EKS-PEM-00065

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PEM-00065

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/LRRK	291.8	2.5E-87	105	353	249

Status

Unreviewed

Ensembl Protein

ENSPMAP00000001585

Gene Name

LRRK2

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPMAG00000001434	ENSPMAP00000001584	ENSPMAT00000001591
ENSPMAG00000001434	ENSPMAP00000001585	ENSPMAT00000001592

Organism

Petromyzon marinus

Protein Length

588

Protein Sequence
(FASTA)

GRAVDHVDSL IEEWFPGLLE PHDGSESSAA LLHQWAGLGP ADDAQPPCVR LAALQDIAES 60

GERVAPAMPR ERIPIAQLAP DVVLADVPDH LQLDLSSFSL EQSAEHLLGE GGFGSVYRAL 120

YGGDQVAVKI FNKHISQTHP HRLMRQELAV LSRSRHPSLV SLLAVGLRPR VLVMELAPRG 180

SLAGVMEREG ELHRTLKHRI ALHVAHGLRF LHASMIIYRD LKPDNVLLFT LQPNAAVIAK 240

IADYGIARHC CTMGMVSPDG TPGYRAPEVV KGGVMYDQQA DVYAFGLLLY DLLTGGRRIV 300

EGLRYPHEFD ELASSGKLPD PVTYYGCSPW PDVQELIAAC LQPEPQHRPA ASQHHSRKAC 360

SNGSLLDRVC NKETSSASNM VCSKHLTAAH ASYPSDETTA GVELCCLDLT GKVLHREVLP 420

DQRVLSLCSA EVNKRQWVLA GTRSGRVWVV SAAPERSRHS LHCLSEPVTA LIFVAAYQNA 480

SAVLAGTANG TLAVFVVNSL ETPGCVVNTV HGVGSPGRPV TCLTVAPSAP LDRTVWGACG 540

TQLFALSNNL QVAKVIETTP MGRRGAVPGS SVACMAVGKQ VFTATEGT 588

Nucleotide Sequence
(FASTA)

GGCCGCGCTG TGGACCACGT GGACTCGCTC ATTGAGGAGT GGTTCCCCGG GCTCCTGGAG 60

CCTCACGACG GCTCTGAGAG CAGCGCCGCG CTGCTGCACC AGTGGGCCGG GCTGGGGCCC 120

GCGGACGACG CGCAGCCGCC CTGCGTGCGC TTGGCCGCCC TGCAGGACAT CGCCGAGTCC 180

GGTGAGCGTG TGGCGCCCGC GATGCCCCGG GAACGGATCC CCATTGCCCA GCTGGCGCCC 240

GATGTGGTGC TGGCCGACGT TCCCGACCAC CTTCAGCTCG ACCTGTCCAG CTTCAGCCTG 300

GAGCAGTCTG CCGAGCACCT GTTAGGTGAA GGAGGGTTTG GATCGGTCTA CCGGGCGCTG 360

TACGGCGGAG ACCAAGTGGC CGTGAAGATC TTCAACAAAC ACATCTCTCA AACGCATCCG 420

CACCGCCTCA TGAGACAGGA GTTGGCAGTC CTCAGCCGCT CGCGCCACCC ATCGCTCGTG 480

TCCCTCCTGG CCGTGGGGCT GCGCCCACGG GTTCTGGTAA TGGAGCTGGC GCCACGGGGC 540

TCCCTTGCTG GCGTGATGGA GCGGGAGGGG GAGCTGCACC GCACCCTCAA GCACCGCATC 600

GCCCTGCACG TTGCACATGG CCTACGGTTT CTGCATGCCT CCATGATCAT TTACCGCGAC 660

CTGAAGCCAG ACAATGTGCT GCTGTTTACG CTGCAACCAA ACGCAGCGGT CATCGCCAAG 720

ATTGCCGATT ACGGCATCGC ACGGCACTGC TGCACCATGG GCATGGTATC TCCCGATGGC 780

ACACCCGGCT ACCGCGCCCC CGAGGTGGTG AAGGGAGGCG TCATGTACGA CCAGCAGGCC 840

GACGTGTACG CGTTTGGGCT CCTGCTCTAC GACCTGCTGA CGGGCGGGCG GCGCATCGTG 900

GAGGGGCTCC GCTATCCCCA CGAGTTTGAC GAGCTCGCCT CCAGCGGGAA GCTGCCCGAC 960

CCAGTGACTT ACTACGGCTG CAGTCCGTGG CCAGACGTGC AAGAACTCAT CGCAGCCTGC 1020

CTGCAGCCAG AGCCTCAGCA CAGGCCCGCA GCCTCACAGC ACCACTCGCG CAAGGCCTGT 1080

TCTAATGGCT CACTTTTGGA TCGGGTCTGC AATAAGGAGA CTAGCTCTGC ATCCAACATG 1140

GTATGCTCAA AGCACTTGAC TGCAGCCCAT GCAAGCTACC CATCGGATGA AACAACGGCT 1200

GGGGTTGAGC TCTGCTGCCT TGACCTCACT GGGAAGGTTC TGCACAGGGA GGTGCTGCCA 1260

GACCAGCGGG TGCTGAGCTT GTGCTCGGCG GAGGTGAACA AGCGTCAGTG GGTGCTGGCG 1320

GGGACACGGT CGGGGCGCGT GTGGGTCGTG AGCGCCGCCC CCGAACGTAG CCGCCACTCC 1380

CTGCACTGCC TGTCGGAGCC GGTCACGGCG CTGATCTTCG TCGCTGCCTA CCAGAACGCA 1440

AGTGCAGTGC TGGCCGGGAC GGCGAATGGG ACGTTGGCTG TGTTCGTTGT GAACTCACTC 1500

GAGACTCCCG GCTGTGTCGT GAACACGGTG CACGGCGTGG GCTCGCCGGG CCGGCCCGTC 1560

ACGTGCCTGA CCGTGGCGCC TTCTGCGCCG CTCGACAGGA CCGTGTGGGG CGCGTGTGGG 1620

ACGCAGCTGT TTGCTCTCAG CAATAACTTA CAAGTGGCCA AAGTCATCGA AACTACACCC 1680

ATGGGAAGGA GAGGCGCGGT TCCTGGGTCG TCCGTTGCAT GCATGGCCGT GGGGAAGCAG 1740

GTCTTCACGG CGACGGAGGG CACG 1764

Domain Profile

S: 4     gsllGrGafGsvyraavkGeevavkafkiaadklkrdslelalkayselrqelsvLlalk  63

         + llG+G+fGsvyra + G++vavk+f+      k+ s ++    +  +rqel+vL++ +

Q: 105   EHLLGEGGFGSVYRALYGGDQVAVKIFN------KHISQTH---PHRLMRQELAVLSRSR  155

         5789************************......8888887...56679***********

S: 64    hPsivsLvgisikPlalvleLaplgsLdrlLsedkksssklgrtltkkialqvargleyL  123

         hPs+vsL++++++P++lv+eLap+gsL  +++++     +l rtl ++ial+va+gl++L

Q: 156   HPSLVSLLAVGLRPRVLVMELAPRGSLAGVMERE----GELHRTLKHRIALHVAHGLRFL  211

         *****************************99754....469*******************

S: 124   hkkkiiyrdLksenvLvwslspkeailikladyGisrqslrsGakgveGteGfraPeivr  183

         h  +iiyrdLk++nvL+++l+p++a+++k+adyGi+r+++ +G+ + +Gt+G+raPe+v+

Q: 212   HASMIIYRDLKPDNVLLFTLQPNAAVIAKIADYGIARHCCTMGMVSPDGTPGYRAPEVVK  271

         ************************************************************

S: 184   gevvydekvdvfsfGlllyell.sgkrpvegeeqlkivekl.lkGkrPvlvkeeevlptp  241

         g v+yd+++dv++fGllly+ll  g+r+veg + ++++++l + Gk+P++v  +++ p+p

Q: 272   GGVMYDQQADVYAFGLLLYDLLtGGRRIVEGLRYPHEFDELaSSGKLPDPVTYYGCSPWP  331

         **********************45689**************99****************9

S: 242   .lldLlveCwkekPekrPtasq  262

          +++L+  C++ +P++rP+asq

Q: 332   dVQELIAACLQPEPQHRPAASQ  353

         4566****************98

Domain Sequence
(FASTA)

EHLLGEGGFG SVYRALYGGD QVAVKIFNKH ISQTHPHRLM RQELAVLSRS RHPSLVSLLA 60

VGLRPRVLVM ELAPRGSLAG VMEREGELHR TLKHRIALHV AHGLRFLHAS MIIYRDLKPD 120

NVLLFTLQPN AAVIAKIADY GIARHCCTMG MVSPDGTPGY RAPEVVKGGV MYDQQADVYA 180

FGLLLYDLLT GGRRIVEGLR YPHEFDELAS SGKLPDPVTY YGCSPWPDVQ ELIAACLQPE 240

PQHRPAASQ 249

Keyword

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>