EKS-ORL-00283

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00283

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/MAPKAPK	372.1	1.8E-111	44	328	285

Status

Unreviewed

Ensembl Protein

ENSORLP00000020746

UniProt Accession

H2MPT4;

Protein Name

Protein Synonyms/Alias

Gene Name

MKNK1

Gene Synonyms/Alias

MKNK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000016569	ENSORLP00000020746	ENSORLT00000020747
ENSORLG00000016569	ENSORLP00000020747	ENSORLT00000020748

Organism

Oryzias latipes

Functional Description

Protein Length

398

Protein Sequence
(FASTA)

AANHPAFSSE TSQPMNIPDA AKKKKKKRNR AADNSASTFD DLYKLTDEVL GQGAFAKVQG 60

CVSLQNGQEF AVKIIEKSAG HSRSRVFREV ETLYQCQGNK NILELTQFCE DGSCFYLVFE 120

KLRGGSILTH IQNRKHFNEL EASRVVRDIA QALDFLHTKG IAHRDLKLEN ILCEFTDRVS 180

PVKICDFDLG SGVKLSSACT PITTPELTTP CGSAEYMAPE VVEVFTDEAS FYDKRCDLWS 240

LGVILYILLS GSPPFTGHCG TDCDWDRGET CKACQSQLFD SIQQGKYEFP DKDWAHITDG 300

AKDLISKLLV RDSTRRLSAA QVLKHPWVQG NAPERGLPTP HILQRNSSTK DLTQFAAEAI 360

AFNRQLSQHD EQQEDVGAIL CSMRLSPPSN SRLARRRA 398

Nucleotide Sequence
(FASTA)

GCTGCAAACC ATCCAGCATT CTCTTCAGAG ACAAGCCAGC CGATGAACAT CCCAGATGCA 60

GCTAAGAAGA AGAAAAAGAA AAGAAACAGA GCAGCAGACA ACTCTGCAAG CACTTTTGAT 120

GATCTCTACA AACTGACAGA CGAGGTGCTT GGTCAGGGGG CGTTTGCTAA AGTTCAGGGA 180

TGTGTGAGTC TGCAGAATGG CCAGGAGTTT GCAGTGAAGA TCATAGAGAA GAGTGCAGGG 240

CACAGTCGCA GCCGAGTATT TCGAGAGGTT GAAACCCTCT ACCAGTGCCA AGGAAACAAA 300

AACATTTTGG AACTAACCCA GTTTTGTGAA GACGGCTCCT GCTTTTACTT GGTGTTTGAA 360

AAGCTGCGTG GCGGATCCAT TCTTACTCAC ATCCAGAATC GAAAGCACTT TAATGAACTA 420

GAAGCCAGCA GAGTAGTCAG GGACATCGCC CAAGCGCTTG ACTTTTTACA CACAAAGGGC 480

ATTGCCCACA GAGACCTTAA GCTGGAAAAC ATTCTGTGTG AGTTCACTGA TAGGGTGTCG 540

CCTGTAAAAA TCTGCGACTT TGATCTGGGA AGTGGTGTTA AGCTCAGCAG TGCCTGTACT 600

CCCATAACTA CCCCTGAACT CACCACACCG TGTGGCTCGG CTGAGTATAT GGCTCCAGAG 660

GTGGTGGAGG TTTTCACGGA TGAAGCCTCC TTTTATGACA AGCGCTGCGA CCTGTGGAGT 720

CTTGGTGTCA TTCTTTACAT CCTGCTCAGT GGAAGCCCCC CCTTCACAGG CCACTGTGGC 780

ACCGACTGTG ATTGGGACAG AGGAGAAACA TGTAAAGCGT GCCAGAGTCA GCTGTTTGAC 840

AGCATCCAAC AAGGCAAATA TGAATTTCCA GACAAGGACT GGGCTCATAT CACAGACGGG 900

GCCAAAGATC TCATCTCCAA GCTGTTGGTT CGGGACTCCA CCCGTCGCCT TAGTGCTGCC 960

CAGGTTCTCA AGCACCCTTG GGTGCAGGGG AACGCACCAG AGAGAGGTCT TCCAACTCCT 1020

CACATCCTGC AGAGAAACAG CAGCACCAAA GATCTGACCC AGTTTGCCGC TGAAGCCATC 1080

GCCTTTAACC GGCAGCTTTC CCAGCATGAC GAGCAGCAGG AGGACGTGGG GGCCATCCTC 1140

TGCTCCATGA GGCTCTCTCC TCCTTCCAAC TCCAGACTGG CCCGCCGGCG GGCG 1194

Domain Profile

S: 1     klteevlGeGisgkvlecvkkktgekyalkil.....kdrkkvrrevelhvqasghkniv  55

         klt+evlG+G+ +kv+ cv+ ++g+++a+ki+     ++r++v+reve+++q++g+kni+

Q: 44    KLTDEVLGQGAFAKVQGCVSLQNGQEFAVKIIeksagHSRSRVFREVETLYQCQGNKNIL  103

         5799********************************************************

S: 56    elidvfensfedekrlllvlekleGGellsriqerkaftekeasevvkdiasalkflhsk  115

         el ++ e    d ++++lv+ekl+GG++l++iq+rk+f+e eas+vv+dia+al+flh+k

Q: 104   ELTQFCE----DGSCFYLVFEKLRGGSILTHIQNRKHFNELEASRVVRDIAQALDFLHTK  159

         ******9....9************************************************

S: 116   niahrDlkpenlLyeskeknapvklcDfglaketeee........eelktpcltaeyvaP  167

         +iahrDlk en+L+e +++++pvk+cDf+l+++++ +        +el+tpc++aey+aP

Q: 160   GIAHRDLKLENILCEFTDRVSPVKICDFDLGSGVKLSsactpittPELTTPCGSAEYMAP  219

         ********************************9954456888888***************

S: 168   evleaekeeallydksCDlWslGvilyillcGypPfyskkg...........raiskklk  216

         ev+e++++ea++ydk+CDlWslGvilyill+G pPf++++g           +a++ +l+

Q: 220   EVVEVFTDEASFYDKRCDLWSLGVILYILLSGSPPFTGHCGtdcdwdrgetcKACQSQLF  279

         ****************************************99******************

S: 217   eriqegkyefPeeeWsevseeakdlirklLkrdpkerltieevlnhpwv  265

         ++iq+gkyefP+++W+++++ akdli+klL+rd++ rl++++vl+hpwv

Q: 280   DSIQQGKYEFPDKDWAHITDGAKDLISKLLVRDSTRRLSAAQVLKHPWV  328

         ************************************************8

Domain Sequence
(FASTA)

KLTDEVLGQG AFAKVQGCVS LQNGQEFAVK IIEKSAGHSR SRVFREVETL YQCQGNKNIL 60

ELTQFCEDGS CFYLVFEKLR GGSILTHIQN RKHFNELEAS RVVRDIAQAL DFLHTKGIAH 120

RDLKLENILC EFTDRVSPVK ICDFDLGSGV KLSSACTPIT TPELTTPCGS AEYMAPEVVE 180

VFTDEASFYD KRCDLWSLGV ILYILLSGSP PFTGHCGTDC DWDRGETCKA CQSQLFDSIQ 240

QGKYEFPDKD WAHITDGAKD LISKLLVRDS TRRLSAAQVL KHPWV 285

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013