EKS-ORL-00065
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORL-00065
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/RAF401.13.0E-120310566257
StatusUnreviewed
Ensembl ProteinENSORLP00000020929
UniProt AccessionH2MQB2;
Protein Name
Protein Synonyms/Alias
Gene NameARAF
Gene Synonyms/Alias ARAF;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSORLG00000016733ENSORLP00000020929ENSORLT00000020930
OrganismOryzias latipes
Functional Description
Protein Length606
Protein Sequence
(FASTA)
MSSTSSSYSS SGETSPEDVP RGGGTIRVYL PNKQRTVVNV RQGQTVYESL DKALKVRGLS 60
QDCCAVFRLL EGRKRLTDWN TDITPLVGEE LLVEVLDDIP LTMHNFVRKT FFKLAYCDFC 120
HKFLFNGFRC QTCGYKFHQH CSSKVPTVCL DMDTVSKRCD SNSCTEDFPV IVLPESSPSQ 180
RNLALTPEPS GMDLLSPPST FHFPVSGGEG QSLQRHRSTS TPNVHMVSTV DLASVSIIEE 240
ALKFNTIVGP EPSPKPSTSP PSFLGSPGKK PPKSPSEHKE RKPSSSDDKK KVHRGNRDSS 300
YYWEVHSREV QIQKRIGTGS FGTVYKGKWH GDVAIKILKV KEPTPEQLQA FKNEMQVLRK 360
TRHVNILLFM GYMTKPNFAI ITQWCEGSSL YRHLHVSETK FDTMRRIDVA RQTAQGMDYL 420
HAKNIIHRDL KSNNIFLHEG WTVKIGDFGL ATVKARWSGS QQVEQPSGSI LWMAPEVIRM 480
QDNNPYTFQS DVYAYGVVLF ELMSGTLPYS NINNRDQIIF MVGRGYLSPD LSKLYSTSPK 540
SMKRLIVDCL KFKRDERPLF PQILVSIEQV QDLLPKIERS RSEPSLHRAV HAEDLNPLLF 600
QTTRLM 606
Nucleotide Sequence
(FASTA)
ATGTCCTCCA CCTCCTCTTC ATACTCCTCC TCAGGGGAGA CCAGTCCGGA GGATGTGCCT 60
CGGGGCGGGG GTACCATCCG AGTCTACCTC CCCAACAAAC AGAGGACAGT GGTCAACGTC 120
CGCCAAGGTC AGACTGTGTA CGAGAGTCTG GATAAAGCTC TCAAAGTGCG AGGCCTCAGC 180
CAAGACTGCT GCGCCGTGTT CCGCCTCCTG GAAGGTCGTA AGAGACTGAC TGACTGGAAC 240
ACAGACATCA CTCCTTTGGT TGGAGAGGAG CTGCTAGTGG AGGTTCTGGA CGACATTCCT 300
CTCACCATGC ACAACTTTGT ACGGAAAACG TTTTTCAAGC TGGCCTACTG TGATTTCTGC 360
CACAAGTTTC TTTTTAATGG CTTCAGATGT CAGACATGTG GCTACAAGTT TCACCAGCAC 420
TGCAGCAGCA AGGTCCCCAC CGTGTGTCTG GACATGGACA CGGTGAGCAA GCGGTGTGAC 480
TCCAACTCCT GCACAGAGGA CTTTCCTGTG ATAGTACTGC CAGAAAGTTC TCCATCTCAG 540
AGAAATTTAG CCTTAACCCC AGAGCCTTCT GGAATGGACC TCCTGTCTCC ACCCTCGACC 600
TTCCACTTTC CCGTATCAGG AGGAGAAGGT CAGTCTCTGC AGAGGCACCG CTCCACATCC 660
ACCCCCAACG TCCACATGGT CAGCACGGTG GACCTCGCCA GTGTCAGCAT CATTGAGGAA 720
GCACTGAAGT TCAACACAAT AGTAGGTCCC GAACCCTCAC CCAAACCCTC CACCAGTCCG 780
CCCTCTTTTC TTGGTTCTCC TGGGAAAAAG CCTCCGAAAT CCCCCTCCGA ACACAAAGAG 840
CGCAAACCTT CCTCGTCTGA TGACAAGAAA AAGGTGCATC GAGGCAACAG GGACTCCAGT 900
TACTACTGGG AGGTCCACTC TCGAGAAGTC CAGATCCAGA AGAGGATAGG CACCGGCTCC 960
TTCGGGACAG TCTACAAGGG AAAGTGGCAC GGCGACGTGG CCATCAAGAT CCTGAAAGTG 1020
AAGGAGCCGA CACCTGAGCA GCTGCAGGCC TTCAAAAATG AAATGCAGGT TCTACGGAAA 1080
ACTCGCCATG TCAACATCCT GCTGTTCATG GGATACATGA CCAAGCCCAA CTTCGCCATC 1140
ATCACGCAGT GGTGTGAGGG CAGCAGCCTC TACCGCCACC TCCACGTGTC GGAAACCAAG 1200
TTTGACACCA TGAGGCGCAT TGACGTGGCC CGACAGACGG CGCAGGGCAT GGATTATCTC 1260
CACGCCAAGA ACATCATTCA CCGAGACCTG AAGTCAAACA ACATTTTTCT CCACGAGGGC 1320
TGGACCGTAA AAATAGGAGA CTTTGGTTTG GCCACGGTGA AGGCTCGATG GAGCGGCTCT 1380
CAGCAGGTGG AGCAGCCCAG TGGATCCATT CTGTGGATGG CTCCTGAAGT GATCCGAATG 1440
CAGGACAACA ACCCGTACAC GTTCCAGTCG GATGTGTATG CGTACGGCGT GGTGCTGTTT 1500
GAGCTCATGT CGGGAACGCT GCCTTACTCC AACATAAACA ACAGAGACCA GATCATCTTC 1560
ATGGTGGGAC GTGGGTACTT GTCTCCTGAC CTCAGTAAGC TCTACAGCAC ATCACCCAAG 1620
TCCATGAAAA GGCTCATCGT CGACTGCTTG AAGTTCAAGA GAGATGAGAG GCCTCTGTTT 1680
CCTCAGATCC TGGTCTCCAT CGAGCAGGTG CAGGACCTGT TACCAAAAAT CGAGCGCAGC 1740
CGCTCAGAGC CTTCGCTCCA CCGGGCCGTC CACGCTGAAG ACCTGAACCC CCTCCTGTTC 1800
CAGACCACCA GACTCATG 1818
Domain Profile
S: 1     velaekiGsGrfGtvyrgkwhGdvavkllnveelseeqleaFkkevaaykktRhenivLF  60
         v+++++iG+G+fGtvy+gkwhGdva+k+l+v+e+++eql+aFk+e+++++ktRh+ni+LF
Q: 310   VQIQKRIGTGSFGTVYKGKWHGDVAIKILKVKEPTPEQLQAFKNEMQVLRKTRHVNILLF  369
         6899********************************************************
S: 61    mGyvskpelaivtslckgssLykllheqetkldlaklidiarqiaqgmdYLhakkilhkD  120
         mGy++kp++ai+t++c+gssLy++lh++etk+d ++ id+arq+aqgmdYLhak+i+h+D
Q: 370   MGYMTKPNFAIITQWCEGSSLYRHLHVSETKFDTMRRIDVARQTAQGMDYLHAKNIIHRD  429
         ************************************************************
S: 121   lksknilleeglkvvitDFgllsvkrllsgrrekqleipkgwilylapeviralsidleq  180
         lks+ni+l+eg +v+i+DFgl++vk ++sg  ++q+e+p+g+il++apevir+      q
Q: 430   LKSNNIFLHEGWTVKIGDFGLATVKARWSG--SQQVEQPSGSILWMAPEVIRM------Q  481
         ******************************..*********************......*
S: 181   delpfskesDvyafGivlyellarelpyke.esadqilfavgrG.lkpdlskvksklpke  238
         d++p++++sDvya+G+vl+el++++lpy++ +++dqi+f+vgrG l+pdlsk++s  pk+
Q: 482   DNNPYTFQSDVYAYGVVLFELMSGTLPYSNiNNRDQIIFMVGRGyLSPDLSKLYSTSPKS  541
         ************************************************************
S: 239   lkellleClkfekeeRPlftqilkk  263
         +k+l+++Clkf+++eRPlf+qil +
Q: 542   MKRLIVDCLKFKRDERPLFPQILVS  566
         **********************976
Domain Sequence
(FASTA)
VQIQKRIGTG SFGTVYKGKW HGDVAIKILK VKEPTPEQLQ AFKNEMQVLR KTRHVNILLF 60
MGYMTKPNFA IITQWCEGSS LYRHLHVSET KFDTMRRIDV ARQTAQGMDY LHAKNIIHRD 120
LKSNNIFLHE GWTVKIGDFG LATVKARWSG SQQVEQPSGS ILWMAPEVIR MQDNNPYTFQ 180
SDVYAYGVVL FELMSGTLPY SNINNRDQII FMVGRGYLSP DLSKLYSTSP KSMKRLIVDC 240
LKFKRDERPL FPQILVS 257
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macropus eugenii"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pongo abelii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00045
EKS-BOT-00052
EKS-CAJ-00052
EKS-CAF-00053
EKS-CAP-00052
EKS-CIS-00058
EKS-DAR-00067
EKS-EQC-00051
EKS-FEC-00050
EKS-GAM-00023
EKS-GAA-00070
EKS-GOG-00051
EKS-HOS-00053
EKS-ICT-00049
EKS-LAC-00056
EKS-LOA-00052
EKS-MAE-00026
EKS-MUM-00053
EKS-MUP-00054
EKS-MYL-00054
EKS-ORN-00071
EKS-ORC-00048
EKS-OTG-00055
EKS-POA-00049
EKS-SUS-00043
EKS-TAR-00072
EKS-TEN-00076
EKS-TUT-00052
EKS-XET-00052
EKS-XIM-00069
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0046872; F:metal ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0005057; F:receptor signaling protein activity
GO:0035556; P:intracellular signal transduction
KEGG
InterPros
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR003116; Raf-like_ras-bd.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00130; C1_1; 1.
PF07714; Pkinase_Tyr; 1.
PF02196; RBD; 1.
SMARTs
SM00109; C1; 1.
SM00455; RBD; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS50898; RBD; 1.
PS00479; ZF_DAG_PE_1; 1.
PS50081; ZF_DAG_PE_2; 1.
Prints
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013