EKS-ORL-00460

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00460

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	355.0	3.6E-106	536	792	257

Status

Unreviewed

Ensembl Protein

ENSORLP00000022142

UniProt Accession

H2MTN6;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K5 (2 of 2)

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000017694	ENSORLP00000022142	ENSORLT00000022143

Organism

Oryzias latipes

Functional Description

Protein Length

948

Protein Sequence
(FASTA)

SPDIAVVEMT DAFRQPSLFY HLGVRESFSM ANNIILYCDT NADSLQSLQE IICQKNTTCS 60

ANYTFIPYMV TPHNKVYCCD SSLMKSLTEL MQPSFEMLLG PICMPLLDRF IQLLRVSEAN 120

SHQYFRETIL NEIRKARDLY SGVELAAELN RIQQRLDNVE CLSVDVVINL LLTYRDIQDY 180

ESIVKLVETL EKLPTFDPMA HPHVKFNYAF ALNRRNLPGD RQKALDIMLP LVDADEQVAS 240

DIYCLVGRIY KDMFLESHFT DTQSRDSSML WFKKGFESEP TLHSGINYAV LLLAAGHQFD 300

TSFELRKVGV KLSSLLGKKG SLDKLQSYWD VGFFLGASIL ACDNTRVIHA SEKLFKLKAP 360

VWYLRSVVET ILIYQHFKKP CSEPPPQNKQ ELVDFWMDFL VEATKKDVSA VRFPVLILEP 420

TKVYQPSYLS INKDVEDNIV SIWHVAPDDK KGIHEWNFNA KSVRGVSISK FDERSAFLYV 480

LHNAEDFQIY FCTEIHCKRF CDLVNSLTEE AWKGPEEGDC DADTLEYDYE YDEHGERVIL 540

GKGTFGVVYA GRDLSNQVRL AIKEIPERDS RYSQPLHEEI ALHKHLKHKN IVQYLGSISE 600

NGFIKIFMEQ VPGGSLSALL RSKWGPLKNN EPTIGFYTRQ ILEGLKYLHD NQIAHRDIKG 660

DNVLINTYSG VLKISDFGTS KRLAGINPCT ETFTGTLQYM APEIIDKGPR GYGKPADIWS 720

LGCTIIEMAT GRPPFYELGE PQAAMFKVGM FKIHPEIPES MSLEAKAFIL RCFEPDPDRR 780

ATAFDLLTDE FLTVTSRRKK SKNSLTDGFM PAAEYLRSIS LPVPVVVEDT SSSSEYGSVS 840

PDNDLNSNPF IFKPSIKCYS EKDVKGPRSL FLSIPVENFE DHSAPPSPDE KDSGFFMLRK 900

DSERRATLHR IMTEDQDKVV ANLMEALGQV REGASLPASE LMAGAASL 948

Nucleotide Sequence
(FASTA)

TCACCAGACA TAGCTGTGGT GGAGATGACC GACGCCTTCC GGCAGCCCTC CCTCTTCTAC 60

CACCTGGGCG TCAGAGAGAG CTTCAGCATG GCCAACAACA TCATCCTGTA CTGTGACACT 120

AATGCCGACT CCCTCCAGTC GCTGCAGGAG ATCATTTGCC AGAAGAACAC TACGTGCTCG 180

GCTAACTACA CCTTCATTCC CTACATGGTC ACACCCCACA ACAAGGTGTA CTGCTGCGAC 240

AGCAGCCTGA TGAAGAGCCT GACCGAGCTG ATGCAGCCCA GCTTCGAGAT GCTGCTGGGG 300

CCTATCTGTA TGCCGCTGCT GGACCGCTTC ATCCAGCTGC TGCGGGTGTC CGAGGCCAAC 360

TCTCATCAGT ATTTTCGCGA GACGATCCTG AATGAGATCC GAAAAGCTCG AGACCTTTAC 420

AGCGGCGTGG AGCTGGCGGC CGAGCTGAAC CGCATCCAGC AGCGGCTGGA CAACGTGGAG 480

TGCCTTTCAG TGGACGTGGT CATCAACCTG CTGCTGACCT ACAGAGACAT CCAGGACTAT 540

GAGTCTATCG TGAAGCTGGT TGAGACTCTG GAAAAGCTTC CAACCTTCGA CCCCATGGCT 600

CATCCCCATG TGAAGTTTAA CTACGCCTTC GCTCTGAACC GGAGGAACCT TCCAGGTGAC 660

AGGCAGAAAG CCCTGGACAT TATGCTGCCC CTGGTGGACG CAGATGAGCA GGTCGCCTCG 720

GACATCTACT GCCTGGTGGG CCGGATCTAC AAGGACATGT TCCTGGAGTC TCACTTCACA 780

GACACTCAGA GCAGAGACAG CAGCATGCTC TGGTTTAAGA AGGGCTTTGA GTCGGAACCA 840

ACACTACACT CTGGCATCAA CTATGCTGTT CTCCTGCTGG CAGCCGGACA CCAGTTCGAC 900

ACATCCTTTG AGCTTCGCAA AGTCGGGGTC AAGCTGAGCA GCCTCCTGGG GAAAAAAGGC 960

AGTCTGGACA AGCTGCAGAG TTACTGGGAT GTGGGTTTCT TCCTGGGTGC CAGCATACTG 1020

GCCTGTGACA ACACCAGGGT CATCCACGCG TCTGAGAAAC TCTTCAAACT CAAAGCCCCC 1080

GTCTGGTATC TGCGCTCAGT GGTGGAGACC ATTTTGATCT ACCAGCACTT CAAAAAGCCC 1140

TGCTCAGAGC CACCACCCCA GAACAAACAG GAGCTGGTGG ACTTTTGGAT GGACTTTCTG 1200

GTGGAGGCAA CCAAAAAAGA TGTTTCCGCC GTCCGATTCC CTGTGTTGAT TCTGGAACCG 1260

ACCAAAGTTT ACCAGCCTTC ATATTTGTCC ATAAATAAAG ATGTGGAGGA CAATATTGTC 1320

TCAATCTGGC ATGTTGCTCC CGATGACAAG AAGGGGATCC ACGAGTGGAA CTTCAACGCC 1380

AAGTCTGTGC GGGGTGTCAG CATCTCCAAG TTTGACGAGC GCAGCGCCTT CCTCTATGTG 1440

CTCCACAATG CAGAGGACTT CCAGATCTAT TTCTGCACAG AGATTCACTG CAAAAGGTTT 1500

TGTGATCTGG TCAACAGTCT CACAGAAGAA GCCTGGAAGG GTCCAGAGGA AGGGGACTGT 1560

GATGCCGACA CATTAGAGTA CGACTACGAG TACGACGAAC ATGGAGAGAG GGTGATTCTG 1620

GGTAAAGGCA CGTTTGGAGT CGTGTATGCT GGAAGAGACC TGAGCAACCA GGTCCGACTG 1680

GCCATCAAGG AGATCCCAGA GAGAGACAGC AGGTACTCCC AGCCGCTCCA CGAGGAGATC 1740

GCCCTCCACA AACACCTGAA GCACAAGAAC ATCGTGCAGT ATCTGGGCTC CATCAGCGAG 1800

AACGGTTTCA TCAAGATCTT CATGGAGCAG GTTCCTGGAG GGAGTCTGTC TGCTCTGCTG 1860

AGGTCCAAGT GGGGTCCTCT GAAGAACAAC GAGCCCACCA TCGGCTTCTA CACGCGGCAG 1920

ATACTGGAGG GCCTCAAATA CCTGCATGAC AACCAGATAG CACATCGAGA CATCAAGGGC 1980

GATAACGTCC TGATCAACAC GTACAGCGGC GTCCTGAAGA TCTCCGACTT TGGCACTTCT 2040

AAGAGGTTGG CTGGAATCAA CCCCTGCACT GAAACTTTCA CAGGGACATT GCAGTACATG 2100

GCCCCTGAAA TTATAGACAA GGGCCCTCGA GGATACGGCA AACCAGCAGA CATCTGGTCC 2160

CTGGGCTGCA CCATTATCGA AATGGCGACT GGGAGACCTC CATTCTACGA GTTGGGAGAG 2220

CCACAAGCTG CCATGTTCAA GGTGGGGATG TTTAAGATCC ACCCAGAGAT CCCAGAGTCC 2280

ATGTCCCTGG AGGCCAAGGC CTTCATCCTG CGCTGCTTTG AGCCCGATCC GGATCGCAGG 2340

GCCACAGCCT TTGATCTCCT TACCGATGAG TTCCTCACCG TCACCAGCCG CAGGAAGAAG 2400

AGCAAGAACA GCCTCACAGA CGGCTTCATG CCTGCTGCAG AGTACCTTCG CAGCATCTCC 2460

CTGCCTGTGC CGGTGGTGGT GGAGGACACC AGCAGCAGCA GCGAGTACGG CTCCGTCTCC 2520

CCTGACAACG ACCTCAACAG CAACCCCTTC ATCTTCAAGC CCAGCATCAA GTGCTACAGC 2580

GAGAAGGACG TCAAGGGACC TCGATCGCTC TTTCTCAGCA TTCCGGTGGA AAACTTTGAG 2640

GACCACAGCG CTCCTCCTTC TCCGGATGAG AAGGACTCTG GCTTCTTCAT GCTTCGGAAG 2700

GATAGCGAGA GGCGAGCGAC GCTGCACCGC ATCATGACTG AGGACCAGGA CAAAGTAGTG 2760

GCGAACCTGA TGGAGGCGCT AGGGCAGGTC AGGGAGGGGG CTTCTCTTCC AGCCTCCGAG 2820

CTGATGGCAG GAGCAGCTTC CCTC 2844

Domain Profile

S: 3     krevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkHen  62

         +r ++gkG+fg vya++d++++ +la+Ke+   pe++s+  ++++l+eEi+l+k+lkH+n

Q: 536   ERVILGKGTFGVVYAGRDLSNQVRLAIKEI---PERDSR--YSQPLHEEIALHKHLKHKN  590

         6789**************************...888775..9******************

S: 63    ivkyyGveveeeelkiflEyvegGslsslle.kygkle..esvikkytkqileglayLHe  119

         iv+y+G+ +e++ +kif+E+v+gGsls+ll+ k+g+l+  e +i +yt+qilegl+yLH+

Q: 591   IVQYLGSISENGFIKIFMEQVPGGSLSALLRsKWGPLKnnEPTIGFYTRQILEGLKYLHD  650

         *******************************9*****98899******************

S: 120   kkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaaelesltGtlaymaPEvikk  178

         ++i HRDiKg+N+l+++ sgv+k+sDFG+skrla +n++   +e++tGtl+ymaPE+i+k

Q: 651   NQIAHRDIKGDNVLINTySGVLKISDFGTSKRLAGINPC---TETFTGTLQYMAPEIIDK  707

         ***************************************...8*****************

S: 179   kekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkd  238

         + +gyg+ aDiWslgc++iem+tg++Pf el+e++a+mfkvg+ k++Peipe++s e+k+

Q: 708   GPRGYGKPADIWSLGCTIIEMATGRPPFYELGEPQAAMFKVGMFKIHPEIPESMSLEAKA  767

         ************************************************************

S: 239   flekcleldpkkrpsaeeLLkhefl  263

         f+ +c+e dp++r++a +LL++efl

Q: 768   FILRCFEPDPDRRATAFDLLTDEFL  792

         **********************996

Domain Sequence
(FASTA)

ERVILGKGTF GVVYAGRDLS NQVRLAIKEI PERDSRYSQP LHEEIALHKH LKHKNIVQYL 60

GSISENGFIK IFMEQVPGGS LSALLRSKWG PLKNNEPTIG FYTRQILEGL KYLHDNQIAH 120

RDIKGDNVLI NTYSGVLKIS DFGTSKRLAG INPCTETFTG TLQYMAPEII DKGPRGYGKP 180

ADIWSLGCTI IEMATGRPPF YELGEPQAAM FKVGMFKIHP EIPESMSLEA KAFILRCFEP 240

DPDRRATAFD LLTDEFL 257

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR025136	; DUF4071.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF13281	; DUF4071; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013