EKS-ORL-00015
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORL-00015
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph475.34.0E-143620875256
StatusUnreviewed
Ensembl ProteinENSORLP00000024998
UniProt AccessionH2N0S8;
Protein Name
Protein Synonyms/Alias
Gene NameEPHA2 (1 of 2)
Gene Synonyms/Alias EPHA2 (1 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSORLG00000020136ENSORLP00000025001ENSORLT00000025002
ENSORLG00000020136ENSORLP00000024998ENSORLT00000024999
OrganismOryzias latipes
Functional Description
Protein Length981
Protein Sequence
(FASTA)
MDFPLGNWLF FSLCLLITRT VITLQSNEVV LLDMRKVGGE LGWLTLPLKE PGWEVTQRTL 60
NGSQFYTYSV CNVEEREQDN WLRTTFIQRG ASVSRVFVEI QFLVRDCNSF DGGSLTCKET 120
FNLFMSESDA DVGMTFRKGQ FKKVATVAPD KISGKGEMNI NTETKVVESL SRKGFYLAFQ 180
DIGACVALLS VRVYYKICPE KVMELALFPE TVASPGLRKV NGKCVDHAVA AELPHSHCSA 240
DGDWVVQVGR CLCQAGYEKV KDSCQGCQPG FFKAEASNRS CEACPANSQA LVSGAQFCFC 300
KDGFYRAPTD LRTGPCTGLP SAPRDLMAST QLPSGKLLLS WKPPEDTGDR EDITYNVECQ 360
RCDGPVCQTC GEKIRYEPGS VGLTDTKVLV SQLDAHLNYT FTVEALSGVS QVLEEEMPSS 420
TSITTSVLFT DPPKPISIQL VEQTPTSLSL SWDVSPRSQP TSYELTYRKK DDNLDKTTYI 480
WLKLEKNYAQ IKDLAPATAY LFRVQALSSD GSHGGFSQEE QFETLSEEHH SKTAVILAAA 540
AGGASMLILV LVVLFVRRRF KISCVSGEEI LTGRDKTTLT FPPQAEQLKP LKTYVDPHTY 600
EDPNVAVLKF ATEIPPSHVT KQKVIGAGEF GEVYKGILKA PGKKEFAVAI KTLKSGYSEK 660
QRQDFLSEAS IMGQFSHQNI IRLEGVVTKF KHAMIVTEYV ENGALDKYLR NHDGEFSSFQ 720
LVGMLRGIAA GMKYLSDMSY VHRDLAARNI LVNNNLECKV SDFGLSRVLE DDPEGTYTTS 780
GGKIPIRWTA PEAIAYRKFT SASDVWSFGI VMWEVMAFGE RPYWDMSNHE VMKAINEAFR 840
LPAPMDCPST VYQLMLQCWL QDRSKRPRFG DIVSLLDKLV RSPDSLKTIA DFDPRISIRL 900
PSTSGSDGSP FRSVSEWLES IKMNQYIDNF TSAGILTMDQ VLQMKNEDVK NIGVRLPGHL 960
KRIAYSILGL KDQTSTLSVF A 981
Nucleotide Sequence
(FASTA)
ATGGATTTTC CTCTTGGAAA TTGGCTTTTC TTCTCTCTGT GCCTGCTGAT TACCAGGACT 60
GTAATAACGT TACAGAGTAA CGAAGTGGTG CTTTTGGACA TGAGGAAGGT CGGAGGGGAG 120
CTGGGCTGGT TGACGCTTCC GCTGAAGGAG CCCGGGTGGG AGGTCACCCA AAGAACCCTT 180
AACGGTTCTC AGTTCTACAC CTACTCAGTC TGCAATGTTG AGGAACGTGA GCAGGACAAC 240
TGGCTGCGTA CCACCTTCAT CCAGCGAGGT GCATCGGTCT CTCGGGTTTT TGTTGAAATT 300
CAGTTTCTTG TCAGAGACTG TAACTCATTT GATGGAGGGT CATTGACGTG CAAGGAAACA 360
TTCAACCTCT TCATGTCCGA GTCGGACGCA GACGTCGGTA TGACCTTCCG CAAGGGCCAG 420
TTCAAGAAGG TGGCCACCGT TGCCCCGGAC AAGATCAGCG GTAAAGGAGA AATGAACATC 480
AACACAGAGA CAAAGGTGGT GGAGAGCCTA TCTCGGAAAG GATTTTACCT GGCGTTTCAA 540
GACATTGGAG CCTGCGTGGC TCTCCTCTCT GTCCGAGTCT ACTACAAAAT CTGCCCAGAA 600
AAGGTCATGG AGCTCGCTCT GTTCCCCGAA ACTGTGGCAA GCCCCGGATT AAGGAAGGTG 660
AATGGGAAGT GTGTGGACCA CGCTGTCGCC GCGGAACTGC CGCACAGCCA CTGCTCTGCG 720
GACGGAGACT GGGTGGTGCA AGTAGGACGA TGTCTGTGCC AAGCAGGTTA TGAGAAGGTG 780
AAAGACTCGT GTCAAGGGTG TCAGCCAGGC TTCTTCAAGG CTGAAGCCTC CAACAGATCG 840
TGCGAGGCTT GCCCTGCCAA CTCTCAGGCT CTGGTCTCTG GAGCCCAGTT TTGCTTCTGC 900
AAGGATGGAT TTTATCGAGC ACCAACAGAT CTGCGCACAG GGCCCTGCAC AGGCCTCCCC 960
TCTGCTCCCC GCGACCTCAT GGCCTCCACC CAGCTCCCGT CAGGGAAACT GCTCCTCTCC 1020
TGGAAGCCGC CTGAAGACAC TGGAGATCGG GAGGACATAA CCTATAATGT GGAGTGCCAG 1080
CGCTGTGACG GTCCTGTCTG TCAAACCTGC GGAGAGAAGA TCCGCTACGA GCCTGGCAGC 1140
GTGGGCCTCA CCGACACCAA GGTGCTAGTG AGCCAGCTGG ATGCACACCT GAACTACACC 1200
TTCACTGTGG AGGCTCTTAG TGGTGTATCT CAGGTTCTTG AGGAGGAAAT GCCATCTTCC 1260
ACCTCCATCA CTACATCTGT GCTCTTCACA GATCCCCCAA AACCTATAAG CATACAACTG 1320
GTTGAACAGA CTCCCACCAG TTTGTCCCTT TCCTGGGATG TCTCCCCTCG TTCTCAGCCA 1380
ACCAGCTATG AACTTACCTA CCGCAAGAAG GACGATAATC TGGATAAAAC GACCTACATT 1440
TGGCTTAAAT TGGAGAAAAA CTACGCTCAG ATCAAGGATC TGGCCCCGGC TACTGCCTAT 1500
CTCTTCAGGG TTCAGGCTCT CAGCAGTGAT GGCAGCCACG GAGGCTTCAG CCAGGAGGAA 1560
CAGTTCGAGA CCTTGTCTGA AGAACACCAT AGCAAGACAG CAGTTATCCT GGCTGCTGCG 1620
GCGGGAGGAG CCAGCATGTT GATCCTTGTG CTTGTGGTTC TGTTTGTGCG CAGACGTTTT 1680
AAAATATCCT GTGTTTCAGG AGAAGAAATT CTCACAGGCA GAGACAAGAC GACACTTACT 1740
TTTCCACCCC AGGCAGAGCA GTTAAAGCCG CTGAAGACGT ACGTGGATCC ACACACATAC 1800
GAGGACCCCA ACGTAGCTGT GCTGAAGTTT GCCACAGAAA TCCCCCCCAG CCATGTAACA 1860
AAACAGAAAG TCATTGGAGC TGGAGAATTT GGAGAGGTGT ACAAAGGAAT TTTAAAGGCT 1920
CCAGGGAAGA AGGAGTTTGC AGTAGCTATC AAGACGCTGA AGTCCGGATA CTCTGAGAAG 1980
CAGAGGCAGG ATTTCCTGAG CGAGGCCTCG ATCATGGGCC AGTTCTCCCA TCAGAACATC 2040
ATCCGTCTGG AGGGCGTGGT TACCAAATTT AAACATGCTA TGATAGTGAC TGAATACGTG 2100
GAGAATGGAG CACTGGACAA ATACCTGAGG AACCACGATG GAGAGTTTTC CTCCTTCCAG 2160
CTGGTGGGCA TGCTGCGTGG AATCGCAGCT GGCATGAAGT ACCTCTCAGA CATGAGTTAC 2220
GTTCACCGGG ACCTGGCTGC TCGCAACATC CTGGTCAACA ACAACCTGGA GTGCAAAGTG 2280
TCTGATTTCG GCCTGTCCCG AGTGCTGGAA GATGATCCTG AGGGGACATA TACCACAAGT 2340
GGAGGTAAAA TTCCCATTCG CTGGACGGCT CCAGAGGCAA TAGCCTACAG GAAGTTTACT 2400
TCAGCAAGTG ATGTTTGGAG TTTTGGCATC GTCATGTGGG AAGTCATGGC GTTTGGAGAA 2460
AGACCCTACT GGGATATGAG TAACCACGAG GTGATGAAGG CTATCAATGA GGCTTTCAGG 2520
CTGCCTGCAC CCATGGACTG CCCTTCAACT GTCTACCAGT TGATGCTGCA GTGCTGGCTG 2580
CAGGATCGGT CAAAGAGGCC GCGCTTCGGA GACATCGTAA GCCTGCTGGA CAAGTTGGTG 2640
CGCAGCCCCG ACTCCCTGAA GACCATTGCA GACTTTGATC CACGCATTTC AATCCGTCTG 2700
CCAAGCACCA GCGGCTCGGA CGGTTCTCCC TTCAGGTCCG TGTCCGAATG GCTGGAGTCC 2760
ATTAAAATGA ACCAGTACAT TGACAACTTC ACATCTGCTG GGATACTCAC CATGGACCAG 2820
GTCTTGCAGA TGAAGAATGA GGACGTCAAG AACATTGGCG TGAGGCTCCC CGGCCATCTA 2880
AAGAGAATCG CTTACAGCAT CTTGGGTTTA AAGGACCAGA CAAGCACCCT GAGTGTGTTT 2940
GCA 2943
Domain Profile
S: 2     kiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhpn  61
         + +kviGaGefGev++G lk+pgk+e avaiktlk+g++ekqr+dflseasi+Gqf+h+n
Q: 620   TKQKVIGAGEFGEVYKGILKAPGKKEFAVAIKTLKSGYSEKQRQDFLSEASIMGQFSHQN  679
         6789********************************************************
S: 62    iirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdmg  121
         iirleGvvtk k  mivtey+engald++lr++dg+f++ qlvgmlrGia+gmkylsdm+
Q: 680   IIRLEGVVTKFKHAMIVTEYVENGALDKYLRNHDGEFSSFQLVGMLRGIAAGMKYLSDMS  739
         ************************************************************
S: 122   yvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrkf  181
         yvhrdlaarnilvn+nl ckvsdfGlsrvledd+e +yttsggkipirwtapeaiayrkf
Q: 740   YVHRDLAARNILVNNNLECKVSDFGLSRVLEDDPEGTYTTSGGKIPIRWTAPEAIAYRKF  799
         ************************************************************
S: 182   tsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldcw  241
         tsasdvws+Giv+wev+++Gerpywdmsn++v+kai+e +rlp+pmdcp+++yqlml+cw
Q: 800   TSASDVWSFGIVMWEVMAFGERPYWDMSNHEVMKAINEAFRLPAPMDCPSTVYQLMLQCW  859
         ************************************************************
S: 242   qkdraerpkfeqivsi  257
          +dr++rp+f +ivs+
Q: 860   LQDRSKRPRFGDIVSL  875
         **************97
Domain Sequence
(FASTA)
TKQKVIGAGE FGEVYKGILK APGKKEFAVA IKTLKSGYSE KQRQDFLSEA SIMGQFSHQN 60
IIRLEGVVTK FKHAMIVTEY VENGALDKYL RNHDGEFSSF QLVGMLRGIA AGMKYLSDMS 120
YVHRDLAARN ILVNNNLECK VSDFGLSRVL EDDPEGTYTT SGGKIPIRWT APEAIAYRKF 180
TSASDVWSFG IVMWEVMAFG ERPYWDMSNH EVMKAINEAF RLPAPMDCPS TVYQLMLQCW 240
LQDRSKRPRF GDIVSL 256
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00009
EKS-ANC-00009
EKS-BOT-00008
EKS-CAF-00010
EKS-CAP-00007
EKS-DAR-00015
EKS-EQC-00010
EKS-FEC-00007
EKS-GAM-00004
EKS-GAA-00015
EKS-HOS-00011
EKS-ICT-00009
EKS-LAC-00010
EKS-LOA-00010
EKS-MAM-00009
EKS-MAE-00001
EKS-MOD-00009
EKS-MUM-00010
EKS-MUP-00010
EKS-MYL-00011
EKS-NOL-00009
EKS-OCP-00002
EKS-ORN-00018
EKS-ORA-00008
EKS-ORC-00009
EKS-OTG-00010
EKS-PAT-00012
EKS-PES-00008
EKS-POA-00010
EKS-RAN-00009
EKS-SAH-00008
EKS-SUS-00007
EKS-TAR-00014
EKS-TEN-00014
EKS-XIM-00015
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005003; F:ephrin receptor activity
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR009030; Growth_fac_rcpt.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013