EKS-ORL-00140

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00140

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Met	442.2	6.9E-133	1064	1324	261

Status

Unreviewed

Ensembl Protein

ENSORLP00000017918

UniProt Accession

H2MH21;

Protein Name

Protein Synonyms/Alias

Gene Name

MST1R (1 of 2)

Gene Synonyms/Alias

MST1R (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000014291	ENSORLP00000017918	ENSORLT00000017919

Organism

Oryzias latipes

Functional Description

Protein Length

1372

Protein Sequence
(FASTA)

MVHWKARWES FIWLQTLLTF ALSNCPSLAP SPVNFSVVYT MPFFQAKGPI QNIVNNSFYQ 60

EVYVASQNVI EAINGSLEKV WELQTGPAGS PECQICELCD IEKDYNFVEN TNNQVLLLDT 120

FFMYLYSCGS SQFGVCYFHQ LNSNGEPPSR TKCLYRKDSN SAAYCPDCVA SPFGTKVSMV 180

EEGHTVYFFV AASVNDSVTQ RYGRKSISVR RPLATEDGFY RDVRGLTVLP SLRRVYHIEY 240

VYSFFTQEFV YFLSVQRESP DQDFSPFQTR LGRLPRSEWE MKRYRELILE CRFEPKRRRR 300

NIPGEPYKDI VYNVVQAAYF GKAGRELAEE LGAEEDEDIL YGVFAVTDDS GVTEDDSALC 360

AFPMDNVNKA ISDGVDDCCE SGPEQLSRGL CHFQICESCP HESMENNATC RDHPTMVSKP 420

YYRVDLFNRK MTNVLLTSLL VTTIDSKTVA HIGTSTGRLL QLVLTRSSPV IFANYSLVES 480

QKVSSIAAVY SSEYLLFVVG DKMIQVPQRG PGCQHFMTCA MCLTAPKFMG CGWCSGVCSW 540

RSECQSRWRN ESCPPVITGF SPRTAAPDGQ TELTVCGREF QSPLRPAITS RTHQIRLGQT 600

ACTVNSLKSN STHLVCKIRS GTTNLFKPVN IMVEVHEDRM ESHYSIDGKA EIPGFTFVIP 660

NITKIKPNYG PRIGGTLITV TGPHLDAGKT RRVTLNDVPC PIQRVTESKG NISSIICLSQ 720

AMSEVRDVPL SVFIDKSRVH TTKVFYYKEN PNITAVLPDC SFHRGSKIVI EGKNLDSVYR 780

TVIRFKPSES HLKPVTAECI GKSQRNRMEC ITPVFQRDET EKGELSFDMD GAVGLWKKEF 840

SYHPSGEPIP FETEEHVLSL YPGFDEVSLH HKKLNLVSSC MTIIMTVADV DCNAKVLDNE 900

ITCRIPKNMS IPSEGLPVKI SINGEVYDVG VVVRVSNHYI VGIVLGILVA LVAGAVLAFV 960

VMKHLRKKKK ASMVEARLAL GSIRSGANAM DLSPVGDYRR VISQSPSTPL VGSVAFQSLS 1020

YSASGIDPVL TPLMPTEKIS ISSFRPELLQ EVKDVLIPAE TLVVQHHRII GKGHFGTVYH 1080

GYLSDSSSRE IHCAVKSLNR ITDVEEVEQF LKEGIIMKGF HHTNVLSLLG ILLPQEGLPL 1140

VVLPYMKHGD LRHFIRCEKR NPTVKDLIGF GLQVAKGMEY LAQKKFVHRD LAARNCMLDE 1200

SYTVKVADFG MARDVFDKEY YSIQDHRKAK LPVKWMAIES LQTQKFTSKS DVWSFGVLMW 1260

EMLTRGASPY PDVDPYDITH YLMKGRRLPQ PQYCPDPLYK IMLQCWDPDS ELRPSFSTLV 1320

VAVSTILSGL EGEHYISLNV TYVNLDQPRP YPALTESADE YDSSDSGGSV SS 1372

Nucleotide Sequence
(FASTA)

ATGGTCCACT GGAAGGCACG ATGGGAGTCA TTCATCTGGC TCCAAACTTT GTTGACTTTT 60

GCCCTTTCAA ACTGTCCTTC ACTGGCCCCC AGTCCTGTGA ACTTCTCAGT TGTCTACACC 120

ATGCCCTTCT TTCAGGCAAA GGGTCCCATC CAGAACATTG TCAACAACTC GTTTTACCAG 180

GAGGTCTATG TGGCTTCTCA GAATGTGATC GAAGCAATCA ACGGGAGCTT GGAGAAAGTC 240

TGGGAGCTCC AAACTGGGCC GGCTGGAAGC CCAGAGTGTC AAATATGTGA ATTATGCGAC 300

ATTGAAAAGG ATTACAATTT TGTAGAGAAC ACTAACAACC AAGTGCTGCT GTTGGATACT 360

TTCTTCATGT ACTTATATTC TTGTGGAAGT TCTCAATTTG GTGTGTGCTA TTTCCACCAG 420

CTCAACTCTA ACGGAGAGCC ACCTTCTCGT ACGAAGTGTT TGTATCGAAA GGACTCTAAC 480

TCTGCTGCTT ACTGTCCTGA TTGTGTGGCC AGCCCTTTTG GGACCAAGGT CTCCATGGTG 540

GAAGAAGGTC ACACTGTCTA CTTCTTTGTT GCAGCTTCAG TCAATGACAG TGTGACCCAG 600

CGTTATGGAA GAAAATCCAT TTCTGTACGC AGGCCACTGG CCACAGAGGA CGGTTTTTAC 660

CGTGATGTAC GAGGACTAAC TGTGCTTCCC AGCCTCCGTA GGGTCTACCA CATCGAGTAT 720

GTCTACAGCT TCTTCACTCA GGAGTTTGTC TACTTCCTCT CAGTCCAGAG AGAGAGTCCG 780

GATCAAGACT TTTCCCCTTT TCAAACCCGT TTGGGACGGC TCCCTCGGAG TGAATGGGAG 840

ATGAAGAGAT ACCGAGAATT GATCCTGGAG TGTCGCTTTG AGCCAAAGCG CAGGCGGAGG 900

AACATACCTG GAGAACCCTA TAAGGATATT GTCTACAATG TGGTCCAAGC GGCCTATTTT 960

GGAAAAGCAG GGAGGGAGCT GGCTGAGGAG TTAGGAGCAG AAGAGGATGA AGACATCCTC 1020

TATGGCGTGT TTGCGGTCAC AGACGACAGC GGGGTCACAG AGGATGACTC CGCTTTGTGC 1080

GCCTTTCCCA TGGACAATGT CAATAAAGCA ATTTCTGACG GGGTGGATGA CTGCTGTGAG 1140

TCTGGGCCAG AGCAGCTCTC CAGAGGACTT TGCCATTTCC AGATTTGTGA GAGCTGTCCT 1200

CATGAGAGCA TGGAGAACAA TGCCACATGC AGAGACCATC CCACCATGGT CTCCAAACCC 1260

TACTACAGAG TGGACCTATT CAATAGAAAG ATGACAAATG TCCTACTTAC TTCCCTCCTG 1320

GTCACAACTA TAGACAGCAA GACCGTTGCA CACATTGGCA CTTCAACTGG ACGTCTTCTA 1380

CAGCTGGTAC TGACGAGATC CAGCCCTGTC ATTTTTGCCA ATTATTCTTT GGTGGAGAGT 1440

CAGAAGGTTT CATCCATCGC TGCTGTGTAC TCTTCAGAGT ATCTACTTTT TGTGGTTGGA 1500

GACAAGATGA TCCAAGTACC TCAGAGAGGG CCCGGGTGCC AACACTTCAT GACCTGTGCT 1560

ATGTGCCTGA CGGCTCCAAA GTTCATGGGC TGTGGATGGT GCTCTGGGGT GTGTTCATGG 1620

AGAAGTGAGT GTCAAAGTCG ATGGAGGAAC GAATCCTGTC CACCAGTAAT TACGGGGTTC 1680

TCTCCACGCA CTGCTGCCCC TGATGGTCAA ACAGAGCTGA CCGTATGTGG GAGGGAGTTC 1740

CAATCCCCCT TAAGACCTGC CATCACCTCC AGAACCCACC AGATCCGACT GGGGCAAACT 1800

GCCTGCACTG TGAACTCTTT GAAAAGCAAC AGCACACACT TAGTGTGTAA AATCCGCTCT 1860

GGAACCACCA ACTTATTCAA ACCAGTCAAC ATCATGGTGG AAGTGCACGA GGACAGGATG 1920

GAGAGCCATT ATTCCATTGA TGGGAAGGCA GAAATACCAG GGTTTACATT TGTGATTCCA 1980

AACATCACAA AAATCAAGCC CAACTATGGG CCTCGCATTG GTGGAACCCT TATAACAGTG 2040

ACTGGACCTC ACTTGGATGC TGGAAAGACC AGAAGAGTCA CACTCAACGA TGTTCCGTGC 2100

CCTATACAAA GGGTGACAGA GTCTAAAGGG AATATTTCAT CCATCATCTG TTTGTCTCAG 2160

GCTATGTCAG AGGTGCGGGA CGTCCCTCTG AGTGTTTTCA TTGACAAGTC CCGTGTTCAC 2220

ACAACCAAAG TGTTTTATTA CAAAGAAAAC CCAAACATTA CAGCCGTGCT GCCTGATTGC 2280

AGCTTTCACA GAGGCTCAAA AATTGTCATT GAAGGGAAAA ACTTGGATTC CGTTTATCGC 2340

ACCGTCATTC GCTTTAAGCC CAGTGAAAGC CACTTGAAGC CGGTCACAGC GGAGTGCATA 2400

GGCAAGTCCC AGAGAAATAG AATGGAATGC ATTACTCCTG TGTTCCAAAG GGACGAGACA 2460

GAAAAGGGGG AACTTTCTTT TGATATGGAT GGAGCAGTGG GCCTTTGGAA GAAGGAGTTT 2520

TCCTATCACC CCTCTGGCGA GCCCATACCT TTTGAAACAG AAGAGCATGT TCTGAGTTTG 2580

TACCCAGGGT TTGATGAAGT GTCACTACAT CATAAAAAGC TGAACCTGGT GAGCTCCTGT 2640

ATGACCATCA TCATGACAGT AGCAGATGTG GATTGCAATG CTAAAGTCCT AGACAACGAG 2700

ATCACCTGCA GGATCCCCAA AAACATGTCC ATCCCCAGTG AGGGGCTGCC GGTGAAGATA 2760

TCGATCAACG GTGAGGTTTA TGATGTCGGC GTTGTGGTGA GGGTCAGCAA CCACTACATA 2820

GTGGGAATAG TTCTGGGGAT CCTGGTGGCT CTGGTGGCCG GAGCTGTGCT GGCTTTTGTT 2880

GTCATGAAAC ATTTGAGAAA GAAGAAGAAA GCCTCCATGG TGGAGGCACG TTTGGCCCTT 2940

GGTTCTATCC GCTCGGGTGC AAATGCTATG GATCTGTCAC CAGTGGGAGA CTACAGAAGA 3000

GTAATCTCCC AAAGTCCTTC TACCCCTCTG GTGGGTTCAG TGGCGTTCCA AAGTCTGTCG 3060

TACTCTGCGA GTGGCATAGA TCCGGTCCTC ACTCCCCTCA TGCCAACAGA GAAGATCTCC 3120

ATCTCCAGCT TTAGGCCTGA GCTGCTGCAG GAGGTAAAAG ATGTTCTCAT CCCTGCTGAG 3180

ACGCTTGTTG TGCAGCATCA TCGGATAATA GGGAAGGGCC ATTTTGGAAC TGTCTATCAT 3240

GGCTACCTCT CGGACTCCTC CAGCAGGGAA ATCCACTGTG CTGTTAAGTC TTTGAATAGA 3300

ATAACAGACG TTGAAGAGGT GGAGCAGTTC TTAAAGGAGG GCATCATAAT GAAGGGTTTC 3360

CACCACACCA ATGTGCTTTC TTTGCTGGGC ATCCTCTTGC CACAGGAAGG GCTGCCCCTG 3420

GTGGTCTTGC CATACATGAA ACATGGGGAT CTGCGCCACT TTATACGCTG CGAGAAGAGG 3480

AATCCCACTG TGAAGGATCT CATTGGCTTT GGACTCCAGG TTGCTAAGGG TATGGAGTAC 3540

TTGGCGCAGA AAAAGTTTGT GCACAGAGAT CTTGCAGCAC GGAATTGCAT GCTGGATGAA 3600

TCCTACACTG TGAAAGTAGC AGATTTTGGG ATGGCCAGAG ATGTTTTTGA TAAGGAATAC 3660

TATAGTATTC AAGACCACAG AAAGGCTAAA TTACCTGTTA AGTGGATGGC CATTGAGAGT 3720

CTGCAGACAC AGAAGTTCAC TTCTAAATCA GATGTGTGGT CTTTTGGGGT GCTGATGTGG 3780

GAGATGCTAA CTAGAGGAGC CAGCCCATAC CCAGATGTGG ATCCATATGA TATAACACAT 3840

TACCTAATGA AGGGCAGGAG GCTTCCTCAG CCGCAGTACT GCCCTGACCC ATTGTATAAA 3900

ATCATGCTCC AGTGCTGGGA CCCTGATTCA GAGCTCAGAC CGAGTTTCTC CACTCTGGTG 3960

GTGGCCGTCT CGACCATTCT TTCAGGCCTG GAGGGAGAAC ATTACATCAG CCTGAATGTC 4020

ACCTATGTGA ACTTGGACCA GCCACGTCCG TACCCTGCCC TCACCGAGTC TGCAGACGAG 4080

TACGACTCTT CAGACTCTGG AGGCTCAGTC TCTTCCTGA 4119

Domain Profile

S: 1     vdkeeviGkGhfGvvykgelsdsaskkikvavksleritdiekveeflreglvmkeldhp  60

         v+++++iGkGhfG+vy+g lsds+s++i++avksl+ritd+e+ve+fl+eg++mk+++h

Q: 1064  VQHHRIIGKGHFGTVYHGYLSDSSSREIHCAVKSLNRITDVEEVEQFLKEGIIMKGFHHT  1123

         56789*******************************************************

S: 61    nvlsllGialddeglplvvlpymkkGdlksfirneernltvkdllefalqvakgmeylas  120

         nvlsllGi l++eglplvvlpymk+Gdl++fir e+rn+tvkdl++f+lqvakgmeyla+

Q: 1124  NVLSLLGILLPQEGLPLVVLPYMKHGDLRHFIRCEKRNPTVKDLIGFGLQVAKGMEYLAQ  1183

         ************************************************************

S: 121   kkfvhrdlaarnclldekltvkvadfGlardvldkelyvveeerdarlpvkwlaleslqt  180

         kkfvhrdlaarnc+lde++tvkvadfG+ardv+dke+y+ +++r+a+lpvkw+a+eslqt

Q: 1184  KKFVHRDLAARNCMLDESYTVKVADFGMARDVFDKEYYSIQDHRKAKLPVKWMAIESLQT  1243

         ************************************************************

S: 181   fkqfttksdvwsfGvllwelltrgatpysevasfdltlylkegrrlrkpeycpdklydvm  240

         +k ft+ksdvwsfGvl+we+ltrga+py++v+++d+t+yl +grrl++p+ycpd ly++m

Q: 1244  QK-FTSKSDVWSFGVLMWEMLTRGASPYPDVDPYDITHYLMKGRRLPQPQYCPDPLYKIM  1302

         **.*********************************************************

S: 241   lkcwkakpaerpqfsdlvsiis  262

         l+cw ++++ rp+fs lv  +s

Q: 1303  LQCWDPDSELRPSFSTLVVAVS  1324

         *****************98876

Domain Sequence
(FASTA)

VQHHRIIGKG HFGTVYHGYL SDSSSREIHC AVKSLNRITD VEEVEQFLKE GIIMKGFHHT 60

NVLSLLGILL PQEGLPLVVL PYMKHGDLRH FIRCEKRNPT VKDLIGFGLQ VAKGMEYLAQ 120

KKFVHRDLAA RNCMLDESYT VKVADFGMAR DVFDKEYYSI QDHRKAKLPV KWMAIESLQT 180

QKFTSKSDVW SFGVLMWEML TRGASPYPDV DPYDITHYLM KGRRLPQPQY CPDPLYKIML 240

QCWDPDSELR PSFSTLVVAV S 261

Keyword

ATP-binding; Complete proteome; Disulfide bond; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Pan troglodytes"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0007275	; P:multicellular organismal development
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR013783	; Ig-like_fold.
IPR014756	; Ig_E-set.
IPR002909	; IPT_TIG_rcpt.
IPR011009	; Kinase-like_dom.
IPR003659	; Plexin-like.
IPR016201	; Plexin-like_fold.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001627	; Semaphorin/CD100_Ag.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016244	; Tyr_kinase_HGF/MSP_rcpt.
IPR015943	; WD40/YVTN_repeat-like_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF01403	; Sema; 1.
PF01833	; TIG; 3.

SMARTs

SM00429	; IPT; 3.
SM00423	; PSI; 1.
SM00630	; Sema; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS51004	; SEMA; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013