EKS-ORL-00023
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORL-00023
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/InsR521.64.2E-15710061274269
StatusUnreviewed
Ensembl ProteinENSORLP00000023219
UniProt AccessionH2MWH4;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NameINSR (2 of 2)
Gene Synonyms/Alias INSR (2 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSORLG00000018568ENSORLP00000023219ENSORLT00000023220
OrganismOryzias latipes
Functional Description
Protein Length1366
Protein Sequence
(FASTA)
LRKYSLMNPL VCVHAVVISS VCLCVSLMQL KICSSIHIRN DVTNFQLLEN CTVIEGHLKI 60
LLMFQTRSED FRGLSFPKLQ VVTDYVLLFR VYGLETLSDL FPNLTVIRGN NLFFNYGLVI 120
FEMRDLKEMG LYSLMNITRG SVRIEENSDL CYLSTLDWSK ILDSVEDNFI VGNKDERECG 180
DLCPGTAEGR TICPQTTING QYKARCWSQK HCQRTCLDKC KHGACNSRGQ CCHDQCLGSC 240
REPGNASSCV ACRNLQHGNT CVDKCPPGYF VFRGWRCVSF SFCQELHDQC SLTKKQNQDR 300
EASCVEYVIH EGACIPECPS GYTTLNSTML TCLPCAGPCP KLCVGNKTID SVTSAQALRG 360
CTVLHGNMII KIRGGNNIAA ELESSLGQIE VITGYLMVRR AYALVSLSFL RKLRIIKGEH 420
LEGDTYAFYA LDNQNLRELW DWSKHNLTIE NGRIFFHYNS KLCMSEIRRM EEITGAKERN 480
QKNDIAVRTN GDQASCETKL LNFTQIKTSF KMIILRWDAF WPSDFRDLLG FMVLYKEAPY 540
KNVTEFDGQD ACGSNSWMIA DVDPPPRPTP GKEPEQPRHL IGPLKPWTQY AIMVKTQLSA 600
SDEHQVHGAK SEIIYVRTNS TKPSAPLDPV SSSKSSSEIS LKWKPPTSPN GNITHYKVIY 660
RRQLEDSDLF KFDYCLQGEH LPREFQQTKT LRMSRSGTTQ MSPPQGCCAC PKTDSQLKKE 720
QEEIEFRKTF ENYLHNEVFE SRPSRRRRSV GVANATDPPL LMSTMSSIEA NATTVLPDDE 780
DSSKVELKVV SKESIVIGNL HYFTSYKIEI IACNHPTDPE GCSLANFRSE RTMPEEKADN 840
IPGQVTHEIV MTEPPYVLIK WNAPPAPNGL IILYEVFYRR VEEKEEQTLC VSRPAYLKTN 900
GTKLPLVQPG NYSVRVRATS LAGNGSFTET IYFFMPHSNP GLVWIVSGPV ICFILLLFVG 960
AGVFVVIKKR QIEGPLGDLI TSPNPEYFSA NDMYVPDEWE VPREKITLLR ELGQGSFGMV 1020
YQGIAKDIVK GDPETRVAVK TVNESASLRE RIEFLNEASV MKAFSCHHVV RLLGVVSKGQ 1080
PTLVVMELMT HGDLKSYLRS LRPDSENNPS GAPPPSLKDM LQMAAEIADG MAYLNAKKFV 1140
HRDLAARNCM VGEDYTVKIG DFGMTRDIYE TDYYRKGGKG LLPVRWMAPE SLKDGVFTAH 1200
SDCWSFGVVL WEISTLAEQP YQGLSNEQVL KFVMDGGFLD RPDNCPERMH SLMQMCWQYN 1260
PKMRPTFLEI IDMLRDDLHP TFHEVSFFHS EDNKVPETEE FDLDLDNMES IPLDPSSYSQ 1320
REESLSRDGV PSVALRGNYE EHVPYTHMNG GKKNGRILLL PRSSPS 1366
Nucleotide Sequence
(FASTA)
TTAAGGAAGT ACTCACTGAT GAATCCTCTA GTGTGTGTTC ATGCAGTGGT GATTTCAAGT 60
GTGTGCTTGT GTGTGTCACT GATGCAGCTA AAGATCTGCT CAAGTATACA CATCCGGAAC 120
GACGTGACCA ACTTCCAGTT GTTGGAGAAC TGCACAGTCA TTGAGGGCCA CCTCAAGATT 180
CTGCTCATGT TTCAGACCAG GAGTGAGGAC TTCAGGGGCC TCAGCTTCCC AAAGCTGCAG 240
GTGGTGACGG ACTATGTCCT GCTGTTTAGA GTCTACGGCC TTGAGACCCT CAGCGATCTC 300
TTCCCCAACC TGACTGTGAT CCGTGGCAAC AATCTGTTCT TCAACTACGG TCTTGTGATT 360
TTCGAGATGC GGGACCTAAA GGAAATGGGC CTTTACAGCC TCATGAACAT AACCCGCGGT 420
TCTGTGAGAA TCGAGGAGAA CTCCGACCTG TGTTACCTGT CCACTTTAGA CTGGTCTAAG 480
ATCTTGGATT CAGTAGAGGA CAACTTCATC GTGGGCAACA AAGACGAGCG AGAGTGTGGG 540
GACCTGTGTC CTGGCACCGC CGAGGGTCGA ACCATCTGTC CCCAGACCAC CATCAACGGA 600
CAGTACAAAG CAAGATGCTG GTCACAGAAA CACTGTCAGA GAACGTGCCT GGATAAATGC 660
AAGCACGGCG CGTGCAACAG CAGGGGTCAG TGCTGCCACG ACCAGTGCCT GGGCAGCTGC 720
AGGGAGCCGG GCAACGCCAG CAGCTGTGTG GCCTGCAGGA ACCTCCAGCA TGGAAACACC 780
TGCGTGGACA AATGTCCTCC GGGATACTTC GTCTTCAGGG GCTGGCGCTG CGTCAGCTTC 840
TCTTTTTGCC AGGAGCTCCA CGACCAGTGC TCGCTGACAA AGAAACAAAA CCAGGACCGG 900
GAGGCGAGCT GCGTTGAGTA CGTCATCCAT GAAGGGGCCT GTATTCCAGA GTGTCCGTCC 960
GGATACACCA CCCTGAACTC CACCATGTTG ACCTGTTTGC CTTGTGCCGG TCCATGTCCT 1020
AAACTGTGCG TTGGAAATAA GACGATTGAC TCGGTAACCT CTGCCCAGGC TTTAAGAGGC 1080
TGCACTGTTC TTCATGGGAA CATGATCATA AAGATAAGAG GAGGAAATAA CATAGCGGCT 1140
GAGTTGGAGT CTAGTCTGGG GCAAATCGAG GTGATCACGG GTTACCTGAT GGTGCGCAGA 1200
GCCTACGCTT TGGTGTCGCT CTCCTTTCTG CGAAAACTGC GAATCATTAA GGGGGAACAT 1260
CTTGAGGGAG ATACATATGC TTTCTACGCA TTGGACAACC AGAACCTCAG AGAATTGTGG 1320
GATTGGTCCA AGCACAACCT GACGATCGAG AACGGTCGGA TCTTCTTCCA CTACAACTCT 1380
AAACTCTGCA TGTCTGAGAT TAGAAGGATG GAAGAGATAA CGGGGGCCAA GGAGCGCAAC 1440
CAGAAGAACG ACATCGCTGT CCGCACCAAC GGAGACCAAG CCTCCTGTGA GACGAAGCTT 1500
CTGAATTTCA CTCAAATAAA GACTTCGTTT AAGATGATCA TCCTGAGGTG GGATGCGTTT 1560
TGGCCTTCGG ACTTCAGAGA CCTGCTGGGA TTTATGGTTC TCTACAAAGA GGCGCCATAC 1620
AAGAACGTGA CAGAGTTTGA CGGACAGGAT GCCTGCGGTT CAAACAGCTG GATGATTGCA 1680
GACGTTGACC CCCCGCCTCG CCCTACTCCC GGCAAAGAAC CAGAACAACC GCGGCACCTG 1740
ATCGGACCGC TGAAACCTTG GACGCAGTAC GCCATCATGG TCAAAACCCA GCTCTCCGCG 1800
TCTGACGAGC ATCAGGTCCA CGGAGCGAAA AGCGAGATCA TTTACGTCCG AACAAACTCC 1860
ACCAAACCTT CTGCCCCCCT GGACCCCGTG TCCTCGTCAA AGTCGTCCTC TGAGATCAGT 1920
CTGAAATGGA AACCTCCCAC CAGTCCAAAC GGCAACATCA CACACTACAA GGTCATCTAT 1980
CGAAGGCAGC TGGAGGACAG CGACCTCTTC AAGTTTGACT ACTGCCTCCA AGGTGAGCAT 2040
CTGCCGCGCG AATTCCAACA AACAAAGACA TTAAGGATGA GCAGAAGTGG AACCACACAG 2100
ATGAGCCCAC CTCAGGGGTG CTGCGCCTGC CCCAAGACGG ACAGCCAGCT GAAGAAGGAG 2160
CAGGAAGAGA TTGAGTTTCG CAAGACCTTT GAGAACTACC TCCATAACGA AGTCTTTGAG 2220
AGCAGACCGT CTCGCCGCCG CCGCTCGGTG GGGGTTGCGA ATGCCACCGA TCCTCCTCTG 2280
TTGATGTCCA CCATGTCCAG CATTGAGGCC AATGCCACCA CTGTGCTCCC TGACGATGAA 2340
GACAGCTCTA AGGTGGAGCT AAAGGTCGTC TCAAAGGAAT CGATTGTCAT TGGTAACCTG 2400
CACTACTTCA CAAGCTACAA AATAGAGATC ATAGCGTGCA ATCATCCTAC AGACCCTGAA 2460
GGCTGCAGTC TGGCCAATTT TCGCAGTGAA AGAACCATGC CGGAGGAAAA AGCGGATAAC 2520
ATTCCGGGCC AAGTGACCCA TGAGATCGTG ATGACCGAGC CTCCCTATGT GTTAATTAAG 2580
TGGAACGCTC CTCCCGCGCC CAATGGACTC ATCATTTTGT ACGAGGTGTT CTACAGGAGG 2640
GTGGAAGAGA AGGAGGAGCA AACCCTCTGT GTGTCTCGGC CCGCCTACCT GAAAACCAAC 2700
GGCACCAAAC TCCCCCTCGT GCAGCCCGGA AACTACAGCG TGAGAGTCCG CGCCACTTCC 2760
CTGGCTGGAA ACGGCTCTTT TACGGAAACC ATTTACTTCT TCATGCCACA TTCCAATCCA 2820
GGGTTGGTTT GGATAGTGAG TGGCCCGGTC ATCTGCTTCA TTCTGCTGTT GTTTGTGGGG 2880
GCCGGCGTCT TTGTGGTCAT CAAGAAGAGG CAAATAGAAG GACCTCTAGG GGACCTCATC 2940
ACTTCACCAA ACCCAGAGTA CTTCAGTGCA AATGACATGT ACGTTCCTGA CGAGTGGGAA 3000
GTTCCCCGGG AAAAGATCAC GCTGCTCAGA GAGCTGGGCC AGGGTTCCTT CGGCATGGTG 3060
TACCAGGGAA TTGCCAAAGA CATCGTCAAA GGAGATCCAG AGACCCGTGT TGCTGTCAAG 3120
ACGGTCAACG AGTCGGCCAG CCTGCGAGAG CGGATCGAGT TCCTCAACGA GGCCTCGGTC 3180
ATGAAGGCCT TCAGCTGTCA CCACGTGGTG CGACTCCTCG GTGTCGTGTC TAAAGGTCAG 3240
CCCACCCTGG TGGTCATGGA ACTGATGACT CATGGGGATT TGAAGAGCTA TCTGAGGAGT 3300
CTGAGGCCAG ACTCTGAGAA CAACCCATCG GGCGCACCGC CACCGTCTCT GAAAGACATG 3360
CTCCAGATGG CAGCAGAAAT TGCAGACGGC ATGGCTTACC TCAACGCCAA GAAGTTTGTC 3420
CACAGAGACC TGGCAGCCAG GAACTGCATG GTGGGAGAGG ACTACACGGT CAAGATTGGG 3480
GACTTCGGCA TGACGCGAGA CATCTACGAG ACGGACTACT ACCGCAAAGG AGGGAAAGGT 3540
CTGCTTCCTG TCAGGTGGAT GGCCCCGGAG TCCCTGAAGG ACGGCGTCTT CACCGCTCAC 3600
TCAGACTGCT GGTCCTTTGG GGTTGTGCTG TGGGAGATCA GTACTCTTGC AGAGCAGCCT 3660
TACCAGGGGC TTTCCAATGA GCAGGTCCTG AAGTTCGTTA TGGACGGAGG ATTCCTGGAC 3720
CGGCCGGACA ATTGTCCAGA AAGGATGCAC AGCCTCATGC AGATGTGCTG GCAGTATAAC 3780
CCCAAGATGC GGCCCACCTT CCTGGAGATC ATCGACATGC TGCGGGACGA CCTGCACCCC 3840
ACTTTCCATG AGGTGTCCTT CTTCCACAGT GAGGACAACA AAGTCCCAGA GACGGAGGAG 3900
TTCGACCTGG ACCTGGACAA CATGGAGAGC ATCCCTCTGG ACCCATCCTC TTACTCCCAG 3960
AGAGAGGAGA GCTTAAGCAG AGACGGCGTT CCCTCCGTGG CTCTGAGGGG GAACTACGAG 4020
GAGCACGTTC CCTACACACA CATGAACGGG GGCAAGAAAA ACGGGAGAAT ACTGTTGTTA 4080
CCCCGATCCA GCCCTTCCTA A 4101
Domain Profile
S: 1     ivllrelGqGsfGmvyeGvakdvvkgeeetrvaiktvneaassrerieflkeasvmkefk  60
         i+llrelGqGsfGmvy+G+akd+vkg+ etrva+ktvne+as reriefl+easvmk+f+
Q: 1006  ITLLRELGQGSFGMVYQGIAKDIVKGDPETRVAVKTVNESASLRERIEFLNEASVMKAFS  1065
         789*********************************************************
S: 61    thhvvrllGvvskgqpalvvmelmkkGdlksylrslrpeeeneaa.lappaldkliqmaa  119
         +hhvvrllGvvskgqp+lvvmelm++Gdlksylrslrp++en+++  +pp+l+++ qmaa
Q: 1066  CHHVVRLLGVVSKGQPTLVVMELMTHGDLKSYLRSLRPDSENNPSgAPPPSLKDMLQMAA  1125
         *****************************************987626799**********
S: 120   eiadGmayleakkfvhrdlaarncmvaedltvkiGdfGmtrdiyetdyyrkggkgllpvr  179
         eiadGmayl+akkfvhrdlaarncmv ed+tvkiGdfGmtrdiyetdyyrkggkgllpvr
Q: 1126  EIADGMAYLNAKKFVHRDLAARNCMVGEDYTVKIGDFGMTRDIYETDYYRKGGKGLLPVR  1185
         ************************************************************
S: 180   wmspeslkdGvftsksdvwsfGvvlweivtlaeqpyqGlsneqvlkfvldggvlekpenc  239
         wm+peslkdGvft++sd wsfGvvlwei tlaeqpyqGlsneqvlkfv+dgg+l++p+nc
Q: 1186  WMAPESLKDGVFTAHSDCWSFGVVLWEISTLAEQPYQGLSNEQVLKFVMDGGFLDRPDNC  1245
         ************************************************************
S: 240   pelltelmrlcwqynpklrpsfleivell  268
         pe+++ lm++cwqynpk+rp+flei+++l
Q: 1246  PERMHSLMQMCWQYNPKMRPTFLEIIDML  1274
         **************************976
Domain Sequence
(FASTA)
ITLLRELGQG SFGMVYQGIA KDIVKGDPET RVAVKTVNES ASLRERIEFL NEASVMKAFS 60
CHHVVRLLGV VSKGQPTLVV MELMTHGDLK SYLRSLRPDS ENNPSGAPPP SLKDMLQMAA 120
EIADGMAYLN AKKFVHRDLA ARNCMVGEDY TVKIGDFGMT RDIYETDYYR KGGKGLLPVR 180
WMAPESLKDG VFTAHSDCWS FGVVLWEIST LAEQPYQGLS NEQVLKFVMD GGFLDRPDNC 240
PERMHSLMQM CWQYNPKMRP TFLEIIDML 269
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Gasterosteus aculeatus"; ?>Oreochromis niloticus"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-GAA-00022
EKS-ORN-00024
EKS-TAR-00027
EKS-TEN-00025
EKS-XIM-00024
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0046777; P:protein autophosphorylation
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR003961; Fibronectin_type3.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016246; Tyr_kinase_insulin-like_rcpt.
IPR002011; Tyr_kinase_rcpt_2_CS.
Pfam
PF00041; fn3; 1.
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00060; FN3; 3.
SM00261; FU; 2.
SM00219; TyrKc; 1.
Prosites
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00239; RECEPTOR_TYR_KIN_II; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013