EKS-ORL-00069

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00069

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	417.7	2.5E-125	4	287	284

Status

Reviewed

Ensembl Protein

ENSORLP00000024000

UniProt Accession

Q9DGD3;

Protein Name

Cyclin-dependent kinase 1

Protein Synonyms/Alias

CDK1; Cell division control protein 2 homolog; Cell division protein kinase 1; p34 protein kinase;

Gene Name

cdk1

Gene Synonyms/Alias

cdk1; cdc2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000019266	ENSORLP00000024000	ENSORLT00000024001

Organism

Oryzias latipes

Functional Description

Plays a key role in the control of the eukaryotic cellcycle. It is required in higher cells for entry into S-phase and mitosis. Component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II. Catalytic component of MPF (By similarity).

Protein Length

303

Protein Sequence
(FASTA)

MEDYVKIEKI GEGTYGVVYK GRHKSTGQVV AMKKIRLESE EEGVPSTAVR EVSLLQELKH 60

PNVVRLLDVL MQESRLYLIF EFLSMDLKKY LDSIPSGQYM DPMLVKSYLY QILEGIYFCH 120

RRRVLHRDLK PQNLLIDNKG VIKLADFGLA RAFGVPVRVY THEVVTLWYR APEVLLGSPR 180

YSTPVDVWST GTIFAELATK KPLFHGDSEI DQLFRIFRTL GTPNNDVWPD VESLPDYKNT 240

FPKWKEGSLS SMVKNLDKNG LDLLAKMLIY NPPKRISARE AMTHPYFDDL DKSTLPAACI 300

NGV 303

Nucleotide Sequence
(FASTA)

ATGGAGGACT ACGTGAAAAT AGAGAAAATC GGAGAAGGGA CATACGGGGT GGTGTACAAA 60

GGCCGGCACA AGTCCACGGG ACAGGTGGTG GCCATGAAGA AGATCCGCCT GGAGAGTGAG 120

GAGGAGGGAG TTCCCAGCAC CGCTGTCAGG GAGGTGTCGC TGCTTCAGGA GCTGAAGCAC 180

CCCAACGTCG TCCGGCTCTT GGATGTCCTG ATGCAGGAAT CTCGCCTCTA CCTGATCTTT 240

GAGTTCCTGT CCATGGACCT GAAGAAGTAC CTGGATAGCA TCCCGTCAGG ACAGTACATG 300

GACCCCATGC TGGTCAAGAG CTACCTCTAT CAGATCCTTG AGGGCATTTA CTTCTGTCAC 360

CGAAGGCGGG TCCTCCACCG CGACCTGAAG CCCCAGAACC TTCTGATTGA TAACAAGGGC 420

GTCATCAAAC TGGCAGACTT TGGCTTGGCC CGGGCCTTCG GTGTTCCCGT CCGGGTCTAC 480

ACCCACGAGG TTGTGACTCT GTGGTATCGA GCTCCTGAGG TCCTTCTGGG TTCCCCCCGA 540

TATTCAACCC CAGTGGACGT GTGGAGCACG GGTACCATCT TTGCTGAACT CGCCACCAAG 600

AAGCCCCTGT TCCACGGAGA CTCCGAGATC GACCAGCTCT TCAGGATCTT TAGGACTCTG 660

GGGACCCCCA ACAATGACGT TTGGCCGGAT GTGGAGAGCC TGCCTGACTA CAAAAACACT 720

TTCCCCAAAT GGAAGGAGGG CAGCCTGTCC TCCATGGTGA AGAACCTGGA CAAGAACGGC 780

CTGGACCTGC TGGCGAAAAT GTTGATCTAC AATCCTCCCA AGAGGATCTC TGCACGTGAG 840

GCCATGACCC ACCCATACTT TGATGACCTG GACAAGTCCA CGCTGCCCGC CGCCTGCATC 900

AACGGCGTCT GA 912

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         y k+ekigeGtyg+vyk+++k+tg+vvA+Kkirle+e+egvp+ta+rE+sll+elkh+n+

Q: 4     YVKIEKIGEGTYGVVYKGRHKSTGQVVAMKKIRLESEEEGVPSTAVREVSLLQELKHPNV  63

         789*********************************************************

S: 61    vkLlevvakdkkklyLvfefleqdLkkllkkkkkk.klsleevkslllqlleglaylHsn  119

         v+Ll+v++ ++++lyL+fefl++dLkk+l++ ++  ++++  vks+l+q+leg+ ++H++

Q: 64    VRLLDVLM-QESRLYLIFEFLSMDLKKYLDSIPSGqYMDPMLVKSYLYQILEGIYFCHRR  122

         ********.99********************98765999*********************

S: 120   kilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYs  179

         ++lHRDlKpqNlLi+++g++klaDfGlaraf++p++ yt+evvTlwYraPe+Llg+ +Ys

Q: 123   RVLHRDLKPQNLLIDNKGVIKLADFGLARAFGVPVRVYTHEVVTLWYRAPEVLLGSPRYS  182

         ************************************************************

S: 180   tavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeykksfp  239

         t vD+Ws g i+ael+t+kplf+g+seidql+rif++lgtp+++vwp+v++lp+yk++fp

Q: 183   TPVDVWSTGTIFAELATKKPLFHGDSEIDQLFRIFRTLGTPNNDVWPDVESLPDYKNTFP  242

         ************************************************************

S: 240   kkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         k+k+ +l+++vk+l++++ldll k+l ++p kRisa+ea++h+yf

Q: 243   KWKEGSLSSMVKNLDKNGLDLLAKMLIYNPPKRISAREAMTHPYF  287

         ********************************************9

Domain Sequence
(FASTA)

YVKIEKIGEG TYGVVYKGRH KSTGQVVAMK KIRLESEEEG VPSTAVREVS LLQELKHPNV 60

VRLLDVLMQE SRLYLIFEFL SMDLKKYLDS IPSGQYMDPM LVKSYLYQIL EGIYFCHRRR 120

VLHRDLKPQN LLIDNKGVIK LADFGLARAF GVPVRVYTHE VVTLWYRAPE VLLGSPRYST 180

PVDVWSTGTI FAELATKKPL FHGDSEIDQL FRIFRTLGTP NNDVWPDVES LPDYKNTFPK 240

WKEGSLSSMV KNLDKNGLDL LAKMLIYNPP KRISAREAMT HPYF 284

Keyword

ATP-binding; Cell cycle; Cell division; Complete proteome; Cytoplasm; Cytoskeleton; Kinase; Mitosis; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005815	; C:microtubule organizing center
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004693	; F:cyclin-dependent protein kinase activity
GO:0008353	; F:RNA polymerase II carboxy-terminal domain kinase activity
GO:0051301	; P:cell division
GO:0007067	; P:mitosis

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013