EKS-ORL-00005

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00005

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Eph	511.3	4.3E-154	633	891	259

Status

Unreviewed

Ensembl Protein

ENSORLP00000024698

UniProt Accession

H2N014;

Protein Name

Protein Synonyms/Alias

Gene Name

EPHB2 (2 of 2)

Gene Synonyms/Alias

EPHB2 (2 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000019878	ENSORLP00000024698	ENSORLT00000024699

Organism

Oryzias latipes

Functional Description

Protein Length

998

Protein Sequence
(FASTA)

YNPKYCCTIP TDAKICFCVS AEVLMDSTTA TAELGWIIYP SQGWEEVSGY DENMSTIRTY 60

QVCNVFDNSQ NNWIRTKYIR RRGAQRIHVL MKFSVRDCSS IPNVPGSCKE TFNLYYYESD 120

SDVATKTFPP WMENPWVKVD TIAADESFSH VDLGGRIMKI NSEVRSFGPV SRSGFYLAFQ 180

DYGACMSLIA VRVFYRKCPR VVQNGAVFPE TLSGAESTSL VAARGVCVPN GEEVDVPIKL 240

YCNGDGEWMV PIGRCMCKAG YEALENGTVC KGNGDGGFFQ SAQGDDRCRQ CPINSRTIHE 300

GATNCICRNS YYRTDSDPPQ MPCTTIPSTP QNVISIVNET SLRLEWNPPQ ESGGRDDVVY 360

NIICKSCGSG RGLCTRCGDN VQFVPRQLGL TNTQVYISDL LAHTQYTFEI QAVNGVSDQS 420

PYSPQYASVN ITTNQAAPSA VSIIHQVSRT PNTITLSWSQ PDQPNGVILD YELQYYEKNQ 480

AEWNSSLIRS QTNTAVVQNL KPGSIYVFQV RARTVAGFGR FSGKMYFQTM TDEEYNSTIQ 540

EKLPLIIGSS AAGVVFIIAI TVVITVCRGR RNSDRPESEY ADKLQHYTSG HSNYGGFLVE 600

VSPGMKIYID PFTYEDPNEA VREFAKEIDI SCVKIEQVIG AGEFGEVCSG NLRQPGKREI 660

LVAIKTLKAG YTERQRRDFL SEASIMGQFD HPNIIHLEGV VTKSSPVMII TEFMENGSLD 720

SFLRQNDGQF TVIQLVGMLR GIAAGMKYLC DMNYVHRDLA ARNILVNSNL VCKVSDFGLS 780

RFLEDDTSDP TYTSALGGKI PIRWTAPEAI QYRKFTSSSD CWSYGIVMWE VMSYGERPYW 840

DMSNQDVINA IEQDYRLPPP MDCPSALHQL MLDCWQKDRN NRPKFSQIVA NLDKMIRNPS 900

SLKAMTPQSS SVHLPLLDRS TPDFSSFGSV DDWLDAIKMG QYKENFSSEG FTSFDVVSQM 960

AMEDILRVGV TLAGHQKKIL NSIQSMRAQL NQITSVEV 998

Nucleotide Sequence
(FASTA)

TACAATCCTA AATATTGTTG CACTATACCA ACAGATGCTA AAATCTGTTT TTGTGTTTCT 60

GCAGAGGTAC TGATGGATTC AACAACAGCT ACAGCAGAAC TGGGCTGGAT CATCTACCCG 120

TCGCAAGGGT GGGAAGAAGT TAGCGGATAT GATGAAAATA TGAGTACTAT CCGCACATAC 180

CAAGTATGCA ACGTCTTCGA TAACAGCCAG AACAACTGGA TTCGCACCAA GTACATCCGT 240

CGACGTGGTG CTCAGAGGAT CCATGTCCTG ATGAAGTTTT CAGTTCGGGA CTGCAGCTCC 300

ATACCCAACG TTCCTGGCTC CTGTAAGGAG ACTTTCAACC TTTATTACTA TGAGTCTGAC 360

TCTGACGTGG CAACTAAAAC CTTCCCTCCA TGGATGGAGA ACCCCTGGGT GAAGGTGGAC 420

ACTATAGCAG CTGATGAGAG CTTTTCTCAT GTTGACCTTG GTGGACGCAT CATGAAAATT 480

AATAGTGAGG TTCGCAGTTT TGGTCCTGTT TCACGTAGTG GGTTCTACCT TGCTTTCCAG 540

GATTATGGAG CTTGCATGTC TCTCATTGCT GTTCGAGTCT TCTACAGAAA ATGTCCAAGA 600

GTTGTCCAGA ACGGTGCTGT TTTTCCTGAA ACTTTGTCTG GAGCAGAAAG CACCTCTTTG 660

GTGGCAGCCA GAGGAGTTTG TGTTCCCAAC GGGGAGGAGG TGGATGTACC CATCAAGTTG 720

TATTGTAATG GGGATGGAGA GTGGATGGTT CCTATTGGAC GCTGCATGTG CAAAGCTGGG 780

TATGAGGCTC TGGAAAATGG CACAGTCTGC AAAGGTAATG GGGATGGGGG GTTTTTTCAA 840

TCTGCCCAGG GAGATGACAG ATGTCGCCAG TGCCCCATCA ACAGTCGAAC AATTCATGAA 900

GGAGCCACAA ACTGCATTTG CCGGAATAGC TACTACCGCA CGGACTCTGA TCCTCCCCAG 960

ATGCCTTGTA CCACCATTCC ATCAACTCCA CAAAATGTCA TCTCGATAGT AAATGAGACT 1020

TCTCTAAGAT TAGAGTGGAA CCCACCACAA GAAAGTGGTG GCCGAGACGA TGTGGTCTAC 1080

AATATCATAT GCAAGAGCTG TGGCAGTGGA CGTGGACTCT GCACCCGCTG TGGAGACAAT 1140

GTCCAATTTG TTCCACGTCA GCTAGGACTC ACCAACACCC AAGTCTACAT CAGCGACCTT 1200

CTGGCTCACA CCCAATACAC CTTTGAAATA CAAGCTGTCA ATGGAGTATC TGACCAGAGC 1260

CCTTATTCAC CACAATATGC ATCTGTCAAC ATCACTACCA ATCAGGCTGC ACCATCAGCA 1320

GTATCAATCA TCCATCAGGT CAGCAGGACA CCTAACACCA TCACTCTGTC CTGGTCCCAG 1380

CCCGACCAGC CCAATGGTGT TATCTTGGAC TATGAGCTGC AGTACTATGA GAAGAACCAG 1440

GCTGAATGGA ACTCATCTCT AATAAGGAGT CAAACGAATA CAGCAGTCGT ACAAAATCTT 1500

AAGCCCGGGA GCATCTACGT CTTTCAGGTT CGAGCTCGGA CTGTCGCTGG ATTTGGACGT 1560

TTTAGTGGCA AGATGTACTT CCAAACCATG ACTGATGAGG AATATAACTC CACTATCCAG 1620

GAGAAGCTTC CCCTCATTAT TGGCTCCTCT GCAGCAGGAG TCGTCTTCAT CATTGCCATC 1680

ACTGTTGTCA TAACAGTTTG TCGCGGCAGG AGAAACTCTG ACCGACCAGA ATCCGAGTAT 1740

GCCGACAAGC TCCAACATTA CACCAGTGGC CACAGTAACT ATGGAGGCTT TCTGGTTGAA 1800

GTGTCACCAG GAATGAAGAT CTACATTGAT CCCTTCACGT ATGAAGATCC CAATGAAGCA 1860

GTCAGAGAGT TTGCTAAGGA GATTGACATT TCCTGTGTCA AGATAGAGCA AGTGATTGGT 1920

GCAGGAGAGT TTGGGGAGGT TTGCAGTGGA AACCTCAGAC AGCCAGGAAA GAGAGAGATT 1980

CTGGTGGCAA TTAAGACGCT AAAGGCAGGC TACACGGAAC GGCAGCGACG GGACTTCCTG 2040

AGTGAAGCCT CCATCATGGG CCAGTTTGAT CACCCCAACA TCATTCATTT GGAGGGAGTA 2100

GTGACCAAGA GCAGTCCTGT TATGATCATC ACAGAGTTTA TGGAGAACGG ATCCCTGGAC 2160

TCCTTCCTCA GGCAAAATGA CGGGCAGTTC ACCGTAATCC AGCTGGTGGG AATGCTGCGA 2220

GGCATAGCAG CGGGGATGAA ATACCTGTGT GACATGAACT ACGTTCATCG GGACCTGGCA 2280

GCCAGGAACA TCCTCGTAAA CAGCAACCTG GTGTGCAAGG TATCCGACTT CGGCCTGTCA 2340

CGCTTCCTAG AGGATGATAC TTCAGACCCA ACTTACACAA GCGCTCTGGG AGGCAAGATT 2400

CCCATCCGCT GGACGGCTCC AGAAGCCATT CAGTACAGGA AGTTCACATC ATCGAGTGAC 2460

TGCTGGAGTT ACGGCATAGT CATGTGGGAG GTGATGTCTT ATGGAGAGAG GCCATACTGG 2520

GACATGAGCA ATCAAGATGT CATCAATGCC ATCGAGCAAG ATTACCGGTT GCCTCCTCCT 2580

ATGGATTGTC CGAGTGCGTT GCATCAGCTG ATGCTAGACT GCTGGCAAAA AGATCGCAAC 2640

AACCGACCCA AATTTAGTCA GATTGTCGCC AACTTGGATA AGATGATTCG TAACCCCAGC 2700

AGCTTGAAGG CCATGACACC TCAGTCATCA AGCGTTCACC TACCTCTGCT GGATCGCAGC 2760

ACTCCAGACT TCTCCTCCTT CGGCTCAGTG GATGACTGGC TTGACGCCAT CAAGATGGGC 2820

CAGTATAAGG AAAACTTCAG CAGTGAGGGG TTCACCAGCT TTGATGTGGT GTCCCAAATG 2880

GCCATGGAGG ACATCCTTCG TGTAGGAGTG ACGCTGGCTG GACATCAGAA GAAGATCCTT 2940

AACAGCATCC AATCCATGAG GGCACAGCTG AACCAGATAA CCTCTGTAGA GGTGTGA 2997

Domain Profile

S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60

         vkie+viGaGefGevcsG+l++pgkrei vaiktlkag+te+qrrdflseasi+Gqfdhp

Q: 633   VKIEQVIGAGEFGEVCSGNLRQPGKREILVAIKTLKAGYTERQRRDFLSEASIMGQFDHP  692

         79**********************************************************

S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120

         nii+leGvvtks+pvmi+te+meng+ldsflr++dgqftviqlvgmlrGia+gmkyl+dm

Q: 693   NIIHLEGVVTKSSPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLCDM  752

         ************************************************************

S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvledds.eaaytts.ggkipirwtapeaiay  178

         +yvhrdlaarnilvnsnlvckvsdfGlsr+ledd+ +++yt++ ggkipirwtapeai+y

Q: 753   NYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTsDPTYTSAlGGKIPIRWTAPEAIQY  812

         **********************************99*****999****************

S: 179   rkftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlml  238

         rkfts+sd wsyGiv+wev+syGerpywdmsnqdvi+aie++yrlpppmdcp+al+qlml

Q: 813   RKFTSSSDCWSYGIVMWEVMSYGERPYWDMSNQDVINAIEQDYRLPPPMDCPSALHQLML  872

         ************************************************************

S: 239   dcwqkdraerpkfeqivsi  257

         dcwqkdr++rpkf+qiv+

Q: 873   DCWQKDRNNRPKFSQIVAN  891

         ****************986

Domain Sequence
(FASTA)

VKIEQVIGAG EFGEVCSGNL RQPGKREILV AIKTLKAGYT ERQRRDFLSE ASIMGQFDHP 60

NIIHLEGVVT KSSPVMIITE FMENGSLDSF LRQNDGQFTV IQLVGMLRGI AAGMKYLCDM 120

NYVHRDLAAR NILVNSNLVC KVSDFGLSRF LEDDTSDPTY TSALGGKIPI RWTAPEAIQY 180

RKFTSSSDCW SYGIVMWEVM SYGERPYWDM SNQDVINAIE QDYRLPPPMD CPSALHQLML 240

DCWQKDRNNR PKFSQIVAN 259

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005887	; C:integral to plasma membrane
GO:0005524	; F:ATP binding
GO:0005003	; F:ephrin receptor activity

KEGG

InterPros

IPR001090	; Ephrin_rcpt_lig-bd_dom.
IPR003961	; Fibronectin_type3.
IPR008979	; Galactose-bd-like.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001660	; SAM.
IPR013761	; SAM/pointed.
IPR021129	; SAM_type1.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016257	; Tyr_kinase_ephrin_rcpt.
IPR001426	; Tyr_kinase_rcpt_V_CS.

Pfam

PF01404	; Ephrin_lbd; 1.
PF00041	; fn3; 2.
PF07714	; Pkinase_Tyr; 1.
PF00536	; SAM_1; 1.

SMARTs

SM00615	; EPH_lbd; 1.
SM00060	; FN3; 2.
SM00454	; SAM; 1.
SM00219	; TyrKc; 1.

Prosites

PS51550	; EPH_LBD; 1.
PS50853	; FN3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00790	; RECEPTOR_TYR_KIN_V_1; 1.
PS00791	; RECEPTOR_TYR_KIN_V_2; 1.
PS50105	; SAM_DOMAIN; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013