EKS-ORL-00077

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00077

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	363.0	1.2E-108	40	324	285

Status

Unreviewed

Ensembl Protein

ENSORLP00000019096

UniProt Accession

H2MK88;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK10

Gene Synonyms/Alias

CDK10;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000015245	ENSORLP00000019096	ENSORLT00000019097

Organism

Oryzias latipes

Functional Description

Protein Length

360

Protein Sequence
(FASTA)

MDATGEEDAD TIRLKSVKDY KTFTVPQNDR FGSCRSVREF EKLNRIGEGT YGIVYRARDT 60

RSNEIVALKK VRMDKEKDGI PISSLREITL LLRLRHPNIV ELKEVVVGSQ LESLFLVMSY 120

CEQDLASLLE NMQTPFSETQ VKCIVLQLLK GLEYLHHNFI IHRDLKVSNL LMTDKGYVKI 180

ADFGLARMYG IPQPLMTPRV VTLWYRAPEV LLGTKIQTTA LDMWAVGCIL AELLAHKPLL 240

PGTSEIQQVD LIVQLLGTPN ENIWPGFSQL PLIGQYSLRK QPYNNLKNKF TWLSDAGHRL 300

LNLLFMYNPL RRATAKDCLE SSYFKEKPLP CEPELMPTFP HHRNKRAAPP AESFSKRSKV 360

Nucleotide Sequence
(FASTA)

ATGGACGCCA CTGGAGAGGA AGATGCAGAC ACGATCCGAC TGAAATCAGT TAAAGACTAT 60

AAAACGTTTA CAGTGCCTCA GAATGACAGA TTTGGGAGCT GCAGAAGTGT CAGAGAGTTT 120

GAGAAACTCA ATCGGATAGG TGAAGGAACC TACGGCATCG TGTACCGAGC CCGCGACACC 180

AGGTCCAATG AAATTGTGGC TCTGAAAAAG GTCAGAATGG ACAAAGAGAA AGACGGGATC 240

CCCATCAGCA GCCTCAGAGA GATCACGCTG CTGCTGAGGC TCAGACACCC CAACATAGTG 300

GAGCTTAAAG AAGTGGTTGT GGGCAGCCAA CTTGAGAGCT TGTTTCTGGT GATGAGTTAC 360

TGTGAGCAGG ACCTGGCCAG TCTGCTGGAG AACATGCAGA CGCCCTTCTC TGAAACCCAG 420

GTCAAGTGTA TTGTTCTTCA GCTGCTCAAA GGACTGGAAT ATCTCCACCA CAACTTCATC 480

ATACACAGGG ACCTGAAGGT GTCTAATCTG CTGATGACAG ACAAAGGCTA CGTTAAGATA 540

GCGGATTTCG GGTTAGCCAG GATGTACGGG ATCCCCCAGC CGCTCATGAC TCCCAGAGTG 600

GTCACGCTGT GGTACCGAGC TCCAGAGGTC CTGCTGGGAA CCAAGATCCA GACGACAGCT 660

CTGGACATGT GGGCAGTGGG CTGTATCCTG GCGGAGCTGC TGGCCCACAA GCCTCTGCTT 720

CCTGGAACCT CTGAGATCCA GCAGGTGGAC CTGATCGTTC AGCTGCTGGG AACTCCCAAT 780

GAGAACATCT GGCCGGGTTT CTCTCAGCTG CCGCTCATCG GTCAGTACAG TCTGAGGAAG 840

CAGCCCTACA ACAACCTGAA GAACAAGTTC ACCTGGTTGT CAGACGCCGG ACACAGACTC 900

CTCAACCTGC TCTTCATGTA CAACCCACTG CGCAGAGCGA CCGCCAAAGA CTGTTTGGAG 960

AGTTCCTACT TCAAAGAGAA GCCCCTGCCT TGTGAACCAG AGCTGATGCC AACGTTCCCC 1020

CACCATCGAA ACAAGAGAGC CGCGCCTCCT GCTGAGAGCT TCTCCAAGCG GAGTAAAGTT 1080

TGA 1083

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         +ekl++igeGtyg vy+a+d++++e+vAlKk+r++kek+g+pi++lrEi+ll +l+h+ni

Q: 40    FEKLNRIGEGTYGIVYRARDTRSNEIVALKKVRMDKEKDGIPISSLREITLLLRLRHPNI  99

         89**********************************************************

S: 61    vkLlevvakdk.kklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsn  119

         v+L+evv+ ++ ++l+Lv+ ++eqdL++ll+++++  +s+++vk ++lqll+gl+ylH+n

Q: 100   VELKEVVVGSQlESLFLVMSYCEQDLASLLENMQT-PFSETQVKCIVLQLLKGLEYLHHN  158

         ********5555**********************9.************************

S: 120   kilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYs  179

          i+HRDlK +NlL++++g +k+aDfGlar ++ p+  +t++vvTlwYraPe+Llg+k  +

Q: 159   FIIHRDLKVSNLLMTDKGYVKIADFGLARMYGIPQPLMTPRVVTLWYRAPEVLLGTKIQT  218

         ************************************************************

S: 180   tavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeyk.ksf  238

         ta+D+W+vgcilaell++kpl++g+sei+q++ i++llgtp+e++wp++s+lp +  +s+

Q: 219   TALDMWAVGCILAELLAHKPLLPGTSEIQQVDLIVQLLGTPNENIWPGFSQLPLIGqYSL  278

         *******************************************************988**

S: 239   pkkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         +k+++++lk+k++ l++++ +ll+ l++++p +R +ak++l+++yf

Q: 279   RKQPYNNLKNKFTWLSDAGHRLLNLLFMYNPLRRATAKDCLESSYF  324

         *********************************************8

Domain Sequence
(FASTA)

FEKLNRIGEG TYGIVYRARD TRSNEIVALK KVRMDKEKDG IPISSLREIT LLLRLRHPNI 60

VELKEVVVGS QLESLFLVMS YCEQDLASLL ENMQTPFSET QVKCIVLQLL KGLEYLHHNF 120

IIHRDLKVSN LLMTDKGYVK IADFGLARMY GIPQPLMTPR VVTLWYRAPE VLLGTKIQTT 180

ALDMWAVGCI LAELLAHKPL LPGTSEIQQV DLIVQLLGTP NENIWPGFSQ LPLIGQYSLR 240

KQPYNNLKNK FTWLSDAGHR LLNLLFMYNP LRRATAKDCL ESSYF 285

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013