EKS-ORL-00409

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00409

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PEK	368.7	2.3E-110	497	958	462

Status

Unreviewed

Ensembl Protein

ENSORLP00000022532

UniProt Accession

H2MUR5;

Protein Name

Protein Synonyms/Alias

Gene Name

EIF2AK3

Gene Synonyms/Alias

EIF2AK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000017993	ENSORLP00000022532	ENSORLT00000022533

Organism

Oryzias latipes

Functional Description

Protein Length

992

Protein Sequence
(FASTA)

RSLVIISTLD GRISALDPHN QGRKQWDLDV GSGSLVSSSL SKPEVFGNKM VIPSLDGALF 60

QWNRDRESME AVPFSVESLL ESSYRIGEDT VLVGGKSLTT YGLGAYSGKL RYICSAGGCN 120

RWGEDEGEAE DVLLLQRTQK TVRAVRPRSG TEKWNFSVGN FELKLLPEIQ SGMNFLEGEM 180

TNEDPWNDNQ RVITDEPKDR EKREDKQNQN QHSDLVIKVS VPDWKVMAFT EPNEQLVWEH 240

QFCTPIASAW LVGGGKVTPI SLFDDTGYRS QSETEDEDDE DPSKSRGSAE SSVYLGMFQG 300

QLYLQSSVRI TEKFSAKAIG SEKDNIIHVP VVKWKPLIHS PSRTPALVGS DEFDKCLSND 360

KYSHDEYSNG ALSVLQYPYD NGYFFPYSKG YREKRDSAIS LIGGNEAASE NRRRKDPVLL 420

LPWWKEILGT IIFCIATTTY IVRKFFHPPA PVAYQRKESE TQCQTDCKFD LEVVESREAV 480

SMEIRSSEYV SRYLTDFEPM QCLGRGGFGV VFEARNKVDD CNYAIKRIRL PNRELAREKV 540

MREVKALAKL EHPGIIRYFN AWQESPPEGW QEEMDQRWLR DSSATDWPMS FVDHMEALSV 600

KVPVSSSVCP CGPDGDFLGA SVVERALLSS STVGFDSGEP SFQPLLGHDS LMSERDSQAD 660

ASDTPHSFEL CPPRGPSDCT SSSFDIVFED SGCDRDADAD TQSDCSAASP NPETDRNSSS 720

SSHTRQAQSG PASSSTPARP TSLTLALPSA PPSQRVQPSP KVYLYIQMQL CRKENLKDWM 780

AQRCLPEQRE HNQCLDIFLQ IAEAVDFLHS KGLMHRDLKP SNIFFTMDDV VKVGDFGLVT 840

AMDQEEDEDE PSTLTPAPLL TRHTGQVGTK LYMSPEQLSG NSYSHKVDIY SLGLILFELL 900

YPFRTQMERV RTLTEVRVLR FPEVFSRNNS QELGMVRSML SLSPSERPEA ADITGTPLFQ 960

ELELPCRLAV RQRSRTYSSS SMGRPSRQTS AT 992

Nucleotide Sequence
(FASTA)

AGGTCTCTCG TGATCATCAG TACCCTGGAT GGACGGATCT CGGCTCTGGA TCCTCACAAC 60

CAGGGCAGGA AGCAGTGGGA CCTGGACGTT GGCTCAGGGA GTTTGGTGTC CTCCAGCCTC 120

AGCAAGCCTG AGGTGTTTGG CAATAAGATG GTCATTCCCT CTCTGGACGG TGCCTTGTTC 180

CAGTGGAACC GGGACAGGGA GAGTATGGAG GCAGTGCCTT TCAGCGTCGA ATCCCTGCTG 240

GAGTCCTCGT ACCGCATCGG AGAGGACACC GTCCTGGTCG GCGGCAAATC ACTCACTACT 300

TATGGCCTGG GGGCTTACAG CGGCAAGCTT CGTTACATTT GCTCTGCGGG GGGCTGCAAT 360

CGATGGGGTG AGGATGAGGG GGAGGCTGAA GATGTGCTCC TGCTTCAGAG GACCCAGAAG 420

ACCGTGCGTG CTGTCAGGCC TCGATCAGGA ACAGAGAAGT GGAACTTCAG TGTCGGAAAC 480

TTTGAGCTGA AACTTCTTCC GGAGATCCAA TCTGGAATGA ACTTCTTGGA GGGAGAAATG 540

ACAAACGAGG ACCCCTGGAA CGACAACCAG AGGGTCATCA CAGATGAACC AAAGGACAGG 600

GAGAAAAGGG AGGACAAACA GAACCAAAAC CAGCACTCGG ACCTCGTCAT CAAAGTGTCT 660

GTTCCAGATT GGAAAGTCAT GGCCTTCACA GAGCCCAACG AGCAGCTGGT CTGGGAGCAT 720

CAGTTTTGCA CGCCCATCGC CTCCGCCTGG CTGGTGGGTG GAGGGAAAGT TACTCCAATC 780

AGCCTGTTTG ATGACACGGG CTACAGGAGC CAGTCTGAAA CCGAAGACGA GGACGACGAA 840

GATCCAAGCA AGAGCCGGGG TTCCGCAGAG TCGAGCGTCT ACCTTGGGAT GTTCCAGGGA 900

CAACTTTACC TTCAGTCATC AGTAAGAATC ACTGAAAAGT TTTCTGCCAA AGCCATCGGG 960

TCAGAGAAAG ACAACATAAT CCACGTACCC GTCGTTAAAT GGAAGCCTCT AATACATTCT 1020

CCGTCCCGGA CTCCAGCTCT GGTCGGTTCT GACGAATTTG ACAAGTGTCT GAGTAACGAC 1080

AAGTACTCCC ACGACGAATA CAGCAACGGA GCCCTGTCCG TTCTTCAGTA CCCATACGAC 1140

AACGGGTACT TCTTCCCCTA CAGCAAAGGC TACCGGGAGA AACGCGACAG CGCCATCAGC 1200

CTGATTGGAG GGAACGAGGC CGCCTCGGAG AACCGCAGGA GAAAAGACCC GGTGCTGCTG 1260

CTGCCCTGGT GGAAGGAGAT CCTCGGCACC ATCATCTTCT GCATCGCCAC CACCACCTAC 1320

ATCGTCCGCA AGTTCTTTCA CCCTCCCGCC CCCGTGGCCT ACCAACGGAA AGAGTCAGAG 1380

ACTCAGTGCC AGACGGACTG TAAGTTCGAC CTTGAAGTTG TGGAGTCCAG AGAGGCGGTT 1440

TCCATGGAGA TCCGCTCCAG TGAATATGTG TCCAGGTACC TGACAGACTT TGAGCCGATG 1500

CAGTGCCTCG GCCGGGGGGG ATTCGGCGTT GTGTTTGAGG CACGCAACAA AGTGGACGAC 1560

TGCAACTACG CCATCAAAAG AATCCGGCTG CCCAACAGGG AGCTGGCCCG GGAGAAGGTG 1620

ATGCGAGAGG TGAAGGCGTT GGCCAAGCTG GAGCACCCGG GGATTATCCG CTACTTCAAC 1680

GCCTGGCAGG AGAGCCCCCC CGAGGGCTGG CAGGAGGAGA TGGACCAGAG GTGGCTGAGA 1740

GACTCCAGTG CTACCGACTG GCCAATGAGC TTTGTTGACC ACATGGAGGC GCTGTCAGTC 1800

AAAGTGCCCG TGTCCAGCTC TGTGTGCCCC TGCGGGCCTG ACGGCGACTT TCTGGGGGCC 1860

TCTGTTGTGG AGCGCGCCCT TCTGTCCAGC AGCACCGTGG GCTTTGACAG CGGAGAGCCG 1920

TCCTTTCAGC CTCTGCTCGG CCACGACAGC CTGATGTCTG AGAGGGACAG CCAGGCCGAC 1980

GCCTCGGACA CGCCCCACTC CTTCGAGCTC TGCCCCCCGC GCGGACCCAG CGACTGCACC 2040

TCCTCCTCCT TCGATATCGT GTTCGAGGAC TCTGGCTGCG ACCGAGACGC AGACGCAGAC 2100

ACGCAGTCGG ACTGCAGCGC GGCCAGCCCC AACCCGGAGA CGGACAGGAA CAGTTCGTCT 2160

TCCTCTCATA CCAGACAAGC CCAGTCTGGC CCCGCCTCCT CCTCAACTCC TGCCAGGCCA 2220

ACGTCTCTTA CCCTGGCTCT TCCTTCAGCT CCTCCAAGCC AGCGAGTCCA GCCTTCACCT 2280

AAGGTGTACC TGTACATCCA GATGCAGCTG TGCCGGAAGG AGAACCTGAA GGACTGGATG 2340

GCTCAGCGCT GCCTGCCTGA ACAAAGAGAG CACAACCAGT GTCTGGACAT CTTCCTGCAG 2400

ATCGCTGAGG CCGTTGACTT CCTGCACAGC AAGGGGCTCA TGCACAGGGA CCTCAAGCCC 2460

TCCAACATCT TCTTCACCAT GGACGACGTG GTCAAAGTGG GGGACTTCGG CCTGGTGACG 2520

GCGATGGACC AGGAGGAGGA TGAGGACGAG CCCAGCACTC TGACGCCGGC CCCGCTTCTG 2580

ACCCGGCACA CGGGCCAGGT GGGCACCAAG CTTTACATGA GCCCGGAGCA GCTCTCCGGA 2640

AACTCCTACT CCCATAAGGT GGACATCTAC TCGCTGGGTC TGATCCTGTT CGAGCTGCTG 2700

TATCCCTTCA GGACGCAGAT GGAGAGAGTG AGGACCCTCA CGGAGGTGAG AGTGCTGCGC 2760

TTCCCAGAGG TCTTCTCCAG AAACAACAGT CAGGAGCTGG GCATGGTCCG CAGCATGCTC 2820

TCCCTGAGCC CCAGCGAACG CCCAGAGGCG GCCGACATCA CAGGAACGCC CCTCTTCCAG 2880

GAGCTGGAGC TGCCTTGCCG GCTGGCTGTG AGGCAGCGCT CCCGCACCTA CAGCTCATCT 2940

TCAATGGGCC GGCCCTCACG CCAAACCTCC GCCACCTGA 2979

Domain Profile

S: 1     feeikvlGkGgfgvVlkaknkldkkeyaikriklnkakkelekverevkaLaklehpniv  60

         fe +++lG+GgfgvV++a+nk+d+++yaikri+l++++ ++ekv+revkaLaklehp+i+

Q: 497   FEPMQCLGRGGFGVVFEARNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGII  556

         799*********************************************************

S: 61    rYfaawleekeesl..............................................  74

         rYf+aw+e+++e++

Q: 557   RYFNAWQESPPEGWqeemdqrwlrdssatdwpmsfvdhmealsvkvpvsssvcpcgpdgd  616

         ************************************************************

S: 75    ............................................................  74

Q: 617   flgasvverallssstvgfdsgepsfqpllghdslmserdsqadasdtphsfelcpprgp  676

         ******************************************999999999999999999

S: 75    ........................tdsseveaeaeleesesseesdtk............  98

                                 t +s+ +a+ +  e+        +

Q: 677   sdctsssfdivfedsgcdrdadadT-QSDCSAASPNPET--------Drnssssshtrqa  727

         9999999999999998888876531.2222222222222........0222222346788

S: 99    ...................................llyiqmelceketLkdwiderklle  123

                                            +lyiqm+lc+ke+Lkdw+ +r+l e

Q: 728   qsgpassstparptsltlalpsappsqrvqpspkvYLYIQMQLCRKENLKDWMAQRCLPE  787

         888999999999999*********************************************

S: 124   srselvm.rlfkqllegleylHskgliHrdLkpsniFldsddqvKigDFgLatalaealk  182

         +r++  + ++f q++e++++lHskgl+HrdLkpsniF+++dd vK+gDFgL+ta+++++

Q: 788   QREHNQClDIFLQIAEAVDFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQEED  847

         *******************************************************99988

S: 183   edvkqdaqske..akhtgqvgtklymsPeqleksqYnkkvDifsLGlilfeLlypfstem  240

         ed  ++ +++   ++htgqvgtklymsPeql++++Y++kvDi+sLGlilfeLlypf t+m

Q: 848   EDEPSTLTPAPllTRHTGQVGTKLYMSPEQLSGNSYSHKVDIYSLGLILFELLYPFRTQM  907

         76555444443559**********************************************

S: 241   ervetltelrdgkipedfddkvpkekkllqkllsrdpkeRpsasellksel  291

         erv+tlte+r +++pe f+ +  +e  +++ +ls +p+eRp+a ++  ++l

Q: 908   ERVRTLTEVRVLRFPEVFSRNNSQELGMVRSMLSLSPSERPEAADITGTPL  958

         ********************9************************987765

Domain Sequence
(FASTA)

FEPMQCLGRG GFGVVFEARN KVDDCNYAIK RIRLPNRELA REKVMREVKA LAKLEHPGII 60

RYFNAWQESP PEGWQEEMDQ RWLRDSSATD WPMSFVDHME ALSVKVPVSS SVCPCGPDGD 120

FLGASVVERA LLSSSTVGFD SGEPSFQPLL GHDSLMSERD SQADASDTPH SFELCPPRGP 180

SDCTSSSFDI VFEDSGCDRD ADADTQSDCS AASPNPETDR NSSSSSHTRQ AQSGPASSST 240

PARPTSLTLA LPSAPPSQRV QPSPKVYLYI QMQLCRKENL KDWMAQRCLP EQREHNQCLD 300

IFLQIAEAVD FLHSKGLMHR DLKPSNIFFT MDDVVKVGDF GLVTAMDQEE DEDEPSTLTP 360

APLLTRHTGQ VGTKLYMSPE QLSGNSYSHK VDIYSLGLIL FELLYPFRTQ MERVRTLTEV 420

RVLRFPEVFS RNNSQELGMV RSMLSLSPSE RPEAADITGT PL 462

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR011047	; Quinonprotein_ADH-like.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 2.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013