EKS-ORL-00075

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00075

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	372.4	1.6E-111	40	337	298

Status

Unreviewed

Ensembl Protein

ENSORLP00000022884

UniProt Accession

H2MVN9;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK9

Gene Synonyms/Alias

CDK9;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000018273	ENSORLP00000022884	ENSORLT00000022885

Organism

Oryzias latipes

Functional Description

Protein Length

393

Protein Sequence
(FASTA)

MQRDKTSNAS AAEKPDREAA IMSKYYDGVE FPFCDEFSKY EKMAKIGQGT FGEVFKAKHR 60

TTGKKVALKK VLMENEKEGF PITALREIKI LQLLKHENVV NLIEICRTKA TQFNRYKGSI 120

YLVFDFCEHD LAGLLSNANV KFTLAEIKKV MQMLLNGLYY IHRNKILHRD MKAANVLITR 180

DGVLKLADFG LARAFSLAKN SQGNRYTNRV VTLWYRPPEL LLGERDYGPP IDLWGAGCIM 240

AEMWTRSPIM QGNTEQHQLT LISQLCGSIT AEVWPGVDKK YELYQKMELP KGQKRKVKDR 300

LKAYVKDAYA LDLIDKLLVL DPAQRIDSDD ALNHDFFWSD PMPSDLKNML STHNTSMFEY 360

LAPPRRRGHI PQQQPNQNRN PATTSQTEFD RVF 393

Nucleotide Sequence
(FASTA)

ATGCAACGAG ACAAAACAAG CAACGCCAGT GCGGCTGAAA AGCCCGACCG GGAGGCCGCC 60

ATAATGTCTA AATACTACGA CGGAGTGGAA TTCCCTTTCT GCGACGAGTT CTCCAAGTAC 120

GAAAAGATGG CGAAGATCGG ACAAGGAACC TTCGGGGAGG TTTTCAAAGC CAAACACAGA 180

ACGACGGGGA AGAAGGTCGC TCTGAAGAAA GTGCTGATGG AAAATGAGAA AGAAGGGTTT 240

CCAATCACAG CTCTGAGGGA GATTAAAATC CTGCAGCTGC TCAAACATGA GAACGTGGTC 300

AATCTGATCG AGATCTGCAG AACCAAAGCT ACTCAGTTCA ACAGATATAA AGGCAGCATC 360

TACCTGGTCT TTGACTTCTG TGAACACGAC CTGGCCGGGC TGCTGAGCAA CGCCAACGTG 420

AAGTTCACGC TGGCGGAGAT CAAGAAGGTC ATGCAGATGC TCCTCAACGG GCTGTACTAC 480

ATCCACAGAA ACAAGATCCT TCACAGAGAC ATGAAGGCCG CCAACGTCCT CATCACCAGA 540

GACGGAGTCC TCAAGCTGGC AGACTTTGGC TTGGCCCGGG CCTTTAGCCT GGCTAAGAAC 600

AGCCAGGGGA ACCGCTACAC CAACCGCGTG GTCACGCTGT GGTACAGACC TCCAGAGCTG 660

CTGTTAGGGG AGCGCGACTA CGGCCCCCCC ATCGATCTGT GGGGGGCGGG CTGCATCATG 720

GCGGAGATGT GGACCAGAAG TCCCATCATG CAAGGCAACA CGGAGCAGCA CCAGCTCACC 780

CTGATCAGCC AGCTGTGTGG CTCCATCACT GCAGAGGTGT GGCCCGGCGT GGACAAAAAG 840

TATGAACTGT ACCAGAAAAT GGAGCTTCCC AAAGGCCAGA AGAGGAAGGT CAAGGACCGC 900

CTCAAAGCCT ACGTGAAGGA CGCCTACGCC CTGGATCTCA TCGACAAGCT GCTGGTTCTG 960

GACCCGGCTC AGCGCATAGA CAGCGACGAC GCCCTGAACC ACGACTTCTT CTGGTCCGAC 1020

CCCATGCCCT CAGACCTCAA GAACATGCTG TCCACTCACA ACACGTCCAT GTTTGAGTAC 1080

CTGGCCCCGC CCAGACGGAG GGGGCACATC CCCCAACAGC AGCCCAACCA GAACCGAAAC 1140

CCGGCCACGA CCAGTCAGAC GGAGTTCGAC CGAGTCTTTT AG 1182

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         yek++kig+Gt+g+v+kak+++tg++vAlKk+ +e+ekeg+pitalrEi++l+ lkh+n+

Q: 40    YEKMAKIGQGTFGEVFKAKHRTTGKKVALKKVLMENEKEGFPITALREIKILQLLKHENV  99

         99**********************************************************

S: 61    vkLlevva.......kdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqllegl  113

         v+L+e++        + k ++yLvf+f+e+dL+ ll++ +  k++l+e+k+++++ll+gl

Q: 100   VNLIEICRtkatqfnRYKGSIYLVFDFCEHDLAGLLSNANV-KFTLAEIKKVMQMLLNGL  158

         ********99999977889**********************.******************

S: 114   aylHsnkilHRDlKpqNlLiskegklklaDfGlaraf....ssplktytkevvTlwYraP  169

          y+H+nkilHRD+K++N+Li+++g+lklaDfGlaraf    +s+ ++yt++vvTlwYr+P

Q: 159   YYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFslakNSQGNRYTNRVVTLWYRPP  218

         *************************************7665555558*************

S: 170   elLlgakeYstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevs  229

         elLlg+++Y+  +D+W++gci+ae++tr+p++qg++e++ql+ i++l+g+++ +vwp+v

Q: 219   ELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLTLISQLCGSITAEVWPGVD  278

         **********************************************************97

S: 230   k.lpeyk.ksfpkkkkkklkekvkklkek..aldllekllaldpkkRisakealqhkyf  284

         k ++ y+ +++pk +k+k+k+++k++ ++  aldl++kll ldp++Ri++++al+h++f

Q: 279   KkYELYQkMELPKGQKRKVKDRLKAYVKDayALDLIDKLLVLDPAQRIDSDDALNHDFF  337

         52677778999999999******887755468*************************98

Domain Sequence
(FASTA)

YEKMAKIGQG TFGEVFKAKH RTTGKKVALK KVLMENEKEG FPITALREIK ILQLLKHENV 60

VNLIEICRTK ATQFNRYKGS IYLVFDFCEH DLAGLLSNAN VKFTLAEIKK VMQMLLNGLY 120

YIHRNKILHR DMKAANVLIT RDGVLKLADF GLARAFSLAK NSQGNRYTNR VVTLWYRPPE 180

LLLGERDYGP PIDLWGAGCI MAEMWTRSPI MQGNTEQHQL TLISQLCGSI TAEVWPGVDK 240

KYELYQKMEL PKGQKRKVKD RLKAYVKDAY ALDLIDKLLV LDPAQRIDSD DALNHDFF 298

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013