EKS-PRC-00015

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PRC-00015

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	323.8	7.2E-97	883	1153	271

Status

Unreviewed

Ensembl Protein

ENSPCAP00000002696

Gene Name

TYK2

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPCAG00000002803	ENSPCAP00000002696	ENSPCAT00000002864

Organism

Procavia capensis

Protein Length

1173

Protein Sequence
(FASTA)

KPDGDRAQPA ATRGDLRVHL HWAGPGGGEP CVTFSEASQT AEEICIYIAH KIGITPLCSN 60

LFALYDAQSQ VWLPPNHILE VPRDSSLNLH YRMRFYFRNW HGMNPQEPTV YRCGPPGAEA 120

SSDQVEHGLQ FLDPASFEYL FEQGKYEFVN DVASLWELSS EEETHHFKNE SLGMAFLHLC 180

HLALHRGVPL EEVAKKISFK DCIPRSFRSQ IRQHNALTRL RLRSIFHKFL RAFQPGHLSQ 240

QLVMVKYLAT LERLAPRFAT ERVPVCHLEL LAQVGREPCY KQDHEQAPLD PGNKYAPGAP 300

THEVLVTGTG GIQWRLVQVE VSHASGGSDG GSRNSQASSC GKKAQAQEGR HQLASRPKGL 360

PWTSFCDFQD ISHLVVKEHR VSIHRQDNKC LELTLPSRAA ALSFVSLVDG YFRLTVDSNH 420

YLCHEVAPPR LVMSIQDGIH GPLLDPFVLA KLQPEDGHYL IHWSTSHLYR LILTVPQRDQ 480

APSSQSFRLR KFTIEQQAGT FMLEGWGRSF PSVGALRATL QDCSLRVGDD CFSLRRCCLP 540

LPRELSNLII MRGPGASPRP LNLSQLSFHR VSPDDITQRS HLGQGTRTNV YEGLLRVEGG 600

GPEEDKEEGE DPSTPSGGRG QELRVVLKVL DPSHHDISLA FYEVASLMSQ VSHVHLAFVH 660

GICVHGSENI LVTEYVEHGP LDVWLRRERG HVPVAWKVAV AQQLASALSY LEDKSLIHGN 720

VCGRNILLAR PGLAEGTSPF IKLSDPGVGL GCLSREERVE RIPWMAPECL SGGANSLSPA 780

ADKWGFGATL LEICFDGEAP LQGRGPSEKE RFYQKQHRLP EPSCPELAIL TSQCLTYEPA 840

QRPSFRTILR DLTRLQPHNL VDVSSVNPDS PASDPTVFHR RYLKKIRDLG EGHFGKVSLY 900

CYDPTNDGTG EMVAVKSLKA GSGPQLRSGW RREIDILRTL YHEHIVKYKG CCEDPGEKSL 960

QLVMEYVPQG SLRDYLPRHG AGLAQLLLFA QQICEGMAYL HAQHYIHRDL AARNVLLDND 1020

RLVKIGDFGL AKAVPEGHEY YRVREDGDSP VFWYAPECLK ECKFYYASDV WSFGVTLYEL 1080

LTRCDSSQSP PTKFIELIGV TQGQMTVLRL TELLERGKRL PRPEACPCEI YQLMKNCWEG 1140

EASFRPTFEN LIPILKTAHE KYQDQAPSVF GVC 1173

Nucleotide Sequence
(FASTA)

AAGCCTGATG GGGACAGAGC TCAGCCCGCG GCCACCAGGG GAGACCTGAG GGTGCACCTG 60

CACTGGGCTG GCCCTGGTGG CGGGGAGCCC TGTGTCACCT TCAGTGAAGC CTCACAGACA 120

GCTGAGGAGA TTTGCATTTA CATTGCACAC AAAATCGGTA TCACTCCCCT CTGCTCCAAT 180

CTGTTTGCCC TCTATGATGC CCAGTCCCAA GTCTGGCTAC CCCCAAACCA CATCTTGGAG 240

GTCCCCAGAG ACTCCAGCCT GAATCTGCAC TACCGCATGA GGTTTTATTT CCGGAACTGG 300

CATGGCATGA ATCCTCAGGA GCCCACTGTG TACCGCTGTG GGCCCCCTGG AGCAGAGGCT 360

TCCTCAGATC AAGTAGAGCA TGGGCTGCAA TTTCTAGACC CAGCCTCCTT TGAGTACCTC 420

TTTGAACAGG GCAAGTATGA GTTTGTGAAT GATGTGGCCT CACTGTGGGA GCTGTCCAGC 480

GAGGAAGAAA CCCACCACTT CAAGAATGAG AGCCTGGGCA TGGCTTTTCT GCACCTCTGC 540

CACCTTGCTC TCCACCGTGG CGTCCCCCTA GAGGAAGTGG CCAAGAAGAT CAGCTTCAAG 600

GACTGCATCC CGCGCTCCTT CCGCAGCCAG ATCCGGCAGC ACAACGCGCT GACACGGCTC 660

CGCCTGCGCA GTATCTTCCA CAAGTTCCTG CGGGCTTTCC AGCCTGGCCA CCTCTCCCAG 720

CAGCTCGTCA TGGTCAAGTA CCTGGCCACG CTTGAGCGGC TGGCGCCTCG CTTTGCCACT 780

GAGCGTGTGC CAGTGTGCCA CCTGGAGCTG CTGGCCCAGG TCGGGAGGGA GCCCTGCTAC 840

AAGCAGGACC ACGAGCAGGC CCCCCTGGAC CCAGGAAATA AGTATGCCCC TGGCGCTCCC 900

ACCCATGAGG TGCTGGTGAC AGGCACTGGG GGTATCCAGT GGCGGCTGGT ACAGGTAGAG 960

GTGAGCCACG CATCTGGTGG CAGTGATGGT GGCAGCAGGA ACTCTCAGGC CAGCTCTTGT 1020

GGGAAGAAAG CCCAGGCTCA GGAGGGGCGT CACCAGCTAG CCAGCAGACC GAAGGGGCTG 1080

CCCTGGACCT CGTTCTGTGA CTTTCAGGAC ATCAGCCACC TGGTGGTGAA AGAGCACCGT 1140

GTCAGCATCC ATCGTCAGGA CAACAAGTGC CTGGAGCTGA CTCTGCCCTC CCGGGCTGCA 1200

GCCCTGTCCT TTGTGTCACT GGTGGATGGG TACTTCCGCC TGACGGTCGA CTCAAACCAT 1260

TACCTGTGCC ATGAGGTGGC ACCCCCACGG CTGGTGATGA GCATCCAGGA TGGAATCCAT 1320

GGTCCCTTGC TGGACCCATT TGTGCTGGCC AAGCTCCAGC CTGAGGATGG CCACTACCTC 1380

ATCCACTGGA GCACCAGCCA CCTCTACCGC CTTATTCTCA CCGTGCCGCA GCGTGACCAG 1440

GCACCCAGCT CCCAGAGCTT CCGCTTACGA AAGTTCACCA TCGAGCAGCA GGCCGGGACC 1500

TTCATGCTGG AGGGCTGGGG CCGGTCTTTC CCCAGCGTGG GCGCGTTGCG GGCCACTCTG 1560

CAGGACTGCT CCCTGCGGGT TGGGGACGAC TGCTTTTCCC TGCGGCGCTG CTGCCTGCCA 1620

CTGCCAAGAG AGCTCTCGAA CCTCATTATT ATGCGGGGAC CTGGGGCCAG CCCCAGGCCA 1680

CTCAACCTCA GCCAGCTCAG CTTCCACCGT GTCAGCCCGG ATGACATCAC CCAGCGGTCC 1740

CACCTGGGCC AGGGCACAAG GACCAATGTG TATGAGGGAC TCCTGCGTGT GGAGGGCGGG 1800

GGCCCTGAGG AAGACAAGGA GGAGGGCGAG GATCCCTCCA CACCCAGCGG AGGCCGTGGG 1860

CAGGAGCTCC GAGTGGTGCT TAAGGTGCTG GACCCCAGTC ACCACGACAT CTCCCTGGCC 1920

TTCTACGAGG TTGCCAGCCT CATGAGCCAG GTCTCACATG TGCACTTGGC CTTCGTACAC 1980

GGCATCTGTG TGCATGGCTC TGAGAACATC CTGGTGACAG AGTACGTGGA GCACGGACCC 2040

CTGGATGTGT GGCTGCGGCG GGAGAGGGGC CATGTGCCTG TGGCCTGGAA GGTGGCAGTG 2100

GCCCAGCAGC TGGCCAGCGC CCTCAGCTAC CTGGAGGACA AGAGCCTGAT TCATGGCAAC 2160

GTGTGTGGCC GGAACATCCT GCTGGCCCGG CCAGGCCTGG CAGAAGGCAC CAGCCCCTTC 2220

ATCAAGCTGA GTGACCCTGG CGTGGGCCTG GGCTGTCTCT CCAGGGAAGA GCGGGTGGAG 2280

CGGATCCCCT GGATGGCCCC TGAGTGTCTG TCTGGCGGGG CCAACAGCCT GAGTCCTGCA 2340

GCCGACAAGT GGGGCTTTGG TGCCACCCTC CTGGAGATCT GCTTTGATGG CGAGGCCCCC 2400

CTGCAGGGCC GTGGTCCCTC TGAGAAGGAG CGTTTCTACC AGAAGCAGCA CCGGCTGCCT 2460

GAGCCGTCAT GCCCAGAGCT GGCTATCCTC ACCAGCCAAT GCCTGACCTA TGAGCCAGCC 2520

CAGAGGCCAT CCTTCCGCAC CATCCTGCGT GACCTCACGC GCCTGCAGCC CCACAATCTT 2580

GTTGATGTCT CCTCGGTGAA CCCTGACTCA CCTGCGTCAG ACCCCACCGT TTTCCACAGG 2640

CGCTATTTGA AAAAGATCCG GGATCTGGGC GAGGGGCACT TCGGCAAGGT CAGCTTATAC 2700

TGCTACGACC CGACTAACGA CGGCACTGGT GAGATGGTAG CCGTGAAGTC CCTCAAGGCT 2760

GGCTCCGGTC CCCAGCTGCG TTCGGGCTGG AGGCGCGAGA TTGACATCCT GCGCACGCTC 2820

TACCACGAGC ATATCGTCAA GTACAAGGGC TGCTGTGAGG ACCCAGGTGA AAAGTCGCTG 2880

CAGCTGGTCA TGGAGTACGT GCCCCAGGGC AGCCTCCGGG ACTACCTGCC GCGGCACGGC 2940

GCGGGGCTGG CCCAGCTGCT GCTCTTCGCC CAGCAGATCT GCGAGGGCAT GGCCTACCTG 3000

CACGCTCAGC ACTATATCCA CCGAGACCTG GCCGCGCGCA ACGTGCTTCT GGACAACGAC 3060

AGGCTGGTCA AGATCGGGGA TTTTGGCCTG GCCAAGGCGG TGCCTGAAGG CCACGAGTAC 3120

TACCGTGTGC GCGAGGACGG GGACAGTCCT GTGTTCTGGT ACGCTCCTGA GTGTCTGAAG 3180

GAGTGTAAGT TCTACTATGC GTCCGATGTG TGGTCCTTTG GGGTCACCTT ATATGAGCTG 3240

CTCACCCGCT GTGATTCCAG CCAAAGCCCC CCCACGAAAT TCATCGAGCT CATAGGTGTC 3300

ACCCAGGGAC AGATGACAGT GCTGAGGCTC ACCGAGTTGC TGGAACGAGG GAAGAGGCTG 3360

CCACGGCCAG AGGCATGTCC CTGTGAGATC TACCAACTCA TGAAGAACTG CTGGGAGGGA 3420

GAAGCCTCCT TCCGCCCAAC CTTTGAGAAC CTCATCCCCA TCCTCAAGAC AGCCCATGAG 3480

AAATACCAAG ACCAGGCCCC CTCGGTGTTT GGCGTGTGCT GA 3522

Domain Profile

S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLk.esgedisrdfkreaeilsqlsh  59

         lk+i++Lg+g+f+kv ++++d+++d t+e+va+k Lk  sg++ ++++ re++il++l+h

Q: 883   LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKSLKaGSGPQLRSGWRREIDILRTLYH  942

         6899*********************************99*********************

S: 60    ehivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYL  117

         ehivk+kg+c ++ge+  +lVmeyv++GsL++yL+++     l++ll +a+q++++m+YL

Q: 943   EHIVKYKGCCEDPGEKslQLVMEYVPQGSLRDYLPRH--GAGLAQLLLFAQQICEGMAYL  1000

         *************************************..56789****************

S: 118   edkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwl  176

         ++++++hrd+aarnvL+++++       vk++d+glakav+++ eYy vre++ds+++w+

Q: 1001  HAQHYIHRDLAARNVLLDNDRL------VKIGDFGLAKAVPEGhEYYRVREDGDSPVFWY  1054

         **********************......********************************

S: 177   apeclseaknlstasdvWsFgvtlyellt.cskgesp.........lrsesle.......  219

         apecl+e+k +++asdvWsFgvtlyellt c++++sp         +     +

Q: 1055  APECLKECK-FYYASDVWSFGVTLYELLTrCDSSQSPptkfieligV-----Tqgqmtvl  1108

         *********.****************************888444443.....45666688

S: 220   rklelleekerlpkpk.cpaelaelmtnclsyepsqrpsFraile  263

         r++elle+++rlp+p+ cp+e+++lm+nc++ e+s+rp+F++++

Q: 1109  RLTELLERGKRLPRPEaCPCEIYQLMKNCWEGEASFRPTFENLIP  1153

         *****************************************9975

Domain Sequence
(FASTA)

LKKIRDLGEG HFGKVSLYCY DPTNDGTGEM VAVKSLKAGS GPQLRSGWRR EIDILRTLYH 60

EHIVKYKGCC EDPGEKSLQL VMEYVPQGSL RDYLPRHGAG LAQLLLFAQQ ICEGMAYLHA 120

QHYIHRDLAA RNVLLDNDRL VKIGDFGLAK AVPEGHEYYR VREDGDSPVF WYAPECLKEC 180

KFYYASDVWS FGVTLYELLT RCDSSQSPPT KFIELIGVTQ GQMTVLRLTE LLERGKRLPR 240

PEACPCEIYQ LMKNCWEGEA SFRPTFENLI P 271

Keyword

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>