EKS-ORL-00188

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00188

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/RSKb	478.5	5.9E-144	415	672	258

Status

Unreviewed

Ensembl Protein

ENSORLP00000018054

UniProt Accession

H2MHE9;

Protein Name

Ribosomal protein S6 kinase

Protein Synonyms/Alias

Gene Name

RPS6KA1

Gene Synonyms/Alias

RPS6KA1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000014406	ENSORLP00000018054	ENSORLT00000018055

Organism

Oryzias latipes

Functional Description

Protein Length

732

Protein Sequence
(FASTA)

IEINTKSFFL FLFFFLYHWK HNHGTCHVLS SLQEDGDVKE YNITNVVKEG SEKADASQFE 60

LLKVLGQGSF GKVFLVRKVT PPDANQLYAM KVLKKATLKV RDRVRTKMER DILADVNHPF 120

VVKLHYAFQT EGKLYLILDF LRGGDLFTRL SKEVMFTEED VKFYLAELAL GLDHLHSLGI 180

IYRDLKPENI LLDEEGHIKL TDFGLCKEAI DHEKKAYSFC GTVEYMAPEV VNRQGHTHSA 240

DWWSFGVLMF EMLTGALPFQ GKDRKETMNL ILKARLGMPQ FLSAEAQSLL RALFKRNPSN 300

RLGSGADGAE EIKRHGFFAT IDWNKLFRKE LKPPFRPAVA RPDDTFYFDS EFTSRTPKDS 360

PGVPPSAGAH QLFRGFSFVA STMLEEDGSV EPPQPPPHPV VKQLHGKNLL FSDGYVLKED 420

IGMGSFSVCK RCIHKATNTE YAVKVIDKTS TDPSEEIDIL LRYGQHPNII TLKDVYDNGK 480

QVFLVTELMR GGELLDRILK QKFFSEREAS AVLHTITKTV EYLHSQGVVH RDLKPSNILY 540

VDESGNPESI RICDFGFAKQ LRANNGLLMT PCYTANFVAP EVLKRQGYDE GCDIWSLGVL 600

LYTMLAGFTP FANGPEDTPN EILNRIGNGH FSLNGGNWDT VSDAAKDLVS KMLHVDPLQR 660

LTAKQVLKHP WIVQREKLPN SQLPHQDPKL VKGAMAATYS ALKNSQPTPE LKPIESSFLA 720

QRRVKKLPST SL 732

Nucleotide Sequence
(FASTA)

ATAGAAATTA ATACAAAGAG TTTTTTTCTT TTTCTTTTCT TTTTCCTTTA TCACTGGAAA 60

CATAATCATG GTACATGTCA TGTATTGAGC AGTCTTCAGG AAGACGGAGA CGTCAAAGAG 120

TACAACATTA CCAATGTGGT TAAAGAGGGT TCGGAGAAGG CAGATGCCTC CCAGTTTGAG 180

CTGCTCAAGG TTTTGGGACA GGGGTCCTTT GGAAAGGTGT TCCTTGTGCG AAAGGTGACT 240

CCTCCAGATG CTAACCAGCT CTATGCCATG AAGGTTCTCA AGAAGGCCAC ACTGAAAGTG 300

AGAGATCGGG TCAGAACCAA GATGGAAAGG GATATCCTTG CTGATGTCAA CCACCCATTT 360

GTCGTCAAGC TCCACTACGC ATTCCAGACT GAAGGAAAGC TTTATCTGAT CCTGGACTTT 420

CTCAGAGGGG GAGATCTTTT CACCAGACTT TCTAAAGAGG TGATGTTCAC TGAGGAAGAC 480

GTGAAGTTTT ACCTAGCAGA GCTGGCGTTG GGACTGGACC ATCTTCACAG CCTTGGCATC 540

ATTTACAGAG ACCTTAAACC AGAAAACATT CTCTTGGATG AGGAGGGACA CATCAAACTC 600

ACAGATTTTG GTTTGTGTAA AGAGGCGATT GACCATGAGA AAAAAGCTTA CTCCTTCTGT 660

GGCACTGTGG AGTACATGGC TCCTGAGGTC GTGAACCGAC AGGGACACAC CCACAGCGCC 720

GACTGGTGGT CATTCGGAGT ACTAATGTTT GAGATGCTGA CAGGAGCGCT TCCATTTCAA 780

GGGAAGGACC GCAAGGAAAC GATGAACCTG ATTCTAAAGG CACGTCTAGG AATGCCTCAA 840

TTCCTGAGTG CGGAGGCCCA GTCTCTGCTC AGAGCTCTGT TCAAGAGGAA TCCCTCCAAC 900

AGACTGGGAT CTGGAGCTGA CGGAGCAGAG GAGATCAAGC GGCATGGATT CTTCGCTACT 960

ATAGACTGGA ATAAACTCTT CAGAAAAGAA CTCAAACCTC CATTCAGACC AGCCGTTGCC 1020

CGTCCAGATG ACACCTTTTA CTTTGATTCA GAGTTCACTT CCCGCACGCC AAAAGACTCT 1080

CCTGGTGTGC CGCCAAGTGC AGGAGCTCAT CAGCTCTTCA GGGGCTTCAG CTTTGTTGCA 1140

TCAACTATGT TGGAGGAGGA TGGTTCGGTG GAGCCGCCAC AGCCCCCACC ACACCCAGTG 1200

GTCAAGCAGC TGCATGGGAA GAACTTGCTG TTCAGCGACG GGTACGTCCT CAAAGAGGAC 1260

ATCGGCATGG GGTCCTTCTC TGTCTGTAAG CGCTGCATCC ACAAAGCCAC CAACACTGAG 1320

TATGCAGTCA AGGTGATTGA CAAGACCAGC ACAGACCCAT CTGAGGAGAT TGACATTCTA 1380

CTTCGATATG GACAGCACCC AAACATCATT ACCCTGAAGG ATGTGTACGA CAACGGGAAG 1440

CAGGTGTTCC TGGTGACGGA GCTGATGCGT GGAGGAGAGC TGCTGGACCG GATCCTCAAG 1500

CAGAAATTCT TTTCAGAGCG AGAGGCCAGC GCTGTACTTC ACACCATCAC CAAGACTGTG 1560

GAGTACCTCC ACTCCCAGGG GGTCGTACAC AGAGACCTGA AGCCCAGTAA CATCCTATAT 1620

GTTGATGAGT CAGGCAATCC CGAGTCCATC AGGATCTGTG ACTTCGGCTT TGCTAAGCAG 1680

TTGCGTGCCA ACAACGGCCT GCTTATGACC CCGTGCTACA CGGCTAACTT TGTGGCTCCT 1740

GAGGTGCTGA AGCGTCAGGG TTATGATGAA GGATGTGACA TCTGGAGCCT GGGAGTTTTA 1800

CTGTACACCA TGCTGGCTGG TTTTACTCCG TTTGCTAACG GACCTGAAGA TACCCCAAAC 1860

GAGATTCTGA ACAGGATAGG GAATGGTCAT TTCAGTCTGA ATGGAGGAAA CTGGGACACA 1920

GTGTCAGACG CAGCCAAGGA CCTTGTCTCT AAGATGCTTC ATGTGGACCC CCTTCAGAGA 1980

CTTACGGCTA AGCAGGTCCT CAAACACCCC TGGATCGTCC AGAGAGAGAA GCTACCCAAC 2040

AGCCAACTTC CACATCAGGA CCCTAAACTG GTCAAGGGTG CAATGGCTGC AACCTACTCT 2100

GCCCTGAAGA ACTCGCAGCC CACTCCAGAG CTGAAACCCA TTGAGAGCTC CTTCCTTGCT 2160

CAGAGGCGTG TGAAGAAGCT TCCCTCCACG TCTCTGTAG 2199

Domain Profile

S: 1     yevkedlGvGsysvckrcvhkatnqefavkiidkskrdtseeieillryeqhpnivtlkd  60

         y++ked+G Gs+svckrc+hkatn+e+avk+idk+ +d+seei+illry+qhpni+tlkd

Q: 415   YVLKEDIGMGSFSVCKRCIHKATNTEYAVKVIDKTSTDPSEEIDILLRYGQHPNIITLKD  474

         679*********************************************************

S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120

         vyd+gk v+lv+el++GGelldri+k+kffsereasa+l+t++k+veylh+qGvvhrdlk

Q: 475   VYDNGKQVFLVTELMRGGELLDRILKQKFFSEREASAVLHTITKTVEYLHSQGVVHRDLK  534

         ************************************************************

S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180

         p+nilyvdes+n+esi+i+dfGfak++ra+ngll+tpcyt+nfvapevlkrqGyde+cd+

Q: 535   PSNILYVDESGNPESIRICDFGFAKQLRANNGLLMTPCYTANFVAPEVLKRQGYDEGCDI  594

         ************************************************************

S: 181   wslGvllytmlaGyvpfangpedtaeeilakikeGkfslsGeawdsvseeakdlvskllt  240

         wslGvllytmlaG++pfangpedt++eil +i++G+fsl+G++wd+vs++akdlvsk+l+

Q: 595   WSLGVLLYTMLAGFTPFANGPEDTPNEILNRIGNGHFSLNGGNWDTVSDAAKDLVSKMLH  654

         ************************************************************

S: 241   vdpakrlkleqllkhswl  258

         vdp +rl+++q+lkh+w+

Q: 655   VDPLQRLTAKQVLKHPWI  672

         *****************8

Domain Sequence
(FASTA)

YVLKEDIGMG SFSVCKRCIH KATNTEYAVK VIDKTSTDPS EEIDILLRYG QHPNIITLKD 60

VYDNGKQVFL VTELMRGGEL LDRILKQKFF SEREASAVLH TITKTVEYLH SQGVVHRDLK 120

PSNILYVDES GNPESIRICD FGFAKQLRAN NGLLMTPCYT ANFVAPEVLK RQGYDEGCDI 180

WSLGVLLYTM LAGFTPFANG PEDTPNEILN RIGNGHFSLN GGNWDTVSDA AKDLVSKMLH 240

VDPLQRLTAK QVLKHPWI 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016239	; Ribosomal_S6_kinase_II.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 2.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 2.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 2.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00108	; PROTEIN_KINASE_ST; 2.

Prints

Created Date

20-Feb-2013