EKS-ORL-00079

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00079

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	349.5	1.6E-104	9	295	287

Status

Unreviewed

Ensembl Protein

ENSORLP00000019056

UniProt Accession

H2MK52;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK4

Gene Synonyms/Alias

CDK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000015209	ENSORLP00000019056	ENSORLT00000019057

Organism

Oryzias latipes

Functional Description

Protein Length

319

Protein Sequence
(FASTA)

MAQCTGLQYE PVAEIGGGAY GTVYKARDIE SGKFVALKNV RVQTDQNGLP VSTVREVALL 60

KRLEQFDHPN VVRLMDVCAT KRSDQETKVT LVFEHVDQDL KTYLERAPAP GLSPERVKDL 120

MKQLLSGLSF LHSNRVMHRD LKPENILVTS QGQVKLADFG LARIYSCHMA LTPVVVTLWY 180

RPPEVLLQSS YATPVDIWST GCIFAEMFRR KPLFCGESEM DQLGKIFEVL GLPPEEEWPT 240

DVTVSRKNFP LLHARPITDF VPEINEEGAQ LLLQMLTFDP LKRVSAVKAL EHPYFQDEEP 300

ATQTESLNQG VKSAAGGIC 319

Nucleotide Sequence
(FASTA)

ATGGCGCAGT GCACCGGTCT GCAGTACGAG CCGGTGGCAG AGATCGGTGG TGGCGCATAC 60

GGGACCGTCT ACAAGGCTCG CGACATCGAG AGTGGCAAGT TCGTCGCCCT GAAGAACGTG 120

CGCGTCCAGA CTGACCAAAA TGGCCTCCCG GTGTCCACGG TCAGAGAGGT GGCGCTGTTG 180

AAGCGCCTAG AGCAGTTTGA CCACCCCAAT GTGGTCAGGC TTATGGATGT GTGTGCCACC 240

AAGAGATCCG ACCAGGAAAC CAAAGTCACT CTGGTGTTTG AGCATGTGGA CCAAGACCTG 300

AAAACGTATC TAGAGAGAGC TCCAGCTCCA GGGTTGTCAC CAGAGCGCGT GAAAGACTTG 360

ATGAAGCAGT TGCTGTCTGG CCTCTCCTTC CTCCACTCAA ACCGCGTGAT GCACAGAGAC 420

CTGAAACCCG AGAACATTCT GGTGACCAGC CAGGGCCAGG TCAAACTAGC AGACTTTGGC 480

TTAGCGAGGA TATACAGCTG CCACATGGCC CTCACTCCTG TGGTGGTGAC GTTGTGGTAT 540

CGACCCCCCG AAGTTCTGCT GCAGTCCAGC TACGCCACTC CTGTGGACAT TTGGAGCACG 600

GGCTGCATTT TTGCTGAAAT GTTTAGACGC AAACCTTTGT TCTGCGGAGA GTCAGAGATG 660

GACCAACTTG GCAAAATCTT CGAAGTTCTT GGCTTACCCC CAGAGGAGGA GTGGCCCACT 720

GATGTTACCG TGTCCAGAAA AAACTTCCCC CTTCTCCATG CTCGCCCAAT AACAGATTTT 780

GTTCCAGAGA TAAATGAGGA GGGGGCCCAA CTATTGCTGC AAATGTTGAC TTTCGACCCT 840

TTGAAACGAG TTTCGGCCGT GAAAGCTCTC GAGCATCCGT ACTTCCAGGA CGAGGAGCCA 900

GCGACTCAGA CAGAAAGCTT GAATCAGGGA GTAAAAAGCG CCGCAGGAGG CATCTGT 957

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkel...kh  57

         ye +++ig G+yg+vyka+d e+g++vAlK++r++++++g+p++++rE++llk+l   +h

Q: 9     YEPVAEIGGGAYGTVYKARDIESGKFVALKNVRVQTDQNGLPVSTVREVALLKRLeqfDH  68

         88899************************************************998889*

S: 58    knivkLlevva....kdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqllegl  113

         +n+v+L++v+a     +++k++Lvfe+++qdLk++l++ ++ +ls+e+vk l++qll+gl

Q: 69    PNVVRLMDVCAtkrsDQETKVTLVFEHVDQDLKTYLERAPAPGLSPERVKDLMKQLLSGL  128

         ***********99866779*****************************************

S: 114   aylHsnkilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLl  173

         ++lHsn+++HRDlKp+N+L++++g++klaDfGlar +s ++  +t++vvTlwYr+Pe+Ll

Q: 129   SFLHSNRVMHRDLKPENILVTSQGQVKLADFGLARIYSCHMA-LTPVVVTLWYRPPEVLL  187

         *************************************99998.*****************

S: 174   gakeYstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpe  233

         ++ +Y t vDiWs gci+ae+++rkplf g+se+dql +if++lg p e++wp+  ++++

Q: 188   QS-SYATPVDIWSTGCIFAEMFRRKPLFCGESEMDQLGKIFEVLGLPPEEEWPTDVTVSR  246

         88.5*************************************************9999988

S: 234   ykksfpkkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

            +fp  +++ +++ v++++e++ +ll ++l++dp kR+sa +al+h+yf

Q: 247   K--NFPLLHARPITDFVPEINEEGAQLLLQMLTFDPLKRVSAVKALEHPYF  295

         5..599999*****************************************9

Domain Sequence
(FASTA)

YEPVAEIGGG AYGTVYKARD IESGKFVALK NVRVQTDQNG LPVSTVREVA LLKRLEQFDH 60

PNVVRLMDVC ATKRSDQETK VTLVFEHVDQ DLKTYLERAP APGLSPERVK DLMKQLLSGL 120

SFLHSNRVMH RDLKPENILV TSQGQVKLAD FGLARIYSCH MALTPVVVTL WYRPPEVLLQ 180

SSYATPVDIW STGCIFAEMF RRKPLFCGES EMDQLGKIFE VLGLPPEEEW PTDVTVSRKN 240

FPLLHARPIT DFVPEINEEG AQLLLQMLTF DPLKRVSAVK ALEHPYF 287

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013