EKS-ORL-00216

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00216

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKA	478.7	4.4E-144	44	298	255

Status

Unreviewed

Ensembl Protein

ENSORLP00000021647

UniProt Accession

H2MSB0;

Protein Name

Protein Synonyms/Alias

Gene Name

PRKACB

Gene Synonyms/Alias

PRKACB;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000017303	ENSORLP00000021647	ENSORLT00000021648

Organism

Oryzias latipes

Functional Description

Protein Length

351

Protein Sequence
(FASTA)

MGNAATAKKG NELESVKEFL AKAKEDFLRK WECPPQSTTC LEDFDRIKTL GTGSFGRVML 60

VKHKSSEQYF AMKILDKQKV VKLKQIEHTL NEKRILQAVS FPFLVRLEYA FKDNSNLYMV 120

MEYVPGGEMF SHLRRIGRFS EPHARFYAAQ IVLTFEYLHS LDLIYRDLKP ENLLIDHHGY 180

IQVTDFGFAK RVKGRTWTLC GTPEYLAPEI ILSKGYNKAV DWWALGVLIY EMAAGYPPFF 240

ADQPIQIYEK IVSGKVRFPS HFSSDLKDLL RNLLQVDLTK RYGNLKNGVN DIKGHKWFAT 300

TDWIAIYERK VEAPFIPKCR GPGDTSNFDD YEEEEIRVSL TEKCAKEFAE F 351

Nucleotide Sequence
(FASTA)

ATGGGGAACG CCGCCACAGC CAAGAAGGGC AACGAGCTGG AGAGCGTCAA AGAGTTTCTT 60

GCCAAAGCCA AAGAAGATTT CTTACGTAAA TGGGAATGCC CACCACAGAG CACAACGTGT 120

CTAGAAGACT TTGACAGAAT AAAGACTCTG GGCACAGGCT CCTTCGGGAG AGTTATGCTG 180

GTCAAACACA AAAGCTCAGA GCAATACTTT GCCATGAAAA TACTGGACAA GCAGAAGGTG 240

GTGAAACTCA AGCAAATAGA ACACACATTA AATGAAAAAA GGATATTACA AGCTGTGAGC 300

TTTCCGTTCC TCGTCAGACT TGAGTACGCG TTTAAGGACA ACTCCAATTT GTACATGGTA 360

ATGGAATACG TTCCAGGAGG GGAGATGTTC TCACACCTAA GACGAATTGG GAGGTTCAGT 420

GAACCACATG CAAGATTCTA CGCTGCTCAG ATAGTGCTGA CATTTGAATA CCTACACTCG 480

CTAGATCTCA TTTACAGAGA CCTAAAACCT GAGAATCTTC TCATCGACCA TCACGGCTAC 540

ATCCAGGTGA CAGACTTTGG ATTTGCCAAG CGAGTAAAAG GGAGAACCTG GACGTTGTGC 600

GGAACACCGG AGTACCTGGC CCCTGAAATC ATTCTCAGCA AAGGCTATAA CAAAGCGGTG 660

GACTGGTGGG CTCTGGGCGT CCTCATCTAT GAAATGGCAG CTGGTTATCC TCCTTTCTTC 720

GCAGATCAGC CTATTCAGAT TTATGAAAAG ATTGTGTCTG GGAAGGTGCG ATTTCCCTCC 780

CACTTCAGCT CGGATTTGAA AGACCTGTTG AGAAACTTGC TGCAGGTGGA CCTGACCAAA 840

CGTTACGGCA ACCTGAAGAA CGGAGTCAAT GACATCAAAG GCCACAAATG GTTCGCCACG 900

ACGGACTGGA TCGCAATCTA CGAGCGAAAG GTGGAAGCCC CTTTCATACC AAAGTGCAGA 960

GGTCCCGGAG ACACCAGCAA CTTTGACGAC TACGAAGAGG AGGAGATCCG CGTTTCTCTA 1020

ACAGAAAAGT GCGCCAAGGA GTTTGCGGAG TTTTAG 1056

Domain Profile

S: 1     ferlktlGtGsfGrvelvrekeskkyyalkvlskekvvklkqvehvknekrvlkavefpf  60

         f+r+ktlGtGsfGrv+lv++k+s++y+a+k+l+k+kvvklkq+eh+ nekr+l+av+fpf

Q: 44    FDRIKTLGTGSFGRVMLVKHKSSEQYFAMKILDKQKVVKLKQIEHTLNEKRILQAVSFPF  103

         789*********************************************************

S: 61    lvkllasfkdesnlylvleyveGGelfsylrkvrrfsekaarfyaaeivlaleylhsldl  120

         lv+l+++fkd+snly+v+eyv+GGe+fs+lr+++rfse++arfyaa+ivl++eylhsldl

Q: 104   LVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDL  163

         ************************************************************

S: 121   iyrdlkpenllldkeGyikvtdfGfakkvkdrtwtlcGtpeylapeiiqskgynkavdww  180

         iyrdlkpenll+d++Gyi+vtdfGfak+vk+rtwtlcGtpeylapeii skgynkavdww

Q: 164   IYRDLKPENLLIDHHGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWW  223

         ************************************************************

S: 181   alGvliyellaGyppffddqpikiyekivsgklkfpsklssdlkdllkkllqvdltkrlg  240

         alGvliye++aGyppff+dqpi+iyekivsgk++fps++ssdlkdll++llqvdltkr+g

Q: 224   ALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRYG  283

         ************************************************************

S: 241   nlkngvedikehkwf  255

         nlkngv+dik hkwf

Q: 284   NLKNGVNDIKGHKWF  298

         **************9

Domain Sequence
(FASTA)

FDRIKTLGTG SFGRVMLVKH KSSEQYFAMK ILDKQKVVKL KQIEHTLNEK RILQAVSFPF 60

LVRLEYAFKD NSNLYMVMEY VPGGEMFSHL RRIGRFSEPH ARFYAAQIVL TFEYLHSLDL 120

IYRDLKPENL LIDHHGYIQV TDFGFAKRVK GRTWTLCGTP EYLAPEIILS KGYNKAVDWW 180

ALGVLIYEMA AGYPPFFADQ PIQIYEKIVS GKVRFPSHFS SDLKDLLRNL LQVDLTKRYG 240

NLKNGVNDIK GHKWF 255

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013