EKS-ORL-00003
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORL-00003
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph514.64.3E-155568825258
StatusUnreviewed
Ensembl ProteinENSORLP00000019849
UniProt AccessionH2MMA8;
Protein Name
Protein Synonyms/Alias
Gene NameEPHA3
Gene Synonyms/Alias EPHA3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSORLG00000015835ENSORLP00000019849ENSORLT00000019850
ENSORLG00000015835ENSORLP00000019848ENSORLT00000019849
OrganismOryzias latipes
Functional Description
Protein Length930
Protein Sequence
(FASTA)
WEEISGVDEH YTPIRTFQVC NVMEYSQNNW LRTNWIPRQS AQKIYVELKF TLRDCNSIPL 60
VLGTCKETFN LLYLETDDDQ GSHFREHQYL KIDTIAADES FTQTDLGDRI LKLNIEVREV 120
GPLTKKGFYL AFQDVGACVA LVSVRVYFKK CPYTVRNLAS FPDTVPMDSQ SLVEVKGSCV 180
NHSKEEEPPR MYCSTEGEWL VPIGKCLCNQ GYEERSSTCQ TCRAGFYKSG FGNTECSKCP 240
PHSFSHHEGS LHCVCEKNYF RAEGDPASMS CTRPPSAPRN VISSINETSV ILEWSWPDNT 300
GGRRDITFAV LCKRCRSVPA DGSQRCEPCR SNVRFVPRAT GLYNTTVTVT DLLAHTNYTF 360
EIEAQNGVSS LAPQMRQYAA VTITTNQAAP SAVSGIRKEK TTRNSVSLAW QEPERPNGII 420
LDYEIKYYEK EEQETSYTIL RARGCNVTLG GLKPNTAYLL QIRARTAAGY GASSTTFQFE 480
TSPDSFSISS ESSQVVLIAI SSAVAIILLT VLLYVLIGSL SKYSGVFTER LQIQVRLPGI 540
RTYIDPHTYE DPSQAVHEFA KELDASCIAI DKVVGAGEFG EVCSGRLRLP SKKEICVAIK 600
TLKGGYTDKQ RRDFLAEASI MGQFDHPNII RLEGVVTRSK PVMIVTEYME NGSLDSFLRK 660
HDAQFTGIQL VGMLRGIASG MKYLSDMGYV HRDLAARNIL VNSNLVCKVS DFGLSRVLED 720
DPEGAYTTRG GKIPIRWTAP EAIAYRKFTS ASDAWSYGIV LWEVMSYGER PYWEMSNQDV 780
IKAVDEGYRL PPPMDCPATL YQLMLDCWQK ERNNRPKFEQ IVSILDKLIR NPGSLKITAN 840
TTSRPANLLL DRSSLEVPSM GTMGDWMDPM RTLPCKEAFS GVSYSSCDTI AKTSTEDLKK 900
VGVTIVGPQK KIVSSLKALD SNTKNGPVPV 930
Nucleotide Sequence
(FASTA)
TGGGAGGAGA TCAGTGGGGT GGATGAGCAC TACACTCCCA TACGAACCTT CCAGGTCTGC 60
AATGTGATGG AGTACAGCCA GAACAACTGG CTTCGCACCA ACTGGATCCC TCGGCAGTCG 120
GCGCAGAAGA TCTACGTGGA GCTGAAGTTC ACTCTGAGGG ACTGCAATTC CATCCCTTTG 180
GTCCTGGGGA CATGCAAGGA GACCTTCAAC CTTCTGTACC TGGAGACAGA TGATGACCAG 240
GGAAGCCATT TTAGAGAGCA TCAGTACCTC AAGATTGACA CCATCGCTGC TGATGAAAGT 300
TTTACCCAAA CGGATCTTGG GGATCGCATT CTCAAACTGA ACATTGAGGT GCGTGAGGTG 360
GGGCCCTTGA CCAAGAAGGG TTTCTACCTC GCGTTCCAGG ACGTGGGGGC CTGTGTTGCT 420
TTAGTTTCCG TGAGGGTTTA CTTTAAAAAG TGCCCATACA CTGTGAGGAA TCTGGCTTCC 480
TTCCCTGACA CGGTGCCCAT GGACTCCCAA TCTCTGGTTG AGGTCAAAGG TTCGTGTGTG 540
AATCACTCCA AAGAGGAGGA ACCTCCAAGA ATGTACTGCA GCACAGAGGG GGAGTGGCTT 600
GTGCCCATCG GGAAGTGTCT CTGTAACCAA GGATACGAGG AGAGAAGCAG CACCTGCCAA 660
ACGTGCAGGG CGGGATTCTA CAAATCTGGC TTCGGCAACA CGGAGTGTTC AAAGTGTCCG 720
CCTCACAGCT TCTCACACCA TGAGGGGTCG CTGCACTGCG TCTGTGAGAA AAACTACTTT 780
CGGGCAGAAG GAGACCCCGC CTCCATGTCC TGTACCAGAC CTCCGTCAGC TCCCCGAAAC 840
GTGATCTCCT CCATCAACGA AACCTCCGTT ATTCTAGAGT GGAGTTGGCC TGACAACACT 900
GGGGGACGGC GAGATATCAC ATTCGCCGTC CTCTGTAAAC GCTGCCGCAG TGTGCCTGCT 960
GATGGGAGCC AGCGCTGTGA GCCTTGTAGG AGCAACGTCC GCTTTGTGCC CAGAGCCACC 1020
GGACTCTACA ACACCACAGT GACAGTAACA GACCTGCTGG CCCACACCAA CTACACTTTT 1080
GAGATTGAGG CGCAGAACGG CGTATCCTCT CTGGCACCTC AGATGAGGCA GTATGCTGCT 1140
GTCACCATCA CTACCAACCA AGCAGCTCCT TCGGCAGTAT CAGGTATCCG AAAAGAGAAA 1200
ACAACTCGAA ACAGCGTCTC CTTGGCGTGG CAGGAGCCAG AAAGACCAAA CGGCATCATC 1260
CTCGACTATG AGATCAAGTA TTATGAAAAG GAGGAGCAGG AGACCAGCTA CACCATCCTC 1320
CGTGCTCGAG GTTGTAATGT GACCCTAGGT GGTCTGAAGC CCAACACAGC CTACCTGCTT 1380
CAGATCAGAG CTCGCACCGC TGCCGGCTAC GGAGCCAGCA GCACCACCTT CCAGTTTGAA 1440
ACTAGTCCTG ACTCCTTTTC AATCTCCAGT GAGAGCAGCC AGGTTGTTTT GATTGCCATT 1500
TCCTCCGCTG TGGCCATCAT CCTTCTCACC GTGCTGCTCT ACGTCCTGAT TGGCAGCTTA 1560
AGTAAATACT CAGGAGTGTT TACAGAGAGG TTACAAATCC AGGTGCGCCT CCCAGGGATC 1620
AGGACATACA TAGACCCCCA CACATATGAG GACCCAAGCC AGGCTGTCCA TGAGTTTGCC 1680
AAGGAGCTGG ACGCTTCATG CATTGCCATT GATAAAGTCG TGGGAGCAGG TGAGTTTGGA 1740
GAGGTGTGCA GTGGTCGTCT AAGGCTCCCC AGCAAAAAGG AGATCTGTGT GGCCATCAAG 1800
ACTCTGAAAG GAGGTTATAC GGATAAACAA AGGCGGGACT TCCTTGCTGA AGCATCAATA 1860
ATGGGGCAGT TTGATCACCC AAACATCATC AGGTTGGAGG GTGTAGTGAC TCGCAGTAAG 1920
CCTGTCATGA TTGTCACAGA ATACATGGAG AACGGATCTC TTGACAGCTT TTTAAGAAAA 1980
CATGACGCCC AGTTCACAGG AATTCAACTG GTTGGGATGC TGCGGGGCAT CGCCTCAGGC 2040
ATGAAGTATT TGTCAGACAT GGGTTACGTT CACCGAGACC TGGCTGCTCG GAACATCCTC 2100
GTCAACAGCA ATCTGGTGTG CAAAGTGTCA GACTTTGGTT TGTCCCGTGT ACTGGAGGAC 2160
GACCCGGAGG GAGCCTACAC CACCAGGGGA GGAAAGATTC CTATCCGGTG GACAGCCCCA 2220
GAGGCTATCG CCTACAGGAA GTTTACATCA GCCAGCGATG CTTGGAGTTA TGGTATTGTG 2280
CTCTGGGAGG TGATGTCATA TGGAGAACGA CCATACTGGG AAATGTCAAA TCAGGATGTA 2340
ATCAAAGCTG TAGATGAGGG ATACCGCCTG CCTCCACCTA TGGACTGCCC TGCCACCCTC 2400
TACCAGCTGA TGTTGGATTG CTGGCAAAAA GAGAGGAACA ATCGACCCAA GTTTGAACAG 2460
ATTGTCAGCA TTTTGGATAA ACTCATTCGC AACCCTGGCA GCCTCAAAAT CACAGCCAAC 2520
ACAACATCCA GGCCAGCCAA TTTATTGTTG GACAGGAGCA GCTTAGAGGT TCCCTCTATG 2580
GGGACGATGG GGGACTGGAT GGATCCGATG AGAACCCTGC CCTGCAAAGA GGCCTTCTCA 2640
GGGGTCAGCT ACAGCTCCTG TGACACAATA GCCAAGACCT CCACAGAGGA TCTGAAAAAG 2700
GTTGGCGTGA CTATTGTTGG ACCACAGAAG AAGATAGTGA GCAGCCTTAA AGCGCTAGAT 2760
TCCAACACGA AGAATGGCCC GGTACCTGTT TAA 2793
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         ++i+kv+GaGefGevcsGrl+lp+k+ei+vaiktlk+g+t+kqrrdfl+easi+Gqfdhp
Q: 568   IAIDKVVGAGEFGEVCSGRLRLPSKKEICVAIKTLKGGYTDKQRRDFLAEASIMGQFDHP  627
         689*********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         niirleGvvt+skpvmivteymeng+ldsflrk+d qft iqlvgmlrGiasgmkylsdm
Q: 628   NIIRLEGVVTRSKPVMIVTEYMENGSLDSFLRKHDAQFTGIQLVGMLRGIASGMKYLSDM  687
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrk  180
         gyvhrdlaarnilvnsnlvckvsdfGlsrvledd+e aytt+ggkipirwtapeaiayrk
Q: 688   GYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEGAYTTRGGKIPIRWTAPEAIAYRK  747
         ************************************************************
S: 181   ftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldc  240
         ftsasd+wsyGivlwev+syGerpyw+msnqdvika++egyrlpppmdcpa+lyqlmldc
Q: 748   FTSASDAWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPATLYQLMLDC  807
         ************************************************************
S: 241   wqkdraerpkfeqivsil  258
         wqk+r++rpkfeqivsil
Q: 808   WQKERNNRPKFEQIVSIL  825
         ***************986
Domain Sequence
(FASTA)
IAIDKVVGAG EFGEVCSGRL RLPSKKEICV AIKTLKGGYT DKQRRDFLAE ASIMGQFDHP 60
NIIRLEGVVT RSKPVMIVTE YMENGSLDSF LRKHDAQFTG IQLVGMLRGI ASGMKYLSDM 120
GYVHRDLAAR NILVNSNLVC KVSDFGLSRV LEDDPEGAYT TRGGKIPIRW TAPEAIAYRK 180
FTSASDAWSY GIVLWEVMSY GERPYWEMSN QDVIKAVDEG YRLPPPMDCP ATLYQLMLDC 240
WQKERNNRPK FEQIVSIL 258
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>
EKS-AIM-00002
EKS-CAJ-00002
EKS-CAF-00003
EKS-EQC-00003
EKS-FEC-00004
EKS-GAG-00003
EKS-GAA-00003
EKS-GOG-00002
EKS-HOS-00003
EKS-ICT-00002
EKS-LOA-00002
EKS-MAM-00002
EKS-MEG-00002
EKS-MOD-00002
EKS-MUM-00002
EKS-MUP-00002
EKS-MYL-00003
EKS-NOL-00002
EKS-ORN-00002
EKS-ORC-00002
EKS-OTG-00001
EKS-PAT-00002
EKS-PES-00003
EKS-POA-00002
EKS-PRC-00002
EKS-RAN-00003
EKS-SUS-00002
EKS-TAG-00004
EKS-TAS-00002
EKS-TEN-00001
EKS-TUT-00001
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005003; F:ephrin receptor activity
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013