EKS-ORL-00357
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORL-00357
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR498.25.6E-150560816257
StatusUnreviewed
Ensembl ProteinENSORLP00000020056
UniProt AccessionH2MMV9;
Protein Name
Protein Synonyms/Alias
Gene NameERBB4 (2 of 2)
Gene Synonyms/Alias ERBB4 (2 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSORLG00000016023ENSORLP00000020055ENSORLT00000020056
ENSORLG00000016023ENSORLP00000020056ENSORLT00000020057
OrganismOryzias latipes
Functional Description
Protein Length868
Protein Sequence
(FASTA)
EILYGGVYVD QNKFLCHADT IHWQDIVKNP GFHPVVVPTN SSVTCPKCHR SCNGRCWGPK 60
DNQCQSLTKT VCAEQCDGRC SGPYVSDCCH RECAGGCFGP KDTDCFACTN FNDSGACVTQ 120
CPQPFFYNPT TFQLEHNPSA RYTYGAFCVK KCPHNFVVDH NSCVRACPTN KMEVEDNHIK 180
MCIPCTDICP KACDGIGTGT LQAAQTVDSS NIDKFVNCTK INGNLVFLIT GIKGDVYHNI 240
EALDPEKLNV FRSVREITGY LNIQSWPDNM TDLIVFSNLA TIGGRALYSG ISLLVLKQQG 300
ISSFLLQSLK EISAGNVHIA ENKQLCYYNT VNWTRLFRSP NQKVLFDFAR GHMVCDPLCS 360
DDGCWGSGPD QCLSCKFFSR GRSCIKSCNL YQGEIREYAN GSVCVECDSQ CEQGDDNTLT 420
CHGSGPEHCV KCLHFKDGPN CVEKCPDGLQ GASSFIFKYA EANNECHPCH PNCTQGCIGP 480
RLQDCIGWMD RTPLIAAGVI GGLFMVVIMA LSVAVSVRRK NIKKKRALRR FLETELVEPL 540
TPSGTAPNQA QLRILKETEL KRIKILGSGA FGTVYKGIWI PEGETVKIPV AIKILNETTG 600
PKANVEFMDE ALIMASMEHP HLVRLLGVCL SPTIQLVTQL MPHGCLLDYV HEHKDNIGSQ 660
LLLNWCVQIA KGMMYLEERR LVHRDLAARN VLVKSPNHVK ITDFGLARLL DVNEKEYNAD 720
GGKMPIKWMA LECIHYRKFT HQSDVWSYGV TIWELMTFGG KPYDGISTRD IPDLLEKGER 780
LPQPPICTID VYMVMVKCWM IDADSRPRFK ELAAEFTRMA RDPQRYLVIQ GDDRMKLPSP 840
NDSKFFQSLL EEEELEDLMD AEEYLVPH 868
Nucleotide Sequence
(FASTA)
GAGATTCTTT ACGGAGGAGT GTACGTTGAC CAGAACAAGT TCCTCTGCCA TGCGGACACA 60
ATCCACTGGC AGGACATAGT GAAAAACCCA GGGTTCCATC CCGTAGTTGT GCCTACCAAC 120
AGCAGTGTCA CATGCCCAAA ATGCCATCGC TCCTGCAACG GACGCTGCTG GGGGCCAAAG 180
GACAACCAGT GTCAAAGCTT AACAAAAACG GTGTGTGCTG AGCAATGTGA TGGACGCTGC 240
TCTGGGCCCT ACGTTAGCGA CTGCTGCCAT CGCGAATGTG CAGGAGGCTG CTTTGGACCA 300
AAGGACACAG ACTGCTTTGC CTGCACAAAC TTCAACGACA GTGGGGCTTG TGTTACCCAG 360
TGTCCTCAGC CATTTTTCTA CAATCCTACA ACCTTCCAAC TGGAGCACAA CCCTAGTGCA 420
AGATACACCT ACGGAGCGTT TTGCGTCAAA AAGTGTCCAC ATAACTTTGT CGTGGACCAT 480
AACTCCTGTG TAAGAGCATG CCCCACCAAT AAGATGGAGG TGGAAGACAA TCACATTAAG 540
ATGTGCATCC CTTGTACTGA CATCTGCCCA AAAGCATGTG ATGGAATAGG TACGGGCACC 600
CTTCAAGCAG CTCAGACGGT GGACTCCAGC AACATTGATA AGTTTGTTAA CTGCACCAAA 660
ATCAACGGCA ACTTGGTCTT TCTGATCACT GGAATCAAAG GGGATGTCTA TCACAACATA 720
GAAGCACTGG ACCCAGAGAA GCTCAATGTT TTTCGGAGTG TTCGGGAAAT CACAGGTTAC 780
CTTAACATCC AATCTTGGCC TGACAACATG ACTGACCTGA TTGTTTTCTC CAACCTGGCA 840
ACTATTGGAG GAAGAGCATT ATACAGTGGC ATTTCCCTGC TGGTGCTGAA ACAACAAGGG 900
ATCTCCTCGT TCTTGCTTCA GTCACTAAAG GAGATCAGTG CAGGAAATGT GCACATTGCT 960
GAGAACAAAC AACTTTGTTA TTACAACACT GTTAACTGGA CAAGGCTGTT CCGATCTCCA 1020
AACCAAAAGG TTTTGTTTGA CTTTGCAAGG GGTCACATGG TCTGTGACCC GCTATGCTCA 1080
GACGATGGCT GTTGGGGTTC CGGCCCAGAC CAGTGCCTGT CCTGCAAGTT CTTCAGTCGT 1140
GGACGATCTT GCATTAAAAG CTGCAACCTT TATCAAGGGG AGATTCGAGA GTATGCCAAC 1200
GGGTCAGTGT GTGTGGAGTG CGATTCCCAA TGTGAACAAG GAGACGACAA CACTTTGACT 1260
TGTCATGGCT CGGGCCCAGA GCATTGTGTG AAATGCCTTC ATTTCAAGGA CGGTCCAAAC 1320
TGTGTTGAAA AGTGTCCCGA TGGGTTGCAG GGGGCCAGCA GCTTCATCTT CAAATACGCT 1380
GAGGCCAACA ACGAATGCCA TCCCTGCCAC CCTAACTGCA CCCAGGGGTG CATTGGACCA 1440
AGACTCCAGG ACTGCATTGG CTGGATGGAC AGAACTCCTC TAATTGCAGC CGGAGTGATT 1500
GGTGGCCTCT TCATGGTGGT GATCATGGCA CTCAGCGTGG CCGTGTCTGT GCGGCGGAAG 1560
AACATTAAGA AGAAGAGGGC CCTTCGCCGT TTTTTGGAAA CGGAGTTGGT TGAACCTTTG 1620
ACACCAAGTG GAACAGCTCC TAATCAAGCC CAGCTTCGCA TCCTGAAAGA AACTGAACTT 1680
AAAAGAATCA AGATCTTGGG ATCTGGAGCT TTTGGAACTG TGTACAAGGG TATTTGGATC 1740
CCAGAAGGTG AAACAGTGAA AATACCTGTG GCCATTAAAA TCCTCAACGA AACCACCGGA 1800
CCAAAGGCCA ATGTGGAGTT CATGGATGAG GCTCTGATCA TGGCGAGCAT GGAGCACCCT 1860
CACCTGGTGC GACTGTTGGG TGTGTGCCTG AGTCCCACCA TCCAGCTTGT TACACAGCTG 1920
ATGCCTCACG GCTGTCTGCT TGATTATGTC CATGAGCACA AGGACAACAT TGGATCACAG 1980
CTATTGCTCA ACTGGTGTGT CCAAATCGCC AAGGGAATGA TGTATTTGGA GGAGCGCAGG 2040
TTGGTCCACC GAGATTTGGC AGCTCGAAAC GTTCTGGTCA AATCTCCAAA CCACGTTAAG 2100
ATAACCGACT TTGGACTGGC TCGACTGCTG GATGTCAATG AGAAAGAATA CAACGCCGAT 2160
GGAGGAAAGA TGCCTATCAA ATGGATGGCG CTGGAGTGCA TCCATTACAG GAAGTTTACT 2220
CATCAGAGTG ATGTTTGGAG CTATGGTGTA ACTATATGGG AGCTGATGAC CTTTGGAGGA 2280
AAACCTTATG ATGGAATTTC AACCAGAGAT ATTCCAGATC TGCTGGAAAA AGGAGAGCGA 2340
CTTCCCCAGC CGCCCATCTG CACGATTGAT GTCTACATGG TCATGGTCAA ATGCTGGATG 2400
ATTGATGCAG ACAGTCGACC GCGGTTTAAA GAGCTGGCTG CAGAGTTCAC TCGAATGGCA 2460
CGTGATCCCC AGCGATACCT GGTCATTCAG GGGGATGATC GCATGAAGCT GCCAAGTCCC 2520
AATGACAGCA AGTTTTTCCA GAGCCTCCTG GAGGAAGAAG AATTAGAGGA CCTAATGGAT 2580
GCAGAGGAGT ACTTGGTGCC CCAC 2604
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         lk++k+lGsGafGtvykGiwipege+vkipvaik+l+e+tg+kan e++deal++as++h
Q: 560   LKRIKILGSGAFGTVYKGIWIPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMEH  619
         699*********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         ++lvrllg+cls t+qlvtql+p+Gclldyv+ehkd++Gsq llnwcvqiakGm+ylee+
Q: 620   PHLVRLLGVCLSPTIQLVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEER  679
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
         rlvhrdlaarnvlvkspnhvkitdfGla+ll+ +eke++a+ggk+pikw+ale+i++rk+
Q: 680   RLVHRDLAARNVLVKSPNHVKITDFGLARLLDVNEKEYNADGGKMPIKWMALECIHYRKF  739
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvt+wel+tfG kpydgi++++ipdllekGerl+qppictidvymv+vkcw
Q: 740   THQSDVWSYGVTIWELMTFGGKPYDGISTRDIPDLLEKGERLPQPPICTIDVYMVMVKCW  799
         ************************************************************
S: 241   midaesrpkfkelaeef  257
         mida+srp+fkela+ef
Q: 800   MIDADSRPRFKELAAEF  816
         ***************99
Domain Sequence
(FASTA)
LKRIKILGSG AFGTVYKGIW IPEGETVKIP VAIKILNETT GPKANVEFMD EALIMASMEH 60
PHLVRLLGVC LSPTIQLVTQ LMPHGCLLDY VHEHKDNIGS QLLLNWCVQI AKGMMYLEER 120
RLVHRDLAAR NVLVKSPNHV KITDFGLARL LDVNEKEYNA DGGKMPIKWM ALECIHYRKF 180
THQSDVWSYG VTIWELMTFG GKPYDGISTR DIPDLLEKGE RLPQPPICTI DVYMVMVKCW 240
MIDADSRPRF KELAAEF 257
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Gasterosteus aculeatus"; ?>Oreochromis niloticus"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>
EKS-GAA-00367
EKS-ORN-00387
EKS-TAR-00389
EKS-XIM-00377
Gene Ontology
GO:0016020; C:membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00261; FU; 4.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013