EKS-ORL-00441
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORL-00441
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src425.86.1E-128241490250
StatusUnreviewed
Ensembl ProteinENSORLP00000021875
UniProt AccessionH2MSY2;
Protein Name
Protein Synonyms/Alias
Gene NameLCK
Gene Synonyms/Alias LCK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSORLG00000017495ENSORLP00000021875ENSORLT00000021876
OrganismOryzias latipes
Functional Description
Protein Length502
Protein Sequence
(FASTA)
MGCACSTDSE EWLENLDDIC EHCNCPIPPQ SSKGKLSIYT DQLIQHPSSH SPPLSPLPDN 60
IALAVYSYEP KHDGDLGFEK GDKLKILNKD DPEWYLAESL TTGQQGYIPF NFIAMTTMET 120
EPWFFRDISR NDAMRLLLAP GNTQGSFLIR ESETTKGSYS LSIRDLDHNA GEGVKHYRIR 180
NLDSGGFYIT AKISFNSLKE LVQHYTREAD GLCSTLGKPC QSRAPQKPWW HDEWEIPRES 240
LKLLRRLGAG QFGEVWMGLY NNDSKVAIKN LKMGTMSVEA FLAEANMMKN LQHPRLVRLF 300
AVVTEEPIYI VTEYMENGSL VDFLKTQEGG NLPINTLIDM ASQVADGMAF IEQRNYIHRD 360
LRAANILVSH ELICKVADFG LARLIEDNEY TAREGAKFPI KWTAPEAINF GTFTIKSDVW 420
SFGILLTEIV TYGRIPYPGM SNPEVIQNLE RGYRMPKPEG CPDGLYAIMC HCWKETPDDR 480
PTFEYLKDVL EDFFASTERQ YH 502
Nucleotide Sequence
(FASTA)
ATGGGATGTG CTTGCAGTAC AGATTCGGAA GAATGGTTGG AGAACCTGGA TGACATTTGC 60
GAACACTGCA ACTGTCCAAT ACCTCCCCAG TCAAGTAAAG GGAAGTTGTC TATTTACACA 120
GACCAGCTGA TTCAACACCC ATCATCGCAT TCGCCGCCCT TGTCGCCGTT ACCAGACAAC 180
ATTGCTCTGG CCGTGTACAG CTACGAACCC AAACATGATG GTGACCTGGG CTTTGAGAAA 240
GGAGACAAAC TCAAAATCCT TAACAAGGAT GACCCAGAGT GGTACCTGGC GGAGTCCCTC 300
ACAACAGGCC AGCAGGGCTA CATCCCATTT AACTTCATTG CAATGACCAC AATGGAGACT 360
GAACCGTGGT TCTTTAGGGA CATTTCTAGA AACGATGCCA TGAGGCTTCT CCTTGCTCCT 420
GGAAACACAC AGGGCTCCTT CCTGATTCGA GAGAGTGAGA CGACCAAAGG GTCATACTCA 480
TTATCAATTC GAGATCTGGA CCACAACGCG GGTGAAGGGG TCAAGCACTA CAGGATCCGT 540
AACCTGGACA GCGGTGGCTT CTACATCACA GCCAAAATCT CCTTCAACTC GCTGAAGGAG 600
CTTGTGCAGC ATTACACACG GGAGGCAGAT GGGCTGTGCT CGACTCTGGG GAAACCATGT 660
CAGTCAAGGG CGCCGCAGAA GCCGTGGTGG CACGACGAGT GGGAGATTCC CAGAGAGTCG 720
CTCAAGCTGC TGCGCCGGCT TGGAGCTGGG CAGTTTGGAG AAGTTTGGAT GGGTCTCTAT 780
AATAATGACA GTAAAGTTGC AATTAAAAAC CTGAAGATGG GCACGATGTC AGTGGAAGCT 840
TTCCTCGCTG AGGCCAACAT GATGAAGAAC TTGCAGCATC CGCGGCTTGT CCGACTCTTT 900
GCCGTGGTTA CTGAGGAGCC CATCTATATT GTTACGGAAT ACATGGAAAA TGGCAGCCTG 960
GTGGATTTTC TAAAAACACA GGAGGGAGGC AATTTACCCA TCAACACTCT GATAGACATG 1020
GCGTCTCAGG TGGCTGATGG CATGGCTTTC ATTGAGCAGA GAAATTACAT CCATCGTGAT 1080
CTGAGAGCTG CAAACATCTT AGTCTCTCAT GAGCTCATCT GCAAGGTTGC TGACTTTGGA 1140
CTGGCAAGAC TCATCGAGGA CAATGAATAC ACAGCCAGAG AGGGTGCAAA GTTTCCCATT 1200
AAATGGACAG CGCCTGAAGC TATCAACTTT GGGACATTCA CCATAAAATC TGATGTGTGG 1260
TCATTTGGGA TCCTGCTTAC GGAAATAGTG ACATATGGAC GAATTCCTTA CCCTGGTATG 1320
TCCAACCCAG AGGTCATTCA AAACCTTGAG CGAGGCTACA GAATGCCAAA ACCAGAAGGG 1380
TGCCCTGATG GGCTTTACGC CATCATGTGC CATTGCTGGA AGGAGACTCC AGACGACAGA 1440
CCCACCTTTG AATACCTGAA GGATGTCTTG GAGGACTTTT TCGCTTCCAC AGAGAGGCAG 1500
TACCATTAG 1509
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         lkl+++lG+GqfGevw+g++++  kva+k lk gt+s eafl+ea+++k+l+h++lv+l+
Q: 241   LKLLRRLGAGQFGEVWMGLYNNDSKVAIKNLKMGTMSVEAFLAEANMMKNLQHPRLVRLF  300
         6899********************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avv+e ePiyivte+m++Gsl+dflk++eg +l++++l+d+a+qva+Gma++e++n+ihr
Q: 301   AVVTE-EPIYIVTEYMENGSLVDFLKTQEGGNLPINTLIDMASQVADGMAFIEQRNYIHR  359
         ****9.******************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+a+n+lv+++l++kvadfGlarlied+eyta+egak+PikWtaPeai++g+ftiksdv
Q: 360   DLRAANILVSHELICKVADFGLARLIEDNEYTAREGAKFPIKWTAPEAINFGTFTIKSDV  419
         ************************************************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240
         WsfGillteivt+G++PypGm+n ev++++ergyr+p+pe cp+ ly ++++cwk++p++
Q: 420   WSFGILLTEIVTYGRIPYPGMSNPEVIQNLERGYRMPKPEGCPDGLYAIMCHCWKETPDD  479
         ************************************************************
S: 241   rPtfetlqevl  251
         rPtfe+l+ vl
Q: 480   RPTFEYLKDVL  490
         *******9875
Domain Sequence
(FASTA)
LKLLRRLGAG QFGEVWMGLY NNDSKVAIKN LKMGTMSVEA FLAEANMMKN LQHPRLVRLF 60
AVVTEEPIYI VTEYMENGSL VDFLKTQEGG NLPINTLIDM ASQVADGMAF IEQRNYIHRD 120
LRAANILVSH ELICKVADFG LARLIEDNEY TAREGAKFPI KWTAPEAINF GTFTIKSDVW 180
SFGILLTEIV TYGRIPYPGM SNPEVIQNLE RGYRMPKPEG CPDGLYAIMC HCWKETPDDR 240
PTFEYLKDVL 250
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00347
EKS-BOT-00370
EKS-CAF-00371
EKS-CAP-00402
EKS-DAR-00750
EKS-DIO-00065
EKS-EQC-00361
EKS-ERE-00004
EKS-FEC-00358
EKS-GAM-00223
EKS-GAA-00453
EKS-GOG-00391
EKS-HOS-00376
EKS-ICT-00351
EKS-LAC-00385
EKS-LOA-00383
EKS-MEG-00303
EKS-MIM-00060
EKS-MOD-00357
EKS-MUM-00403
EKS-MUP-00365
EKS-MYL-00368
EKS-OCP-00080
EKS-ORN-00480
EKS-ORC-00349
EKS-OTG-00374
EKS-POA-00359
EKS-RAN-00384
EKS-SAH-00340
EKS-SOA-00006
EKS-SUS-00324
EKS-TAR-00475
EKS-TEN-00475
EKS-TUT-00115
EKS-XET-00485
EKS-XIM-00468
Gene Ontology
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013