EKS-ORL-00510

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00510

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/DMPK	497.8	8.7E-150	22	288	267

Status

Unreviewed

Ensembl Protein

ENSORLP00000020134

UniProt Accession

H2MN33;

Protein Name

Protein Synonyms/Alias

Gene Name

CDC42BPA

Gene Synonyms/Alias

CDC42BPA;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000016081	ENSORLP00000020131	ENSORLT00000020132
ENSORLG00000016081	ENSORLP00000020132	ENSORLT00000020133
ENSORLG00000016081	ENSORLP00000020134	ENSORLT00000020135
ENSORLG00000016081	ENSORLP00000020135	ENSORLT00000020136

Organism

Oryzias latipes

Functional Description

Protein Length

1588

Protein Sequence
(FASTA)

FLSAAKPFTS KVKQMRLHKE DFEILKVIGR GAFGEVAVVK VKNTDKVFAM KILNKWEMLK 60

RAETACFREE RDVLVNGDCQ WITTLHYAFQ DDNNLYLVMD YYVGGDLLTL LSKFEDRLPE 120

DMAKFYLAEM VLAIDSVHQL HYVHRDIKPD NILLDKKGHI RLADFGSCLK LMEDGTVQSS 180

VAVGTPDYIS PEILQAMEDG KGKYGPECDW WSLGVCMYEM LYGETPFYAE SLVETYGKIM 240

NHKERFQFPQ QLTDVSEEAK DLIRRLICSR EHRLGQNGIE DFKQHPFFSG IDWDNIRTCE 300

APYIPEVSSP TDTSNFDVDD DCLKNSETMP PPSHTAFSGH HLPFVGFTYT SKCTFSDRGC 360

LRQLSGERGQ TGEDQVDLDV KRRLEDSLAT EAYERRIRRL EQEKTELSRK LHESTQTVQA 420

LQHPTTESPL SSTKEVEIRS LKTEIEILKK QIAESGQLEK KLEDVTSSRR DLEDSSKHVR 480

TLEKQLKSLT QERDEMQKVE VLAEEHAAEA QKEKKIRERN EQYSRQLEEE LEGLKSKQSG 540

SSVTPAAADQ TQEVGHLRGE MERKTLLYEE ELARREAQHS TELKTLRKEL RDAESQQLTL 600

QKEILMLKDK LDQARRRSII DREEIEMEYK QKYETERVLL TEENKKLSND LDKLSRMFEK 660

VSSSHQHLED EMKELADKKE SVAHWEAQIT EIIQWVSDEK DARGYLQALA TKMTEELEGL 720

KNTSLGARAT DMPWKMRRLA KLDMSARLEL QSALDAEIKA KQAIQDELTQ VKADCFSTEG 780

KLQDMESKNK ELLAEIEHLK KETEELRLRR GVKHQDSQNS FLAFLNAPTS ALDQFDLIDH 840

QPRSVQTPTM RSGGYGSMGR CSPKPKAHQF VVKSFSAPTK CNQCTSLMVG LIRQGCMCEV 900

CNFSCHVTCA DKAPAVCPVP QDQTKGSLGI DPQRGIGTAY EGYVRVPKPT GVKKGWQRAM 960

AVVCDFKLFL YELGEGKAAQ PSVIVSQVID MRDEEFSVSS VLASDVIHAS RKDIPCIFRV 1020

TASHLSASSS QKTSILMLAD SDQERNKWVG LLGELHRILK KNKLKDRFVY VPKEAYDSTL 1080

PLIKGTQSAA IIDHERVALG NEEGLFVIHV TKDEIIRVGD NKKVYQIDPI PQEHLLAVIS 1140

GKNRHVRLVP IMALDGRETD CQKLVETKGC QRIASGPVRN GSLMCLCVAM KTKIICYEVN 1200

RSKAHYRRLR DVQAPAAIQW MGLFGDRLYV GYQSGFVRYS IPDNMAMVSL LHPEDHTLAF 1260

IPQQNLEALC AVEISSKELL LCFSSIGVYV DSHGHRSRQQ ELMWPATPNA ACYNAPYLSV 1320

YSENAVDVFD VNTMEWIQTI PLKKVRPLNV DGSLNLLGLE TVRLIYFRNK MAEGDELVVP 1380

ETSDQSRKQM VRSNNNKRRF SFRVPEEERL QQRREMLRDP EMRNKLISNP TNFNHVAHMG 1440

PGDGIQILKD LPMNLRLQES RAGFSGSASI ASITKNRGEP GRSMSASSGL GIRPSSQNGS 1500

ALRRELSGGS YGSKRQTMTS PSESSLSSGG GMDCIDAPLS QFDKEDSDSP RHSTASNSST 1560

FSSPPSPASP HKTKSLSLES TDRTGWDT 1588

Nucleotide Sequence
(FASTA)

TTTCTCTCTG CAGCCAAACC ATTCACCTCC AAAGTGAAGC AAATGCGCCT TCACAAAGAA 60

GACTTTGAGA TACTTAAGGT GATCGGACGA GGCGCCTTTG GAGAGGTTGC TGTGGTAAAA 120

GTGAAAAACA CAGATAAAGT TTTCGCCATG AAGATCCTCA ACAAATGGGA GATGTTGAAG 180

CGAGCAGAGA CTGCGTGTTT TCGGGAGGAG CGAGACGTGC TGGTAAACGG AGACTGCCAG 240

TGGATCACCA CCCTGCACTA CGCCTTCCAG GATGACAATA ATCTGTACCT GGTTATGGAC 300

TACTACGTGG GCGGGGACCT GCTGACTCTC CTCAGCAAGT TTGAGGACCG TTTGCCTGAA 360

GATATGGCCA AGTTCTACCT TGCTGAAATG GTGTTGGCCA TTGATTCTGT CCACCAGCTA 420

CACTACGTCC ACAGGGACAT CAAGCCGGAC AACATTCTGC TGGATAAGAA GGGTCACATC 480

CGCCTGGCAG ACTTCGGCTC CTGCCTTAAA CTCATGGAGG ACGGAACTGT CCAGTCCTCG 540

GTGGCAGTGG GAACTCCAGA CTACATTTCC CCAGAGATCC TTCAGGCCAT GGAGGATGGA 600

AAAGGAAAGT ACGGCCCCGA GTGCGACTGG TGGTCTCTGG GTGTGTGCAT GTATGAAATG 660

CTGTACGGCG AGACTCCTTT CTATGCAGAG TCCCTGGTGG AAACCTATGG GAAGATCATG 720

AACCACAAGG AGCGATTCCA GTTCCCGCAG CAGCTAACCG ATGTGTCAGA GGAAGCCAAA 780

GATCTGATTC GCCGGCTCAT CTGCAGTCGG GAGCACAGGC TGGGCCAGAA CGGCATTGAG 840

GACTTCAAGC AGCACCCTTT CTTCTCTGGC ATTGATTGGG ACAACATCCG TACTTGTGAA 900

GCCCCCTACA TCCCAGAAGT CAGCAGTCCC ACAGATACCT CCAACTTTGA CGTTGATGAC 960

GACTGTCTAA AAAACTCTGA GACCATGCCT CCTCCGTCGC ACACAGCCTT CTCTGGTCAC 1020

CATCTGCCCT TTGTTGGTTT CACCTACACA AGTAAATGCA CCTTTTCAGA TCGGGGCTGT 1080

CTGCGGCAGC TCTCGGGGGA GCGGGGTCAG ACGGGGGAGG ACCAAGTGGA CCTGGATGTG 1140

AAGCGCAGGC TGGAGGACAG CCTGGCCACT GAGGCCTACG AGAGGAGGAT ACGGCGGCTG 1200

GAGCAGGAGA AGACGGAGCT GAGCCGCAAG CTGCACGAGT CGACTCAAAC GGTTCAGGCG 1260

CTCCAGCATC CGACCACAGA GAGCCCCCTC AGCTCCACCA AAGAGGTGGA GATAAGGAGC 1320

CTGAAAACTG AGATTGAAAT CCTCAAGAAA CAGATAGCAG AATCTGGCCA ACTGGAGAAG 1380

AAGCTGGAGG ATGTGACGTC AAGTCGCAGG GACCTGGAGG ATTCATCTAA ACACGTCAGG 1440

ACTCTGGAGA AACAGCTGAA GAGCCTGACC CAGGAGAGGG ACGAGATGCA GAAGGTCGAG 1500

GTGCTGGCAG AGGAGCATGC AGCCGAGGCT CAGAAGGAGA AGAAGATCAG GGAGCGGAAT 1560

GAGCAGTACA GCAGGCAGCT GGAGGAGGAG CTGGAAGGCC TGAAGTCAAA ACAGTCTGGC 1620

TCCTCGGTCA CGCCGGCCGC AGCAGACCAG ACGCAGGAGG TGGGCCACCT GCGTGGAGAG 1680

ATGGAGAGGA AGACGCTCTT GTACGAGGAG GAGCTGGCTC GAAGGGAGGC GCAGCACAGC 1740

ACCGAGCTAA AGACCCTGCG GAAGGAGCTG AGAGACGCTG AGAGCCAGCA GCTGACCCTA 1800

CAGAAGGAGA TCCTGATGCT CAAAGACAAG CTGGACCAGG CTCGCCGCCG AAGCATAATT 1860

GACCGAGAAG AGATTGAGAT GGAGTACAAG CAAAAGTACG AGACAGAACG AGTTCTGCTC 1920

ACAGAGGAGA ACAAAAAGCT GTCCAATGAT CTAGACAAGC TGAGCAGAAT GTTTGAGAAG 1980

GTGAGCAGCT CCCATCAGCA TCTGGAGGAC GAGATGAAGG AGCTGGCTGA CAAAAAGGAG 2040

AGCGTGGCCC ACTGGGAGGC GCAGATCACA GAAATCATCC AATGGGTGAG TGATGAGAAG 2100

GACGCTCGGG GTTACCTTCA AGCTCTGGCC ACTAAGATGA CGGAGGAACT GGAGGGGCTG 2160

AAGAACACCA GCCTTGGAGC CAGAGCCACA GACATGCCAT GGAAGATGCG GCGTTTGGCT 2220

AAGCTGGACA TGTCGGCGCG GCTGGAGCTG CAGTCCGCTC TGGACGCCGA GATCAAAGCC 2280

AAACAAGCCA TCCAGGACGA GCTGACCCAA GTCAAGGCCG ACTGCTTTTC CACAGAGGGA 2340

AAACTGCAGG ACATGGAGAG TAAAAACAAG GAGCTTCTGG CTGAGATTGA ACATCTGAAG 2400

AAGGAGACGG AGGAGCTGCG GCTCAGAAGA GGTGTCAAGC ACCAGGATTC CCAGAATTCT 2460

TTCTTGGCTT TCCTTAACGC CCCCACCTCG GCCCTCGACC AGTTCGATCT GATCGACCAT 2520

CAGCCCCGCT CGGTGCAGAC CCCCACCATG CGCTCGGGGG GTTATGGCAG CATGGGCCGC 2580

TGCTCGCCGA AGCCCAAAGC ACATCAGTTT GTGGTGAAGT CCTTCAGCGC CCCTACCAAG 2640

TGTAACCAGT GCACCTCACT CATGGTGGGG CTCATTCGAC AAGGCTGCAT GTGTGAAGTG 2700

TGTAACTTCT CCTGTCATGT GACCTGTGCG GACAAAGCTC CGGCCGTGTG TCCCGTCCCC 2760

CAGGATCAGA CTAAGGGTTC GCTGGGGATC GACCCCCAAA GGGGCATCGG TACCGCCTAT 2820

GAAGGCTACG TCAGGGTGCC CAAACCCACC GGGGTGAAGA AGGGCTGGCA GAGGGCGATG 2880

GCTGTAGTCT GTGACTTCAA GCTCTTCCTC TACGAGCTGG GAGAAGGAAA AGCCGCACAG 2940

CCGAGCGTCA TCGTCAGCCA AGTCATCGAT ATGAGAGATG AAGAGTTCTC CGTCAGCTCC 3000

GTCTTAGCCT CAGACGTCAT CCATGCCAGC CGCAAAGACA TTCCCTGTAT CTTCAGAGTG 3060

ACGGCCTCCC ACCTGTCCGC CTCCAGCAGC CAAAAGACCT CCATCCTGAT GCTGGCGGAC 3120

AGCGACCAGG AGAGAAACAA GTGGGTGGGG CTCCTCGGTG AGCTCCACCG CATCCTCAAG 3180

AAAAACAAGC TGAAGGACCG CTTTGTCTAC GTCCCGAAGG AGGCGTACGA CAGCACGCTG 3240

CCGCTCATCA AGGGCACCCA GTCTGCTGCC ATCATAGATC ACGAACGTGT GGCGCTGGGC 3300

AATGAGGAAG GCCTTTTTGT CATCCATGTT ACCAAAGATG AAATCATCCG GGTGGGCGAC 3360

AACAAAAAGG TTTACCAGAT TGACCCCATC CCCCAGGAGC ACCTGCTAGC GGTCATCTCA 3420

GGCAAGAACC GCCACGTCCG CCTCGTCCCC ATAATGGCGC TGGACGGACG TGAGACCGAT 3480

TGCCAGAAGC TAGTTGAAAC TAAGGGCTGC CAGAGGATCG CGTCCGGTCC AGTCCGAAAC 3540

GGCTCGCTCA TGTGCCTTTG TGTGGCCATG AAGACTAAAA TCATCTGTTA TGAGGTGAAT 3600

AGGAGCAAAG CCCATTACCG CCGTCTGCGA GACGTTCAAG CTCCTGCTGC GATTCAGTGG 3660

ATGGGTCTGT TTGGAGATCG CCTTTATGTG GGGTACCAGT CGGGCTTCGT GCGCTACAGC 3720

ATCCCTGACA ACATGGCCAT GGTGAGCCTC CTCCACCCCG AGGACCACAC GCTGGCCTTC 3780

ATCCCACAGC AGAACCTGGA GGCGCTGTGC GCCGTGGAGA TCTCCAGCAA AGAGCTGCTG 3840

CTCTGCTTCA GCTCCATCGG GGTGTACGTG GACTCACACG GCCACCGCTC ACGCCAGCAG 3900

GAGCTCATGT GGCCGGCCAC GCCCAACGCT GCCTGCTACA ACGCCCCCTA CCTGTCAGTG 3960

TACAGCGAGA ACGCCGTGGA CGTGTTTGAC GTCAACACCA TGGAGTGGAT CCAGACCATT 4020

CCTCTCAAGA AGGTACGACC TCTGAATGTG GACGGCTCTC TGAACCTGCT GGGCCTGGAA 4080

ACTGTGCGCC TCATCTACTT CAGAAACAAG ATGGCCGAGG GCGATGAGCT GGTCGTCCCG 4140

GAGACGTCAG ACCAGAGCAG GAAGCAGATG GTGCGCAGCA ACAACAACAA GAGGAGATTC 4200

TCGTTCCGAG TGCCTGAAGA GGAGCGCCTT CAACAGAGAA GAGAGATGCT GCGAGACCCA 4260

GAGATGAGGA ACAAACTGAT CTCCAACCCC ACCAACTTCA ACCACGTGGC CCACATGGGA 4320

CCAGGAGACG GGATCCAGAT CCTCAAAGAC CTGCCCATGA ACCTCCGTCT TCAGGAGAGC 4380

CGCGCAGGAT TCAGCGGCTC CGCCAGCATC GCCTCCATCA CCAAGAACCG GGGGGAGCCG 4440

GGCCGCTCTA TGAGCGCCAG CAGCGGACTG GGCATACGCC CGTCCTCCCA GAACGGCAGC 4500

GCTCTGCGGC GGGAGCTGTC GGGAGGAAGC TATGGGTCCA AACGGCAGAC CATGACGTCT 4560

CCCTCGGAGA GCTCCCTGTC CTCTGGAGGA GGGATGGACT GCATCGACGC TCCTCTCTCG 4620

CAGTTCGACA AGGAGGACTC GGACTCCCCC CGTCATTCCA CGGCCTCCAA CAGCTCCACC 4680

TTCAGCAGCC CCCCCAGCCC GGCGTCCCCA CACAAGACCA AGTCCCTCTC CCTGGAGAGC 4740

ACGGACAGAA CGGGGTGGGA CACATGA 4767

Domain Profile

S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60

         feilkviGrGafgevavv+ k+t+kv+amkil+k+e+lkrae+a+freerdvlv++d++w

Q: 22    FEILKVIGRGAFGEVAVVKVKNTDKVFAMKILNKWEMLKRAETACFREERDVLVNGDCQW  81

         89**********************************************************

S: 61    ivqlqyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelg  120

         i++l+yafqd+++lylvm+y+vGGdlltllsk+ed+lpe++a+fylae+vla+dsvh+l+

Q: 82    ITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMAKFYLAEMVLAIDSVHQLH  141

         ************************************************************

S: 121   yvhrdikpdnilldksGhikladfGsclklnedgtvkssvavGtpdyispevlkaleegk  180

         yvhrdikpdnilldk+Ghi+ladfGsclkl+edgtv+ssvavGtpdyispe+l+a+e+gk

Q: 142   YVHRDIKPDNILLDKKGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEDGK  201

         ************************************************************

S: 181   geygkecdwwslGvilyellvgetpfyaeslvetyskilnhkeslkfpede.kvseeakd  239

         g+yg+ecdwwslGv++ye+l+getpfyaeslvety+ki+nhke+++fp++  +vseeakd

Q: 202   GKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPQQLtDVSEEAKD  261

         **************************************************98********

S: 240   likklltsreerlgregiedlkkhpff  266

         li++l++sre+rlg++gied+k+hpff

Q: 262   LIRRLICSREHRLGQNGIEDFKQHPFF  288

         **************************9

Domain Sequence
(FASTA)

FEILKVIGRG AFGEVAVVKV KNTDKVFAMK ILNKWEMLKR AETACFREER DVLVNGDCQW 60

ITTLHYAFQD DNNLYLVMDY YVGGDLLTLL SKFEDRLPED MAKFYLAEMV LAIDSVHQLH 120

YVHRDIKPDN ILLDKKGHIR LADFGSCLKL MEDGTVQSSV AVGTPDYISP EILQAMEDGK 180

GKYGPECDWW SLGVCMYEML YGETPFYAES LVETYGKIMN HKERFQFPQQ LTDVSEEAKD 240

LIRRLICSRE HRLGQNGIED FKQHPFF 267

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity
GO:0031532	; P:actin cytoskeleton reorganization
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR014930	; Myotonic_dystrophy_kinase_coil.
IPR000095	; PAK_box_Rho-bd.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR026611	; Ser/Thr_kinase_MRCK.

Pfam

PF00130	; C1_1; 1.
PF00780	; CNH; 1.
PF08826	; DMPK_coil; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 1.
SM00036	; CNH; 1.
SM00285	; PBD; 1.
SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50219	; CNH; 1.
PS50108	; CRIB; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

Created Date

20-Feb-2013