EKS-ORL-00172

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00172

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	531.5	4.0E-160	383	659	277

Status

Unreviewed

Ensembl Protein

ENSORLP00000017516

UniProt Accession

H2MFY7;

Protein Name

Protein Synonyms/Alias

Gene Name

MFR4

Gene Synonyms/Alias

MFR4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000013964	ENSORLP00000017516	ENSORLT00000017517
ENSORLG00000013964	ENSORLP00000017514	ENSORLT00000017515

Organism

Oryzias latipes

Functional Description

Protein Length

727

Protein Sequence
(FASTA)

RWFARVYLFL KALPACTLGS TSQGLELNSA DVLPGSGDDD EDNGLGDSSA ESENDQVYLS 60

RGPFWTHTQR MEKKLYAVPA GNTVRFRCPA MGTPIPTIRW LKNGREFRGE HRIGGIKLRH 120

QHWSLVMESV VPSDRGNYTC VVENEYGSIS HNYVLDVLER SPHRPILQAG LPANTTAVIG 180

SDVQFRCKVY SDAQPHIQWL KHIEINGSRF APDGVPYVNV LKTGSLNMSD VEVLYLSKVT 240

MEDAGEYTCL AGNSIGYAHQ SAWLTVLSEE EAADSMETME TKYTDIVIYA CGFLALIMAV 300

IIVVLCRMQV QPRREPFDAL PVQKLSKFPL RRQYSVESNS SGKSSASLMR VARLSSSCSP 360

MLAGVMEFEL PYDPEWEFPR ENLTLGKPLG EGCFGQVVRA EAYGINKDGP EQATTVAVKM 420

LKDDATDKDL ADLISEMELM KVMDKHKNII NLLGVCTQDG PLYVLVEYAS KGSLREYLRA 480

RRPPGMDYTF DVTKVPEEQL TFKDLLSCAY QVARGMEYLA SKRCIHRDLA ARNVLVTEDN 540

VMKIADFGLA RGVHQIDYYK KTTNGRLPVK WMAPEALFDR VYTHQSDVWS FGVLMWEIFT 600

LGGSPYPGIP VEELFKLLKE GHRMDKPSNC THELYMLMTE CWHAIPNQRP TFKKLVEELD 660

KALLSISDEY LDLSTPFEQY SPSCEDTSSS CSSDNDSVFT HDALSTDPCL LSYQDVHSRI 720

DTKTALR 727

Nucleotide Sequence
(FASTA)

AGATGGTTTG CAAGAGTGTA TTTGTTCCTG AAAGCATTAC CTGCATGCAC TCTGGGAAGC 60

ACTTCCCAAG GTTTAGAATT GAACTCAGCA GATGTCCTTC CAGGGTCTGG AGATGATGAT 120

GAGGACAATG GATTGGGAGA TTCATCTGCT GAGAGTGAAA ATGACCAAGT GTACCTTTCT 180

AGAGGTCCCT TCTGGACTCA CACCCAGCGT ATGGAGAAGA AGCTGTACGC CGTCCCTGCA 240

GGCAACACAG TGAGGTTTCG CTGCCCGGCC ATGGGCACCC CAATCCCAAC TATTCGCTGG 300

CTGAAAAACG GACGGGAATT CAGAGGAGAG CATCGGATCG GGGGGATCAA GCTGCGGCAC 360

CAGCACTGGA GCTTGGTGAT GGAGAGCGTC GTGCCCTCGG ACAGAGGAAA CTACACCTGT 420

GTGGTGGAAA ACGAATACGG TTCCATCTCC CATAACTATG TCCTGGATGT TCTGGAGCGC 480

TCCCCCCACA GGCCCATTCT GCAGGCGGGT CTACCAGCCA ATACCACAGC AGTGATAGGA 540

AGTGACGTTC AATTCCGCTG TAAGGTCTAC AGCGATGCCC AGCCTCACAT TCAGTGGCTG 600

AAGCACATTG AAATTAACGG CAGTCGCTTC GCCCCTGATG GGGTTCCCTA CGTAAACGTC 660

CTCAAGACAG GCAGTCTGAA CATGTCCGAC GTGGAGGTGC TCTACCTGTC AAAAGTTACC 720

ATGGAGGATG CAGGAGAGTA CACCTGTCTG GCTGGAAATT CAATTGGCTA CGCCCACCAG 780

TCTGCCTGGC TTACTGTGCT GTCAGAAGAA GAAGCAGCTG ACTCCATGGA AACCATGGAA 840

ACCAAATACA CGGACATCGT CATTTACGCC TGTGGATTCC TGGCCTTAAT CATGGCGGTC 900

ATCATTGTGG TGCTGTGCCG GATGCAGGTC CAGCCCAGAC GAGAGCCGTT TGATGCCCTT 960

CCAGTTCAGA AGCTCTCCAA ATTCCCTCTT CGTAGACAGT ACTCGGTGGA GTCCAACTCA 1020

TCAGGGAAGT CCAGCGCCTC TCTGATGAGG GTGGCTCGCC TCTCGTCCAG CTGCTCCCCC 1080

ATGCTGGCAG GAGTCATGGA GTTTGAGCTT CCCTACGATC CAGAGTGGGA GTTCCCCAGA 1140

GAGAATTTAA CGCTTGGCAA GCCTCTGGGG GAAGGCTGCT TTGGTCAGGT GGTTAGGGCT 1200

GAGGCCTACG GCATCAACAA GGACGGCCCG GAGCAGGCCA CCACGGTGGC CGTGAAAATG 1260

CTCAAAGATG ACGCTACAGA CAAAGACCTG GCTGACCTTA TCTCTGAAAT GGAGCTGATG 1320

AAGGTGATGG ACAAGCACAA GAACATCATA AACCTGCTGG GAGTCTGCAC ACAGGACGGC 1380

CCTCTTTATG TGCTGGTGGA GTATGCATCC AAAGGCAGTT TGAGGGAGTA CCTGCGGGCC 1440

AGGCGACCTC CAGGCATGGA TTACACCTTT GATGTGACCA AAGTGCCAGA GGAACAGCTC 1500

ACCTTCAAAG ACCTGCTGTC CTGTGCCTAC CAGGTGGCCC GAGGAATGGA GTACCTGGCC 1560

TCCAAAAGGT GCATCCACAG GGACCTGGCA GCCAGGAACG TTCTGGTGAC GGAGGACAAC 1620

GTGATGAAGA TTGCAGACTT TGGCCTGGCC AGAGGAGTCC ACCAGATTGA CTACTACAAG 1680

AAAACCACCA ATGGGCGTCT GCCAGTGAAA TGGATGGCAC CAGAAGCTCT GTTTGACAGA 1740

GTCTACACAC ACCAAAGTGA TGTGTGGTCG TTTGGTGTCC TTATGTGGGA GATTTTCACG 1800

TTGGGGGGTT CGCCGTACCC CGGCATCCCC GTCGAGGAGC TCTTCAAACT GCTAAAGGAG 1860

GGACACCGCA TGGACAAACC TTCCAACTGC ACACATGAAC TATATATGCT GATGACCGAG 1920

TGCTGGCACG CCATTCCAAA CCAGAGACCG ACGTTCAAGA AGCTGGTGGA GGAGCTGGAC 1980

AAGGCTCTGC TCTCCATTTC TGACGAGTAC TTGGACCTGT CCACGCCTTT CGAGCAGTAC 2040

TCCCCTTCCT GTGAGGACAC GTCCAGCTCC TGCTCATCTG ACAACGACTC CGTTTTTACC 2100

CACGATGCCT TGTCCACTGA TCCCTGCCTC CTGAGCTACC AGGACGTGCA CTCCCGGATA 2160

GACACAAAGA CGGCTCTCCG ATAG 2184

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         l+lgk+lGeG+fGqvv+aea g++kd +++++tvavkmlk+datdkdladl+seme++k+

Q: 383   LTLGKPLGEGCFGQVVRAEAYGINKDGPEQATTVAVKMLKDDATDKDLADLISEMELMKV  442

         79**********************************************************

S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120

         + khkniinllG+ctq+Gplyv+veya+kG lre+lrarrp+g++++ d +k++eeqlt+

Q: 443   MDKHKNIINLLGVCTQDGPLYVLVEYASKGSLREYLRARRPPGMDYTFDVTKVPEEQLTF  502

         ************************************************************

S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180

         kdl+s+ayqvarGmeylask+cihrdlaarnvlvtednv+kiadfGlar+vh+idyykkt

Q: 503   KDLLSCAYQVARGMEYLASKRCIHRDLAARNVLVTEDNVMKIADFGLARGVHQIDYYKKT  562

         ************************************************************

S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240

         tnGrlpvkwmapealfdrvyt+qsdvwsfGvl+wei+tlGgspypgi+veelfkllkeGh

Q: 563   TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH  622

         ************************************************************

S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         rm+kp++ct+ely+lm+ecwha +++rptfk+lve+l

Q: 623   RMDKPSNCTHELYMLMTECWHAIPNQRPTFKKLVEEL  659

         ***********************************86

Domain Sequence
(FASTA)

LTLGKPLGEG CFGQVVRAEA YGINKDGPEQ ATTVAVKMLK DDATDKDLAD LISEMELMKV 60

MDKHKNIINL LGVCTQDGPL YVLVEYASKG SLREYLRARR PPGMDYTFDV TKVPEEQLTF 120

KDLLSCAYQV ARGMEYLASK RCIHRDLAAR NVLVTEDNVM KIADFGLARG VHQIDYYKKT 180

TNGRLPVKWM APEALFDRVY THQSDVWSFG VLMWEIFTLG GSPYPGIPVE ELFKLLKEGH 240

RMDKPSNCTH ELYMLMTECW HAIPNQRPTF KKLVEEL 277

Keyword

ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Danio rerio"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Latimeria chalumnae"; ?>Monodelphis domestica"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0008284	; P:positive regulation of cell proliferation

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR013151	; Immunoglobulin.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 2.
PF00047	; ig; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 4.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 4.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013