EKS-ORL-00316

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00316

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	415.0	1.4E-124	12	264	253

Status

Unreviewed

Ensembl Protein

ENSORLP00000020298

UniProt Accession

H2MNJ0;

Protein Name

Protein Synonyms/Alias

Gene Name

PLK3

Gene Synonyms/Alias

PLK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000016212	ENSORLP00000020302	ENSORLT00000020303
ENSORLG00000016212	ENSORLP00000020298	ENSORLT00000020299
ENSORLG00000016212	ENSORLP00000020295	ENSORLT00000020296

Organism

Oryzias latipes

Functional Description

Protein Length

590

Protein Sequence
(FASTA)

QVVTDSRTGR SYSKGKLLGK GGFARCYEMT DLSSNKMYAV KVIPQSRVSK PHQREKITNE 60

IELHRTLAHK HVVKFSHYFE DQENIYIFLE LCSRKSLAHI WKARHTLTEP EVRYYLRQII 120

SGLKYLHNRG ILHRDLKLGN FFINENMDLR LGDFGLAAKL ETVEQRKKTI CGTPNYLAPE 180

VLNRQGHGTE SDVWSLGCVM YTLMCGSPPF ETLDLKETYK CIKEVRYNLP SSLSPAAQKL 240

ISGILQKNPS DRLTLDQILN HEFFKGFTPD KLPPSSCVMV PELHPPSPAK KFFSKMAKSL 300

FGKKKSKEPN QTSFQEAVEC CAVTSPTGQL VSSVPLEPTP AEEESRKSIS RSFKGTMASG 360

TEPCEDVLTP AAVAETAMKV LKDCLTAMPA ANRNPPCLSR PQSFLWVTKW VDYSNKYGFG 420

YQLSNQNIGV LFNEGTHLSL CDQRQTVHYC LTNNKHFTFA ANSLPEQLRS QKQIVELMAN 480

YMEQNLMEGG DLHCEEQASA LPPLLLQWVK TDHALVMLFN NGTLQVNFYT DHTKIIVCKS 540

SDDSYLLTYI SRERVSYTYL LSMLKEMGCT SELRHRLGYV VQLLQHHTDA 590

Nucleotide Sequence
(FASTA)

CAGGTGGTGA CGGACTCCAG GACGGGGAGA TCCTACAGCA AAGGGAAGCT TTTGGGAAAG 60

GGAGGTTTTG CTCGCTGCTA TGAGATGACA GACCTGTCCA GTAACAAAAT GTATGCCGTC 120

AAGGTGATAC CACAGAGCCG AGTGTCTAAA CCACACCAGA GGGAGAAGAT CACAAATGAG 180

ATCGAGCTGC ACAGAACCCT GGCACACAAG CATGTGGTGA AGTTCTCCCA TTATTTTGAA 240

GACCAAGAAA ACATCTACAT ATTCCTGGAG CTCTGCAGTC GTAAGTCCCT CGCACACATT 300

TGGAAGGCCA GGCACACACT GACAGAGCCC GAGGTGCGGT ATTACCTCAG ACAGATCATA 360

TCGGGTCTCA AGTACCTGCA CAACAGAGGC ATCCTGCACC GAGACCTCAA ACTAGGTAAC 420

TTCTTCATCA ATGAGAACAT GGATCTGCGG CTCGGAGACT TTGGTCTTGC TGCAAAGCTG 480

GAGACTGTGG AACAGAGGAA GAAAACTATC TGTGGAACTC CGAACTACCT GGCCCCAGAG 540

GTGCTGAACA GGCAAGGACA CGGCACAGAG TCTGACGTCT GGTCTCTTGG ATGTGTCATG 600

TACACACTGA TGTGTGGCAG CCCTCCTTTT GAGACTCTTG ACTTGAAAGA AACGTACAAA 660

TGTATAAAGG AAGTTCGATA CAACCTTCCC TCCAGTCTCT CCCCGGCTGC ACAGAAACTC 720

ATCTCAGGCA TTCTGCAGAA AAACCCCAGT GACAGACTGA CTTTGGATCA GATCCTAAAC 780

CACGAGTTCT TCAAAGGTTT TACTCCAGAC AAGCTTCCAC CCAGCAGCTG TGTGATGGTG 840

CCAGAGCTCC ACCCGCCAAG CCCCGCCAAG AAATTCTTCT CTAAAATGGC CAAGAGCCTC 900

TTTGGCAAGA AGAAATCAAA AGAACCAAAC CAAACCAGTT TCCAAGAGGC AGTGGAATGT 960

TGTGCAGTGA CCTCTCCCAC GGGTCAGCTG GTCAGCTCTG TGCCCCTGGA GCCGACTCCT 1020

GCTGAGGAGG AATCCAGGAA GTCCATCTCC CGCTCTTTTA AAGGCACCAT GGCCAGCGGC 1080

ACTGAACCAT GTGAGGATGT CCTGACTCCT GCAGCTGTTG CTGAAACGGC CATGAAGGTT 1140

TTGAAGGACT GCCTGACCGC GATGCCTGCA GCCAATAGAA ACCCCCCATG CTTATCAAGA 1200

CCCCAGTCGT TCCTGTGGGT GACTAAATGG GTTGACTACT CAAACAAATA TGGCTTTGGC 1260

TACCAGCTCT CAAACCAAAA CATAGGGGTG CTCTTCAACG AGGGAACACA TCTCAGTCTG 1320

TGCGACCAGC GTCAGACAGT TCATTACTGC TTGACCAACA ATAAGCACTT CACTTTCGCT 1380

GCCAACTCTC TACCTGAACA GCTTCGCAGC CAAAAGCAAA TAGTGGAACT CATGGCAAAC 1440

TACATGGAGC AGAACCTTAT GGAGGGTGGA GATCTTCACT GTGAGGAGCA GGCTTCTGCA 1500

CTTCCGCCTT TGCTCCTTCA GTGGGTAAAG ACTGACCATG CTCTTGTCAT GCTCTTCAAT 1560

AATGGCACTC TGCAGGTCAA CTTTTACACA GACCACACAA AGATCATTGT GTGCAAGTCG 1620

TCCGACGACT CCTACCTGCT CACGTACATC AGTCGAGAGC GTGTCTCGTA CACATACCTC 1680

CTCAGCATGC TGAAGGAGAT GGGCTGCACG TCTGAGCTGC GTCACAGACT CGGATACGTG 1740

GTCCAGCTGC TCCAGCACCA CACGGATGCC TGA 1773

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         y++gkllGkGgfa+cye++dl++++++avkv+p+s++ k++qrek+++eie+hr+l+hk+

Q: 12    YSKGKLLGKGGFARCYEMTDLSSNKMYAVKVIPQSRVSKPHQREKITNEIELHRTLAHKH  71

         89**********************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrrkaltepevryylrqivsglkylhekri  120

         +vk++++fed+en+y++lelcsr+sla+++k+r++ltepevryylrqi+sglkylh++ i

Q: 72    VVKFSHYFEDQENIYIFLELCSRKSLAHIWKARHTLTEPEVRYYLRQIISGLKYLHNRGI  131

         ************************************************************

S: 121   lhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghslev  180

         lhrdlklgn+f+ne++++++gdfGla++le+ e+rkkt+cGtPny+aPevl+++gh++e+

Q: 132   LHRDLKLGNFFINENMDLRLGDFGLAAKLETVEQRKKTICGTPNYLAPEVLNRQGHGTES  191

         ************************************************************

S: 181   diWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePee  240

         d+WslGc++ytl++G+PPfet +lkety++ik+ +y+lPssls++a++li+ +l+k+P++

Q: 192   DVWSLGCVMYTLMCGSPPFETLDLKETYKCIKEVRYNLPSSLSPAAQKLISGILQKNPSD  251

         ************************************************************

S: 241   rpsleevlkdefl  253

         r++l+++l++ef+

Q: 252   RLTLDQILNHEFF  264

         ************8

Domain Sequence
(FASTA)

YSKGKLLGKG GFARCYEMTD LSSNKMYAVK VIPQSRVSKP HQREKITNEI ELHRTLAHKH 60

VVKFSHYFED QENIYIFLEL CSRKSLAHIW KARHTLTEPE VRYYLRQIIS GLKYLHNRGI 120

LHRDLKLGNF FINENMDLRL GDFGLAAKLE TVEQRKKTIC GTPNYLAPEV LNRQGHGTES 180

DVWSLGCVMY TLMCGSPPFE TLDLKETYKC IKEVRYNLPS SLSPAAQKLI SGILQKNPSD 240

RLTLDQILNH EFF 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR020658	; Ser/Thr_kinase_Plk3.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 2.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013