EKS-ORL-00494

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00494

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/SGK	533.2	1.5E-160	82	339	258

Status

Unreviewed

Ensembl Protein

ENSORLP00000020685

UniProt Accession

H2MPM1;

Protein Name

Protein Synonyms/Alias

Gene Name

SGK1

Gene Synonyms/Alias

SGK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000016520	ENSORLP00000020683	ENSORLT00000020684
ENSORLG00000016520	ENSORLP00000020685	ENSORLT00000020686

Organism

Oryzias latipes

Functional Description

Protein Length

375

Protein Sequence
(FASTA)

MKDKTTALTS FMKQRRMGLN DFIQRLATNS YACKHPEVQS ILNLSPPQDA ELMNVNPSPP 60

SSPSQQINLG PSSNPSAKPS DFHFLKVIGK GSFGKVLLAR HRTDDQFYAV KVLQKKAILK 120

KKEEKHIMSE RNVLLKNVKH PFLVGLHYSF QTADKLYFVL DYINGGELFY HLQRERCFLE 180

PRARFYAAEI ASALGYLHSL NIVYRDLKPE NILLDSQGHI ILTDFGLCKE NIEPNGTTST 240

FCGTPEYLAP EVLHKQPYDR TVDWWCLGAV LYEMLYGLPP FYSRNTAEMY DNILNKPLQL 300

KPNISNSARN LLEGLLQKDR TKRLGCTNDF IEIKNHVFFS PINWDELNAK KITPPFNPNV 360

TGPNDLRHFD PEFTD 375

Nucleotide Sequence
(FASTA)

ATGAAAGACA AAACGACCGC TTTGACGTCT TTTATGAAAC AAAGGAGGAT GGGTTTGAAT 60

GACTTCATTC AGAGGCTCGC CACAAACTCC TACGCCTGCA AACATCCGGA AGTTCAGTCC 120

ATTCTGAACT TGAGTCCCCC GCAGGATGCT GAGCTGATGA ACGTGAACCC TTCACCTCCG 180

TCCAGCCCAT CCCAGCAGAT CAACCTCGGC CCATCTTCTA ATCCTTCAGC CAAACCCAGC 240

GACTTCCACT TCCTTAAAGT GATCGGCAAA GGCAGCTTCG GGAAGGTGCT GCTGGCACGC 300

CACCGCACAG ACGACCAGTT TTACGCAGTC AAAGTGTTAC AGAAGAAGGC CATTCTCAAG 360

AAGAAAGAGG AGAAGCACAT CATGTCAGAG AGGAATGTGC TGCTAAAGAA TGTCAAGCAT 420

CCATTCTTGG TTGGCCTGCA TTATTCTTTC CAAACAGCAG ACAAACTGTA TTTTGTCTTG 480

GACTACATTA ACGGAGGAGA GCTGTTCTAC CACCTGCAGA GAGAACGCTG CTTCCTGGAG 540

CCCAGAGCCA GGTTCTACGC AGCAGAGATA GCCAGTGCAC TAGGATACCT TCACTCCCTA 600

AACATCGTCT ACAGAGACCT AAAGCCTGAA AATATCCTGC TTGACTCACA AGGACACATC 660

ATTCTAACAG ATTTTGGGCT CTGCAAGGAA AACATCGAGC CTAATGGGAC CACATCGACC 720

TTCTGCGGTA CGCCAGAGTA TCTGGCTCCT GAGGTGTTAC ACAAGCAGCC GTACGACAGG 780

ACAGTAGACT GGTGGTGTTT AGGAGCTGTT CTCTATGAGA TGCTGTATGG CCTGCCTCCG 840

TTCTACAGCC GTAACACAGC AGAGATGTAC GACAACATCC TGAACAAGCC CCTGCAGCTG 900

AAACCCAACA TCTCCAACTC AGCCAGGAAC CTGCTGGAAG GTCTGCTGCA AAAAGATCGC 960

ACCAAGAGAC TGGGCTGCAC AAACGACTTT ATTGAAATCA AGAACCACGT ATTCTTTTCA 1020

CCAATCAACT GGGATGAGCT TAATGCCAAG AAAATCACCC CCCCTTTCAA CCCTAATGTG 1080

ACTGGACCCA ATGACCTGCG GCACTTTGAT CCAGAGTTCA CGGAT 1125

Domain Profile

S: 1     fdflkvigkgsfgkvllakrkadekfyavkvlqkkailkkkeekhimaernvllknvkhp  60

         f+flkvigkgsfgkvlla++++d++fyavkvlqkkailkkkeekhim+ernvllknvkhp

Q: 82    FHFLKVIGKGSFGKVLLARHRTDDQFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHP  141

         9***********************************************************

S: 61    flvglhysfqtaeklyfvldyvnggelffhlqrersfleprarfyaaeiasalgylhsln  120

         flvglhysfqta+klyfvldy+nggelf+hlqrer+fleprarfyaaeiasalgylhsln

Q: 142   FLVGLHYSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLN  201

         ************************************************************

S: 121   ivyrdlkpenilldskghvvltdfglckeeieaedttstfcgtpeylapevlrkkpydrt  180

         ivyrdlkpenillds+gh++ltdfglcke+ie + ttstfcgtpeylapevl+k+pydrt

Q: 202   IVYRDLKPENILLDSQGHIILTDFGLCKENIEPNGTTSTFCGTPEYLAPEVLHKQPYDRT  261

         ************************************************************

S: 181   vdwwclgavlyemlyglppfysrdvaemydnilnkplqlkpgisvaalelleellekdrk  240

         vdwwclgavlyemlyglppfysr++aemydnilnkplqlkp+is++a++lle+ll+kdr+

Q: 262   VDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNISNSARNLLEGLLQKDRT  321

         ************************************************************

S: 241   krlgakedfleiknhvff  258

         krlg  +df+eiknhvff

Q: 322   KRLGCTNDFIEIKNHVFF  339

         *****************9

Domain Sequence
(FASTA)

FHFLKVIGKG SFGKVLLARH RTDDQFYAVK VLQKKAILKK KEEKHIMSER NVLLKNVKHP 60

FLVGLHYSFQ TADKLYFVLD YINGGELFYH LQRERCFLEP RARFYAAEIA SALGYLHSLN 120

IVYRDLKPEN ILLDSQGHII LTDFGLCKEN IEPNGTTSTF CGTPEYLAPE VLHKQPYDRT 180

VDWWCLGAVL YEMLYGLPPF YSRNTAEMYD NILNKPLQLK PNISNSARNL LEGLLQKDRT 240

KRLGCTNDFI EIKNHVFF 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013