EKS-ORL-00128

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00128

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/MLCK	391.9	1.4E-117	453	708	256

Status

Unreviewed

Ensembl Protein

ENSORLP00000024981

UniProt Accession

H2N0R4;

Protein Name

Protein Synonyms/Alias

Gene Name

MYLK

Gene Synonyms/Alias

MYLK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000020132	ENSORLP00000024981	ENSORLT00000024982

Organism

Oryzias latipes

Functional Description

Protein Length

893

Protein Sequence
(FASTA)

MDFKANLKGV KPKTEDKSNS PNQVDFRSVL GKKGGTAASN KPAETPGKNV SDFRSILTNK 60

KKPTSPENNS ERVNNFVDGK IHERNQVSAP ALEFVEKLSD VSVLDGQRLR LECRLAATAA 120

DAAVTWTLDG KIIKPSKFII LANEGGLCSL TIDKALPEDQ GQYKCRAEKS TGSAECSCTV 180

LVDATDPAEN SPVDKKSKKA TPTSESEARI KKPTAKTPPK QALPPQILHF PEDMKILAGQ 240

KVEILCKFSG APPITCTWLK FRKPILDSSS DISVESTDSS STLTISSGQQ EHCGCYSVEL 300

KNGFGMRQAA LNLTIVDKPD PPAKVPAASD IRRSSLTLSW YGPTYDGGSA VQSYHLEIWD 360

SAEPQWKQLV SCNSTSYNVQ NLLPDRQYKF RVRAQNIYGI GEPSVESEPV TVRLEDEENQ 420

EEAEAEEDDE DLEKEPEYRD VNIRTDMKVK ELYDVEERLG TGKFGQVFKL VEKATKKVWA 480

GKFIKAYSAK EKENVRQEIS IMNSLHHPKL VQCVDAFEGK SDMVMVLEMI SGGELFERII 540

DEDFELTERE VIKYMLQIID GVNFIHKQGI VHLDLKPENI MCINKTGSKI KLIDFGLARR 600

LENAGTLKVL FGTPEFVAPE VINYEAISYP TDMWSIGVIC YILLSGLSPF MGDSDNETLS 660

NVTSASWDFE DEAFDEISEN AKDFITNLLK KDMRARLTCA QCFEHPWLKQ DTNTMKAKKL 720

SKERMKKYIL RRKWQKTGHA VRAIGRLSSM AMMAGVSAKK GSPTEEDNQF LECLEYEQRA 780

ECKPSFSKVI RDVEVVEGSA ARFDCKIEGY PDPEVVWYKD DQPIKETRHF QIDYDEDGNC 840

SLIISEVSGD DDAKYTVKAV NILGEATCTA ELLVEVMAGA GETQQEQDGA RCS 893

Nucleotide Sequence
(FASTA)

ATGGATTTTA AGGCCAATCT TAAGGGTGTC AAGCCCAAGA CAGAAGACAA GAGCAACTCT 60

CCCAACCAGG TCGACTTCCG AAGTGTGCTG GGGAAGAAGG GTGGTACTGC TGCAAGCAAC 120

AAGCCAGCTG AGACACCAGG CAAGAATGTC AGTGACTTCC GTTCCATTCT CACTAACAAG 180

AAGAAGCCGA CAAGTCCTGA GAACAACAGT GAGAGGGTGA ACAATTTTGT AGATGGAAAG 240

ATACATGAGA GGAATCAAGT AAGTGCACCT GCACTGGAGT TTGTGGAGAA GCTGAGTGAT 300

GTGAGTGTAC TGGACGGTCA GCGGCTCCGG CTGGAGTGTC GCCTCGCCGC CACTGCTGCT 360

GATGCTGCCG TCACCTGGAC CCTGGACGGG AAGATCATTA AACCATCCAA GTTCATTATT 420

CTTGCCAATG AAGGGGGTCT GTGCTCTCTG ACCATAGACA AGGCTCTGCC AGAGGATCAG 480

GGCCAGTACA AATGCAGAGC GGAGAAGTCG ACGGGCTCAG CCGAGTGTTC TTGCACAGTT 540

CTTGTTGACG CTACAGACCC AGCAGAAAAC TCTCCTGTGG ACAAGAAGTC CAAGAAGGCG 600

ACTCCAACCT CAGAGAGTGA GGCCAGAATA AAGAAGCCTA CGGCAAAGAC TCCGCCCAAA 660

CAAGCTCTGC CTCCTCAGAT CCTGCATTTT CCAGAGGACA TGAAGATCCT GGCTGGACAG 720

AAGGTGGAGA TTCTGTGCAA GTTCTCTGGA GCTCCGCCCA TCACATGCAC CTGGCTGAAG 780

TTCAGAAAAC CAATCCTGGA CAGTTCGTCT GACATTTCCG TGGAGAGCAC AGACAGCAGC 840

AGCACGCTGA CCATCAGCAG CGGCCAGCAG GAGCACTGCG GCTGCTACTC CGTGGAGCTG 900

AAGAACGGCT TTGGGATGCG ACAGGCCGCC CTCAACCTCA CCATAGTGGA TAAGCCTGAC 960

CCACCAGCAA AAGTCCCTGC CGCCTCAGAC ATCCGGCGGT CCAGCCTGAC ACTGTCATGG 1020

TACGGGCCAA CCTACGATGG AGGCAGTGCC GTGCAGTCCT ACCACTTAGA GATCTGGGAT 1080

TCTGCAGAGC CGCAGTGGAA ACAGTTGGTG TCCTGCAACA GCACATCCTA CAATGTGCAA 1140

AACCTTCTTC CAGATCGTCA GTACAAGTTC CGTGTCCGGG CGCAAAACAT CTACGGCATC 1200

GGAGAGCCGA GCGTCGAGTC GGAACCTGTG ACTGTTAGGC TGGAAGATGA AGAAAACCAG 1260

GAGGAGGCTG AGGCAGAGGA GGACGATGAA GACTTGGAAA AAGAGCCTGA ATACAGAGAT 1320

GTGAACATTC GAACTGACAT GAAAGTGAAA GAGCTGTACG ACGTGGAGGA ACGATTGGGG 1380

ACGGGGAAGT TTGGTCAGGT CTTCAAGCTG GTGGAGAAAG CCACAAAGAA GGTTTGGGCA 1440

GGAAAATTCA TCAAGGCGTA CTCAGCAAAG GAGAAGGAAA ATGTCCGGCA GGAGATCAGC 1500

ATCATGAACA GCCTCCATCA CCCCAAACTG GTCCAATGTG TGGATGCTTT TGAGGGCAAG 1560

TCAGACATGG TCATGGTCCT GGAGATGATC TCAGGCGGTG AGCTTTTTGA GCGGATTATC 1620

GACGAGGACT TTGAGCTGAC TGAGAGAGAG GTGATCAAAT ACATGCTCCA GATCATTGAT 1680

GGTGTCAACT TCATCCACAA GCAAGGCATC GTTCACCTCG ACCTCAAACC AGAGAACATC 1740

ATGTGCATCA ATAAGACCGG CAGCAAAATC AAACTGATAG ATTTTGGCCT CGCCAGACGA 1800

CTAGAAAACG CTGGAACCTT GAAGGTTTTG TTTGGAACTC CAGAGTTTGT GGCTCCAGAA 1860

GTGATCAACT ATGAAGCCAT CAGTTACCCC ACTGACATGT GGAGCATAGG AGTCATCTGT 1920

TACATCCTTT TAAGCGGGTT GTCTCCTTTC ATGGGTGACA GTGACAATGA GACCCTGTCC 1980

AACGTCACCT CGGCCTCATG GGACTTTGAG GATGAAGCAT TCGATGAAAT CTCAGAAAAT 2040

GCCAAAGACT TCATCACAAA CCTGCTAAAA AAAGACATGA GGGCTCGGCT GACCTGCGCT 2100

CAGTGCTTTG AACACCCCTG GCTGAAGCAG GACACCAACA CCATGAAAGC CAAGAAGCTC 2160

TCCAAGGAGC GGATGAAAAA GTACATCTTG AGGAGGAAAT GGCAGAAAAC AGGGCACGCT 2220

GTCCGGGCCA TCGGCAGACT GTCATCTATG GCCATGATGG CTGGAGTCAG CGCCAAGAAG 2280

GGCTCCCCCA CCGAAGAGGA CAACCAGTTC CTGGAGTGCT TGGAGTACGA GCAGAGAGCT 2340

GAGTGTAAGC CAAGCTTCAG CAAGGTCATC AGAGATGTGG AGGTCGTGGA GGGCAGTGCC 2400

GCCCGCTTCG ACTGCAAAAT AGAAGGCTAT CCTGACCCGG AGGTGGTGTG GTACAAAGAT 2460

GACCAGCCCA TCAAAGAAAC TCGGCACTTT CAGATCGACT ACGACGAAGA TGGAAACTGC 2520

AGTCTAATCA TTTCAGAGGT GTCGGGTGAC GATGACGCCA AATACACAGT GAAGGCGGTT 2580

AACATCCTTG GGGAAGCAAC CTGCACCGCC GAGCTGCTGG TGGAGGTGAT GGCAGGAGCT 2640

GGCGAGACTC AGCAGGAGCA GGATGGAGCT CGCTGTTCC 2679

Domain Profile

S: 1     ysikeelgkGkfgvvvkavekstgkklaakivkvrkekdkeevkkEieilnqlrHekliq  60

         y+++e+lg+Gkfg+v+k vek+t+k++a+k++k+ ++k+ke+v++Ei+i+n+l+H+kl+q

Q: 453   YDVEERLGTGKFGQVFKLVEKATKKVWAGKFIKAYSAKEKENVRQEISIMNSLHHPKLVQ  512

         7899********************************************************

S: 61    lydafeskeeivlvlElveggelferiveedyeltEeevvlfvrqvlealeylHkkgivH  120

         ++dafe k+++v+vlE+++ggelferi++ed+eltE+ev++++ q++++++++Hk+givH

Q: 513   CVDAFEGKSDMVMVLEMISGGELFERIIDEDFELTEREVIKYMLQIIDGVNFIHKQGIVH  572

         ************************************************************

S: 121   ldlkpenillqskkskqiKlidFGlarklkkkeklkvlfgtpefvaPEvvnkepvslatD  180

         ldlkpeni++ +k++++iKlidFGlar+l+++ +lkvlfgtpefvaPEv+n+e +s+ tD

Q: 573   LDLKPENIMCINKTGSKIKLIDFGLARRLENAGTLKVLFGTPEFVAPEVINYEAISYPTD  632

         ************************************************************

S: 181   mWsvGvityvLlsGlsPFlgdndeetlenvssakydfdeeafkevseeakdFiskllvke  240

         mWs+Gvi+y+LlsGlsPF+gd+d+etl+nv+sa++df++eaf+e+se+akdFi++ll+k+

Q: 633   MWSIGVICYILLSGLSPFMGDSDNETLSNVTSASWDFEDEAFDEISENAKDFITNLLKKD  692

         ************************************************************

S: 241   kkkRmsaeeaLkhkwl  256

         +++R++++++++h+wl

Q: 693   MRARLTCAQCFEHPWL  708

         ***************8

Domain Sequence
(FASTA)

YDVEERLGTG KFGQVFKLVE KATKKVWAGK FIKAYSAKEK ENVRQEISIM NSLHHPKLVQ 60

CVDAFEGKSD MVMVLEMISG GELFERIIDE DFELTEREVI KYMLQIIDGV NFIHKQGIVH 120

LDLKPENIMC INKTGSKIKL IDFGLARRLE NAGTLKVLFG TPEFVAPEVI NYEAISYPTD 180

MWSIGVICYI LLSGLSPFMG DSDNETLSNV TSASWDFEDE AFDEISENAK DFITNLLKKD 240

MRARLTCAQC FEHPWL 256

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Repeat; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR003961	; Fibronectin_type3.
IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR020675	; Myosin_light_ch_kinase-rel.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00041	; fn3; 1.
PF07679	; I-set; 3.
PF00069	; Pkinase; 1.

SMARTs

SM00060	; FN3; 1.
SM00409	; IG; 1.
SM00408	; IGc2; 2.
SM00220	; S_TKc; 1.

Prosites

PS50853	; FN3; 1.
PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013