EKS-ORL-00318

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00318

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	368.9	1.6E-110	13	265	253

Status

Unreviewed

Ensembl Protein

ENSORLP00000019987

UniProt Accession

H2MMP1;

Protein Name

Protein Synonyms/Alias

Gene Name

PLK4

Gene Synonyms/Alias

PLK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000015971	ENSORLP00000019987	ENSORLT00000019988

Organism

Oryzias latipes

Functional Description

Protein Length

959

Protein Sequence
(FASTA)

MSLSIGDKIE DFRVLTLLGK GSFACVYRAK SVKTGLEVAI KTIDKKAMQK AGMVQRVSNE 60

VEIHCRLKHP SVLELYNYFE DSNYVYLVLE MCHNGEMSRY LKERKKPFSE DEARHFMHQI 120

VKGMLYLHTH GILHRDLTLS NLLLTSNMNI KIADFGLATQ LKLPHEKHFT MCGTPNYISP 180

EVATRSAHGL ESDVWSLGCM FFAFLMGRPP FDTDTVKHTL SKVVLGDYEM PTHVSVEAQD 240

LIDQLLQKDP AHRPSLSAVL DHPFMTKSLL VRTKELGVGD EGSIDSGIAT ISTASTSTSS 300

GTRLQRRTKH MIASTLPNRM APIPSLARQP NVLEGGDEWH QQHSLDTFHR EGRSRTAHGG 360

NAAQPHSRFL RRAHSSERCG PAALGQRSSQ AELERWSSEG TLAVVGSQMF PMNCSQHPHS 420

EHGRHSSPPV KQSARKMLLF RPTLSDFKGL DECNYQNETI SPNLCALQLA STPLQPKKKT 480

PKHHFYWSGS LRLMSGSGPR PTENSTHSSS GSFHSSTGAL GVHNSWTDKP GSRGVHSLHS 540

QHSDSYRENT PEAEYRLSKG GDLKLSLAKP SSDKQKKTLR DVVPPLCAAR LKPIRQKTKN 600

AVVSILDTGE VCMELVKCQN GQERVKEVLR ISCDGTMVTI YQPNGGKGFP VLDCPPAAPE 660

DILICSYEDL PEKYWKKYQY ASKFVQLVKS KTPKVTLYTK FAKVMLMENS PNADLEVCFY 720

DGAKTHKTPE LIRVVEKSGK SYTVKGDVGL GGLSPESRLY VELSDEGHSM CLSLEAAITA 780

EEQRSNKKVP FFPITIGRMN FHFTCFICLL HRRPVTSDAP CLPLQQMLRN TASPPKSTQI 840

TPSMISYDGS DFTTASMSRK CSPVRQDLVQ SSGKVLKSIF VPNVGWASQV KLTSGEVWVQ 900

FNDGSQLVVQ AGVSCITYTS PDGRITRYKE NEKLPENVKE KLHCLSTILG LLANPSTLH 959

Nucleotide Sequence
(FASTA)

ATGAGTCTTT CTATCGGCGA TAAAATCGAG GATTTTAGGG TCCTCACCCT TCTGGGCAAA 60

GGCTCCTTTG CATGTGTTTA TCGGGCAAAA TCAGTCAAGA CTGGGCTTGA GGTTGCCATC 120

AAAACGATTG ACAAGAAAGC AATGCAGAAA GCTGGCATGG TCCAGCGTGT GTCCAATGAG 180

GTGGAGATCC ACTGCAGACT CAAACACCCC TCCGTACTTG AGCTCTACAA TTATTTTGAA 240

GACAGCAACT ATGTCTATTT GGTATTGGAG ATGTGCCACA ACGGCGAGAT GAGTCGGTAC 300

CTCAAAGAGC GAAAGAAGCC TTTCTCTGAG GATGAAGCGA GACATTTCAT GCACCAAATC 360

GTGAAGGGAA TGCTGTATTT GCATACTCAC GGCATCTTAC ACAGAGATCT GACCTTGTCC 420

AACCTTCTGC TGACCAGCAA CATGAACATT AAGATAGCGG ATTTTGGCTT GGCCACTCAG 480

CTCAAACTGC CACATGAGAA GCACTTCACT ATGTGTGGGA CTCCCAACTA CATTTCCCCA 540

GAGGTTGCCA CCCGAAGCGC CCACGGCCTG GAGTCAGACG TCTGGTCTTT GGGGTGTATG 600

TTCTTCGCGT TCCTGATGGG GCGCCCTCCC TTTGACACGG ACACGGTGAA GCACACCTTG 660

TCTAAAGTTG TTCTCGGGGA TTATGAGATG CCCACTCATG TCTCTGTTGA GGCTCAGGAT 720

TTGATTGATC AGTTGCTGCA GAAAGACCCC GCCCACAGGC CCAGCCTGTC AGCAGTACTG 780

GACCATCCGT TCATGACCAA GAGCCTGCTG GTCAGGACCA AAGAGCTGGG AGTGGGAGAT 840

GAAGGGTCCA TAGACAGTGG CATCGCCACC ATCTCCACAG CCTCTACTTC CACCAGCAGC 900

GGCACACGTC TCCAGAGGCG AACCAAACAC ATGATTGCGT CGACTCTTCC GAATCGCATG 960

GCGCCCATCC CGAGTCTTGC CCGCCAACCA AACGTCTTAG AGGGGGGAGA CGAGTGGCAT 1020

CAACAACACT CCCTGGACAC ATTTCACAGA GAAGGCAGGA GCAGGACAGC TCACGGCGGA 1080

AACGCTGCTC AGCCACACTC TCGCTTCCTC AGGAGGGCAC ACTCGTCAGA GCGCTGCGGT 1140

CCTGCTGCAC TTGGACAGAG GTCGTCCCAG GCTGAGCTGG AGAGGTGGAG TTCAGAGGGG 1200

ACTCTGGCTG TTGTCGGGAG CCAAATGTTC CCCATGAACT GCTCTCAGCA TCCGCATTCA 1260

GAGCATGGCC GGCACTCGTC ACCTCCTGTC AAACAATCAG CAAGGAAAAT GCTACTTTTT 1320

AGACCAACTT TGTCAGATTT TAAGGGTTTG GACGAATGTA ATTACCAAAA TGAAACAATC 1380

TCACCAAATT TATGCGCTCT TCAGCTAGCT TCCACCCCCT TACAACCTAA AAAAAAAACA 1440

CCAAAGCACC ATTTTTATTG GAGTGGGTCT TTAAGGCTGA TGTCAGGTTC TGGGCCAAGG 1500

CCCACAGAGA ACAGCACCCA CAGCAGCAGT GGCAGCTTTC ACAGCAGCAC AGGAGCTCTA 1560

GGGGTCCACA ACTCCTGGAC AGACAAACCT GGGAGCCGGG GTGTTCACTC TCTCCATAGC 1620

CAGCACTCCG ACTCATACAG GGAGAACACA CCCGAAGCAG AGTACCGCCT GTCAAAAGGA 1680

GGGGATCTAA AGCTTTCTTT AGCCAAACCC AGTTCAGACA AGCAGAAGAA AACCCTGAGA 1740

GATGTAGTCC CACCTCTGTG TGCAGCCAGA CTGAAACCTA TCAGGCAGAA GACCAAAAAC 1800

GCAGTTGTGA GCATACTGGA CACAGGAGAA GTGTGCATGG AGTTGGTAAA ATGCCAAAAC 1860

GGGCAAGAAA GGGTGAAGGA AGTTCTACGG ATTTCCTGTG ATGGAACAAT GGTAACAATA 1920

TATCAGCCTA ATGGAGGAAA AGGGTTTCCT GTGCTGGATT GTCCTCCTGC TGCTCCGGAG 1980

GATATTCTCA TCTGCAGCTA TGAGGATCTT CCAGAGAAAT ACTGGAAAAA ATACCAGTAT 2040

GCTTCCAAAT TTGTGCAGCT TGTGAAATCC AAAACTCCTA AAGTGACCCT TTACACCAAG 2100

TTTGCAAAAG TCATGCTGAT GGAAAACTCG CCCAACGCTG ACCTCGAAGT TTGCTTTTAT 2160

GACGGTGCAA AGACCCACAA GACACCGGAA CTTATACGAG TCGTGGAGAA GAGCGGAAAG 2220

TCGTACACCG TGAAAGGAGA CGTGGGGCTG GGCGGCCTGA GTCCGGAGAG CAGGTTGTAC 2280

GTCGAGCTGT CCGACGAGGG TCACAGCATG TGTCTGTCAC TAGAGGCCGC CATTACGGCA 2340

GAGGAGCAAC GGAGCAACAA AAAAGTTCCT TTTTTCCCCA TAACTATCGG CAGAATGAAT 2400

TTTCACTTTA CATGCTTCAT CTGTTTGCTT CACAGGAGAC CTGTCACCTC AGATGCCCCC 2460

TGTTTGCCTT TGCAGCAGAT GCTCCGCAAT ACAGCTTCAC CTCCAAAATC CACACAAATC 2520

ACTCCTTCTA TGATTTCCTA CGATGGGTCT GATTTCACCA CAGCAAGCAT GAGTAGAAAA 2580

TGCTCTCCGG TGCGGCAGGA CCTGGTTCAG AGTTCAGGGA AGGTGCTGAA ATCAATATTT 2640

GTGCCCAACG TTGGGTGGGC TTCCCAGGTG AAGCTGACGA GCGGAGAGGT GTGGGTGCAG 2700

TTCAACGACG GCTCTCAGCT TGTGGTTCAG GCGGGAGTTT CCTGCATTAC TTACACTTCT 2760

CCGGATGGGA GGATCACCAG GTATAAAGAG AATGAAAAGC TACCAGAAAA CGTCAAGGAA 2820

AAGCTGCACT GTCTCTCGAC TATTCTCGGA CTGCTGGCAA ACCCGTCCAC ACTGCAT 2877

Domain Profile

S: 2     ergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkni  61

         ++  llGkG+fa +y++k+++t+ ++a+k+++k++++k+ + ++v++e+eih++lkh+++

Q: 13    RVLTLLGKGSFACVYRAKSVKTGLEVAIKTIDKKAMQKAGMVQRVSNEVEIHCRLKHPSV  72

         56689*******************************************************

S: 62    vklyeffedkenvylvlelcsrrslaellkrr.kaltepevryylrqivsglkylhekri  120

         ++ly++fed+++vylvle+c+++++ ++lk+r k+++e e+r++++qiv+g++ylh++ i

Q: 73    LELYNYFEDSNYVYLVLEMCHNGEMSRYLKERkKPFSEDEARHFMHQIVKGMLYLHTHGI  132

         ******************************99899*************************

S: 121   lhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghslev  180

         lhrdl+l+nl+l++++++ki+dfGlat+l+ ++e++ t+cGtPnyi+Pev+++++h+le+

Q: 133   LHRDLTLSNLLLTSNMNIKIADFGLATQLKLPHEKHFTMCGTPNYISPEVATRSAHGLES  192

         ************************************************************

S: 181   diWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePee  240

         d+WslGc+++++l+G+PPf+t+++k+t++k++  +y++P+++s ea++li +ll+k+P++

Q: 193   DVWSLGCMFFAFLMGRPPFDTDTVKHTLSKVVLGDYEMPTHVSVEAQDLIDQLLQKDPAH  252

         ************************************************************

S: 241   rpsleevlkdefl  253

         rpsl++vl+++f+

Q: 253   RPSLSAVLDHPFM  265

         ***********98

Domain Sequence
(FASTA)

RVLTLLGKGS FACVYRAKSV KTGLEVAIKT IDKKAMQKAG MVQRVSNEVE IHCRLKHPSV 60

LELYNYFEDS NYVYLVLEMC HNGEMSRYLK ERKKPFSEDE ARHFMHQIVK GMLYLHTHGI 120

LHRDLTLSNL LLTSNMNIKI ADFGLATQLK LPHEKHFTMC GTPNYISPEV ATRSAHGLES 180

DVWSLGCMFF AFLMGRPPFD TDTVKHTLSK VVLGDYEMPT HVSVEAQDLI DQLLQKDPAH 240

RPSLSAVLDH PFM 253

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008266	; Tyr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

Created Date

20-Feb-2013