EKS-ORL-00168

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00168

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Csk	429.8	3.0E-129	195	432	238

Status

Unreviewed

Ensembl Protein

ENSORLP00000018026

UniProt Accession

H2MHC1;

Protein Name

Protein Synonyms/Alias

Gene Name

CSK (1 of 2)

Gene Synonyms/Alias

CSK (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000014381	ENSORLP00000018026	ENSORLT00000018027

Organism

Oryzias latipes

Functional Description

Protein Length

451

Protein Sequence
(FASTA)

MSGIHAPWTS GTECVAKYNF QTANEQDLPF CKGDVLTIIG VTRDPNWYRA RNTTGREGTI 60

PANYVQKREG VKSGGKLSLM PWFHGKITRE QAERLLYPPE TGLFLVREST NYPGDYTLCV 120

SCDGKVEHYR IIYHNGKLTI DEEEYFENLM QLVEHYTKDA DGLCTRLIKP KLMEGTVAAQ 180

DEFSRSGWAL NRKELKLLQT IGKGEFGDVI LGDYRGTRVA VKCIKNDATA QAFIAEASVM 240

TQLRHNNLVQ LLGVIVEERG SLYIVTEYMA KGSLVDYLRS RGRSVLGGDC LLKFSLDVCE 300

AMEYLEANNF VHRDLAARNV LVSDDNIAKV SDFGLTKEAS SIQDTAKLPV KWTSPEALRE 360

KRFSTKSDVW SYGILLWEIY SFGRVPYPRI PLKDVVPRVE KGYKMDAPDG CPPVVYDLMK 420

QCWWATHRSD PQHGTPLLQS ATHVPSHTPP L 451

Nucleotide Sequence
(FASTA)

ATGTCTGGGA TCCATGCCCC ATGGACATCC GGCACAGAGT GTGTAGCCAA GTACAACTTC 60

CAGACTGCCA ACGAACAGGA CCTGCCTTTC TGTAAAGGGG ATGTTCTGAC CATCATTGGA 120

GTCACCAGGG ATCCAAACTG GTACCGAGCG AGGAACACAA CGGGCAGAGA GGGCACCATT 180

CCAGCCAACT ATGTCCAGAA AAGGGAAGGA GTCAAGTCGG GAGGAAAACT CAGTTTGATG 240

CCTTGGTTTC ATGGGAAGAT AACTCGTGAG CAGGCGGAGC GGCTTCTCTA CCCCCCAGAA 300

ACCGGGCTGT TCCTGGTGAG GGAGAGCACC AACTATCCGG GGGACTACAC CCTGTGTGTC 360

AGCTGCGACG GGAAGGTGGA GCACTACCGC ATCATCTACC ACAACGGCAA ACTCACCATC 420

GATGAGGAGG AATACTTTGA GAATCTCATG CAGCTGGTGG AGCACTACAC CAAAGACGCT 480

GATGGCCTTT GCACCAGGCT GATTAAACCC AAGTTGATGG AGGGGACAGT GGCAGCGCAG 540

GACGAGTTCT CCAGGAGCGG CTGGGCCTTG AACAGGAAGG AGCTGAAACT CCTCCAGACC 600

ATCGGCAAAG GGGAGTTTGG AGATGTGATA TTGGGAGACT ACAGGGGGAC CAGAGTGGCA 660

GTCAAATGTA TCAAAAATGA TGCGACAGCG CAGGCTTTCA TCGCCGAGGC TTCAGTCATG 720

ACGCAGCTGA GGCACAACAA CCTGGTGCAG TTGCTGGGTG TGATCGTGGA GGAGAGGGGC 780

AGCCTTTACA TCGTCACAGA ATACATGGCC AAGGGCAGCC TGGTGGACTA CCTTCGCTCC 840

AGAGGAAGGT CTGTTCTTGG GGGAGACTGT TTACTCAAGT TCTCACTTGA CGTGTGTGAA 900

GCCATGGAGT ACTTGGAAGC CAACAACTTT GTCCACAGAG ACCTGGCAGC TCGAAACGTG 960

CTGGTGTCTG ACGACAACAT CGCCAAAGTC AGCGACTTCG GCCTCACCAA GGAGGCCTCC 1020

TCCATTCAGG ACACTGCCAA GCTGCCCGTC AAGTGGACCT CACCAGAAGC ACTAAGAGAG 1080

AAGAGGTTTT CCACCAAGTC AGACGTCTGG AGTTATGGAA TCCTACTTTG GGAGATTTAC 1140

TCCTTTGGGC GTGTGCCTTA CCCCAGAATT CCGCTGAAAG ACGTGGTCCC CCGAGTGGAA 1200

AAGGGGTACA AGATGGACGC CCCGGACGGC TGCCCCCCAG TGGTGTACGA CCTGATGAAG 1260

CAGTGCTGGT GGGCGACCCA TCGCTCGGAT CCGCAGCACG GGACCCCCCT GTTGCAGAGC 1320

GCCACACATG TGCCGTCACA CACTCCTCCT TTG 1353

Domain Profile

S: 1     lklgetigkgefgdvllgeyrgekvavkvikndataqafldeasvmtklehenlvkllgv  60

         lkl +tigkgefgdv+lg+yrg +vavk+ikndataqaf++easvmt+l+h+nlv+llgv

Q: 195   LKLLQTIGKGEFGDVILGDYRGTRVAVKCIKNDATAQAFIAEASVMTQLRHNNLVQLLGV  254

         6899********************************************************

S: 61    ileek.glylvteyvakgslvdylrsrgrallekkqllkfaldvaegmeyleskklvhrd  119

         i+ee+ +ly+vtey+akgslvdylrsrgr++l+ ++llkf+ldv+e+meyle++++vhrd

Q: 255   IVEERgSLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEANNFVHRD  314

         ****988*****************************************************

S: 120   laarnvlvsedlvakvsdfglakeeskdldsgklpvkwtapealkekkfstksdvwsfgi  179

         laarnvlvs+d++akvsdfgl+ke+s+ +d++klpvkwt+peal+ek+fstksdvws+gi

Q: 315   LAARNVLVSDDNIAKVSDFGLTKEASSIQDTAKLPVKWTSPEALREKRFSTKSDVWSYGI  374

         ************************************************************

S: 180   llweifsfgrvpypriplkdvvkavekgykmeapegcppevyelmkeaweleaakrps  237

         llwei+sfgrvpypriplkdvv++vekgykm+ap+gcpp vy+lmk++w +   + p+

Q: 375   LLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPVVYDLMKQCWWATHRSDPQ  432

         *************************************************988777665

Domain Sequence
(FASTA)

LKLLQTIGKG EFGDVILGDY RGTRVAVKCI KNDATAQAFI AEASVMTQLR HNNLVQLLGV 60

IVEERGSLYI VTEYMAKGSL VDYLRSRGRS VLGGDCLLKF SLDVCEAMEY LEANNFVHRD 120

LAARNVLVSD DNIAKVSDFG LTKEASSIQD TAKLPVKWTS PEALREKRFS TKSDVWSYGI 180

LLWEIYSFGR VPYPRIPLKD VVPRVEKGYK MDAPDGCPPV VYDLMKQCWW ATHRSDPQ 238

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013