EKS-ORL-00169
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORL-00169
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/FGFR554.92.9E-167398674277
StatusUnreviewed
Ensembl ProteinENSORLP00000022509
UniProt AccessionH2MUP1;
Protein NameFibroblast growth factor receptor
Protein Synonyms/Alias
Gene NameMFR3
Gene Synonyms/Alias MFR3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSORLG00000017972ENSORLP00000022508ENSORLT00000022509
ENSORLG00000017972ENSORLP00000022509ENSORLT00000022510
ENSORLG00000017972ENSORLP00000022507ENSORLT00000022508
OrganismOryzias latipes
Functional Description
Protein Length738
Protein Sequence
(FASTA)
EDVVLGLGDP LEISCEIEDP SEPITWFKDD AWLLPTNRTR VSNRMLRIIN VSYEDSGVYT 60
CRLARTNALL SNYTIKVTAA APYWTKPDRM DKKLLAVPAA NTVKFRCPAN GNPIPTIHWL 120
KNGKEFKGEQ RMGGIKLRHQ QWSLVMESAV PSDRGNYTCV VQNKYGTISQ TYQLDVLERS 180
PHRPILQAGL PANQTVFVGN DVEFHCKVYS DAQPHIQWLK HIEVNGTRYG PDGVPYVNIL 240
KTAGINTTDK ELEVLFLSNV SFEDAGEYTC LAGNSIGFTH NSAWLTVLPV SNPKLEDEYA 300
DILIYVTGCV LFILAVVIVI LCRMRMTTQK TVPAPPVQKL SKFPLKRQVS LDSNSSMNSN 360
TPLVRIARLS SSDGPMLANV LELELPSDPK WEFPRTRLTL GKPLGEGCFG QVVMAEAIGI 420
DKEKPNKPLT VAAKMLKDDA TDKDLSDLVS EMEMMKMIGK HKNIINLLGA CTQDGPLYVL 480
VEFASKGNLR EYLRARRPPG MDYSFDTCKI PDEQLTFKDL VSCAYQVARG MEYLASQKCI 540
HRDLAARNVL VTDDNVMKIA DFGLARDVHN IDYYKKTTNG RLPVKWMAPE ALFDRVYTHQ 600
SDVWSYGVLL WEIFTLGGSP YPGIPVEELF KLLKEGHRMD KPANCTHELY MIMRECWHAV 660
PSQRPTFRQL VEDLDRILSM TSTDDYLDLS VPFEQYSPTC QDSNSTCSSG DDSVFAHDPL 720
PDEPCLPKQL PSNGVIRT 738
Nucleotide Sequence
(FASTA)
GAGGACGTGG TTCTGGGCTT GGGCGACCCG CTGGAAATAT CCTGTGAAAT AGAAGACCCC 60
TCGGAGCCCA TCACCTGGTT TAAAGACGAT GCTTGGCTGT TGCCGACCAA CCGAACGCGG 120
GTCAGCAACC GGATGCTGCG CATCATCAAC GTGTCGTACG AGGACTCTGG AGTTTACACG 180
TGTCGGCTCG CCCGTACCAA CGCGCTGCTG AGCAACTACA CCATCAAGGT GACAGCGGCG 240
GCGCCGTACT GGACCAAGCC TGACCGAATG GACAAGAAGC TGCTGGCGGT CCCGGCAGCC 300
AACACGGTCA AGTTCCGCTG TCCAGCGAAT GGAAACCCCA TACCCACAAT CCACTGGCTG 360
AAGAATGGCA AGGAGTTCAA GGGCGAGCAG AGGATGGGGG GCATCAAGCT CAGACACCAG 420
CAGTGGAGCT TAGTGATGGA GAGCGCCGTG CCGTCAGACC GCGGGAACTA CACCTGTGTG 480
GTGCAGAACA AGTACGGCAC CATCAGCCAG ACCTACCAGC TGGATGTTCT CGAGCGATCG 540
CCTCACAGGC CCATCCTCCA GGCGGGCCTG CCGGCCAATC AGACGGTGTT TGTGGGCAAC 600
GACGTGGAGT TTCATTGTAA GGTTTACAGC GACGCTCAGC CGCACATCCA GTGGCTCAAA 660
CACATCGAGG TGAACGGCAC TCGATACGGC CCCGACGGCG TTCCGTACGT CAACATCCTG 720
AAGACGGCTG GTATTAACAC CACCGATAAG GAGCTCGAGG TCCTCTTCTT GTCCAATGTG 780
TCCTTTGAGG ATGCGGGCGA GTACACTTGT CTGGCAGGGA ACTCTATCGG CTTTACTCAC 840
AACTCTGCTT GGCTGACGGT GCTTCCAGTT TCAAACCCCA AGTTGGAGGA TGAGTACGCC 900
GACATCCTCA TCTATGTGAC GGGATGTGTG CTCTTCATCC TGGCTGTGGT TATTGTCATC 960
CTCTGCCGGA TGAGGATGAC CACGCAGAAA ACGGTCCCCG CACCTCCCGT GCAGAAACTC 1020
TCAAAGTTCC CTCTCAAGAG ACAGGTTTCC TTGGATTCAA ACTCCTCCAT GAACTCCAAC 1080
ACACCTCTGG TCCGGATCGC CCGCCTGTCA TCCAGCGACG GGCCGATGCT GGCCAACGTG 1140
TTAGAGCTGG AGCTGCCCTC TGACCCCAAG TGGGAGTTTC CTCGGACACG GCTGACTCTG 1200
GGCAAACCTC TAGGGGAGGG CTGCTTCGGT CAGGTGGTCA TGGCTGAGGC CATCGGCATT 1260
GATAAGGAGA AGCCCAATAA GCCACTGACT GTTGCTGCAA AAATGCTGAA AGATGATGCA 1320
ACGGATAAAG ACTTGTCAGA CCTGGTATCA GAAATGGAGA TGATGAAGAT GATAGGCAAA 1380
CACAAAAACA TCATCAACTT GCTTGGAGCT TGCACGCAGG ACGGTCCTCT ATATGTCCTG 1440
GTGGAGTTTG CCTCAAAGGG GAACCTGAGG GAGTACCTGC GAGCGCGGCG GCCGCCTGGC 1500
ATGGACTACT CCTTCGACAC CTGCAAAATT CCAGATGAGC AGCTCACCTT CAAAGACCTG 1560
GTGTCCTGCG CCTATCAGGT GGCCAGAGGC ATGGAGTACC TGGCTTCGCA GAAGTGTATT 1620
CACAGAGACC TGGCAGCCAG AAACGTCCTG GTGACCGACG ACAATGTGAT GAAAATCGCA 1680
GACTTTGGAC TTGCCAGGGA TGTGCACAAC ATAGACTACT ACAAAAAGAC CACCAACGGT 1740
CGCCTGCCCG TGAAATGGAT GGCTCCGGAG GCTCTGTTCG ACCGGGTCTA CACGCACCAG 1800
AGCGATGTAT GGTCTTACGG GGTTTTGCTG TGGGAGATCT TCACCCTGGG AGGTTCTCCA 1860
TACCCGGGAA TCCCAGTGGA GGAGCTCTTC AAGCTGCTGA AGGAGGGACA TCGGATGGAC 1920
AAACCTGCCA ACTGCACTCA CGAGCTGTAC ATGATCATGA GGGAGTGCTG GCATGCGGTC 1980
CCCTCCCAAA GGCCCACGTT CAGACAGCTG GTTGAAGATC TAGACCGGAT TTTATCGATG 2040
ACCTCCACAG ATGACTACCT GGACCTGTCG GTGCCCTTTG AGCAGTATTC TCCCACCTGT 2100
CAGGACTCCA ACAGCACCTG CTCCTCTGGA GACGACTCCG TGTTTGCCCA CGACCCGCTG 2160
CCCGACGAGC CCTGTCTTCC AAAGCAGCTG CCCAGCAACG GCGTGATCAG GACATAA 2217
Domain Profile
S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60
         l+lgk+lGeG+fGqvv+aeaig+dk+k++k  tva kmlk+datdkdl+dlvseme++k+
Q: 398   LTLGKPLGEGCFGQVVMAEAIGIDKEKPNKPLTVAAKMLKDDATDKDLSDLVSEMEMMKM  457
         79**********************************************************
S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120
         iGkhkniinllGactq+Gplyv+ve+a+kGnlre+lrarrp+g+++s d++k+++eqlt+
Q: 458   IGKHKNIINLLGACTQDGPLYVLVEFASKGNLREYLRARRPPGMDYSFDTCKIPDEQLTF  517
         ************************************************************
S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180
         kdlvs+ayqvarGmeylas+kcihrdlaarnvlvt+dnv+kiadfGlardvh+idyykkt
Q: 518   KDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTDDNVMKIADFGLARDVHNIDYYKKT  577
         ************************************************************
S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240
         tnGrlpvkwmapealfdrvyt+qsdvws+Gvllwei+tlGgspypgi+veelfkllkeGh
Q: 578   TNGRLPVKWMAPEALFDRVYTHQSDVWSYGVLLWEIFTLGGSPYPGIPVEELFKLLKEGH  637
         ************************************************************
S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277
         rm+kpa+ct+ely++mrecwha++s+rptf+qlvedl
Q: 638   RMDKPANCTHELYMIMRECWHAVPSQRPTFRQLVEDL  674
         ***********************************97
Domain Sequence
(FASTA)
LTLGKPLGEG CFGQVVMAEA IGIDKEKPNK PLTVAAKMLK DDATDKDLSD LVSEMEMMKM 60
IGKHKNIINL LGACTQDGPL YVLVEFASKG NLREYLRARR PPGMDYSFDT CKIPDEQLTF 120
KDLVSCAYQV ARGMEYLASQ KCIHRDLAAR NVLVTDDNVM KIADFGLARD VHNIDYYKKT 180
TNGRLPVKWM APEALFDRVY THQSDVWSYG VLLWEIFTLG GSPYPGIPVE ELFKLLKEGH 240
RMDKPANCTH ELYMIMRECW HAVPSQRPTF RQLVEDL 277
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00142
EKS-CAE-00120
EKS-CAF-00155
EKS-CAP-00149
EKS-DRM-00072
EKS-EQC-00146
EKS-GAG-00124
EKS-GAA-00177
EKS-GOG-00150
EKS-ICT-00141
EKS-LAC-00156
EKS-LOA-00146
EKS-MEG-00114
EKS-MOD-00146
EKS-MUM-00152
EKS-MUP-00153
EKS-ORN-00181
EKS-OTG-00154
EKS-PAT-00138
EKS-PES-00131
EKS-PEM-00080
EKS-RAN-00146
EKS-SAH-00141
EKS-TAG-00175
EKS-TAR-00190
EKS-TEN-00186
EKS-XET-00135
EKS-XIM-00175
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0005007; F:fibroblast growth factor-activated receptor activity
GO:0008284; P:positive regulation of cell proliferation
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016248; Tyr_kinase_fibroblast_GF_rcpt.
Pfam
PF07679; I-set; 3.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00408; IGc2; 3.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013