EKS-ORL-00442

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00442

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	418.1	1.3E-125	139	392	254

Status

Unreviewed

Ensembl Protein

ENSORLP00000022519

UniProt Accession

H2MUQ2;

Protein Name

Protein Synonyms/Alias

Gene Name

FRK

Gene Synonyms/Alias

FRK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000017982	ENSORLP00000022518	ENSORLT00000022519
ENSORLG00000017982	ENSORLP00000022519	ENSORLT00000022520

Organism

Oryzias latipes

Functional Description

Protein Length

409

Protein Sequence
(FASTA)

IRKMLPELVK ICYVFLIILQ VVFPETKRLD AEKMLLAEGN SHGAFLIRDC ESQKGELSLS 60

VLDSGKVKHY KLRKAPNGDF FVSKNRSFAN LKELVEFYSK QADGLCVRLG QPCKKLEAPQ 120

TFGLSYNTAD IWEIDRSSIK MENKLGAGQF GEVYEGLWNN TTPVAVKTLK PGSMDPKDFL 180

MEAQIMKKLR HPKLIQLYAV CTLQEPIYII TELMKHGSLL DYLQKDKGVT LAISDQIEMA 240

AQVASGMAYL ELQNYIHRDL AARNVLVGEN NICKVADFGL ARVFMKESEN VYEAREGTKF 300

PVKWTAPEAI HENRFTIKSD VWSFGILLYE IMTFGQVPYP GMSNIQVTQR ITTGYRMPCP 360

PNCPKLLYDI MLECWKESDQ ERPTFETLQW KLEDYFEMDM NSYDDAARY 409

Nucleotide Sequence
(FASTA)

ATCAGAAAGA TGCTGCCAGA ACTTGTTAAA ATATGTTATG TGTTCCTGAT TATCTTGCAG 60

GTGGTCTTTC CAGAAACTAA GAGGCTGGAT GCTGAGAAGA TGCTGCTGGC TGAAGGGAAC 120

TCTCACGGTG CTTTCCTCAT CAGAGACTGT GAGAGTCAGA AGGGAGAGCT GTCCCTCTCA 180

GTATTGGACA GTGGAAAGGT GAAGCATTAC AAGCTAAGGA AAGCCCCCAA CGGTGACTTC 240

TTTGTGTCTA AGAACAGATC CTTTGCAAAT TTGAAAGAGT TGGTGGAATT TTACTCCAAA 300

CAGGCTGACG GTCTGTGCGT ACGTCTTGGC CAACCGTGCA AAAAGTTGGA GGCCCCGCAG 360

ACCTTCGGTC TGTCCTACAA CACAGCGGAC ATCTGGGAGA TCGATCGCAG CTCCATCAAA 420

ATGGAGAATA AACTGGGAGC CGGCCAGTTT GGAGAAGTGT ATGAGGGCCT GTGGAACAAC 480

ACCACACCTG TAGCTGTGAA GACCCTCAAA CCCGGCTCCA TGGATCCGAA GGACTTCCTG 540

ATGGAGGCTC AGATCATGAA GAAGCTGCGG CATCCCAAGC TAATCCAGCT GTACGCCGTC 600

TGCACATTGC AGGAGCCCAT CTACATCATC ACTGAGCTGA TGAAGCATGG CAGCCTGTTG 660

GACTACCTGC AGAAGGATAA AGGTGTCACT TTGGCCATCT CGGACCAAAT CGAAATGGCC 720

GCTCAGGTGG CGTCAGGCAT GGCTTATCTG GAGTTACAGA ACTACATCCA CAGAGACCTG 780

GCAGCCCGGA ACGTTCTGGT GGGGGAGAAC AACATCTGTA AGGTGGCAGA CTTTGGCCTT 840

GCCAGGGTCT TCATGAAAGA AAGTGAAAAT GTGTATGAGG CCAGGGAGGG AACCAAGTTC 900

CCCGTGAAGT GGACCGCACC AGAGGCCATC CATGAGAACA GATTCACCAT CAAGTCAGAT 960

GTTTGGTCCT TTGGCATTTT GCTGTATGAA ATCATGACAT TTGGGCAGGT GCCTTACCCA 1020

GGAATGTCCA ACATTCAGGT GACTCAGAGA ATCACTACAG GCTACAGGAT GCCCTGCCCC 1080

CCCAACTGCC CCAAGCTCCT GTACGACATC ATGTTGGAGT GCTGGAAGGA GAGCGACCAG 1140

GAACGGCCTA CGTTTGAGAC CCTTCAGTGG AAACTGGAGG ATTACTTTGA AATGGACATG 1200

AACTCTTACG ATGATGCTGC CCGGTATTAG 1230

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         +k+++klG+GqfGev++g+w+++++vavktlk+g+++p++fl eaqi+kklrh+kl++ly

Q: 139   IKMENKLGAGQFGEVYEGLWNNTTPVAVKTLKPGSMDPKDFLMEAQIMKKLRHPKLIQLY  198

         68999*******************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         av++ +ePiyi+telm++Gslld+l++++g +l +++++++aaqva+Gmayle +n+ihr

Q: 199   AVCTLQEPIYIITELMKHGSLLDYLQKDKGVTLAISDQIEMAAQVASGMAYLELQNYIHR  258

         ************************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlie...ddeytakegaklPikWtaPeaiklgkftik  177

         dlaarnvlvge++++kvadfGlar++    ++ y+a+eg+k+P+kWtaPeai++++ftik

Q: 259   DLAARNVLVGENNICKVADFGLARVFMkesENVYEAREGTKFPVKWTAPEAIHENRFTIK  318

         ************************765467999***************************

S: 178   sdvWsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkd  237

         sdvWsfGill+ei+t G+vPypGm+n +v ++++ gyr+p+p +cp+ ly+++lecwk++

Q: 319   SDVWSFGILLYEIMTFGQVPYPGMSNIQVTQRITTGYRMPCPPNCPKLLYDIMLECWKES  378

         ************************************************************

S: 238   peerPtfetlqevl  251

          +erPtfetlq++l

Q: 379   DQERPTFETLQWKL  392

         ***********986

Domain Sequence
(FASTA)

IKMENKLGAG QFGEVYEGLW NNTTPVAVKT LKPGSMDPKD FLMEAQIMKK LRHPKLIQLY 60

AVCTLQEPIY IITELMKHGS LLDYLQKDKG VTLAISDQIE MAAQVASGMA YLELQNYIHR 120

DLAARNVLVG ENNICKVADF GLARVFMKES ENVYEAREGT KFPVKWTAPE AIHENRFTIK 180

SDVWSFGILL YEIMTFGQVP YPGMSNIQVT QRITTGYRMP CPPNCPKLLY DIMLECWKES 240

DQERPTFETL QWKL 254

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013