EKS-ORL-00175

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00175

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/NDR	509.5	3.2E-153	643	948	306

Status

Unreviewed

Ensembl Protein

ENSORLP00000022059

UniProt Accession

H2MTF9;

Protein Name

Protein Synonyms/Alias

Gene Name

LATS1

Gene Synonyms/Alias

LATS1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000017630	ENSORLP00000022059	ENSORLT00000022060
ENSORLG00000017630	ENSORLP00000022058	ENSORLT00000022059

Organism

Oryzias latipes

Functional Description

Protein Length

1055

Protein Sequence
(FASTA)

MRRAEKPEGY RQMRPKTFPV SNYNGNSQQM LQEIRNSLRN LTKPSDQPKG DTGGPGKMAP 60

EDPRQQGRSG NLKNQYQKAL QEIRKSLVPY KVNGSGDEES TTSGADGNKS QDQSGFEEEM 120

PDYMLKPSYQ DPMRDQMTAS SSNSSALKAP EAFHMPQVVL RRPSWKGSME SLGSRHGPNM 180

VDGMMYRSDS PGPPPSFSQA HPTANQRVNP PLPPQMRSVT PPPNRAMPPA PSWDNNPQTN 240

RLPGNMDFFP TRISPVPQAP WADGYPTPAA PNQRVIGPAA GSHQPIIMQS SGGSKFTFPS 300

SWTQSGSSQP EHVSGGSRQP PPPYPLTQSS STDPQVGGPA SSPSYINGGG IPPSLMISNR 360

NSHNLEMYGI APQSWSQSQP PPANCNSNQD LSPSWQHNVP VRSNSFNTPQ LNGRPAHPAS 420

SQPSATTVTA ITPAPILNPV RSTKVHKPEP QTAVAPTHPP WIQQGALPGP TYSEPSLPVS 480

QAPVEAPGYQ GPPPPYPKHL LQPAYVVGTN KLSREEAAEE EASGENSREK APENPETAAA 540

EKERKQITTS PVPVRRNKKD EPRGESGRVA LYSPQAFKFF MEQHVENILK NHQQRIRRRK 600

QLESEMQRVG LSSEAQEQMR MMLCQKESNY IRLKRAKMEK SMFKQIKTLG IGAFGQVCLA 660

RKEDTGSLYA MKTLRKKDVL LRNQVAHVKA ERDILAEADN EWVVRLYYSF QDKDNLYFVM 720

EYIPGGDMMS LLIRLGIFKE DLAQFYIAEL TCAVESVHKM GFIHRDIKPD NILIDRDGHI 780

KLTDFGLCTG FRWTHDSKYY QSGDHVRQDS MDFSKEWEES ANCRCSDRLK PLERRKAREH 840

QRCLAHSLVG TPNYIAPEVL LRSGYTQLCD WWSVGVILYE MVVGQPPFFA NTPLETQKKV 900

INWKTTLHIP PQAKLSPEAS DLIVKLCRDP KDRLGTNGAD EIKAHSFFRT IDFSSDLRQQ 960

VAPYIPTIAH SMDTSNFDPV DPDKLRSMDS ENNHNDTLTS LFRNGKHPEH AFYEFTFRRF 1020

FDGYGHPYSC PKPIEYDEDC EGVPPDAQGQ EQVYV 1055

Nucleotide Sequence
(FASTA)

ATGAGGAGAG CGGAGAAGCC CGAGGGCTAC AGACAGATGA GACCTAAGAC CTTCCCCGTC 60

AGCAACTACA ATGGCAACAG CCAGCAGATG CTGCAGGAAA TACGCAACAG CCTGCGGAAC 120

CTGACCAAGC CCTCGGATCA GCCGAAAGGG GACACCGGGG GACCTGGAAA GATGGCCCCT 180

GAAGATCCAC GGCAGCAGGG GCGCAGCGGG AACCTCAAAA ACCAATACCA GAAGGCTTTA 240

CAGGAGATCC GCAAGTCCCT TGTTCCGTAT AAAGTGAACG GTTCTGGGGA CGAGGAGTCC 300

ACCACGTCAG GTGCTGATGG AAACAAGTCC CAGGACCAAT CTGGGTTTGA GGAGGAAATG 360

CCAGACTACA TGTTAAAGCC GAGTTACCAG GACCCAATGA GAGATCAGAT GACTGCTTCC 420

AGTTCAAACT CTTCAGCCCT GAAAGCCCCG GAAGCCTTCC ACATGCCGCA GGTGGTGCTG 480

CGGAGGCCGA GCTGGAAAGG CTCCATGGAG TCTTTGGGCT CTCGCCACGG CCCCAATATG 540

GTGGACGGGA TGATGTACCG CTCGGACAGC CCCGGACCCC CCCCTTCGTT CTCGCAGGCT 600

CACCCGACTG CCAACCAGAG GGTCAACCCC CCCCTCCCTC CTCAGATGCG CAGCGTCACA 660

CCTCCCCCCA ACCGGGCCAT GCCACCTGCG CCGTCCTGGG ACAACAACCC GCAGACTAAC 720

CGCCTCCCTG GAAATATGGA TTTCTTCCCC ACCCGCATAT CCCCGGTGCC TCAGGCCCCC 780

TGGGCTGATG GGTATCCAAC CCCCGCAGCC CCGAACCAGC GAGTGATCGG CCCCGCCGCT 840

GGAAGTCACC AGCCCATCAT AATGCAAAGC TCCGGGGGGA GCAAGTTCAC CTTTCCCTCT 900

AGCTGGACTC AGAGTGGTTC CTCCCAACCG GAGCATGTGT CAGGGGGGAG CAGACAGCCC 960

CCTCCCCCTT ACCCTCTTAC TCAGAGCAGC TCCACTGACC CCCAGGTGGG GGGACCCGCC 1020

TCGTCTCCTT CCTACATCAA CGGCGGCGGG ATCCCTCCAT CCCTGATGAT CAGTAACCGG 1080

AACAGCCACA ACCTGGAGAT GTACGGCATT GCCCCCCAGT CCTGGTCCCA GAGCCAGCCC 1140

CCGCCTGCCA ACTGCAACAG CAACCAGGAC CTGTCCCCGT CGTGGCAGCA CAACGTGCCC 1200

GTCCGCTCCA ATTCTTTCAA CACCCCCCAG CTGAACGGTA GGCCTGCTCA CCCCGCCAGC 1260

TCCCAGCCCT CTGCCACCAC CGTCACCGCC ATCACGCCGG CCCCCATCCT GAACCCCGTC 1320

AGGAGCACCA AAGTCCATAA ACCCGAGCCT CAGACAGCTG TCGCCCCCAC GCACCCTCCC 1380

TGGATCCAAC AGGGGGCGCT GCCGGGACCT ACATACTCGG AGCCCTCCCT CCCCGTTTCC 1440

CAGGCTCCTG TTGAGGCGCC TGGCTATCAG GGCCCTCCCC CGCCCTACCC CAAGCACCTC 1500

CTACAGCCAG CGTATGTTGT TGGCACCAAC AAGCTGAGCA GAGAGGAGGC GGCAGAGGAG 1560

GAGGCAAGTG GCGAGAACTC CAGAGAGAAG GCGCCAGAAA ACCCTGAAAC TGCGGCAGCA 1620

GAGAAGGAGA GGAAGCAGAT CACCACCTCG CCCGTCCCCG TCCGCCGCAA CAAGAAGGAC 1680

GAGCCCAGGG GGGAGTCCGG GAGGGTGGCA CTGTACTCCC CCCAGGCCTT CAAGTTCTTC 1740

ATGGAGCAAC ACGTGGAAAA CATCCTGAAG AACCACCAGC AGAGGATCCG GAGGAGGAAG 1800

CAGCTGGAGA GCGAGATGCA GCGGGTGGGG TTGTCCTCAG AAGCTCAGGA GCAGATGCGG 1860

ATGATGCTCT GCCAGAAGGA GTCCAACTAC ATCCGCCTGA AGCGCGCCAA GATGGAGAAG 1920

TCCATGTTCA AGCAGATCAA GACTCTGGGC ATCGGGGCCT TCGGTCAGGT GTGCCTGGCC 1980

AGAAAAGAAG ACACGGGGTC GCTGTACGCC ATGAAGACCC TCCGCAAGAA GGACGTTCTC 2040

CTGAGGAACC AGGTGGCGCA TGTGAAGGCT GAGAGGGACA TCCTGGCGGA GGCAGACAAC 2100

GAGTGGGTGG TGCGGCTCTA CTACTCCTTC CAGGACAAGG ACAACCTGTA CTTTGTCATG 2160

GAGTACATCC CCGGGGGGGA CATGATGAGC CTCCTCATCC GGCTGGGCAT CTTCAAGGAG 2220

GACCTGGCGC AGTTCTACAT CGCCGAGCTG ACCTGCGCCG TGGAGAGCGT CCACAAGATG 2280

GGCTTCATCC ACAGAGACAT CAAGCCGGAC AACATCCTTA TCGACCGAGA CGGACACATC 2340

AAGCTGACAG ACTTCGGCCT CTGCACCGGT TTCCGCTGGA CGCACGACTC CAAGTACTAC 2400

CAGAGCGGAG ACCACGTGAG GCAGGACAGC ATGGACTTCA GCAAGGAGTG GGAGGAGTCT 2460

GCCAACTGCC GCTGCTCAGA CCGCCTGAAG CCGCTGGAGA GGAGGAAGGC TCGGGAGCAC 2520

CAGCGCTGCC TGGCCCACTC CCTGGTGGGA ACGCCCAACT ACATCGCCCC AGAAGTGCTG 2580

CTCAGATCAG GTTACACGCA GCTCTGCGAC TGGTGGAGCG TGGGCGTCAT CTTGTACGAA 2640

ATGGTGGTGG GACAGCCGCC GTTCTTCGCC AACACCCCAT TGGAGACCCA GAAAAAGGTG 2700

ATCAACTGGA AGACCACGCT GCACATCCCC CCTCAGGCCA AGCTCAGCCC CGAAGCGTCT 2760

GATCTCATCG TCAAACTGTG TCGCGACCCC AAAGACCGCC TCGGCACCAA CGGCGCTGAC 2820

GAAATCAAAG CCCACTCTTT CTTCAGGACC ATCGACTTCT CCAGTGACCT CAGGCAGCAG 2880

GTGGCGCCCT ACATCCCCAC CATCGCCCAC TCCATGGACA CCTCCAACTT CGACCCTGTG 2940

GACCCGGACA AACTGCGGAG CATGGACAGC GAGAACAACC ACAACGACAC GCTGACGTCG 3000

CTGTTCCGCA ACGGCAAGCA TCCCGAGCAC GCCTTCTACG AGTTCACCTT CCGACGCTTC 3060

TTCGACGGCT ACGGACACCC GTACAGCTGC CCCAAACCCA TCGAGTACGA TGAGGACTGC 3120

GAGGGTGTGC CCCCAGACGC GCAGGGCCAG GAGCAGGTCT ACGTGTAG 3168

Domain Profile

S: 1     feklkvigkGafGevrlvrkkdtkevyalkilrkkdllkknqvahvkaerdilaeadsew  60

         f+++k++g+GafG+v+l+rk+dt+++ya+k+lrkkd+l +nqvahvkaerdilaead+ew

Q: 643   FKQIKTLGIGAFGQVCLARKEDTGSLYAMKTLRKKDVLLRNQVAHVKAERDILAEADNEW  702

         899*********************************************************

S: 61    vvklyysfqdkenlylvmeylPGGdlmtllikkeilkeelarfyiaelvlavesvhklGf  120

         vv+lyysfqdk+nly+vmey+PGGd+m+lli+ +i+ke+la+fyiael++avesvhk+Gf

Q: 703   VVRLYYSFQDKDNLYFVMEYIPGGDMMSLLIRLGIFKEDLAQFYIAELTCAVESVHKMGF  762

         ************************************************************

S: 121   ihrdlkPdnllidakGhikltdfGlctGlkkthrseyykelekakeddlease.......  173

         ihrd+kPdn+lid++GhikltdfGlctG+++th+s+yy++ +++++d++++s+

Q: 763   IHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHVRQDSMDFSKeweesan  822

         **************************************************9999******

S: 174   .....elkvlerrkkkknrrllayslvGtpdyiapevlekkgynklcdwWslGvilyeml  228

              +lk+lerrk+++++r+la+slvGtp+yiapevl+++gy++lcdwWs+Gvilyem+

Q: 823   crcsdRLKPLERRKAREHQRCLAHSLVGTPNYIAPEVLLRSGYTQLCDWWSVGVILYEMV  882

         ****99******************************************************

S: 229   vGypPflaetpqetykkvinwketlkfpeevelseeakdlierliadaekrlgkkGvdei  288

         vG+pPf a+tp et+kkvinwk+tl++p++++ls+ea+dli +l+ d+++rlg++G+dei

Q: 883   VGQPPFFANTPLETQKKVINWKTTLHIPPQAKLSPEASDLIVKLCRDPKDRLGTNGADEI  942

         ************************************************************

S: 289   kkhpff  294

         k+h+ff

Q: 943   KAHSFF  948

         *****9

Domain Sequence
(FASTA)

FKQIKTLGIG AFGQVCLARK EDTGSLYAMK TLRKKDVLLR NQVAHVKAER DILAEADNEW 60

VVRLYYSFQD KDNLYFVMEY IPGGDMMSLL IRLGIFKEDL AQFYIAELTC AVESVHKMGF 120

IHRDIKPDNI LIDRDGHIKL TDFGLCTGFR WTHDSKYYQS GDHVRQDSMD FSKEWEESAN 180

CRCSDRLKPL ERRKAREHQR CLAHSLVGTP NYIAPEVLLR SGYTQLCDWW SVGVILYEMV 240

VGQPPFFANT PLETQKKVIN WKTTLHIPPQ AKLSPEASDL IVKLCRDPKD RLGTNGADEI 300

KAHSFF 306

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 2.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013