EKS-ORL-00139

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00139

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Met	450.2	2.6E-135	1079	1341	263

Status

Unreviewed

Ensembl Protein

ENSORLP00000024532

UniProt Accession

H2MZM4;

Protein Name

Protein Synonyms/Alias

Gene Name

MET

Gene Synonyms/Alias

MET;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000019737	ENSORLP00000024532	ENSORLT00000024533

Organism

Oryzias latipes

Functional Description

Protein Length

1409

Protein Sequence
(FASTA)

NRMDSLLYSM LLWVLCPSVR GWCDHASERT DLNLSVTYDL PTFTADFPVQ NMVIVDGIIY 60

VGAINRIYAL APNLTKLSEY HTGPLSANET CGQTQARRNS NEKVDNHNIA LVGEKMYDQG 120

LYSCGSVDNG VCRRHVLNEG NGLKTVDEDV YCFADKVQLG NGQPSDSDMV VSPSGSQVLN 180

VESNFIHFFV GNSEIPGKDN VKGMTTHPHT ISLRKMRTSQ DGFTFESGSS YMDLIPSLRG 240

NYYLRYVYSF HSGPFTYFLT VQKVSWDSQA YHTRIVRMCS SDKSIRRYVE MPLECISTNK 300

RRRRSGSLKV FNILQAAHFT RVGKDEEKLF AAFAQGKPNS PEPTANSAIC IMTIKQINER 360

FRSNIQGCST VEPYHFTGSD RKSCHNLTSS DECDIHEGIS EGKESAYRLQ VTNFVQRLEY 420

WHTDLANTLV TSVLAAPVND GAVIYLGTAD GRHIQVLYSR SSSPHVNVRL DSRPVSTSVV 480

LPATAHSKGA VIVATGNKIT KIPLIGPGCS QMTTCTSCLL SSNVTECGWC NGRCTRKNEC 540

PSSSTWTQDY CMPVITKFSP ASGPLLGSTI VTICGHNFGF NKTKTFKGSE TLMLSVNVAG 600

VPCKFTKGGV GCRWTEIQCS PASKGNFTLS GHKVKVTSGN KVATMESFTF VDPVINDIFP 660

TFGPKSGNTM LTIRGAFLDT GNQQSVTIGE KICKIQSLTS TMITCKTPSH AFTSKEWVKL 720

TIDSVKRQAA TQFTYNEDPI IINIQPSHSF MSGGCTVSAR GFFLQSGLQP QMVLTVSLKN 780

TTVFHVSCVY GENQTSIQCT TPSLAKLALH KAVVTKVTFV LDGYSTPQLD LVYVEDPLFH 840

DPKLTSKDNK SIVELKGDRM DREAMNCKLL TVSNHSCESL TVVGNTLECT VPPELQNKEL 900

QVEWRQADSI RTLGRVMLAQ EQDYTVLILC CILFSLLLLL LGSVLMWRRN KHVDDLSEVW 960

YDSRGHIQHL DRLANARSVS PTNEMVSHES VDYRTTLLDD QGVDRPETCR VPPPIYGGNG 1020

ELLSPRLGAL SSGMSLAMEG DLVSPLLMAP VHIDPSCLHP DLLTEVQHVV ITREQLLLHL 1080

NQVIGRGHFG CVYHGTLLEP DGQKLHCAVK SLNLKQGITD LEEVSQFLKE GIIMKDFSHP 1140

NVLSLLGICL PPEGSPLVVL PYMKHGDLRN FIRDEVHNPT VKDLMGFGLQ VARGMEYLAS 1200

KKFVHRDLAA RNCMLDESYT VKVADFGLAR DIYDKEYYSV HNKSGVKLPV KWMALESLQT 1260

HKFTTKSDVW SFGVLLWELM TRGAPPYSDV NSFDITVFLL QGRRLLQPEF CPDALYTVMV 1320

ECWHPKPERR PSFSELVSRI SAIFSSFSGE HYVLLNTTYV NIDKMTPYPS LLTSTASSSS 1380

SASSPEASTS TSLPPHSPLF CHAERGCCT 1409

Nucleotide Sequence
(FASTA)

AACAGGATGG ATTCCCTTCT CTACTCCATG TTGCTGTGGG TCCTTTGTCC CAGTGTGAGA 60

GGCTGGTGTG ACCATGCATC TGAGAGGACA GATCTCAACC TTTCTGTCAC TTACGACCTC 120

CCAACATTCA CTGCAGACTT TCCAGTCCAG AACATGGTGA TTGTGGATGG GATCATCTAT 180

GTCGGTGCAA TAAACAGGAT TTATGCCTTA GCCCCTAACC TGACAAAACT ATCAGAGTAC 240

CACACAGGAC CACTGTCGGC TAACGAGACC TGCGGCCAGA CACAGGCCAG AAGGAACAGC 300

AATGAGAAGG TTGACAACCA CAACATTGCT TTAGTGGGTG AGAAGATGTA CGACCAAGGC 360

TTGTACAGCT GTGGCTCTGT AGACAATGGA GTCTGCCGTC GCCATGTCCT GAACGAGGGC 420

AATGGCCTGA AAACCGTTGA TGAAGATGTA TATTGCTTTG CAGACAAGGT GCAGCTGGGT 480

AACGGTCAGC CCAGTGACTC TGATATGGTT GTGAGCCCAT CAGGGTCTCA GGTGCTCAAC 540

GTGGAGAGCA ACTTTATACA CTTTTTTGTT GGGAACTCTG AAATTCCAGG TAAAGACAAC 600

GTAAAAGGCA TGACAACACA TCCTCACACC ATCTCGCTGC GGAAGATGAG GACAAGCCAA 660

GATGGTTTCA CTTTTGAGTC CGGCTCCTCA TACATGGACC TGATTCCGTC CCTAAGAGGA 720

AACTATTACC TGCGCTATGT TTACTCATTC CACAGTGGAC CCTTCACCTA CTTCCTCACC 780

GTACAAAAGG TGAGCTGGGA CTCTCAAGCC TACCATACAC GCATCGTCCG GATGTGCTCC 840

TCCGACAAGT CCATCCGTCG CTATGTGGAG ATGCCCCTGG AGTGCATCAG CACTAACAAG 900

AGGCGGCGAC GCTCTGGAAG CCTTAAGGTC TTTAACATTC TGCAGGCTGC TCATTTCACA 960

AGGGTGGGAA AAGACGAAGA GAAGCTGTTT GCCGCCTTTG CCCAAGGAAA GCCAAACTCT 1020

CCGGAGCCAA CCGCCAACTC AGCCATCTGC ATTATGACCA TAAAACAAAT CAACGAGAGG 1080

TTCAGGTCAA ACATACAAGG TTGCAGCACA GTGGAGCCGT ATCACTTCAC TGGATCGGAC 1140

AGGAAGTCCT GCCACAACCT GACCTCCTCA GATGAGTGTG ACATCCATGA AGGCATCAGT 1200

GAGGGAAAAG AGAGTGCATA TCGCCTGCAG GTGACCAACT TTGTCCAGAG GTTGGAGTAC 1260

TGGCACACAG ACTTGGCAAA CACATTAGTT ACCTCAGTCC TGGCGGCTCC CGTCAATGAT 1320

GGCGCCGTTA TATATCTTGG AACTGCAGAC GGACGCCATA TTCAGGTGCT GTATTCCCGC 1380

TCCAGCTCTC CACATGTGAA TGTTCGCCTG GACTCGAGAC CCGTCTCTAC CAGTGTAGTG 1440

CTGCCAGCTA CGGCACACTC AAAGGGAGCC GTAATAGTGG CCACAGGTAA CAAGATCACT 1500

AAAATCCCGC TGATTGGCCC TGGCTGCAGT CAGATGACTA CCTGCACGTC GTGTTTGCTG 1560

TCGTCGAATG TGACAGAGTG CGGTTGGTGC AACGGACGGT GCACCAGAAA GAATGAGTGT 1620

CCGTCCTCTT CCACATGGAC TCAGGACTAC TGCATGCCTG TGATTACCAA ATTTTCTCCG 1680

GCCTCTGGAC CACTGCTGGG CTCCACGATT GTGACGATCT GCGGCCACAA CTTTGGCTTT 1740

AACAAAACGA AGACGTTCAA AGGTTCTGAG ACTCTGATGC TATCTGTGAA TGTGGCAGGA 1800

GTGCCGTGCA AGTTCACAAA AGGGGGGGTC GGGTGTAGAT GGACTGAGAT CCAGTGTTCC 1860

CCGGCGTCGA AAGGGAACTT CACTCTGTCA GGACACAAAG TGAAAGTTAC CAGCGGTAAT 1920

AAGGTGGCCA CAATGGAGAG TTTCACGTTT GTGGATCCTG TGATCAATGA CATCTTTCCC 1980

ACATTTGGTC CAAAGTCTGG AAACACCATG TTAACCATTA GAGGGGCTTT CCTGGATACT 2040

GGAAATCAGC AATCTGTGAC CATAGGGGAG AAGATTTGTA AAATCCAGAG TTTGACATCC 2100

ACCATGATCA CCTGTAAGAC ACCTTCACAT GCTTTTACCT CAAAGGAGTG GGTGAAGCTC 2160

ACAATTGATT CAGTTAAACG CCAAGCCGCC ACGCAGTTTA CCTACAATGA AGACCCCATC 2220

ATCATCAACA TCCAGCCTTC ACATTCCTTC ATGAGCGGAG GCTGCACGGT GTCGGCTCGT 2280

GGCTTCTTCC TCCAATCTGG ACTTCAACCA CAGATGGTTC TCACCGTCAG TCTGAAAAAC 2340

ACTACAGTCT TCCATGTGAG CTGCGTGTAT GGTGAAAACC AGACCTCCAT CCAGTGCACG 2400

ACACCTTCCC TCGCCAAACT GGCTCTTCAC AAAGCCGTGG TCACCAAAGT GACTTTTGTC 2460

CTGGATGGCT ACTCAACTCC TCAGCTGGAC CTGGTTTATG TGGAGGATCC ATTATTCCAT 2520

GACCCAAAGC TGACTTCAAA GGACAACAAG AGCATCGTTG AGCTTAAAGG TGATCGGATG 2580

GACAGGGAGG CAATGAATTG TAAACTCCTG ACCGTTTCCA ACCACAGCTG TGAGAGCCTG 2640

ACAGTGGTTG GAAACACTTT GGAGTGCACG GTGCCCCCTG AGCTGCAGAA CAAGGAGCTG 2700

CAGGTAGAGT GGCGACAGGC AGACTCCATC AGGACTCTGG GCAGAGTGAT GCTGGCGCAG 2760

GAGCAGGACT ACACCGTCCT CATTTTGTGC TGCATTCTCT TCAGCTTGTT GTTGCTGCTG 2820

CTGGGATCAG TGCTGATGTG GAGAAGGAAC AAGCATGTTG ACGATCTGTC GGAGGTGTGG 2880

TATGATAGCC GGGGTCACAT CCAGCATCTG GACCGGCTGG CAAACGCGAG GAGCGTGAGT 2940

CCCACCAATG AAATGGTCTC CCACGAGTCA GTGGACTATA GAACAACTCT GCTGGATGAT 3000

CAGGGTGTTG ACAGGCCTGA GACGTGCCGG GTGCCCCCCC CTATCTATGG GGGTAACGGG 3060

GAGCTGCTGT CTCCTAGACT GGGAGCACTG AGCTCTGGGA TGAGCCTGGC CATGGAGGGC 3120

GATTTGGTGT CCCCTCTTCT GATGGCCCCC GTCCACATCG ACCCATCCTG CCTCCACCCA 3180

GACCTGCTTA CTGAGGTGCA GCATGTGGTG ATCACCAGGG AACAGCTGCT GCTCCACCTG 3240

AACCAGGTCA TCGGCAGAGG TCACTTCGGC TGTGTTTATC ATGGGACGCT GCTCGAGCCA 3300

GACGGCCAGA AGCTGCACTG TGCGGTCAAG TCCCTAAATC TTAAACAAGG CATCACAGAC 3360

TTGGAAGAGG TGTCCCAGTT CCTGAAGGAA GGGATCATCA TGAAAGACTT CAGTCATCCC 3420

AACGTCCTCT CTCTGCTGGG AATCTGCCTT CCACCAGAGG GTTCACCGCT GGTGGTTCTG 3480

CCATATATGA AGCATGGCGA CCTGCGGAAC TTCATCCGTG ACGAAGTGCA CAACCCCACC 3540

GTGAAGGACC TGATGGGTTT TGGGCTTCAG GTGGCCCGTG GAATGGAGTA TCTAGCCAGC 3600

AAAAAGTTTG TCCACCGAGA TCTGGCTGCC AGGAACTGCA TGCTGGATGA GAGCTACACA 3660

GTAAAGGTGG CTGACTTCGG CCTGGCTAGA GACATCTATG ACAAAGAATA TTACAGCGTC 3720

CACAACAAGA GCGGGGTCAA GCTGCCCGTC AAATGGATGG CTCTGGAAAG TCTGCAGACG 3780

CACAAGTTTA CCACCAAGTC AGATGTGTGG TCATTTGGGG TGCTGCTTTG GGAGCTGATG 3840

ACTCGTGGAG CCCCGCCATA CTCTGATGTG AACTCTTTCG ACATCACCGT GTTTCTCCTG 3900

CAGGGCAGGA GGCTGCTGCA GCCCGAGTTC TGCCCTGACG CCCTCTACAC GGTCATGGTG 3960

GAGTGCTGGC ATCCAAAGCC TGAGCGGCGG CCCTCCTTCT CAGAACTGGT GTCTCGCATC 4020

TCTGCCATCT TCTCCAGCTT CAGCGGAGAG CACTACGTCC TCCTGAATAC CACTTACGTC 4080

AACATTGACA AAATGACCCC CTACCCCTCC CTGCTCACCT CCACAGCTTC ATCCTCCTCT 4140

TCGGCTTCCT CCCCCGAGGC CTCTACCTCC ACGTCCCTGC CGCCGCACTC CCCGCTCTTC 4200

TGTCACGCAG AGCGAGGATG CTGCACCTGA 4230

Domain Profile

S: 2     dkeeviGkGhfGvvykgelsdsaskkikvavksl...eritdiekveeflreglvmkeld  58

         + ++viG+GhfG+vy+g+l++++++k ++avksl   + itd+e+v++fl+eg++mk+++

Q: 1079  HLNQVIGRGHFGCVYHGTLLEPDGQKLHCAVKSLnlkQGITDLEEVSQFLKEGIIMKDFS  1138

         789*******************************665679********************

S: 59    hpnvlsllGialddeglplvvlpymkkGdlksfirneernltvkdllefalqvakgmeyl  118

         hpnvlsllGi+l++eg+plvvlpymk+Gdl++fir+e +n+tvkdl++f+lqva+gmeyl

Q: 1139  HPNVLSLLGICLPPEGSPLVVLPYMKHGDLRNFIRDEVHNPTVKDLMGFGLQVARGMEYL  1198

         ************************************************************

S: 119   askkfvhrdlaarnclldekltvkvadfGlardvldkelyvveeerdarlpvkwlalesl  178

         askkfvhrdlaarnc+lde++tvkvadfGlard++dke+y+v+++ + +lpvkw+alesl

Q: 1199  ASKKFVHRDLAARNCMLDESYTVKVADFGLARDIYDKEYYSVHNKSGVKLPVKWMALESL  1258

         ************************************************************

S: 179   qtfkqfttksdvwsfGvllwelltrgatpysevasfdltlylkegrrlrkpeycpdklyd  238

         qt+k fttksdvwsfGvllwel+trga+pys+v+sfd+t++l +grrl +pe+cpd+ly

Q: 1259  QTHK-FTTKSDVWSFGVLLWELMTRGAPPYSDVNSFDITVFLLQGRRLLQPEFCPDALYT  1317

         ****.*******************************************************

S: 239   vmlkcwkakpaerpqfsdlvsiis  262

         vm +cw++kp++rp+fs+lvs+is

Q: 1318  VMVECWHPKPERRPSFSELVSRIS  1341

         **********************98

Domain Sequence
(FASTA)

HLNQVIGRGH FGCVYHGTLL EPDGQKLHCA VKSLNLKQGI TDLEEVSQFL KEGIIMKDFS 60

HPNVLSLLGI CLPPEGSPLV VLPYMKHGDL RNFIRDEVHN PTVKDLMGFG LQVARGMEYL 120

ASKKFVHRDL AARNCMLDES YTVKVADFGL ARDIYDKEYY SVHNKSGVKL PVKWMALESL 180

QTHKFTTKSD VWSFGVLLWE LMTRGAPPYS DVNSFDITVF LLQGRRLLQP EFCPDALYTV 240

MVECWHPKPE RRPSFSELVS RIS 263

Keyword

ATP-binding; Complete proteome; Disulfide bond; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity
GO:0004872	; F:receptor activity
GO:0007275	; P:multicellular organismal development

KEGG

InterPros

IPR013783	; Ig-like_fold.
IPR014756	; Ig_E-set.
IPR002909	; IPT_TIG_rcpt.
IPR011009	; Kinase-like_dom.
IPR003659	; Plexin-like.
IPR016201	; Plexin-like_fold.
IPR002165	; Plexin_repeat.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001627	; Semaphorin/CD100_Ag.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR015943	; WD40/YVTN_repeat-like_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF01437	; PSI; 1.
PF01403	; Sema; 1.
PF01833	; TIG; 2.

SMARTs

SM00429	; IPT; 3.
SM00423	; PSI; 1.
SM00630	; Sema; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS51004	; SEMA; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013