EKS-ORL-00470

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00470

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/PDGFR	581.2	9.8E-175	578	931	354

Status

Unreviewed

Ensembl Protein

ENSORLP00000024620

UniProt Accession

H2MZV1;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

PDGFRA

Gene Synonyms/Alias

PDGFRA;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000019815	ENSORLP00000024620	ENSORLT00000024621

Organism

Oryzias latipes

Functional Description

Protein Length

1070

Protein Sequence
(FASTA)

MGGVRTFAVF KKFLVLLVLG TSAVARPTIT PNLKELFLQP HSFLNLTCFG ESKKVSWVKP 60

LPENSIVITG NNSATLLISR VTVGNTGFYV CNYEEQQDSE VDIYVFVTDP SNLFVPESPE 120

NIHLILSQHM VEIPCRVSHS NAHVILRRVP SGEPISSPYD AKIGFFGIDV PGQYQCESSV 180

NGHTVKSDIY IVTHEGGTAL HVELKAKRTA LLVGETITVT CLARGPEILE DNWKYPGKAA 240

NRGTKTVREN KKDQEILYTL TIPQASVKDS GSYSCSIVDI ANNEIQTKEQ EIQVFAGEFV 300

SIDPEFGEHE SAELDEVREF RANVHSFPNA RVTWIKDGIL LSDVTAEIST SLRQTSETSY 360

MSVLTLIRAK GEDSGNYTMR VENGNQSRHV SLILEVKVPA VIVDLMDIHH GSAIGQSVVC 420

ITRGRPTPAV EWFICKSIKH CGNNSSFWVP LATNSTDIVF DSHFEGNNLE SQVVFGHLES 480

TLAVRCLARN EMATVSREVK LVSSGPHPEL TVAAAVLVLL VIVIISLIVL VVIWKQKPRY 540

EIRWRVIESV SPDGHEYIYV DPMQLPYDSR WEFPRDRLVL GRVLGSGAFG KVVEGTAYGL 600

SRSQPVMKVA VKMLKPTARS SEKQALMSEL KIMTHLGPHL NIVNLLGACT KSGPIYIITE 660

YCFYGDLVNY LHKNRENFLS LSPEKNRKEM DIFGINPADE SSRSYVILSF ESKGDYMDMK 720

QADNTQYVPM LEMNNASKYS DVQRSNYDHP PSQKGSSECE MENLLSDDTT EGLTTTDLLS 780

FTYQVAKGME FLSSKNCVHR DLAARNVLLS QGKIVKICDF GLARDIMHDS NYVSKGSTFL 840

PVKWMAPESI FDNLYTTLSD VWSYGILLWE IFSLGGTPYP GMVVDSSFYN KIKSGYRMSK 900

PEHAPQDIYE TMMKCWNSDP EKRPSFMGLS ESVALLLPSS YRRHYERVNR DFLKSDHPAV 960

TRVCMENDTD YVDIPYKNQG KLKERESGFD EQRLSSDSGY IIPLPDLDPL SDEEYGKRNR 1020

HSSQTSEESA IETGSSSSTY PKREGETLED ITLLDETCLD CSDLVEDSFL 1070

Nucleotide Sequence
(FASTA)

ATGGGTGGGG TGAGAACATT TGCTGTGTTT AAGAAATTCC TGGTGCTGCT GGTTCTAGGC 60

ACCTCTGCAG TTGCAAGACC AACCATCACC CCAAACCTAA AGGAACTTTT TCTACAACCT 120

CACTCTTTCC TCAACTTGAC CTGCTTTGGG GAGAGTAAAA AAGTCTCCTG GGTCAAGCCC 180

CTGCCAGAAA ACTCCATAGT CATTACAGGG AACAACTCAG CCACTCTGCT CATTTCCAGA 240

GTCACTGTGG GGAACACAGG CTTTTATGTG TGCAATTATG AAGAGCAGCA AGATAGTGAA 300

GTTGACATTT ATGTCTTTGT TACAGATCCC AGCAACCTGT TTGTCCCCGA GTCTCCAGAA 360

AACATTCATC TCATCCTCTC CCAACACATG GTGGAAATCC CGTGCCGTGT ATCTCACTCG 420

AACGCTCACG TCATCCTGAG GAGGGTGCCC AGTGGAGAGC CGATTTCCTC TCCCTACGAT 480

GCAAAGATAG GCTTTTTTGG GATTGATGTT CCTGGGCAGT ACCAGTGTGA AAGTTCTGTC 540

AATGGCCACA CTGTAAAGAG TGACATTTAC ATCGTGACCC ATGAAGGTGG AACAGCGCTT 600

CATGTTGAAC TGAAAGCTAA AAGGACCGCC CTACTGGTGG GAGAAACAAT CACTGTCACC 660

TGCCTGGCTC GAGGACCCGA GATCCTGGAG GACAACTGGA AATACCCGGG CAAAGCGGCT 720

AACCGTGGTA CCAAAACAGT GCGCGAGAAC AAGAAAGATC AGGAGATCCT CTACACCCTG 780

ACAATCCCAC AGGCCTCAGT CAAAGACAGT GGCAGCTACT CCTGTTCTAT TGTTGATATA 840

GCTAACAATG AAATTCAGAC AAAAGAACAA GAAATTCAGG TGTTTGCTGG TGAATTTGTA 900

TCAATTGATC CGGAGTTCGG GGAGCACGAA TCTGCAGAGC TGGATGAAGT TCGGGAATTC 960

AGGGCAAATG TCCACTCCTT TCCCAATGCC CGTGTCACTT GGATCAAAGA TGGGATTCTT 1020

CTCAGTGATG TGACAGCAGA GATCTCCACC AGCCTGCGGC AAACCAGCGA GACCAGTTAC 1080

ATGAGTGTTC TCACACTGAT CCGGGCTAAG GGGGAGGACA GTGGGAATTA CACCATGCGA 1140

GTGGAGAACG GAAACCAGAG TCGACATGTC AGCTTAATCC TAGAGGTCAA AGTGCCTGCT 1200

GTCATCGTGG ACCTGATGGA CATCCATCAT GGCTCAGCCA TAGGCCAGTC TGTGGTGTGC 1260

ATAACCAGAG GGCGGCCCAC ACCTGCGGTG GAGTGGTTCA TCTGCAAGAG CATCAAACAC 1320

TGTGGCAACA ACTCATCTTT TTGGGTGCCC CTCGCTACCA ACTCCACAGA CATCGTGTTT 1380

GATTCGCACT TCGAAGGCAA TAACCTGGAG AGCCAGGTCG TGTTTGGTCA CCTGGAGAGC 1440

ACGCTGGCGG TCCGCTGCCT AGCCAGGAAT GAAATGGCCA CTGTCAGCAG GGAGGTCAAA 1500

CTGGTGTCTA GCGGCCCCCA CCCTGAGCTG ACTGTGGCTG CTGCCGTACT GGTGCTCCTG 1560

GTCATTGTCA TCATCTCACT CATTGTCTTG GTTGTCATCT GGAAACAGAA GCCACGATAT 1620

GAGATCCGCT GGAGGGTCAT AGAGTCTGTT AGTCCAGACG GCCACGAATA CATCTATGTG 1680

GACCCCATGC AGCTTCCCTA CGACTCTAGA TGGGAGTTTC CCCGTGACAG ACTTGTGCTT 1740

GGTCGTGTCC TGGGCTCTGG AGCATTTGGG AAGGTGGTTG AAGGAACTGC CTATGGACTC 1800

AGTCGCTCTC AACCAGTCAT GAAAGTGGCT GTAAAAATGT TAAAACCCAC AGCCCGCTCC 1860

AGCGAGAAAC AGGCCCTCAT GTCAGAACTG AAGATCATGA CTCATCTCGG ACCCCACCTC 1920

AACATTGTGA ACCTTCTGGG AGCATGCACC AAGTCAGGCC CTATTTACAT TATCACGGAG 1980

TACTGCTTCT ACGGAGATCT GGTCAACTAC CTGCACAAGA ACAGGGAGAA CTTCCTCAGC 2040

CTGAGCCCAG AAAAAAATAG AAAAGAGATG GATATATTTG GGATCAATCC TGCAGATGAG 2100

AGCAGTAGGA GCTATGTGAT CCTGTCCTTT GAAAGTAAAG GGGACTACAT GGATATGAAG 2160

CAGGCTGACA ACACTCAGTA TGTGCCAATG CTGGAGATGA ACAATGCCTC CAAGTACTCA 2220

GACGTCCAGA GGTCAAACTA CGATCACCCT CCCTCGCAGA AAGGCTCAAG TGAATGTGAG 2280

ATGGAAAACC TGCTGTCAGA TGACACCACT GAAGGCCTAA CAACCACTGA CCTGCTGAGC 2340

TTTACCTACC AGGTGGCCAA AGGAATGGAA TTTCTCTCTT CCAAAAATTG CGTGCACCGA 2400

GACCTTGCAG CCAGGAACGT ACTCCTCTCT CAGGGCAAGA TAGTGAAGAT CTGTGACTTT 2460

GGACTGGCCC GGGACATCAT GCATGACAGC AATTATGTCT CCAAAGGGAG TACCTTTCTT 2520

CCTGTGAAAT GGATGGCACC AGAAAGCATT TTTGACAACC TGTACACCAC CCTCAGTGAT 2580

GTTTGGTCTT ACGGCATCCT CCTTTGGGAG ATTTTTTCGT TAGGTGGGAC CCCTTACCCT 2640

GGGATGGTGG TGGACTCCAG CTTCTACAAC AAGATCAAGA GTGGATATAG GATGTCCAAA 2700

CCTGAACACG CACCGCAAGA TATATATGAG ACGATGATGA AGTGCTGGAA CAGTGATCCA 2760

GAGAAGAGGC CCTCCTTCAT GGGTCTAAGT GAAAGTGTAG CATTGCTGCT GCCCTCCAGC 2820

TATAGGAGGC ATTATGAGAG GGTAAACCGG GACTTCCTGA AAAGTGACCA TCCTGCTGTC 2880

ACCCGGGTGT GCATGGAAAA CGACACCGAC TATGTTGACA TTCCCTACAA GAACCAAGGC 2940

AAGCTGAAGG AGCGGGAGAG CGGCTTTGAT GAGCAGCGCC TGAGCTCAGA TAGTGGCTAC 3000

ATCATTCCAC TCCCTGACCT GGACCCCCTC TCTGATGAAG AATATGGAAA AAGGAACAGA 3060

CATAGCTCTC AGACATCTGA GGAGAGCGCC ATCGAGACAG GGTCGAGCAG CTCCACCTAT 3120

CCTAAACGTG AAGGAGAGAC GCTCGAGGAC ATCACACTGC TGGACGAGAC GTGTCTGGAC 3180

TGTAGTGACC TGGTGGAGGA CAGCTTTCTC TAA 3213

Domain Profile

S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60

         l+lG+vlGsGafGkvve+tayGls+s++v+kvavkmlk+tarssek+almselki++hlG

Q: 578   LVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLG  637

         78**********************************************************

S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120

         +h+nivnllGactk+Gpiy+iteyc+yGdl+nyl+++re+fl+ s ek   +++e+d+++

Q: 638   PHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRENFLSLSPEK---NRKEMDIFG  694

         ******************************************988888...567788888

S: 121   l.ladkslrsksslssesseeyvdlkkd................vsdvssskadklasek  163

         + +ad+s rs+++ls+es+++y+d+k++                +sdv++s++d++ s+k

Q: 695   InPADESSRSYVILSFESKGDYMDMKQAdntqyvpmlemnnaskYSDVQRSNYDHPPSQK  754

         889************************99****************************999

S: 164   kksalerevkaaleeedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteG  223

          +   e e+++ l+++ +e+l+ +dllsf+yqvakGmefl+skncvhrdlaarnvll++G

Q: 755   GS--SECEMENLLSDDTTEGLTTTDLLSFTYQVAKGMEFLSSKNCVHRDLAARNVLLSQG  812

         55..56778889************************************************

S: 224   kvvkicdfGlardimkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweif  283

         k+vkicdfGlardim+dsnyv+kG+++lpvkwmapesifd+lyt+ sdvwsyGillweif

Q: 813   KIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIF  872

         ************************************************************

S: 284   slGstpypgllvdskfyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlve  342

         slG+tpypg++vds fy++ik+Gyrm++p++a+++iye m kcw+++pekrpsf  l+e

Q: 873   SLGGTPYPGMVVDSSFYNKIKSGYRMSKPEHAPQDIYETMMKCWNSDPEKRPSFMGLSE  931

         ******************************************************98875

Domain Sequence
(FASTA)

LVLGRVLGSG AFGKVVEGTA YGLSRSQPVM KVAVKMLKPT ARSSEKQALM SELKIMTHLG 60

PHLNIVNLLG ACTKSGPIYI ITEYCFYGDL VNYLHKNREN FLSLSPEKNR KEMDIFGINP 120

ADESSRSYVI LSFESKGDYM DMKQADNTQY VPMLEMNNAS KYSDVQRSNY DHPPSQKGSS 180

ECEMENLLSD DTTEGLTTTD LLSFTYQVAK GMEFLSSKNC VHRDLAARNV LLSQGKIVKI 240

CDFGLARDIM HDSNYVSKGS TFLPVKWMAP ESIFDNLYTT LSDVWSYGIL LWEIFSLGGT 300

PYPGMVVDSS FYNKIKSGYR MSKPEHAPQD IYETMMKCWN SDPEKRPSFM GLSE 354

Keyword

ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005887	; C:integral to plasma membrane
GO:0005524	; F:ATP binding
GO:0005021	; F:vascular endothelial growth factor-activated receptor activity
GO:0048010	; P:vascular endothelial growth factor receptor signaling pathway
GO:0038084	; P:vascular endothelial growth factor signaling pathway

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016243	; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824	; Tyr_kinase_rcpt_3_CS.
IPR009134	; Tyr_kinase_VEGFR_rcpt_N.

Pfam

PF07679	; I-set; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00409	; IG; 3.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 4.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00240	; RECEPTOR_TYR_KIN_III; 1.

Prints

PR01832

; VEGFRECEPTOR.

Created Date

20-Feb-2013