EKS-ORL-00358
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORL-00358
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR491.65.4E-148532788257
StatusUnreviewed
Ensembl ProteinENSORLP00000022143
UniProt AccessionH2MTN5;
Protein Name
Protein Synonyms/Alias
Gene NameEGFR (1 of 2)
Gene Synonyms/Alias EGFR (1 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSORLG00000017692ENSORLP00000022143ENSORLT00000022144
ENSORLG00000017692ENSORLP00000022141ENSORLT00000022142
OrganismOryzias latipes
Functional Description
Protein Length1008
Protein Sequence
(FASTA)
NISCFGISGK KCHSSCFNGS CWAPGPQYCQ TLTKLNCAQQ CSKRCKGPSP SDCCNEHCAA 60
GCTGPRPTDC LACRDFRDDG VCKDSCPGLM RYDPNLHLLV PNPNGKYSFG ATCVKNCPHN 120
YVVTDHGACV RTCSGNTYEV DEGGIRKCAK CNGPCPKVCN GLGTGNLTHT LSINATNIDS 180
FKNCTKINGN IAFIHTSIYG VTNIIEKSQQ KNNTINKLCV ASGYLWIQTW PKNMSSLSPF 240
ENLEIIRGRT KQRGSRSVAI TQLDISYLGL RSLKEISDGD VVIIKNHNLC YTNRSHWKGL 300
FKSKTQSANV DENASATACA LMNSTCDRKC AADGCWGPGP DMCFACRDYS RGGRCVDSCN 360
ILEGEPREAV MNKTCVECDP ECQRMNGTAT CSASGPGNCA KCANFQDGLY CVSRCPQGVP 420
GEDDTLVWKY ADERNVCQLC HKNCTQGTQS RTEACLSFSS TGLSMIAAGV VGGLLTVLVT 480
GLSVFVLLRR RYIKRKRTMR RLLQERELVE PLTPSGQAPN QALLRILKES EFKKIKVLGS 540
GAFGTVYKGL WVPEGEDVKI PVAIKVLREA TSPKANKEIL DEAYVMASVE NPHVCRLLGI 600
CLTSTVQLIT QLMPYGCLLD YVKEKKDNIG SQHLLNWCVQ IAKGMNYLEE RHLVHRDLAA 660
RNVLVKTPNH VKITDFGLAK LLNADEKEYH ADGGKVPIKW MALESILTRT YTHQSDVWSY 720
GVTVWELMTF GTKPYDGIPA SEIAGILEKG DRLPQPPICT IDVYMIMVKC WMIDAESRPR 780
FRELIGEFTK MARDPSRYLV IQGDDRMHLP SPTDTKFYRS LIGGEDTEES VDADEYLLPQ 840
HGFFSSPSTS QTPLLHSTVS FLFQKERLQN GFPSRDGSMI LRYIPDPTDL SLDEAFQPAP 900
GPTDYMNQNG VSDVANPIYQ NPRPPRATLP TISSDGAETE YLNCFKNGPE YLNESPPALS 960
SNGVVHGVQM CQPQNSMDNP DYQQDFTPTL KTHANGHIPA AENAEYLG 1008
Nucleotide Sequence
(FASTA)
AATATTTCAT GTTTTGGGAT TTCAGGTAAA AAATGCCACT CAAGCTGCTT CAACGGGTCG 60
TGCTGGGCTC CTGGTCCTCA ATACTGTCAG ACCTTAACCA AACTGAACTG TGCACAGCAG 120
TGCTCCAAAA GATGCAAAGG ACCTTCTCCC AGCGACTGCT GCAACGAGCA TTGTGCAGCG 180
GGCTGCACGG GACCCAGACC CACCGACTGT CTGGCCTGTC GGGACTTCCG AGACGACGGG 240
GTGTGTAAGG ACTCCTGTCC CGGCCTCATG CGCTACGATC CAAACCTCCA CCTGTTGGTT 300
CCAAACCCAA ATGGAAAGTA CAGTTTTGGT GCCACCTGTG TAAAGAACTG CCCACATAAT 360
TATGTTGTGA CGGATCATGG TGCGTGCGTA CGGACGTGCA GCGGTAACAC CTATGAAGTG 420
GATGAAGGAG GGATCAGGAA GTGTGCCAAG TGCAACGGAC CCTGTCCAAA AGTGTGTAAT 480
GGACTTGGAA CAGGAAACCT GACCCACACT CTGTCCATCA ATGCCACAAA CATCGACTCC 540
TTCAAAAACT GCACTAAAAT CAATGGGAAC ATTGCTTTTA TTCACACATC TATTTATGGG 600
GTCACAAACA TTATTGAAAA ATCACAGCAG AAAAACAACA CAATAAACAA ACTGTGTGTT 660
GCTTCAGGAT ACCTGTGGAT TCAGACGTGG CCAAAGAACA TGAGCTCGCT CAGCCCTTTT 720
GAGAATCTGG AGATCATTCG AGGAAGAACA AAACAAAGGG GTAGCCGCAG CGTTGCCATT 780
ACTCAGCTTG ACATCAGCTA CCTGGGCCTT CGTTCCCTCA AAGAAATCAG CGATGGTGAC 840
GTGGTCATCA TCAAGAACCA CAATCTCTGC TACACCAACA GAAGCCACTG GAAAGGCCTC 900
TTCAAGTCCA AAACACAAAG CGCCAATGTG GACGAAAATG CAAGCGCCAC AGCCTGTGCT 960
CTGATGAACA GCACGTGTGA CAGGAAGTGT GCCGCAGACG GCTGCTGGGG GCCCGGCCCG 1020
GACATGTGCT TCGCCTGTCG TGACTACAGT CGTGGAGGGA GATGTGTCGA CTCCTGCAAC 1080
ATCCTGGAGG GTGAGCCGCG GGAAGCAGTC ATGAATAAAA CCTGTGTGGA GTGTGACCCC 1140
GAGTGTCAGC GCATGAATGG GACAGCAACC TGCAGCGCTT CTGGTCCTGG AAATTGTGCC 1200
AAGTGTGCCA ACTTCCAAGA TGGGCTTTAC TGTGTGTCCC GCTGTCCTCA AGGCGTGCCT 1260
GGAGAGGACG ACACCCTGGT GTGGAAATAC GCGGATGAGA GGAATGTGTG TCAGCTATGC 1320
CACAAAAACT GCACCCAAGG GACACAGTCA AGAACAGAGG CCTGCCTGTC TTTTAGCTCC 1380
ACAGGTCTTT CTATGATCGC GGCTGGAGTA GTGGGTGGAC TGCTCACTGT ACTTGTGACC 1440
GGCCTTTCCG TCTTTGTGTT GCTACGGCGA CGATACATCA AGCGGAAAAG GACCATGCGC 1500
AGGCTGCTGC AGGAGAGAGA GCTTGTTGAA CCTCTCACCC CGAGTGGACA GGCTCCAAAC 1560
CAGGCTCTGC TGCGGATCCT GAAGGAATCT GAGTTTAAGA AAATCAAAGT GCTCGGTTCA 1620
GGAGCATTTG GCACCGTTTA CAAGGGTTTG TGGGTACCTG AGGGTGAGGA TGTGAAGATC 1680
CCAGTGGCCA TCAAGGTGTT GAGAGAAGCC ACATCACCCA AAGCCAACAA AGAGATCTTG 1740
GATGAAGCGT ATGTGATGGC CAGTGTGGAA AACCCCCACG TGTGTCGCCT GCTTGGTATT 1800
TGTCTCACCT CAACCGTGCA GCTGATAACA CAGCTGATGC CCTACGGCTG CCTGCTGGAC 1860
TATGTCAAAG AGAAAAAGGA CAACATCGGC TCCCAGCACC TGCTCAACTG GTGTGTGCAG 1920
ATAGCCAAGG GGATGAACTA CTTGGAGGAG CGCCATTTGG TCCACCGTGA CTTGGCTGCT 1980
CGAAATGTGC TTGTGAAGAC CCCTAATCAT GTCAAGATCA CTGACTTTGG TCTGGCCAAG 2040
CTCCTCAATG CAGATGAGAA GGAGTACCAC GCAGATGGAG GGAAGGTGCC AATAAAATGG 2100
ATGGCTCTTG AATCAATCCT GACCAGAACC TACACTCACC AGAGTGACGT ATGGAGCTAC 2160
GGTGTCACAG TCTGGGAGCT GATGACATTT GGGACCAAAC CGTATGACGG GATTCCAGCC 2220
AGTGAAATAG CCGGAATTCT GGAGAAAGGA GATCGACTCC CTCAACCTCC AATCTGTACC 2280
ATCGATGTCT ACATGATCAT GGTGAAATGT TGGATGATCG ACGCCGAAAG TCGGCCTCGC 2340
TTTAGAGAAC TGATCGGCGA GTTTACGAAA ATGGCTCGAG ATCCGTCCCG CTATCTCGTT 2400
ATTCAGGGTG ATGATCGGAT GCACCTGCCG AGCCCGACAG ACACAAAGTT CTATCGCAGT 2460
TTGATCGGCG GGGAGGACAC GGAGGAGTCC GTGGATGCAG ATGAGTATCT GTTGCCACAG 2520
CACGGCTTCT TCAGCAGTCC GAGCACCTCC CAAACCCCTC TGCTTCACTC TACAGTAAGC 2580
TTTCTCTTTC AAAAAGAAAG GTTACAGAAT GGATTCCCAA GCAGAGATGG AAGCATGATT 2640
CTCCGATATA TTCCCGACCC CACAGACCTA TCCTTGGATG AAGCCTTCCA GCCCGCTCCA 2700
GGTCCTACAG ATTATATGAA CCAGAACGGA GTTTCAGATG TGGCCAATCC CATTTACCAG 2760
AATCCCAGGC CCCCCCGTGC CACTCTTCCC ACCATCTCAT CCGACGGCGC CGAGACTGAG 2820
TACCTGAACT GTTTTAAGAA CGGACCCGAA TATCTCAACG AGTCCCCCCC CGCGCTCTCA 2880
TCCAATGGCG TGGTCCACGG CGTTCAGATG TGTCAGCCCC AGAACAGCAT GGATAACCCA 2940
GACTACCAAC AGGACTTCAC TCCCACCCTA AAGACTCACG CCAACGGGCA CATACCGGCG 3000
GCGGAGAACG CAGAGTACCT CGGC 3024
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         +kk+kvlGsGafGtvykG+w+pege+vkipvaikvl+e+t++kanke+ldea+v+as+++
Q: 532   FKKIKVLGSGAFGTVYKGLWVPEGEDVKIPVAIKVLREATSPKANKEILDEAYVMASVEN  591
         59**********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         ++++rllg+cl+st+ql+tql+p+Gclldyv+e+kd++Gsq+llnwcvqiakGm+ylee+
Q: 592   PHVCRLLGICLTSTVQLITQLMPYGCLLDYVKEKKDNIGSQHLLNWCVQIAKGMNYLEER  651
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
         +lvhrdlaarnvlvk+pnhvkitdfGlakll+adeke++a+ggkvpikw+alesil+r+y
Q: 652   HLVHRDLAARNVLVKTPNHVKITDFGLAKLLNADEKEYHADGGKVPIKWMALESILTRTY  711
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvtvwel+tfG+kpydgipa+ei  +lekG+rl+qppictidvym++vkcw
Q: 712   THQSDVWSYGVTVWELMTFGTKPYDGIPASEIAGILEKGDRLPQPPICTIDVYMIMVKCW  771
         ************************************************************
S: 241   midaesrpkfkelaeef  257
         midaesrp+f+el+ ef
Q: 772   MIDAESRPRFRELIGEF  788
         **************999
Domain Sequence
(FASTA)
FKKIKVLGSG AFGTVYKGLW VPEGEDVKIP VAIKVLREAT SPKANKEILD EAYVMASVEN 60
PHVCRLLGIC LTSTVQLITQ LMPYGCLLDY VKEKKDNIGS QHLLNWCVQI AKGMNYLEER 120
HLVHRDLAAR NVLVKTPNHV KITDFGLAKL LNADEKEYHA DGGKVPIKWM ALESILTRTY 180
THQSDVWSYG VTVWELMTFG TKPYDGIPAS EIAGILEKGD RLPQPPICTI DVYMIMVKCW 240
MIDAESRPRF RELIGEF 257
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ciona savignyi"; ?>Danio rerio"; ?>Gasterosteus aculeatus"; ?>Oreochromis niloticus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-CIS-00072
EKS-DAR-00652
EKS-GAA-00368
EKS-ORN-00386
EKS-SAH-00279
EKS-TAR-00390
EKS-TEN-00385
EKS-XET-00371
EKS-XIM-00378
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004716; F:receptor signaling protein tyrosine kinase activity
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0023014; P:signal transduction by phosphorylation
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00261; FU; 4.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013