EPS-ORL-00040

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-ORL-00040

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	189.5	1.1E-55	1043	1288	246

Status

Unreviewed

Ensembl Protein

ENSORLP00000021525

UniProt Accession

H2MRZ1;

Protein Name

Protein Synonyms/Alias

Gene Name

PHLPP1

Gene Synonyms/Alias

PHLPP1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000017203	ENSORLP00000021526	ENSORLT00000021527
ENSORLG00000017203	ENSORLP00000021525	ENSORLT00000021526

Organism

Oryzias latipes

Functional Description

Protein Length

1581

Protein Sequence
(FASTA)

SSSLLLRRRR LKRNLSATAA AASSPSAVTA KMSSALSSAS LHTRSLDRKT LLRHRQNLQL 60

QPADRDWVRA DLHRGCIHVH HRLTASYPRP VLCTMDTTAG EVALRLSVKS HSKSSSVLRI 120

FARDTSKTDQ NGNCKVNPQS ESQDNITCSL SDLTSNIDTP NEEDSEHKNG TDSFGLNSGS 180

DVESCAFDDL SSGAQLSEHR DSLSDDMILG TEASILSPSF DSATEGHDMY GSSSDELELD 240

CPVPSAGLRS VSRHHTNGIP SANANYKHRS GGLLTDTSNS LGQDISRNTR GGLHPSNSAG 300

SLSRDCSTGV APDGQDLDNK QGAVKLGQTE HQNEVSSDSS PALYVQLHGE TVRRLSPDER 360

PLQIQNDFLF KLGFKDPWRV QEEGLDTEIG SLLRFYAGKP QTIESSERVQ LSGTYNVRKG 420

KLQLPVNRWT RRQVILCGTC LIVSSVKESQ SGKMHILPLI GGKVEEVKKH NHCLAFSSAG 480

PQSQTYYVSF DSFTEHLRWH RHAAKMVSQR INSVDLSCCS LEHLPSNLFY SHDLTHLNLK 540

HNFLPADQCL QQLQRFTCLR SLNLSNNHLG QFPLAICDIT TLTEVNLSCN YLLSVPSSVG 600

AMTNLQTFLL DGNCLSDLPS ELGSLQRLGY LGLSFNQFNH VPQVLERLSS MEKLCMAGNY 660

LETLTLQNFR LLHVKHIDLR LNKISVMVPD EPDLLRHVTQ LDVRDNRLTD LDASVFPRLE 720

MLHCERNRII SLRVKGCLLK GLYASNNELR QLDVSPVPSN LSYMDVSRNN LESLPDWLVD 780

SKRLEVLDVS HNLVTELPAR LFCSSSLRKL SAGHNRLQKL PERVERPLLE VLDVQHNQLV 840

ELPCNLFLKS DSLRCLNASA NKLELLPPSS LSEESHSILQ ELYLTNNWLT DKCVPMLTGH 900

THLRVLHMAY NHLQTFPASK MAKLEELEEV DLSGNMLKTV PTTIMNCRRM HTLIAHSNTI 960

EVFPEVMQLM EMKCVDLSCN ELSEITLPEN LPPKLQELDL TGNPRLNLDH KTLEQLNNIR 1020

CFRIDLPPTF SSNEASGGPA VWSHGYTEAS GVKNKLCVAA LSVNSFCGSR EALYGVFDGD 1080

RNVEVPYLLQ CTMNDVLAEE RHKTKSEEDY MTNTFLVMQR KLGTAGQKLG GSAALCHIRH 1140

DPTDLGGCFT LTAANVGKCQ AILCRDGKPL SLSLLHNVGL EEEYRRVRQH RAIITEDNKV 1200

NGVTDCTRIM GYSFLYPSVV PCPYVKTVTL TPQDEFFILG SRGLWDAVSP TEAVEAIRNV 1260

PDGLAAAKKL CTLAQGYGCT DSISAVVVQL SVSEDCCSCC CSEPQQPPPS PGLGAYPPSA 1320

SSIKERPSDG SLPVPPSSCS EISSEISTSE MSSEVGSTAS SDEPPQSSLV VLQEQPHHPP 1380

RSCCALHPAC LAGSFQRQLS SATFSSALSD NGLDSEDEEP IAGVFSNGSR VEVEADVHCL 1440

KRSPSIHERN LLTLPPPPPP PPSTPEPLED GVEMNQAEPE NGFERDESWQ GDVGKLSGKR 1500

RENGSVARQE KSHNLIEVAA DAPSKKPGGY FTAPAQPDPD DQFIIPPELE EEVKEIMKQH 1560

QQKQQKPPRT DQPTDYYDTP L 1581

Nucleotide Sequence
(FASTA)

TCCAGCTCTC TCCTGTTGCG ACGGCGGCGC TTGAAGAGGA ACCTCTCCGC CACGGCGGCA 60

GCAGCATCCA GCCCCTCAGC TGTCACCGCC AAGATGAGCT CGGCCCTGTC CTCCGCGTCT 120

CTGCACACAC GCAGTCTGGA CAGGAAGACG CTGCTGAGGC ACCGGCAGAA CCTGCAGCTG 180

CAGCCCGCAG ACCGCGACTG GGTGAGAGCA GATCTGCACC GCGGCTGCAT TCACGTCCAC 240

CACAGACTGA CAGCCTCGTA CCCCAGGCCG GTTCTCTGCA CTATGGACAC CACCGCCGGG 300

GAGGTGGCGC TCCGCCTGAG CGTTAAATCC CACAGCAAGT CGAGCTCCGT GCTGCGCATT 360

TTTGCAAGAG ATACCTCCAA GACTGACCAA AATGGCAACT GCAAGGTGAA CCCGCAGTCA 420

GAGTCACAAG ACAATATAAC CTGTTCATTA TCTGATTTAA CCTCCAACAT CGATACACCC 480

AACGAAGAAG ATTCGGAGCA CAAGAATGGC ACGGATAGCT TTGGATTGAA CTCTGGCTCA 540

GACGTGGAGA GCTGTGCATT TGACGACCTC AGTTCTGGGG CCCAGCTCAG TGAGCACAGA 600

GACTCCCTCA GTGATGATAT GATTCTGGGC ACTGAGGCAT CCATCCTCAG TCCTTCCTTT 660

GATAGTGCCA CAGAGGGCCA TGACATGTAT GGGAGCTCCT CAGACGAACT GGAGCTGGAC 720

TGTCCTGTGC CCAGTGCAGG CTTACGCTCT GTATCCCGAC ACCACACCAA TGGCATCCCT 780

TCTGCCAACG CCAACTACAA GCACCGCAGC GGGGGGCTTT TAACCGACAC CTCAAACAGT 840

TTGGGCCAGG ATATCAGTCG AAACACACGG GGTGGCCTGC ACCCCAGCAA CAGTGCTGGG 900

TCTTTATCAA GAGACTGCTC TACAGGTGTT GCACCTGATG GCCAAGATCT AGACAACAAA 960

CAAGGTGCTG TGAAACTGGG CCAGACGGAA CACCAAAATG AAGTTTCTTC TGATTCCAGC 1020

CCTGCGCTGT ATGTTCAGCT GCACGGTGAA ACTGTAAGGA GGCTCAGTCC AGATGAGAGG 1080

CCCCTGCAGA TCCAGAATGA CTTTCTCTTT AAGCTTGGAT TTAAGGATCC GTGGAGAGTT 1140

CAAGAAGAAG GCCTTGACAC AGAAATTGGC TCCTTGTTGC GCTTTTACGC AGGTAAACCC 1200

CAAACCATTG AGAGTTCTGA GCGGGTGCAG CTGTCTGGAA CCTACAACGT AAGGAAAGGG 1260

AAGCTTCAGC TCCCGGTCAA CCGCTGGACC AGACGCCAGG TCATCCTGTG TGGCACCTGC 1320

CTCATCGTCT CCTCCGTCAA AGAGAGCCAA TCAGGGAAGA TGCACATTCT GCCGCTCATT 1380

GGAGGAAAAG TAGAGGAGGT GAAGAAGCAC AATCATTGTT TGGCTTTCAG CTCGGCAGGC 1440

CCTCAGAGTC AAACCTACTA CGTCAGCTTT GACAGTTTCA CCGAGCACCT GCGCTGGCAC 1500

AGACACGCTG CCAAGATGGT GTCACAGAGG ATCAACTCAG TGGACCTGTC CTGCTGCAGC 1560

CTGGAGCATC TTCCTTCCAA CCTCTTCTAT AGCCACGATC TCACTCATCT CAACCTCAAA 1620

CACAACTTTC TGCCAGCAGA CCAGTGCCTT CAGCAGCTAC AAAGGTTCAC TTGCCTGCGG 1680

AGCCTCAACT TGTCCAACAA TCACTTGGGT CAGTTCCCGC TGGCCATCTG TGACATCACC 1740

ACCCTGACAG AGGTCAACCT CAGCTGCAAC TACCTGCTTT CTGTCCCCAG TTCTGTGGGT 1800

GCCATGACTA ATTTACAGAC GTTCCTGCTG GATGGAAACT GCTTAAGCGA CCTGCCCTCT 1860

GAGCTTGGTT CTTTGCAGAG ACTTGGATAT TTAGGCCTGT CCTTCAACCA GTTCAACCAC 1920

GTGCCGCAGG TGCTGGAGAG GTTGTCCTCC ATGGAGAAGC TGTGCATGGC AGGGAACTAC 1980

CTGGAAACGC TCACCCTGCA GAACTTCAGG CTGCTTCACG TCAAACACAT TGATCTGAGA 2040

TTGAATAAAA TCTCCGTCAT GGTGCCGGAT GAGCCGGACC TGCTGAGACA CGTGACCCAG 2100

CTGGATGTGA GGGATAACAG GCTCACAGAC CTTGATGCCT CTGTCTTTCC AAGGCTGGAG 2160

ATGCTTCACT GCGAGAGGAA CCGCATCATT AGTCTGCGAG TCAAGGGATG CTTGCTCAAA 2220

GGCCTATATG CATCCAACAA CGAGCTGCGG CAGCTGGATG TCAGTCCTGT GCCCTCCAAT 2280

CTTAGTTACA TGGACGTCTC AAGGAATAAT TTAGAGTCTT TGCCAGACTG GCTGGTTGAC 2340

TCGAAGAGGC TGGAAGTTCT GGACGTCAGC CACAACCTGG TCACCGAGCT CCCGGCGAGG 2400

TTGTTTTGCA GCAGCAGTCT GAGGAAGCTG AGTGCAGGAC ACAACCGCCT GCAGAAGCTG 2460

CCTGAGAGAG TGGAGCGCCC TCTGCTGGAG GTTCTCGATG TCCAGCACAA TCAACTAGTG 2520

GAGCTTCCCT GCAACCTGTT CCTTAAATCT GACAGCTTAC GGTGTCTAAA TGCCTCAGCC 2580

AATAAGCTGG AACTCCTGCC GCCCTCCAGC CTGTCAGAGG AAAGCCACAG CATCCTGCAG 2640

GAGCTGTACC TGACCAACAA CTGGCTGACA GACAAGTGTG TGCCCATGCT CACTGGCCAC 2700

ACACACCTTC GAGTTTTGCA CATGGCCTAC AACCATCTCC AGACCTTTCC AGCGAGTAAA 2760

ATGGCCAAAT TGGAGGAGCT GGAGGAGGTG GATCTGAGCG GAAACATGCT GAAGACCGTC 2820

CCCACCACCA TCATGAACTG CAGGCGAATG CACACTCTGA TCGCCCACTC CAACACCATC 2880

GAGGTCTTTC CTGAGGTCAT GCAGCTGATG GAGATGAAAT GCGTGGATCT CAGCTGCAAT 2940

GAGCTGAGCG AGATCACTCT CCCAGAAAAC CTGCCCCCGA AGCTTCAAGA GCTTGACCTG 3000

ACGGGAAACC CTCGTCTCAA CTTGGACCAC AAGACTCTAG AGCAGCTTAA TAATATTCGC 3060

TGCTTTCGCA TCGATCTGCC TCCAACCTTC TCATCGAACG AGGCATCTGG TGGGCCTGCT 3120

GTGTGGAGCC ATGGTTACAC GGAGGCCTCA GGCGTCAAGA ACAAACTATG TGTCGCAGCT 3180

CTCTCGGTCA ACAGTTTCTG CGGCTCTCGT GAAGCTCTGT ACGGCGTCTT CGATGGAGAC 3240

AGAAACGTGG AAGTGCCCTA CCTCCTGCAG TGCACCATGA ATGACGTGTT AGCTGAAGAA 3300

CGGCACAAGA CAAAAAGTGA GGAGGACTAC ATGACCAACA CCTTTCTCGT CATGCAAAGG 3360

AAACTGGGAA CTGCAGGGCA GAAACTCGGT GGCTCTGCAG CCTTGTGTCA CATTCGCCAC 3420

GACCCCACCG ACCTGGGGGG CTGCTTCACC CTCACTGCTG CTAACGTGGG AAAGTGCCAG 3480

GCCATCCTGT GCCGCGATGG AAAGCCGCTG TCGCTGTCGC TGCTGCACAA TGTCGGGTTG 3540

GAGGAAGAGT ATCGGAGAGT CAGGCAGCAC AGAGCCATCA TCACTGAGGA CAATAAAGTG 3600

AATGGGGTGA CCGATTGCAC TCGAATTATG GGCTACTCCT TCCTTTACCC TTCGGTTGTC 3660

CCTTGTCCGT ACGTGAAGAC AGTCACTCTC ACTCCTCAGG ATGAGTTCTT CATTCTGGGG 3720

AGCCGTGGCC TGTGGGATGC TGTGTCCCCC ACCGAAGCCG TGGAGGCCAT TCGGAATGTT 3780

CCTGACGGGC TGGCTGCCGC CAAGAAGCTG TGCACGCTGG CGCAGGGCTA CGGCTGCACC 3840

GACAGCATCA GCGCCGTTGT GGTCCAGCTC AGTGTGAGTG AAGATTGCTG CTCCTGCTGC 3900

TGCTCTGAGC CCCAACAGCC TCCTCCCAGC CCTGGCCTGG GGGCCTATCC CCCGTCAGCC 3960

TCCTCCATCA AGGAGAGGCC CTCGGACGGC TCCCTCCCCG TACCCCCCTC GTCCTGCAGT 4020

GAAATCAGCA GTGAGATTAG CACCAGCGAG ATGAGCAGTG AGGTTGGTTC CACAGCCTCC 4080

TCCGATGAGC CCCCGCAGAG CTCCCTGGTG GTCCTGCAGG AGCAGCCTCA CCACCCCCCT 4140

CGCAGCTGCT GCGCTCTCCA TCCCGCCTGC TTGGCCGGAT CCTTTCAGAG GCAGCTGTCC 4200

AGCGCCACCT TCTCCAGCGC CTTGTCTGAC AACGGCCTGG ACAGTGAGGA TGAAGAGCCC 4260

ATCGCTGGGG TCTTCTCCAA CGGGAGCCGC GTAGAAGTGG AAGCAGACGT CCACTGCCTC 4320

AAAAGATCCC CCTCCATCCA TGAGCGCAAC CTGCTCACTC TTCCCCCACC GCCCCCTCCA 4380

CCACCAAGCA CCCCAGAGCC TTTAGAGGAT GGGGTGGAGA TGAACCAAGC AGAACCCGAG 4440

AACGGGTTTG AGAGGGATGA GTCCTGGCAA GGAGACGTGG GAAAGCTTTC AGGAAAACGG 4500

AGAGAAAATG GTTCAGTGGC ACGCCAGGAA AAAAGCCACA ACCTCATCGA AGTGGCGGCC 4560

GACGCTCCAT CAAAGAAACC TGGAGGTTAC TTCACAGCTC CTGCCCAACC GGATCCAGAC 4620

GACCAGTTCA TCATCCCGCC GGAGCTGGAG GAGGAGGTGA AGGAAATCAT GAAGCAGCAT 4680

CAGCAGAAGC AGCAGAAGCC TCCCAGGACG GATCAACCAA CAGACTATTA TGACACGCCT 4740

CTCTGA 4746

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         ++g+++ +g +n+++ a+ s+++f+ s+e+     ++gv+DG+++ ev + +++++ ++l

Q: 1043  SHGYTEASGVKNKLCVAALSVNSFCGSREA-----LYGVFDGDRNVEVPYLLQCTMNDVL  1097

         689***********************9885.....9************************

S: 62    aeelesseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikds......  115

         aee      +++  +++++++Fl ++++l       ++ +k G +a +++i+++

Q: 1098  AEERH----KTKSEEDYMTNTFLVMQRKL------GTAGQKLGGSAALCHIRHDptdlgg  1147

         ***66....9999999*************......99***********************

S: 116   ..klyvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvLa  173

           +l+ anvG+++a+Lcr+gk+++ls  H++  e+E++R++++ + +++++  +v+Gv+

Q: 1148  cfTLTAANVGKCQAILCRDGKPLSLSLLHNVGLEEEYRRVRQHRAIITEDN--KVNGVTD  1205

         ********************************************9999998..*******

S: 174   vsRalGdlylkpyvtpePevtshrltsedefliLasDGlwdvvsneeavslvrdvlekke  233

         ++R +G  +l+p v+p P v  ++lt++def+iL+s Glwd vs+ eav+++r+v +

Q: 1206  CTRIMGYSFLYPSVVPCPYVKTVTLTPQDEFFILGSRGLWDAVSPTEAVEAIRNVPD---  1262

         *********************************************************...

S: 234   aeqeaakkLvklalargskdnvsaivv  260

            +aakkL++la+ +g++d++sa+vv

Q: 1263  -GLAAAKKLCTLAQGYGCTDSISAVVV  1288

         .************************97

Domain Sequence
(FASTA)

SHGYTEASGV KNKLCVAALS VNSFCGSREA LYGVFDGDRN VEVPYLLQCT MNDVLAEERH 60

KTKSEEDYMT NTFLVMQRKL GTAGQKLGGS AALCHIRHDP TDLGGCFTLT AANVGKCQAI 120

LCRDGKPLSL SLLHNVGLEE EYRRVRQHRA IITEDNKVNG VTDCTRIMGY SFLYPSVVPC 180

PYVKTVTLTP QDEFFILGSR GLWDAVSPTE AVEAIRNVPD GLAAAKKLCT LAQGYGCTDS 240

ISAVVV 246

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>