EKS-PEM-00258

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PEM-00258

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	325.0	2.1E-97	20	322	303

Status

Unreviewed

Ensembl Protein

ENSPMAP00000003320

Gene Name

MAPK4

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPMAG00000003042	ENSPMAP00000003320	ENSPMAT00000003335

Organism

Petromyzon marinus

Protein Length

554

Protein Sequence
(FASTA)

MAEKFNSLQN LHGFELGPRY VDLKPLGFGG NGLVFSAVDS DCDKRVAIKK LVLSGPHSLK 60

HALREIKIIR RLDHDNIVRV FEVLGPAGQR LPLGQAGIGT SALAELECVY IVQDYLETDL 120

ARVLEQGSAL SEEHARLFMY QLLRGLKYIH SANVLHRDLK PANLFINTEE LLLKIGDFGL 180

ARILDPHYSH KGYLSEGLVT KWYRSPRLLL SPNNYTKAID MWAAGCIFAE MLSGKTLFAG 240

AHELEQMQLI LQTIPVMRDE DHQELLNVIP VFVDKERREP PKPLALLLPN VSKEALDFLQ 300

QILTFNPMDR LTAEQALAHP YMSLYAFPQD EPVARQPFHI EDEIDDALLT DESHSQQAQW 360

SRYPDSTDTD WYSHGELDVA QKDPRAMASS SSEEDGVQLD PRKFSEGEHV SYSSSSSLDQ 420

LWSTSEEMHD EHHHHHHHHE NKFCESECSH SCGYKAGSPY HPGSVVLREK EVHHYYEPKL 480

ILDLSNWKEQ IRVRPPREKK RAGVGGSKSS KPNKCERNGA VKAQLAQEGK DEAKSKKSFD 540

LDAFFADTIR LSSR 554

Nucleotide Sequence
(FASTA)

ATGGCGGAGA AGTTCAATAG TCTGCAGAAT CTCCACGGGT TTGAGTTGGG TCCCCGCTAT 60

GTGGACCTGA AACCACTTGG CTTTGGCGGC AATGGGCTGG TGTTCTCGGC TGTGGACAGT 120

GACTGCGACA AGCGTGTGGC TATCAAGAAG CTGGTGTTAA GCGGACCGCA TAGTCTCAAG 180

CACGCGTTGC GTGAAATCAA GATCATCCGT CGCTTGGACC ATGACAACAT TGTCAGGGTG 240

TTCGAGGTGC TGGGCCCTGC TGGACAGCGC CTTCCCCTTG GCCAGGCTGG CATTGGCACA 300

TCGGCACTGG CGGAGCTGGA GTGTGTGTAC ATCGTGCAAG ACTACCTGGA GACGGACCTT 360

GCCCGTGTGC TGGAGCAGGG CAGCGCCCTG TCGGAGGAGC ACGCGCGCCT CTTTATGTAC 420

CAGCTGCTCC GCGGACTCAA GTACATCCAC TCGGCCAACG TGCTGCACCG TGACCTCAAG 480

CCGGCCAACC TGTTCATTAA CACCGAGGAG CTGCTCCTTA AGATCGGCGA CTTTGGGCTT 540

GCGCGCATCC TCGATCCACA CTACTCGCAC AAGGGCTACC TTTCTGAGGG GTTGGTGACC 600

AAGTGGTATC GCTCACCACG CCTCCTCCTG TCCCCTAACA ACTACACTAA GGCCATCGAC 660

ATGTGGGCCG CCGGATGTAT ATTTGCTGAG ATGCTCTCAG GAAAGACCCT CTTTGCCGGA 720

GCGCACGAGC TGGAGCAGAT GCAGCTGATA TTACAGACGA TTCCCGTAAT GCGCGATGAG 780

GATCACCAGG AGCTGCTCAA CGTCATCCCG GTGTTTGTGG ACAAGGAGCG CCGTGAACCC 840

CCCAAGCCGC TTGCCTTGCT ACTGCCCAAT GTCAGCAAGG AGGCTTTGGA TTTCCTTCAG 900

CAAATCCTCA CCTTCAATCC GATGGACCGC CTGACCGCTG AGCAGGCCCT GGCCCACCCC 960

TACATGAGCC TCTACGCCTT CCCACAAGAC GAGCCGGTGG CACGCCAGCC CTTCCACATC 1020

GAAGACGAGA TCGACGATGC GCTGCTGACA GACGAAAGCC ACAGCCAGCA GGCACAGTGG 1080

AGCCGATACC CAGACAGTAC CGACACGGAT TGGTACAGCC ACGGGGAGCT GGACGTCGCC 1140

CAGAAGGACC CTCGAGCAAT GGCCTCCAGC TCCTCGGAGG AGGACGGTGT CCAGCTGGAC 1200

CCGCGCAAGT TTTCCGAGGG CGAGCACGTA TCCTACTCAT CGTCATCGTC GCTCGACCAG 1260

CTGTGGTCCA CCAGCGAGGA GATGCACGAC GAGCACCACC ATCACCACCA CCACCACGAG 1320

AACAAGTTCT GCGAGTCAGA GTGCAGCCAC TCGTGCGGCT ACAAGGCGGG CTCGCCGTAC 1380

CACCCCGGGA GCGTGGTGCT CAGGGAGAAG GAGGTGCACC ACTACTACGA GCCCAAGCTC 1440

ATCTTGGACC TGTCCAATTG GAAAGAGCAG ATCCGCGTGC GGCCTCCGCG GGAGAAGAAG 1500

CGAGCGGGGG TGGGCGGCAG CAAGAGCAGC AAGCCCAACA AGTGCGAGCG CAACGGGGCG 1560

GTCAAAGCGC AGCTAGCCCA GGAGGGTAAG GACGAGGCTA AGTCTAAAAA GAGTTTCGAT 1620

CTCGACGCTT TCTTTGCCGA CACTATCCGC CTAAGCAGCA GG 1662

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y +lkplg G +g+v+savd+++++rvaikkl+  ++  +s+k++lRE+k++++l+h+Ni

Q: 20    YVDLKPLGFGGNGLVFSAVDSDCDKRVAIKKLV--LSGPHSLKHALREIKIIRRLDHDNI  77

         7789****************************9..9************************

S: 61    iklldvftpee.............eleelkdvYlvtelmetdLkkviksq.klsdehikl  106

         +++++v+ p+               l el+ vY+v++++etdL++v+++   ls+eh++l

Q: 78    VRVFEVLGPAGqrlplgqagigtsALAELECVYIVQDYLETDLARVLEQGsALSEEHARL  137

         *********9999********999999**********************99*********

S: 107   llyqilrglkylHsanviHrDlKPsNllvnedce.lkildFGlarsadkekekk..ltey  163

         ++yq+lrglky+Hsanv+HrDlKP+Nl++n++   lki dFGlar+ d+++++k  l+e

Q: 138   FMYQLLRGLKYIHSANVLHRDLKPANLFINTEELlLKIGDFGLARILDPHYSHKgyLSEG  197

         ******************************876549***************9999*****

S: 164   vatrwYraPeillslkeytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtp  223

         ++t+wYr+P++lls ++ytka+D+W++GCI+aE+l+gk+lf+g++e++q+++il++++

Q: 198   LVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLSGKTLFAGAHELEQMQLILQTIPVM  257

         ************************************************************

S: 224   seeflkkieseearnyikslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveea  283

         ++e+ +++ +  +  ++ +  +++ k+++ l+p+ s+eald+l+++L+++p++R+++e+a

Q: 258   RDEDHQELLNV-IPVFVDKERREPPKPLALLLPNVSKEALDFLQQILTFNPMDRLTAEQA  316

         **********5.************************************************

S: 284   LehpYl  289

         L+hpY+

Q: 317   LAHPYM  322

         *****7

Domain Sequence
(FASTA)

YVDLKPLGFG GNGLVFSAVD SDCDKRVAIK KLVLSGPHSL KHALREIKII RRLDHDNIVR 60

VFEVLGPAGQ RLPLGQAGIG TSALAELECV YIVQDYLETD LARVLEQGSA LSEEHARLFM 120

YQLLRGLKYI HSANVLHRDL KPANLFINTE ELLLKIGDFG LARILDPHYS HKGYLSEGLV 180

TKWYRSPRLL LSPNNYTKAI DMWAAGCIFA EMLSGKTLFA GAHELEQMQL ILQTIPVMRD 240

EDHQELLNVI PVFVDKERRE PPKPLALLLP NVSKEALDFL QQILTFNPMD RLTAEQALAH 300

PYM 303

Keyword

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>