EKS-ORL-00319

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00319

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	469.4	7.1E-141	193	506	314

Status

Unreviewed

Ensembl Protein

ENSORLP00000021696

UniProt Accession

H2MSF8;

Protein Name

Protein Synonyms/Alias

Gene Name

DYRK2

Gene Synonyms/Alias

DYRK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000017348	ENSORLP00000021696	ENSORLT00000021697

Organism

Oryzias latipes

Functional Description

Protein Length

578

Protein Sequence
(FASTA)

QTLLSLSLCP SGKLGEPVCS PGHSGSQTTS PVALPPLRTN NPLTVAGGSK ATMAEPQVHV 60

TPLYEENMNK RPVLTSQPNG LAPLSSTRPG LPLPERQSSE AAQHGRQSSA TSNKPADSKP 120

KTNPLTAEQA MKQFMSKMSS FEHHEVFSFS EVYFIGPSAK KRSGVLGGPN NGGYDDDQGS 180

YIQVPHDHIA YRYEVLKVIG KGSFGQVVKA FDHKTQTHVA LKMVRNEKRF HRQAAEEIRI 240

LEHLKKQDKD SSMNVIHMLE NFTFRNHICM TFELLSMNLY ELIKKNKFQG FSLPLVRKFA 300

HSILQCLDAL HKNRIIHCDL KPENILLKQQ GRSGIKVIDF GSSCFEHQRV YTYIQSRFYR 360

APEVILGSRY GMPIDMWSLG CILAELLTGY PLLPGEDEAD QLACIIELLG MPSQKILDAS 420

KRAKNFVSSK GYPRYCTVTT LSDGTTVLNG GRSRRGKVRG PPGSKVWSTA LKGCDDPLFL 480

DFLKQCLEWD PAHRMTPSQA LRHSWLRRRL PKPPTGTTPG DKTSSSKRAT TDGTITSNSK 540

LVTSSTTSSS SKTRTNLAAI TDANGNIQPR TVLPKLVS 578

Nucleotide Sequence
(FASTA)

CAGACTCTCC TCTCTCTCTC TCTGTGTCCT TCAGGCAAAT TGGGCGAGCC GGTCTGCTCT 60

CCCGGTCACA GCGGCTCTCA GACCACGTCA CCAGTCGCCC TGCCGCCGCT CCGCACCAAC 120

AACCCCCTGA CGGTAGCCGG GGGCTCCAAA GCCACCATGG CGGAGCCGCA GGTCCACGTC 180

ACCCCGCTGT ACGAGGAAAA CATGAACAAG CGCCCGGTCC TGACCTCTCA GCCCAACGGC 240

CTGGCTCCAC TCAGCTCCAC CCGGCCAGGC CTCCCTCTGC CAGAGCGACA GTCCTCTGAG 300

GCGGCCCAGC ACGGACGCCA GAGCAGCGCC ACCTCCAACA AGCCCGCCGA CAGCAAGCCA 360

AAGACGAACC CTCTGACGGC CGAGCAGGCC ATGAAGCAGT TCATGTCCAA GATGTCCTCG 420

TTCGAACACC ACGAAGTGTT CAGCTTCTCC GAGGTGTATT TCATTGGTCC AAGCGCAAAG 480

AAGAGGTCAG GGGTTCTCGG CGGTCCCAAC AACGGCGGTT ATGATGATGA TCAGGGGTCT 540

TACATCCAGG TCCCACACGA CCACATCGCC TACCGCTACG AAGTCCTGAA AGTCATCGGC 600

AAAGGGAGCT TCGGACAGGT GGTGAAGGCC TTCGACCACA AAACTCAGAC CCACGTGGCC 660

CTGAAGATGG TCCGCAACGA GAAGCGCTTC CACCGGCAGG CGGCGGAGGA GATCCGCATC 720

CTGGAGCACC TGAAGAAGCA GGACAAGGAC TCCAGCATGA ACGTCATCCA CATGCTGGAG 780

AACTTCACCT TCCGCAACCA CATCTGCATG ACCTTCGAGC TGCTCAGCAT GAACCTGTAC 840

GAGCTCATCA AGAAGAACAA GTTCCAGGGC TTCAGCCTCC CGCTGGTCAG GAAGTTCGCC 900

CACTCCATCC TGCAGTGTCT GGACGCGCTG CACAAGAACC GGATCATCCA CTGCGACCTC 960

AAACCTGAGA ACATTTTACT CAAGCAGCAA GGCCGGAGCG GCATCAAGGT CATTGACTTT 1020

GGTTCCAGCT GCTTTGAACA TCAGAGGGTT TACACCTACA TCCAGTCCAG GTTTTACCGA 1080

GCACCAGAGG TCATTCTAGG TTCCAGGTAT GGGATGCCCA TCGACATGTG GTCGCTGGGC 1140

TGCATCCTCG CCGAGCTCCT GACTGGTTAC CCGCTGTTAC CAGGGGAAGA CGAAGCCGAC 1200

CAGCTCGCCT GCATCATAGA ACTCCTAGGC ATGCCAAGTC AGAAGATCTT GGATGCCTCC 1260

AAGCGGGCCA AGAACTTTGT GTCCTCCAAG GGATACCCGC GGTACTGCAC CGTCACCACG 1320

CTGAGCGACG GCACCACGGT GCTGAACGGA GGACGCTCGC GGCGAGGGAA GGTACGCGGT 1380

CCCCCCGGCA GCAAGGTGTG GAGTACGGCG CTGAAGGGCT GCGACGACCC GCTCTTCCTG 1440

GACTTCCTCA AACAGTGTTT AGAGTGGGAC CCAGCGCACC GGATGACGCC GAGCCAGGCT 1500

CTGCGCCATT CGTGGCTCAG GAGGCGACTC CCCAAGCCAC CAACAGGAAC CACTCCGGGA 1560

GACAAGACCT CTTCGTCCAA ACGTGCCACC ACTGACGGCA CCATCACCTC CAATTCTAAG 1620

CTCGTAACCT CCTCAACAAC CTCCTCCTCC TCCAAAACCA GGACTAACTT AGCTGCAATC 1680

ACTGACGCCA ATGGCAACAT CCAGCCTAGG ACGGTGCTGC CCAAACTTGT CAGCTGA 1737

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         yevl+vigkGsfgqVvka d+kt+++va+k+++n+krf+rqa+eE++iLe+l+k+dk+++

Q: 193   YEVLKVIGKGSFGQVVKAFDHKTQTHVALKMVRNEKRFHRQAAEEIRILEHLKKQDKDSS  252

         9***********************************************************

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120

         +nv+++le f+frnh+c++fells+nLyel+kknkf+g+sl lvrk+a++il++L++L++

Q: 253   MNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHK  312

         ************************************************************

S: 121   lkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglkyd  180

         ++iiH+DlKPeNill++++rs +kviDFGss++++q+ +ytyiqsrfYraPE+ilg +y

Q: 313   NRIIHCDLKPENILLKQQGRSGIKVIDFGSSCFEHQR-VYTYIQSRFYRAPEVILGSRYG  371

         *************************************.**********************

S: 181   eaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftkke  240

         + iDmWSlGc+laEl+tG+pL+pGe+e dqla+i+e+lg+p++k+l+++k+ak+f+++k+

Q: 372   MPIDMWSLGCILAELLTGYPLLPGEDEADQLACIIELLGMPSQKILDASKRAKNFVSSKG  431

         ************************************************************

S: 241   apkyilktkksdrkkklvlnvkkaakkrkaplskelgealkekedklfkdllkrmleldp  300

         +p+y+++t+ sd +++l+ ++++++k r +p+sk +++alk ++d lf d+lk++le+dp

Q: 432   YPRYCTVTTLSDGTTVLNGGRSRRGKVRGPPGSKVWSTALKGCDDPLFLDFLKQCLEWDP  491

         ************************************************************

S: 301   akRitpkealkhpfv  315

         a+R+tp++al+h+++

Q: 492   AHRMTPSQALRHSWL  506

         *************96

Domain Sequence
(FASTA)

YEVLKVIGKG SFGQVVKAFD HKTQTHVALK MVRNEKRFHR QAAEEIRILE HLKKQDKDSS 60

MNVIHMLENF TFRNHICMTF ELLSMNLYEL IKKNKFQGFS LPLVRKFAHS ILQCLDALHK 120

NRIIHCDLKP ENILLKQQGR SGIKVIDFGS SCFEHQRVYT YIQSRFYRAP EVILGSRYGM 180

PIDMWSLGCI LAELLTGYPL LPGEDEADQL ACIIELLGMP SQKILDASKR AKNFVSSKGY 240

PRYCTVTTLS DGTTVLNGGR SRRGKVRGPP GSKVWSTALK GCDDPLFLDF LKQCLEWDPA 300

HRMTPSQALR HSWL 314

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013