EKS-ORL-00192

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00192

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKG	474.3	9.7E-143	459	717	259

Status

Unreviewed

Ensembl Protein

ENSORLP00000022254

UniProt Accession

H2MTZ5;

Protein Name

Protein Synonyms/Alias

Gene Name

PRKG2

Gene Synonyms/Alias

PRKG2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000017779	ENSORLP00000022254	ENSORLT00000022255

Organism

Oryzias latipes

Functional Description

Protein Length

768

Protein Sequence
(FASTA)

MGNASIRSKC CKSTEGSVST STKDQQAKQP TRDSLRVRVE ELEREVKLKD EELGAREQHI 60

KALQEQLAKQ TQVLSELSEE LHAKSITLNM LQDAMRSEPS TGLAFRPASV RASGKSSPNL 120

SVRTKDTPNR RKGAKSGVSA EPTSSSLQKF SFEKARVPKD ARNLALVSCA LVQTKKLKKI 180

NSEMLKVNLE GLYGRIYTAR FKILPGGGPG ELLVERQLSV ACGTARLEGL KECSVISQLA 240

NGFECREETD MIGAIGSFPS WRPSINEFQV ILSQTASLET REKYKSFSKV LKILPSLLSV 300

EGVWLLTCSL LEYYDKGEYI IREGEEGSTF YIIAQGKVKV TQTTEAHKLP QIINALQKGD 360

YFGEKALVSD DVRSANIIAD DNGVECLVID RETFDQTVGN FNELQKHLQG YVASLDRDDK 420

KRHLKKSVSR HQSQSLSPGF MQLKDMVSLF TSSRPFHHLE VIATLGVGGF GRVELVKVKG 480

EDVTFALKAI KKKHVVENKQ EEHIHSERRI LAEARSPFIV RLYRTFKDSK YVYMLLEACL 540

GGEVWSLLRD RGSFDDPTAK FCIGCVTEAF EYLHRKGVLY RDLKPENLLL DMEGYVKLVD 600

FGFAKKIRSG QKTWTFCGTP EYVAPEIILN KGHNFSVDFW ALGILVFELL TGSPPFSGSD 660

QMTIYTFILK GIEKMDFPKM ISKRPEDLIR KLCRRNPSER LGNLKNGITD IKKHRWFTGF 720

NWEGLKARTL ASPLKRELKG PMDHSYFDSY PPDEDSPPDE LSGWDEDF 768

Nucleotide Sequence
(FASTA)

ATGGGGAACG CTTCCATCAG GTCCAAGTGC TGCAAGAGCA CCGAAGGCTC TGTTTCCACG 60

TCCACCAAGG ACCAGCAGGC CAAACAGCCC ACCCGGGATT CGCTCAGGGT CCGAGTGGAG 120

GAGCTGGAGC GAGAGGTCAA GTTGAAGGAC GAGGAGCTCG GGGCCAGAGA GCAGCACATC 180

AAAGCTCTTC AGGAGCAGCT CGCCAAGCAG ACGCAGGTTC TGTCTGAGCT GAGCGAGGAG 240

CTTCACGCCA AGAGCATCAC ACTCAACATG CTGCAGGACG CCATGAGGAG CGAACCCTCC 300

ACCGGGCTGG CTTTTCGACC CGCCTCTGTG AGAGCCAGCG GGAAGAGCAG CCCCAACCTC 360

AGCGTTCGCA CCAAGGACAC TCCCAACAGG AGAAAAGGGG CTAAATCCGG GGTGTCGGCC 420

GAGCCCACGT CCAGCAGCCT GCAGAAGTTC TCCTTCGAGA AAGCCCGGGT CCCAAAGGAT 480

GCGAGGAATT TGGCTTTGGT GTCTTGTGCT CTCGTGCAAA CTAAAAAGTT AAAAAAAATA 540

AATAGTGAGA TGTTGAAGGT GAACTTGGAG GGCCTCTATG GCCGCATTTA CACTGCACGG 600

TTCAAAATTT TGCCAGGAGG TGGTCCCGGA GAACTGCTGG TGGAGCGGCA GTTGAGTGTG 660

GCGTGTGGCA CGGCGAGGCT GGAGGGCTTG AAAGAGTGTA GTGTCATCAG CCAATTGGCT 720

AATGGATTTG AGTGCAGAGA AGAAACAGAT ATGATTGGTG CTATAGGAAG TTTCCCGTCT 780

TGGAGGCCAT CTATCAACGA ATTTCAAGTG ATTCTCTCGC AGACAGCATC CCTGGAGACA 840

CGTGAGAAAT ACAAATCTTT TTCTAAAGTA TTAAAGATTC TCCCAAGCCT GCTTTCAGTG 900

GAAGGGGTGT GGCTTCTAAC ATGCTCACTC CTGGAGTACT ATGACAAGGG AGAGTACATC 960

ATCCGAGAAG GAGAAGAAGG CAGCACCTTC TACATCATCG CGCAGGGAAA GGTGAAGGTG 1020

ACTCAAACCA CGGAGGCCCA CAAGCTTCCA CAGATCATCA ACGCGCTGCA GAAGGGCGAC 1080

TACTTTGGAG AGAAGGCCCT GGTCAGCGAC GATGTGAGGT CAGCCAACAT CATCGCTGAC 1140

GACAACGGGG TGGAGTGCCT CGTCATCGAC AGAGAAACAT TCGATCAGAC TGTGGGAAAC 1200

TTCAATGAGC TACAGAAGCA CCTCCAAGGT TACGTGGCGT CCCTGGATCG AGACGACAAG 1260

AAGAGGCACC TCAAGAAGTC GGTGTCACGC CACCAGAGTC AGTCGCTGTC TCCGGGCTTC 1320

ATGCAGCTGA AAGACATGGT CTCGCTCTTT ACCTCGTCCA GGCCCTTCCA TCATCTGGAA 1380

GTTATTGCCA CTCTTGGTGT TGGGGGGTTT GGCCGAGTAG AACTGGTGAA GGTGAAGGGC 1440

GAGGACGTCA CCTTTGCCCT GAAGGCCATC AAGAAGAAAC ACGTGGTGGA GAACAAGCAG 1500

GAGGAGCACA TCCACTCAGA GAGGAGGATC CTGGCAGAGG CGCGCTCGCC CTTCATTGTG 1560

AGACTGTATC GCACCTTCAA AGACAGCAAA TATGTCTACA TGCTGCTGGA GGCGTGCCTG 1620

GGTGGGGAGG TGTGGAGTCT TCTCAGAGAC AGGGGGAGCT TTGATGACCC CACTGCCAAG 1680

TTCTGCATCG GCTGCGTCAC AGAGGCCTTC GAGTACCTCC ATCGCAAAGG AGTCCTGTAC 1740

CGAGACCTGA AGCCTGAAAA CCTCCTGCTG GACATGGAGG GATACGTCAA ACTGGTGGAC 1800

TTTGGTTTTG CCAAGAAGAT CAGATCTGGC CAAAAGACAT GGACCTTCTG TGGCACACCA 1860

GAGTACGTGG CTCCAGAGAT CATCCTCAAT AAAGGCCACA ACTTCAGTGT AGACTTCTGG 1920

GCTCTGGGAA TCCTGGTCTT TGAGCTTCTA ACGGGCAGCC CCCCATTTTC TGGCAGTGAC 1980

CAGATGACAA TCTACACATT CATCCTGAAA GGCATTGAGA AGATGGACTT CCCAAAAATG 2040

ATTTCCAAAA GACCAGAGGA CCTTATACGG AAACTATGCA GGCGGAATCC ATCAGAGCGA 2100

CTAGGGAACC TGAAAAATGG AATAACTGAC ATCAAGAAAC ACAGGTGGTT TACCGGCTTC 2160

AACTGGGAGG GGCTGAAGGC CAGGACGTTG GCCTCCCCAC TGAAAAGAGA ACTCAAGGGG 2220

CCGATGGATC ACAGTTACTT TGACAGCTAC CCTCCAGATG AAGATAGCCC CCCAGATGAG 2280

CTGTCTGGCT GGGACGAGGA CTTCTGA 2307

Domain Profile

S: 1     lkviatlgvggfgrvelvkvksdeskafalkilkkkhivdtkqqehvlsekrileeaksd  60

         l+viatlgvggfgrvelvkvk  e  +falk++kkkh+v++kq+eh+ se+ril ea+s+

Q: 459   LEVIATLGVGGFGRVELVKVKG-EDVTFALKAIKKKHVVENKQEEHIHSERRILAEARSP  517

         689******************9.889**********************************

S: 61    fivklyrtfkdekyvyllleaclggelwtilrdrgsfddktakfivacvvealeylhskn  120

         fiv+lyrtfkd+kyvy+lleaclgge+w++lrdrgsfdd takf+++cv+ea+eylh+k+

Q: 518   FIVRLYRTFKDSKYVYMLLEACLGGEVWSLLRDRGSFDDPTAKFCIGCVTEAFEYLHRKG  577

         ************************************************************

S: 121   iiyrdlkpenllldeegylklvdfgfakklksgkktwtfcgtpeyvapeiilnkghdlsv  180

         ++yrdlkpenllld egy+klvdfgfakk++sg+ktwtfcgtpeyvapeiilnkgh++sv

Q: 578   VLYRDLKPENLLLDMEGYVKLVDFGFAKKIRSGQKTWTFCGTPEYVAPEIILNKGHNFSV  637

         ************************************************************

S: 181   dywalgilvyelltgkppfsgvdplktynlilkgidklelprkitkeaedlikklcrdnp  240

         d+walgilv+elltg+ppfsg+d++++y+ ilkgi+k+++p+ i+k++edli+klcr np

Q: 638   DFWALGILVFELLTGSPPFSGSDQMTIYTFILKGIEKMDFPKMISKRPEDLIRKLCRRNP  697

         ************************************************************

S: 241   aerlgylkggikdikkhkwf  260

         +erlg+lk+gi+dikkh+wf

Q: 698   SERLGNLKNGITDIKKHRWF  717

         *******************9

Domain Sequence
(FASTA)

LEVIATLGVG GFGRVELVKV KGEDVTFALK AIKKKHVVEN KQEEHIHSER RILAEARSPF 60

IVRLYRTFKD SKYVYMLLEA CLGGEVWSLL RDRGSFDDPT AKFCIGCVTE AFEYLHRKGV 120

LYRDLKPENL LLDMEGYVKL VDFGFAKKIR SGQKTWTFCG TPEYVAPEII LNKGHNFSVD 180

FWALGILVFE LLTGSPPFSG SDQMTIYTFI LKGIEKMDFP KMISKRPEDL IRKLCRRNPS 240

ERLGNLKNGI TDIKKHRWF 259

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005952	; C:cAMP-dependent protein kinase complex
GO:0005524	; F:ATP binding
GO:0008603	; F:cAMP-dependent protein kinase regulator activity
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR002373	; cAMP/cGMP_kin.
IPR018490	; cNMP-bd-like.
IPR018488	; cNMP-bd_CS.
IPR000595	; cNMP-bd_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR014710	; RmlC-like_jellyroll.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00027	; cNMP_binding; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00100	; cNMP; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00888	; CNMP_BINDING_1; 1.
PS00889	; CNMP_BINDING_2; 1.
PS50042	; CNMP_BINDING_3; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00103

; CAMPKINASE.

Created Date

20-Feb-2013