EKS-ORL-00009
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORL-00009
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph504.07.2E-152656913258
StatusUnreviewed
Ensembl ProteinENSORLP00000018422
UniProt AccessionH2MIE3;
Protein Name
Protein Synonyms/Alias
Gene NameEPHA4 (2 of 2)
Gene Synonyms/Alias EPHA4 (2 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSORLG00000014683ENSORLP00000018422ENSORLT00000018423
OrganismOryzias latipes
Functional Description
Protein Length1020
Protein Sequence
(FASTA)
LAGFQAAHMA AKLWRTLSAS IWILTLASSS RTRIYPPNEV TLLDTRTVPG ELKWAARPSE 60
GGWEEVSIMD EKNIPIRTYQ VCNVLGPNQN NWLRTDWIPR SGAQRVYVEV KFTLRDCNSL 120
PGVTGTCKET FNLYYHESNE DRESYIKESS FIKVDTVAAD ESFTQVDVGD RIMKLNTEVR 180
DVKVTNRKGF YLAFQDVGAC IALVSVRVFY KTCPLTIRNL ATFPDTVTGA DTSSLVEVRG 240
SCVNQSEERE EPKMYCGADG EWLVPIGGCL CNPGYEEKGG SCQACSAGFY KAKSSDIGCS 300
KCPPHSHSLR DGANVCDCHS GFFRADADPP SMACTQPPSA PQQLISVVNE TSVVLEWTPP 360
RRLGGRSDIG YNVECLICQT GHCLPCTPDV HFSPSQTDLL TTKVVVSELR AHTHYTFIVY 420
ARNGVSQASG SGAAQSASVS VTTNQAAPSP VSSIQVTDVT RHSLSLLWQQ PDRPNGVILE 480
YEVKFYEKDQ RERSYRIIRT FLQSVDVTGL KPLTVYVFHV RARTAAGYGE YSSPFEFSTN 540
SDICVAAAED TEIRYFSIIT RLSRLIVTLL LSTLYKRNCL LCPCEQPVTL CSLCHWLLLL 600
RSKYSKTKQD SEEEKHLNPG AVSILPGVKI YVDPFTYEDP DQAVHEFAKE IDVSSIHIEK 660
VIGMGEFGEV CSGRLRVQGK RETYVAIKSL KAGYSDKQRR DFMSEASIMG QFDHPNIIRL 720
EGVVTRCKPL MIITEYMENG SLDAYLRKHD GQFTVIQLIG MLRGIASGMK YLSDMNYVHR 780
DLAARNILVN SNLVCKVSDF GLSRVLEDDP EAAYTTRGGK IPIRWTAPEA IAYRKFTTAS 840
DVWSYGIVMW EVVSYGERPY WDMNNQDVIK AIEEGYRLPA PMDCPVVLHQ LMLDCWERER 900
AERPTFSQIL NMLDKLIRNP GTLRRTGGDS FHRSPGTLIE SGVGSEWTLC EWLQSIGLER 960
YRDTLAAAGY TSLDSLLALT HQEMDRLGII TPSHQDMLIA SVQQELLSRM QHMQHSMVPV 1020
Nucleotide Sequence
(FASTA)
CTCGCAGGCT TCCAGGCGGC ACACATGGCT GCTAAATTAT GGCGAACCTT GTCGGCGTCC 60
ATCTGGATCC TTACGCTTGC TTCCAGCTCG AGGACGAGGA TTTATCCCCC CAACGAAGTG 120
ACCCTGCTGG ACACCAGAAC AGTGCCAGGA GAGCTGAAAT GGGCTGCTCG CCCTTCAGAA 180
GGAGGATGGG AGGAAGTCAG CATTATGGAT GAGAAGAACA TCCCCATCAG GACGTACCAG 240
GTGTGCAACG TCTTAGGACC TAACCAGAAC AACTGGCTGA GGACAGACTG GATCCCTCGG 300
TCCGGCGCTC AGCGGGTCTA CGTGGAAGTC AAATTCACTT TGAGGGACTG CAACAGCCTG 360
CCAGGAGTCA CTGGCACCTG CAAGGAGACA TTCAATCTGT ACTACCATGA GTCAAACGAA 420
GACAGAGAGA GCTACATCAA AGAGAGCAGC TTCATTAAGG TGGACACAGT GGCAGCAGAT 480
GAGAGCTTCA CCCAGGTTGA TGTTGGAGAC CGTATCATGA AACTCAACAC AGAGGTGCGA 540
GATGTGAAAG TGACAAACCG GAAAGGTTTC TACCTGGCCT TTCAGGACGT CGGCGCCTGC 600
ATCGCTTTGG TTTCGGTTCG AGTTTTCTAC AAAACATGTC CGCTCACCAT TCGGAATTTA 660
GCGACTTTTC CTGACACAGT CACCGGTGCT GACACGTCTT CCCTAGTGGA GGTTAGAGGG 720
TCATGTGTTA ACCAATCAGA AGAAAGAGAG GAACCTAAAA TGTACTGCGG AGCGGATGGA 780
GAGTGGTTGG TTCCAATTGG TGGATGTCTC TGCAATCCAG GATATGAGGA GAAGGGCGGT 840
TCATGTCAAG CCTGTTCAGC TGGTTTCTAC AAAGCCAAAT CCTCGGACAT TGGCTGCTCC 900
AAGTGTCCTC CCCACAGCCA CTCGCTCAGA GACGGGGCTA ATGTGTGTGA CTGCCACTCA 960
GGATTCTTCC GTGCAGATGC TGACCCTCCC TCCATGGCGT GCACCCAGCC ACCATCAGCT 1020
CCACAGCAGC TCATCTCTGT GGTGAATGAG ACATCGGTGG TCTTGGAGTG GACCCCCCCT 1080
CGCCGCCTTG GAGGAAGGAG CGACATCGGC TACAATGTGG AGTGTCTCAT CTGTCAAACT 1140
GGGCACTGTC TGCCCTGCAC CCCAGATGTG CATTTCTCTC CCAGCCAGAC CGACCTGCTG 1200
ACCACCAAGG TGGTGGTGAG CGAGCTGAGG GCCCACACTC ACTACACCTT CATCGTCTAT 1260
GCGCGAAATG GGGTCTCCCA GGCTAGTGGA TCAGGGGCTG CGCAGAGTGC ATCTGTCAGC 1320
GTCACAACAA ACCAAGCTGC TCCTTCCCCG GTGTCATCCA TCCAAGTCAC TGATGTCACA 1380
AGACACAGTT TGTCGTTGTT ATGGCAACAG CCGGATCGAC CCAACGGGGT CATCCTTGAA 1440
TACGAGGTCA AATTCTACGA AAAGGATCAG AGGGAGAGGT CTTATCGCAT AATCAGGACC 1500
TTCTTACAGA GTGTCGATGT CACGGGTCTC AAGCCCCTCA CTGTTTATGT ATTCCATGTG 1560
CGTGCACGCA CAGCTGCTGG ATACGGAGAG TACAGCTCTC CCTTTGAATT CTCCACCAAT 1620
TCAGATATAT GCGTAGCTGC AGCAGAAGAC ACAGAAATTA GATATTTTTC CATTATTACT 1680
AGATTAAGTC GATTAATCGT TACACTCTTA CTATCCACAC TCTATAAAAG AAACTGTCTG 1740
CTCTGCCCAT GTGAACAGCC CGTCACTCTC TGTTCTCTTT GTCATTGGCT TCTGTTACTG 1800
AGAAGCAAGT ACAGCAAGAC AAAGCAGGAC TCGGAGGAGG AGAAGCATCT GAATCCAGGT 1860
GCAGTATCTA TTCTCCCAGG AGTTAAAATC TACGTGGATC CCTTTACCTA TGAAGACCCA 1920
GATCAGGCCG TCCACGAGTT TGCCAAAGAG ATAGATGTCA GCAGTATTCA CATCGAGAAG 1980
GTTATTGGCA TGGGAGAGTT TGGGGAGGTG TGCAGCGGCC GGCTCCGTGT CCAGGGTAAG 2040
AGGGAGACCT ACGTCGCCAT CAAAAGCTTA AAGGCAGGCT ATTCGGACAA ACAGAGACGG 2100
GACTTTATGT CAGAGGCCTC CATCATGGGA CAGTTTGATC ATCCCAATAT CATCAGGCTG 2160
GAGGGTGTTG TTACAAGATG CAAGCCGTTG ATGATCATCA CTGAATACAT GGAAAACGGA 2220
TCCCTGGATG CATATCTCAG AAAACATGAT GGCCAGTTCA CAGTGATCCA GCTGATAGGC 2280
ATGCTGCGCG GCATCGCCTC AGGTATGAAG TACCTGTCAG ACATGAACTA CGTACACAGA 2340
GACCTGGCAG CTCGAAACAT CCTGGTAAAC AGCAACCTGG TGTGCAAAGT GTCAGATTTT 2400
GGCCTAAGTC GAGTTCTGGA GGACGACCCT GAGGCGGCTT ACACAACAAG GGGAGGGAAG 2460
ATTCCCATCA GATGGACAGC TCCTGAGGCC ATCGCGTACA GAAAGTTTAC CACAGCCAGT 2520
GATGTGTGGA GTTACGGTAT CGTCATGTGG GAGGTGGTTT CTTATGGAGA GAGACCATAC 2580
TGGGACATGA ACAACCAGGA TGTGATTAAA GCGATAGAGG AGGGGTACCG ACTGCCTGCT 2640
CCCATGGACT GTCCGGTGGT GCTGCACCAG CTCATGCTGG ACTGTTGGGA GAGGGAGCGA 2700
GCAGAGAGAC CCACCTTCAG CCAGATACTG AACATGCTGG ATAAACTCAT CCGCAATCCT 2760
GGGACCCTGC GTCGCACAGG AGGGGACAGC TTTCACAGAT CTCCGGGCAC ACTAATAGAG 2820
TCTGGAGTGG GCTCAGAATG GACTTTGTGT GAGTGGCTGC AGTCCATTGG GTTGGAGCGG 2880
TACAGAGACA CCCTCGCAGC AGCAGGTTAC ACCAGCCTGG ACAGTCTCCT GGCTCTCACA 2940
CACCAGGAAA TGGACAGACT TGGAATAATC ACACCGTCAC ATCAGGACAT GCTTATTGCC 3000
AGCGTGCAGC AAGAACTGTT GTCTCGAATG CAGCACATGC AACACTCCAT GGTCCCGGTC 3060
TGA 3063
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         ++iekviG GefGevcsGrl+++gkre++vaik+lkag+++kqrrdf+seasi+Gqfdhp
Q: 656   IHIEKVIGMGEFGEVCSGRLRVQGKRETYVAIKSLKAGYSDKQRRDFMSEASIMGQFDHP  715
         78**********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         niirleGvvt++kp+mi+teymeng+ld++lrk+dgqftviql+gmlrGiasgmkylsdm
Q: 716   NIIRLEGVVTRCKPLMIITEYMENGSLDAYLRKHDGQFTVIQLIGMLRGIASGMKYLSDM  775
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrk  180
         +yvhrdlaarnilvnsnlvckvsdfGlsrvledd+eaaytt+ggkipirwtapeaiayrk
Q: 776   NYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRK  835
         ************************************************************
S: 181   ftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldc  240
         ft+asdvwsyGiv+wev+syGerpywdm+nqdvikaieegyrlp+pmdcp  l+qlmldc
Q: 836   FTTASDVWSYGIVMWEVVSYGERPYWDMNNQDVIKAIEEGYRLPAPMDCPVVLHQLMLDC  895
         ************************************************************
S: 241   wqkdraerpkfeqivsil  258
         w+++raerp+f+qi ++l
Q: 896   WERERAERPTFSQILNML  913
         **************9875
Domain Sequence
(FASTA)
IHIEKVIGMG EFGEVCSGRL RVQGKRETYV AIKSLKAGYS DKQRRDFMSE ASIMGQFDHP 60
NIIRLEGVVT RCKPLMIITE YMENGSLDAY LRKHDGQFTV IQLIGMLRGI ASGMKYLSDM 120
NYVHRDLAAR NILVNSNLVC KVSDFGLSRV LEDDPEAAYT TRGGKIPIRW TAPEAIAYRK 180
FTTASDVWSY GIVMWEVVSY GERPYWDMNN QDVIKAIEEG YRLPAPMDCP VVLHQLMLDC 240
WERERAERPT FSQILNML 258
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Gasterosteus aculeatus"; ?>Oreochromis niloticus"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-GAA-00020
EKS-ORN-00009
EKS-TAR-00008
EKS-TEN-00006
EKS-XIM-00013
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005003; F:ephrin receptor activity
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR009030; Growth_fac_rcpt.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013