EKS-ORL-00171
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORL-00171
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/FGFR544.44.6E-164461737277
StatusUnreviewed
Ensembl ProteinENSORLP00000017825
UniProt AccessionH2MGT2;
Protein NameFibroblast growth factor receptor
Protein Synonyms/Alias
Gene NameMFR1
Gene Synonyms/Alias MFR1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSORLG00000014206ENSORLP00000017825ENSORLT00000017826
OrganismOryzias latipes
Functional Description
Protein Length805
Protein Sequence
(FASTA)
HIIYWCFLIL KCKLLLKPDG VLPSSSVDAQ PELFTLHLGS RLVLSCSVKD SLHAVNWTKD 60
QIAVVNGEHV RINNGQLEIE TVELSDSGLY TCTTFGNHSL YFNVTVVYNL ASSEDDDDEE 120
ESSSEETKLL GSQKLMPMAP QWIDPEKMEK KLHAVPASKT VKFRCPASGN PIPTLKWYKN 180
GREFKKDHRI GGFKVREHMW SIIMESVVPS DKGNYTCVVE NQYGSINHTY QLDVVERSPH 240
RPILQAGLPA NRSVVVGSDV EFHCKVFSDP QPHIQWLKHI EVNGSGVGPD GLPHVKILKT 300
AGLNTTDKEM EVLQLRNVSF GDAGQYTCLA GNSIGFSHHT AWLTVLEAVT QYPPTSHTYL 360
EVGIYCAGFF FIAVMVAIAV IIKIRSTSKK SDFNSQLAVH KLAKSIPLRR QVSVDSSSSN 420
HSGVMLVRPS RLSSSASPML SGVSEYELPQ DPRWEVPRDK LVLGKPLGEG CFGQVMMGEV 480
LGLDKEKPNR VTNVAVKMLK SDATEKDLSD LISEMEMMKI IGKHKNIINL LGACTQDGPL 540
YVIVEYASKG NLREYLRARR PPGMEYCYNP DQVSVETMSI KDLVSCAYQV ARGMEYLASK 600
KCIHRDLAAR NVLVTEDNVM KIADFGLARD IHHIDYYKKT TNGRLPVKWM APEALFDRIY 660
THQSDVWSFG VLLWEIFTLG GSPYPGVPVE ELFKLLKEGH RMDKPSTCTH ELYMMMRDCW 720
HAVPSQRPTF KQLVEDLDRC LAMTSNQEYL ELSVPLDQYS PSYPDTRSST CSSGEDSVFS 780
HDAGAEEPCL PKFPPHSNGA AIKKR 805
Nucleotide Sequence
(FASTA)
CACATCATTT ACTGGTGTTT CCTGATCCTT AAATGCAAGT TACTTTTGAA GCCAGATGGA 60
GTACTCCCAT CAAGCTCTGT GGATGCTCAA CCAGAGCTGT TCACGCTTCA TCTTGGGAGT 120
CGTTTGGTTC TCAGTTGCTC TGTAAAGGAT TCCCTCCACG CTGTCAACTG GACCAAAGAC 180
CAAATTGCTG TTGTGAACGG GGAACACGTC CGGATTAACA ATGGCCAGCT GGAAATCGAG 240
ACTGTGGAGC TAAGCGACTC TGGCCTGTAC ACGTGCACCA CTTTCGGCAA CCACAGCCTC 300
TACTTCAACG TCACAGTAGT CTATAACTTG GCCTCCTCTG AAGACGACGA TGACGAGGAA 360
GAATCTTCAT CAGAGGAAAC TAAATTGTTG GGGAGTCAGA AACTGATGCC GATGGCTCCA 420
CAATGGATTG ATCCAGAAAA AATGGAGAAG AAGCTTCACG CTGTTCCAGC AAGTAAGACA 480
GTGAAGTTTC GATGTCCTGC CAGTGGCAAC CCAATCCCCA CTCTGAAATG GTACAAGAAC 540
GGGAGGGAGT TCAAGAAAGA CCATCGCATT GGAGGCTTTA AGGTTCGTGA ACACATGTGG 600
TCCATCATCA TGGAGTCTGT AGTCCCGTCT GATAAGGGGA ACTACACCTG CGTGGTGGAA 660
AACCAATATG GAAGCATTAA TCACACCTAT CAGCTGGATG TTGTTGAGCG CTCCCCCCAC 720
AGGCCCATAC TGCAGGCCGG GTTGCCAGCC AATCGCTCAG TAGTGGTGGG GAGTGATGTG 780
GAATTTCATT GCAAGGTTTT CAGTGATCCA CAGCCTCACA TTCAGTGGCT GAAGCATATT 840
GAGGTCAATG GGAGCGGCGT CGGACCTGAT GGTTTACCAC ATGTCAAAAT TCTTAAGACC 900
GCTGGCCTTA ACACCACGGA CAAGGAAATG GAAGTCCTGC AACTGAGAAA TGTGTCTTTT 960
GGTGACGCTG GGCAATATAC CTGCTTGGCA GGCAATTCTA TCGGGTTCTC TCATCACACT 1020
GCATGGTTGA CCGTTTTGGA AGCTGTCACT CAATACCCCC CCACCAGTCA TACCTACCTG 1080
GAAGTAGGCA TTTACTGTGC TGGCTTCTTT TTCATCGCTG TCATGGTTGC CATTGCCGTC 1140
ATCATCAAAA TTCGCTCCAC ATCGAAGAAG AGTGACTTCA ACAGTCAGCT GGCAGTTCAC 1200
AAGCTGGCTA AAAGCATCCC TCTGCGCAGA CAGGTGTCAG TGGACTCGAG CTCCTCCAAC 1260
CATTCTGGAG TAATGCTGGT TCGTCCCTCC CGCCTCTCCT CCAGTGCCTC TCCTATGCTG 1320
TCAGGAGTGT CTGAATACGA ACTGCCCCAG GATCCACGCT GGGAGGTCCC AAGGGACAAA 1380
CTCGTTCTTG GAAAGCCACT GGGTGAAGGA TGCTTTGGTC AGGTGATGAT GGGGGAGGTG 1440
CTGGGTCTGG ACAAAGAAAA GCCAAACCGC GTGACGAATG TTGCAGTGAA AATGTTAAAG 1500
TCTGACGCCA CAGAAAAAGA CCTTTCAGAC CTGATTTCTG AGATGGAGAT GATGAAGATC 1560
ATTGGGAAAC ACAAGAACAT CATCAACCTG CTGGGAGCCT GCACACAGGA TGGTCCTCTA 1620
TACGTGATAG TGGAATATGC ATCCAAGGGA AATTTGAGGG AATACCTGCG TGCTCGCCGC 1680
CCCCCTGGTA TGGAGTACTG CTACAACCCA GACCAGGTTT CAGTGGAGAC CATGTCCATC 1740
AAAGACCTGG TGTCTTGTGC TTACCAAGTG GCTCGAGGCA TGGAGTACTT GGCCTCTAAA 1800
AAGTGCATTC ACAGAGATCT TGCTGCTCGC AATGTTTTGG TAACTGAAGA CAATGTGATG 1860
AAAATAGCTG ACTTTGGCCT CGCCAGGGAC ATCCACCACA TTGATTATTA CAAGAAAACT 1920
ACCAATGGTC GTTTACCAGT CAAGTGGATG GCGCCTGAGG CACTATTTGA TCGAATATAC 1980
ACGCATCAAA GTGATGTATG GTCATTTGGA GTGCTGCTTT GGGAGATCTT CACCCTCGGA 2040
GGCTCTCCAT ACCCGGGTGT GCCAGTAGAG GAGCTGTTCA AGCTGCTGAA GGAAGGTCAC 2100
CGCATGGACA AGCCTTCAAC GTGCACTCAT GAACTGTACA TGATGATGAG GGACTGCTGG 2160
CATGCAGTTC CCTCTCAAAG GCCCACCTTC AAACAGCTGG TGGAGGACCT GGATCGTTGT 2220
CTAGCTATGA CATCCAACCA GGAGTATTTA GAGCTCTCTG TTCCTTTGGA CCAATATTCT 2280
CCCAGCTATC CTGACACCCG GAGCTCCACG TGCTCCTCTG GTGAAGACTC TGTGTTCTCT 2340
CACGATGCTG GAGCAGAGGA GCCCTGCCTG CCAAAGTTCC CTCCTCACTC CAATGGGGCA 2400
GCAATCAAAA AACGCTGA 2418
Domain Profile
S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60
         lvlgk+lGeG+fGqv++ e++gldk+k+++ + vavkmlk+dat+kdl+dl+seme++k+
Q: 461   LVLGKPLGEGCFGQVMMGEVLGLDKEKPNRVTNVAVKMLKSDATEKDLSDLISEMEMMKI  520
         79**********************************************************
S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120
         iGkhkniinllGactq+Gplyviveya+kGnlre+lrarrp+g+e+++++ ++s e+++ 
Q: 521   IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYCYNPDQVSVETMSI  580
         ************************************************************
S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180
         kdlvs+ayqvarGmeylaskkcihrdlaarnvlvtednv+kiadfGlard+h+idyykkt
Q: 581   KDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKT  640
         ************************************************************
S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240
         tnGrlpvkwmapealfdr+yt+qsdvwsfGvllwei+tlGgspypg++veelfkllkeGh
Q: 641   TNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGH  700
         ************************************************************
S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277
         rm+kp++ct+ely++mr+cwha++s+rptfkqlvedl
Q: 701   RMDKPSTCTHELYMMMRDCWHAVPSQRPTFKQLVEDL  737
         ***********************************97
Domain Sequence
(FASTA)
LVLGKPLGEG CFGQVMMGEV LGLDKEKPNR VTNVAVKMLK SDATEKDLSD LISEMEMMKI 60
IGKHKNIINL LGACTQDGPL YVIVEYASKG NLREYLRARR PPGMEYCYNP DQVSVETMSI 120
KDLVSCAYQV ARGMEYLASK KCIHRDLAAR NVLVTEDNVM KIADFGLARD IHHIDYYKKT 180
TNGRLPVKWM APEALFDRIY THQSDVWSFG VLLWEIFTLG GSPYPGVPVE ELFKLLKEGH 240
RMDKPSTCTH ELYMMMRDCW HAVPSQRPTF KQLVEDL 277
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00140
EKS-BOT-00147
EKS-CAJ-00152
EKS-CAF-00156
EKS-CAP-00148
EKS-CII-00090
EKS-CIS-00182
EKS-DAR-00434
EKS-EQC-00147
EKS-FEC-00138
EKS-GAM-00076
EKS-GAG-00126
EKS-GAA-00173
EKS-GOG-00148
EKS-HOS-00154
EKS-ICT-00142
EKS-LAC-00157
EKS-LOA-00147
EKS-MAM-00145
EKS-MUM-00153
EKS-MUP-00152
EKS-MYL-00157
EKS-NOL-00142
EKS-ORN-00183
EKS-ORA-00126
EKS-ORC-00139
EKS-OTG-00153
EKS-PAT-00139
EKS-POA-00144
EKS-RAN-00147
EKS-SAH-00143
EKS-SUS-00129
EKS-TAG-00177
EKS-TAR-00192
EKS-TEN-00184
EKS-XET-00136
EKS-XIM-00177
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0005007; F:fibroblast growth factor-activated receptor activity
GO:0008284; P:positive regulation of cell proliferation
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016248; Tyr_kinase_fibroblast_GF_rcpt.
Pfam
PF07679; I-set; 3.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00408; IGc2; 3.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013