EPS-ORL-00028

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-ORL-00028

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	283.4	2.5E-84	23	292	270

Status

Unreviewed

Ensembl Protein

ENSORLP00000019753

UniProt Accession

H2MM16;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1A

Gene Synonyms/Alias

PPM1A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000015773	ENSORLP00000019753	ENSORLT00000019754

Organism

Oryzias latipes

Functional Description

Protein Length

386

Protein Sequence
(FASTA)

MGAFLDKPKM EKHNNSGEGN ELRFGLSSMQ GWRVEMEDAH TAVVSLPSPL QCWSFFAVYD 60

GHAGSQVAKY CCEHLLEHIT SSQGFQSALK EKSESTVDKV KDGIRSGFLM FDEHIRNLSE 120

KKHSNDRSGS TAVGVMISPS HLYFINCGDS RGILSRSGLV KFFTEDHKPS NPLEKERIQN 180

AGGSVMIQRV NGSLAVSRAL GDFDYKCVDG KGPTEQLVSP EPEVYAIERS EKDDEFIILA 240

CDGIWDVMGN EEVCSFVRSR LEVTDDLERV CNEIVDTCLY KGSRDNMSVV LICFPGAPKV 300

SQEAVMREME LDKFLEARVE EILKTEWDKG TPDLVNVMRM LTSETIPNLP PGGELASKRS 360

LIEAVFNRLN PSKNDETISP FMFDVW 386

Nucleotide Sequence
(FASTA)

ATGGGTGCAT TTCTGGACAA ACCAAAGATG GAAAAACATA ACAACTCTGG GGAGGGAAAC 60

GAGCTAAGGT TTGGGTTGAG CAGCATGCAG GGATGGCGGG TTGAGATGGA AGATGCGCAC 120

ACAGCAGTAG TTAGTTTGCC TTCGCCTCTT CAGTGCTGGT CATTTTTTGC TGTATATGAT 180

GGGCATGCTG GCTCTCAGGT GGCCAAGTAC TGCTGTGAGC ACCTGCTAGA GCACATCACT 240

AGTAGCCAAG GCTTCCAGAG TGCTCTGAAG GAGAAATCTG AAAGCACGGT GGATAAAGTT 300

AAGGATGGCA TCCGCTCTGG ATTCTTGATG TTTGACGAAC ACATACGAAA CTTGTCTGAA 360

AAGAAGCATA GTAATGACCG CAGTGGCTCC ACCGCTGTAG GGGTGATGAT TTCTCCAAGC 420

CATTTGTACT TCATTAACTG TGGGGACTCG CGTGGAATCC TTAGCAGGAG TGGATTGGTG 480

AAATTCTTCA CAGAGGATCA CAAGCCAAGC AACCCACTAG AGAAGGAAAG GATCCAGAAT 540

GCTGGTGGCT CAGTCATGAT CCAGCGTGTT AATGGGTCTC TAGCTGTATC CAGAGCTCTG 600

GGTGATTTTG ACTATAAGTG TGTGGATGGC AAAGGCCCCA CAGAGCAGCT CGTCTCTCCA 660

GAGCCTGAAG TTTATGCAAT AGAAAGAAGT GAGAAGGACG ATGAATTCAT CATACTTGCT 720

TGTGATGGCA TCTGGGATGT TATGGGGAAT GAGGAAGTGT GTAGCTTTGT GAGATCAAGA 780

TTAGAGGTTA CGGATGATCT TGAAAGAGTC TGCAATGAAA TTGTGGACAC CTGCTTGTAC 840

AAGGGAAGTC GAGATAATAT GAGTGTTGTG TTAATCTGCT TTCCTGGGGC CCCAAAGGTA 900

TCTCAAGAAG CAGTGATGCG AGAGATGGAA CTGGACAAGT TCTTGGAGGC CAGAGTTGAA 960

GAGATCCTTA AAACTGAGTG GGATAAAGGT ACTCCTGATT TGGTCAATGT TATGCGAATG 1020

TTAACCTCTG AGACCATACC AAACCTCCCT CCGGGTGGAG AGCTGGCAAG CAAACGAAGT 1080

CTTATTGAAG CAGTGTTCAA CAGACTTAAC CCATCAAAAA ACGATGAAAC AATTAGCCCT 1140

TTTATGTTTG ATGTTTGG 1158

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         ++g++s++g+r emeda+t+   +++ p+  ++++ff+vyDGh+gs+vak+c e+l e++

Q: 23    RFGLSSMQGWRVEMEDAHTA---VVSLPSPLQCWSFFAVYDGHAGSQVAKYCCEHLLEHI  79

         5799**************87...7778888899***************************

S: 62    aeele.......sseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikd  114

         +           +ses+ +kvk+ ++++Fl +de++++l+ek++++d+sGstav ++i++

Q: 80    TSSQGfqsalkeKSESTVDKVKDGIRSGFLMFDEHIRNLSEKKHSNDRSGSTAVGVMISP  139

         ***8899**9999999999*****************************************

S: 115   sklyvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvLav  174

         s+ly++n+GdSr +L+r+g ++  ++dHkps++ E+eRi++aggsv+ +   Rv+G+Lav

Q: 140   SHLYFINCGDSRGILSRSGLVKFFTEDHKPSNPLEKERIQNAGGSVMIQ---RVNGSLAV  196

         *******************99****************************...********

S: 175   sRalGdlylk.........pyvtpePevtshrltsede.fliLasDGlwdvvsneeavsl  224

         sRalGd+++k         ++v+pePev+ ++++++d+ f+iLa+DG+wdv+ nee++s+

Q: 197   SRALGDFDYKcvdgkgpteQLVSPEPEVYAIERSEKDDeFIILACDGIWDVMGNEEVCSF  256

         *********************************887777*********************

S: 225   vrdvlekkeaeqeaakkLvklalargskdnvsaivv  260

         vr++le +++++ +++++v+++l +gs+dn+s++++

Q: 257   VRSRLEVTDDLERVCNEIVDTCLYKGSRDNMSVVLI  292

         *******************************99875

Domain Sequence
(FASTA)

RFGLSSMQGW RVEMEDAHTA VVSLPSPLQC WSFFAVYDGH AGSQVAKYCC EHLLEHITSS 60

QGFQSALKEK SESTVDKVKD GIRSGFLMFD EHIRNLSEKK HSNDRSGSTA VGVMISPSHL 120

YFINCGDSRG ILSRSGLVKF FTEDHKPSNP LEKERIQNAG GSVMIQRVNG SLAVSRALGD 180

FDYKCVDGKG PTEQLVSPEP EVYAIERSEK DDEFIILACD GIWDVMGNEE VCSFVRSRLE 240

VTDDLERVCN EIVDTCLYKG SRDNMSVVLI 270

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0000287	; F:magnesium ion binding
GO:0030145	; F:manganese ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR001932	; PP2C-like.
IPR012911	; PP2C_C.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481	; PP2C; 1.
PF07830	; PP2C_C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013