV AVNEGKNLIP MDPNGLSDPY 120
VKLKLIPDPK NETKQKTKTI RSNLNPKWNE NFTFKLKPSD KDRRLSIEVW DWDRTTRNDF 180
MGALSFGVSE LMKSPAYGWY KLLCQEEGEY YNVPISVEDD GNEELRQKFE KAKLGPGKKV 240
INETEESRSN QMLTNSLNQV KLNDLSFLAV LGKGSFGKVM LAEMKATGEL YAVKILKKDV 300
VIQDDDVECT MVEKRVLAQQ DKPPFLTQLH SCFQTVDRLY FVMEYVNGGD LMYHIQQVGK 360
FKEPQAVFYA AEIAVGLFFL HRKGIIYRDL KLDNVMLDAE GHIKIADFGM CKENMLEGVT 420
TRTFCGTPDY IAPEIIAYQP YGLSVDWWAY GVLLYEMLAG QPPFDGEDED ELFQSIMEHN 480
VSYPKSMSKE AVSICKGLMT KHPSKRLGCS REEERDIREH AFFRRIDWDR LQNREIQPPF 540
KPKV 544
Nucleotide Sequence
(FASTA)
CAGAAATGCC ACTCAGAAGT TCATCGCAGT TTTCGCGGAC TGTCGCGAGG AAAACCAGAC 60
TACGATCCCA GAACAAAGCA CAAGTTCAAG ATCCACACAT TTGGCAGCCC CACTTTCTGC 120
GACCACTGTG GCTCTCTGCT TTATGGTCTC ATTCACCAGG GGATGAAGTG TGACTCGTGC 180
GATATGAACG TTCACAAGCA GTGTGTGATG AACGTGCCCA GCCTGTGTGG AATGGATCAC 240
ACTGAGAAAA GGGGCCGTCT TCTCCTCAGG TGTGAGGTCA GTGGGGACAA GCTGAAGGTC 300
GCAGTGAACG AAGGGAAGAA CCTGATCCCT ATGGACCCCA ACGGCCTGTC TGATCCATAC 360
GTAAAGCTGA AGCTCATCCC AGATCCCAAA AATGAGACCA AGCAGAAAAC CAAAACCATC 420
CGCTCCAACC TCAACCCCAA ATGGAACGAG AACTTCACTT TCAAGCTGAA GCCCTCAGAT 480
AAGGACCGCA GGCTGTCAAT TGAAGTGTGG GACTGGGATC GAACCACCAG GAATGACTTC 540
ATGGGAGCTC TATCGTTTGG AGTTTCCGAG CTCATGAAGT CTCCAGCCTA TGGATGGTAT 600
AAACTACTGT GCCAGGAGGA GGGGGAGTAC TACAATGTTC CCATATCCGT AGAAGATGAT 660
GGCAATGAGG AGCTGAGGCA GAAATTTGAG AAGGCCAAAC TGGGTCCTGG GAAGAAGGTG 720
ATCAATGAAA CGGAGGAAAG CCGCTCCAAC CAGATGCTGA CAAACAGCCT GAACCAGGTC 780
AAACTCAATG ACTTGTCCTT TCTGGCTGTG CTGGGCAAAG GCAGCTTTGG CAAGGTCATG 840
TTGGCCGAAA TGAAGGCTAC CGGAGAGCTT TACGCCGTGA AGATCCTAAA AAAAGATGTG 900
GTGATCCAGG ACGATGACGT TGAGTGCACA ATGGTGGAGA AGAGAGTCCT GGCCCAACAG 960
GACAAGCCAC CCTTCCTGAC GCAGCTGCAC TCGTGCTTTC AGACCGTGGA CCGACTTTAC 1020
TTTGTCATGG AGTACGTAAA TGGGGGAGAC CTCATGTACC ACATTCAACA AGTGGGCAAG 1080
TTCAAGGAAC CTCAGGCAGT ATTCTACGCA GCAGAGATTG CGGTTGGTCT CTTTTTTCTG 1140
CACAGGAAAG GAATCATTTA CAGGGACTTG AAGTTGGACA ACGTGATGCT GGATGCTGAG 1200
GGTCACATTA AGATCGCTGA CTTTGGCATG TGCAAAGAGA ACATGTTAGA AGGTGTGACA 1260
ACACGGACCT TCTGCGGCAC CCCAGACTAC ATAGCTCCAG AGATCATCGC ATATCAGCCG 1320
TACGGACTCT CTGTAGACTG GTGGGCGTAT GGAGTTCTGC TGTATGAAAT GCTGGCTGGA 1380
CAGCCTCCAT TTGATGGAGA GGATGAAGAT GAGTTGTTCC AGTCCATTAT GGAGCACAAT 1440
GTGTCCTATC CCAAGTCCAT GTCTAAAGAG GCTGTCTCTA TCTGCAAAGG GCTGATGACC 1500
AAACACCCCT CCAAGCGTCT GGGCTGCAGC CGTGAAGAAG AGAGGGACAT CAGAGAGCAC 1560
GCTTTCTTCA GGCGGATTGA CTGGGATCGC CTCCAGAACC GAGAGATACA GCCGCCCTTC 1620
AAGCCTAAAG TG 1632
Domain Profile
S: 2     ellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkpf  61
         ++l vlGkGsfgkv+lae+k t elya+k+lkkdvv+qdddve+t+vekrvla+++k+pf
Q: 266   SFLAVLGKGSFGKVMLAEMKATGELYAVKILKKDVVIQDDDVECTMVEKRVLAQQDKPPF  325
         699*********************************************************
S: 62    lvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekgi  121
         l+ql+scfqt drl+fv+eyvnGGdlm+hiq+++k+ke++a+fyaaei+++l+flh+kgi
Q: 326   LTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEIAVGLFFLHRKGI  385
         ************************************************************
S: 122   iyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygksv  181
         iyrdlkldnv+ldaeGhik+adfG+cke++leg tt+tfcGtPdyiaPei+++++yg sv
Q: 386   IYRDLKLDNVMLDAEGHIKIADFGMCKENMLEGVTTRTFCGTPDYIAPEIIAYQPYGLSV  445
         ************************************************************
S: 182   dwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpek  241
         dwwa+Gvllyemlagq+Pf+gededelf+si+e++v+yPks+skeav+i+kgl+tk+p+k
Q: 446   DWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSMSKEAVSICKGLMTKHPSK  505
         ************************************************************
S: 242   rlGvkeegeedikehaff  259
         rlG+++e e+di+ehaff
Q: 506   RLGCSREEERDIREHAFF  523
         *****************9
Domain Sequence
(FASTA)
SFLAVLGKGS FGKVMLAEMK ATGELYAVKI LKKDVVIQDD DVECTMVEKR VLAQQDKPPF 60
LTQLHSCFQT VDRLYFVMEY VNGGDLMYHI QQVGKFKEPQ AVFYAAEIAV GLFFLHRKGI 120
IYRDLKLDNV MLDAEGHIKI ADFGMCKENM LEGVTTRTFC GTPDYIAPEI IAYQPYGLSV 180
DWWAYGVLLY EMLAGQPPFD GEDEDELFQS IMEHNVSYPK SMSKEAVSIC KGLMTKHPSK 240
RLGCSREEER DIREHAFF 258
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Sequence SourceEnsembl
Orthology
Ortholog group
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0046872; F:metal ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0035556; P:intracellular signal transduction
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR000008; C2_Ca-dep.
IPR008973; C2_Ca/lipid-bd_dom_CaLB.
IPR020477; C2_dom.
IPR018029; C2_membr_targeting.
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00130; C1_1; 1.
PF00168; C2; 1.
PF00069; Pkinase; 1.
SMARTs
SM00109; C1; 1.
SM00239; C2; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS50004; C2; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS00479; ZF_DAG_PE_1; 1.
PS50081; ZF_DAG_PE_2; 1.
Prints
PR00360; C2DOMAIN.
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013