EKS-PEM-00180

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PEM-00180

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PEK	328.4	2.1E-98	616	1042	427

Status

Unreviewed

Ensembl Protein

ENSPMAP00000007704

Gene Name

EIF2AK4

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPMAG00000006975	ENSPMAP00000007704	ENSPMAT00000007738

Organism

Petromyzon marinus

Protein Length

1689

Protein Sequence
(FASTA)

LGGGRGGKKN SAGALEQDSY EDRQENELEV LTAIYGSELT DLRKSAESSV RRPPQVCISL 60

APHDSTGSAC YVTVDLTVSC PPRYPDELPE IELNNAKGLS NESVKELQAQ LTTLVSELRG 120

EVMIFQLAHH VKNFLIDLNV PPPCSFYEEM LRNQALQQQR LAQEQETAFR EKLQQEESEK 180

RAIDHELMRR EEEKREERKR KELAKQQQMR EEMAGSPTND GGVSSQPSRK PTNGSGEWNE 240

GEGSSRARSR SASRSSKRER LTSMCSSDNC SPGAEVLKFH TQGERSVYRG KCIGESTHLR 300

RQVFNALDNS TGELVVVYEW VLRWPVGHPD LRTSEDKEHM EKCRKQVHGA SAELQSLLKL 360

RHEALVPYLG MESQETETAL TVHLLAEHVS GTSLAGHLAR TGPLPVETVR QYASQLLHVL 420

DYLHASSVVH RDLRLSSVLL DCATGLLRVA DYSLARRLAD ACVASEQPGR PGVPRVHFVE 480

PECGPGAGAA AARSQPPKTG KKGDVWRLGV LLEQLAVGRE SSNDDTPPAD LPIDLREFLS 540

RCLCMDDKER WSTQQLLEHP FIKTPVSCSP STRPPRVHAA ADDVNYAEAL IPSRDILGMC 600

SHLDSQRQLS RYYTEFEELA LLGKGAFGAV IKVKNKLDGC YYALKRIAVN PTSRQFRRIK 660

GEVTLLSRLN HENIVRYYNA WIERYELSPS DAKETPDVAN VRGRGPAMHL SRLSGIAGLD 720

DVEANAPPPV TASTRTVASG SVEWSMSYEH SVSARCGPST TGGSPSDSSD EDDEDDVVFG 780

RSFVPSGSDS DCDVVFENSG EKNQSEESHD SSLSDKELSK NRAPVCQPTP TVVHHLFIQM 840

EYCERSTLRD TIDKGLHMET DRMWRLFREI LDGLAYIHEQ GMIHRDLKPV NIFLDSSDSV 900

KIGDFGLATD HRLVATESSK IDVSTANIEL PTENMDVTGG LTGQIGTALY VSPEVLGNIK 960

AVYNQKVDLY SLGIIFFEMT YHPMTTASER VAVLQKLRLP TIQFPEDFHP QTLKQQAFII 1020

RWLLNHDAGQ RPTAQELLKS EQLPPPQLEE SELHEVLRHT LANPDGKAYR SLVGELFSQR 1080

VALPADFTYD IDVHKGNFSA TSSMVQSYVY ETVCKVFERH GGAVKLHMPL LMPKNRYLYE 1140

NNEAAVFMDH SGFLVLLPHD LRVPFARFVA RNNVTNLKRY CVERVFRPRK LHRAHPRELI 1200

ECAFDIVTSA GGCLPDAEII YTTSEIIQEF PVLQDRNYCV HLNHTALIKA ILIHCGIPED 1260

KHHQVYGILC DTMNEKRTKQ QIMASLCSLG LHPDTVTLLF HFVERRGNRM DVLAALRPLA 1320

GKHSKTVGLV KQGLSYLEEV MKHLEYMCIR HQVVISLGLV YKVQLHSGLI FQFTSFVRRK 1380

NKTVLDILAA GGRYDNLISM FRAPQSSGPV PSAVGVSLAL DKITSAILSK EDPPSFNLCD 1440

VLVGAVGDAM RPRACSLVKD MWAAGLRAGV HYDVAQSQVD LHDYCRQADI PFLVLLESGT 1500

VRVKAVDKEW QSEKKVVDFE VISFLQQNLK SRAAEERNCR DTSEGVIVTT QKGPSFNSTG 1560

ASETFGSVTV PNINFVTTEK LPYNTKKRYE TQIISRIHPV VSNMFHKHLD VEVIAVDLPG 1620

NMMKNFAHLE WCEDEESFEE SRKELIGKLP KQRKYLEDIC DEIHELKIEK RVPIVIVYSY 1680

RDDVHRFIF 1689

Nucleotide Sequence
(FASTA)

CTTGGGGGAG GACGCGGGGG TAAGAAGAAT TCTGCGGGCG CCTTGGAGCA AGACTCGTAC 60

GAGGACCGTC AGGAGAACGA GCTGGAGGTG CTCACGGCCA TCTACGGCAG CGAATTAACC 120

GACCTGAGGA AATCAGCCGA GTCAAGCGTG CGTCGCCCGC CACAGGTGTG CATCTCCCTG 180

GCACCCCACG ATAGCACTGG AAGTGCGTGC TACGTGACGG TGGATCTCAC AGTCAGCTGC 240

CCTCCACGCT ATCCGGACGA GCTCCCAGAA ATTGAGCTGA ACAATGCCAA AGGCCTGTCC 300

AATGAGAGTG TGAAAGAGCT GCAAGCCCAG CTGACAACCC TGGTATCTGA ACTGCGTGGA 360

GAGGTGATGA TCTTCCAGCT GGCCCACCAC GTAAAGAACT TCCTGATTGA CCTCAACGTG 420

CCACCTCCGT GTTCTTTCTA CGAGGAAATG CTGCGTAATC AAGCATTGCA GCAACAAAGG 480

CTGGCTCAGG AGCAAGAGAC GGCGTTCCGT GAAAAGCTGC AACAGGAGGA GAGCGAGAAA 540

CGTGCAATTG ATCATGAACT TATGCGACGA GAGGAAGAGA AGCGAGAGGA GCGGAAGAGG 600

AAGGAATTGG CTAAGCAGCA GCAGATGCGC GAGGAAATGG CGGGCAGCCC CACGAATGAC 660

GGTGGCGTGA GCAGCCAGCC ATCACGGAAA CCAACCAATG GGTCTGGGGA ATGGAACGAG 720

GGCGAGGGCT CAAGTCGCGC GCGGAGCCGC TCTGCGAGCC GCTCCAGCAA GAGGGAGCGT 780

CTCACATCCA TGTGCAGCAG TGACAACTGC AGCCCAGGGG CGGAGGTGCT CAAGTTCCAC 840

ACGCAAGGGG AGCGCTCCGT GTACCGTGGA AAGTGCATCG GTGAGAGCAC TCACTTGCGC 900

CGCCAAGTAT TCAACGCGCT GGACAACAGC ACGGGCGAGC TGGTGGTCGT GTACGAGTGG 960

GTGCTGCGCT GGCCGGTAGG ACACCCCGAC CTCCGCACCA GCGAAGACAA GGAGCACATG 1020

GAGAAATGCC GCAAGCAGGT GCATGGAGCC AGTGCAGAGT TACAGTCGCT GTTGAAACTG 1080

CGGCACGAGG CGTTGGTGCC TTACCTTGGC ATGGAGAGCC AGGAGACGGA GACGGCCCTC 1140

ACCGTGCACC TGCTGGCCGA GCACGTCTCC GGCACGAGCC TGGCCGGCCA CCTTGCCCGC 1200

ACTGGCCCCT TGCCGGTGGA GACGGTACGC CAGTACGCTT CCCAGCTGCT GCACGTGCTC 1260

GACTATCTGC ACGCCAGCTC GGTGGTGCAC CGTGACCTGC GTCTGTCGAG CGTGCTGCTG 1320

GACTGCGCGA CTGGCCTGCT CCGCGTCGCC GACTACAGCC TGGCGCGCCG GCTCGCTGAC 1380

GCGTGCGTGG CAAGCGAGCA GCCCGGTCGG CCCGGCGTGC CGCGGGTCCA CTTCGTGGAG 1440

CCCGAGTGCG GTCCTGGGGC CGGTGCTGCG GCAGCCCGCT CGCAGCCGCC GAAGACCGGG 1500

AAGAAGGGCG ACGTGTGGCG GCTCGGCGTG CTGCTGGAGC AGCTCGCGGT GGGACGGGAG 1560

AGCAGCAACG ATGACACACC GCCTGCTGAT CTCCCCATTG ACTTGCGGGA GTTCCTTAGC 1620

CGGTGCTTGT GCATGGACGA CAAGGAAAGG TGGAGCACCC AGCAGCTGCT GGAGCATCCG 1680

TTCATCAAGA CGCCTGTCTC ATGCTCGCCA TCCACGAGGC CGCCGCGTGT TCATGCGGCC 1740

GCAGATGACG TGAACTATGC GGAGGCCCTC ATCCCGTCTC GTGATATCCT GGGCATGTGC 1800

TCCCACCTCG ACTCGCAGCG CCAGCTCTCC CGTTACTACA CCGAGTTCGA GGAGCTCGCC 1860

CTCCTCGGCA AGGGCGCCTT TGGGGCTGTC ATCAAGGTGA AGAACAAGCT GGACGGCTGC 1920

TACTATGCCC TCAAGCGCAT CGCCGTGAAC CCCACCAGCC GGCAGTTCCG CCGCATCAAG 1980

GGCGAGGTGA CCCTGCTTTC CCGCCTCAAC CACGAGAACA TCGTCCGCTA CTACAACGCC 2040

TGGATCGAGC GCTACGAGCT CTCGCCGTCA GATGCCAAAG AGACTCCCGA CGTGGCTAAC 2100

GTGCGGGGCC GAGGGCCGGC GATGCATCTG AGCCGCCTGT CGGGCATCGC GGGCCTGGAC 2160

GACGTGGAGG CGAACGCGCC CCCTCCCGTG ACGGCGTCGA CGCGGACGGT GGCGTCGGGC 2220

TCGGTGGAGT GGAGCATGTC GTACGAGCAC TCGGTGAGCG CGCGCTGCGG CCCCTCCACG 2280

ACCGGAGGCA GCCCCAGCGA CTCGAGCGAC GAGGACGACG AGGACGACGT CGTCTTCGGC 2340

CGGTCCTTTG TACCTTCGGG CAGTGATTCT GACTGCGACG TCGTGTTTGA GAACTCGGGT 2400

GAAAAAAACC AGAGTGAGGA GTCTCATGAC AGCTCACTGT CTGATAAAGA GTTGAGCAAA 2460

AACCGAGCAC CGGTCTGCCA GCCCACACCA ACAGTGGTCC ACCATCTCTT CATACAGATG 2520

GAATACTGCG AGAGGAGCAC TCTACGCGAC ACCATAGACA AGGGCCTGCA CATGGAGACG 2580

GATCGCATGT GGCGCCTTTT CCGTGAAATC CTGGATGGCC TGGCTTACAT TCATGAGCAG 2640

GGCATGATCC ACAGAGACCT CAAGCCAGTA AATATCTTCC TGGATTCTTC AGACAGCGTG 2700

AAGATTGGAG ACTTTGGTTT GGCTACAGAT CACCGGCTCG TTGCAACTGA ATCAAGCAAG 2760

ATAGATGTTT CAACGGCAAA TATAGAACTT CCCACGGAGA ATATGGATGT AACAGGTGGG 2820

CTCACTGGGC AGATTGGCAC AGCACTTTAC GTGAGTCCGG AGGTTTTGGG GAACATCAAA 2880

GCGGTCTACA ATCAGAAAGT AGATCTGTAC AGCCTGGGCA TCATCTTCTT TGAGATGACC 2940

TACCATCCAA TGACGACGGC ATCAGAGAGG GTGGCTGTTC TGCAGAAGCT ACGCCTGCCG 3000

ACCATTCAGT TCCCTGAAGA TTTTCATCCG CAAACACTAA AGCAGCAGGC GTTCATCATC 3060

CGCTGGCTGC TGAACCACGA CGCGGGCCAG CGCCCCACAG CGCAGGAGCT GCTCAAGAGC 3120

GAGCAGCTCC CTCCGCCACA ACTCGAGGAG TCGGAGCTGC ACGAGGTGCT CCGGCACACG 3180

CTCGCGAACC CTGACGGCAA GGCCTACCGC TCGCTCGTCG GGGAGCTTTT CTCCCAGCGC 3240

GTGGCGCTAC CCGCGGACTT CACCTACGAC ATCGACGTGC ACAAGGGGAA TTTTTCTGCC 3300

ACTTCCAGCA TGGTGCAAAG CTACGTTTAC GAAACTGTCT GCAAAGTCTT TGAGAGGCAC 3360

GGAGGTGCGG TGAAACTCCA CATGCCACTA CTCATGCCCA AGAATCGGTA CCTTTACGAG 3420

AACAACGAGG CAGCGGTATT CATGGACCAC AGCGGCTTCC TTGTGCTGCT TCCCCACGAC 3480

CTGCGGGTTC CCTTTGCACG GTTTGTGGCA AGAAACAATG TCACCAACCT CAAAAGGTAC 3540

TGCGTGGAGC GTGTGTTCCG GCCCAGGAAG CTGCACCGCG CGCACCCACG CGAGCTCATC 3600

GAGTGCGCGT TCGACATCGT CACGTCGGCC GGTGGCTGTC TCCCGGACGC CGAGATCATT 3660

TACACCACGT CCGAGATCAT ACAGGAGTTC CCGGTTCTGC AGGATCGCAA CTACTGTGTG 3720

CATCTGAACC ACACAGCCCT CATAAAGGCC ATCCTTATCC ACTGTGGCAT TCCAGAAGAC 3780

AAGCACCACC AGGTTTACGG CATTCTCTGT GATACCATGA ATGAGAAGCG AACAAAGCAG 3840

CAGATAATGG CAAGTCTGTG TAGCCTGGGT CTGCATCCCG ACACAGTCAC GCTGCTGTTC 3900

CACTTTGTGG AGCGGCGCGG GAATAGGATG GACGTCTTGG CGGCACTAAG GCCGCTCGCG 3960

GGCAAACACT CCAAGACGGT GGGGCTGGTC AAGCAGGGGC TTAGCTACCT GGAGGAGGTC 4020

ATGAAGCACC TGGAGTACAT GTGCATTCGG CATCAGGTTG TGATAAGCCT CGGGCTCGTT 4080

TACAAAGTGC AGCTTCACAG CGGACTCATC TTCCAATTCA CCAGCTTTGT CCGGCGCAAA 4140

AACAAAACAG TGCTGGATAT CTTGGCCGCT GGGGGGCGCT ACGATAACCT GATTTCAATG 4200

TTTCGAGCAC CGCAGTCATC GGGGCCTGTT CCCTCTGCGG TTGGGGTTAG CCTGGCGCTC 4260

GACAAGATCA CTTCAGCCAT CCTAAGCAAG GAGGACCCGC CGTCCTTCAA TCTGTGCGAT 4320

GTTCTGGTTG GCGCTGTCGG GGACGCCATG CGTCCCAGGG CGTGCTCCTT GGTCAAGGAC 4380

ATGTGGGCAG CTGGCCTTCG TGCAGGGGTG CACTACGACG TGGCGCAGTC GCAGGTGGAC 4440

CTACACGATT ACTGCAGGCA AGCAGACATC CCTTTCCTGG TGCTGTTGGA GTCCGGGACT 4500

GTGCGAGTGA AGGCCGTAGA TAAGGAATGG CAGTCGGAGA AAAAGGTTGT CGACTTTGAA 4560

GTTATCAGCT TTCTTCAGCA GAATTTGAAA AGTCGCGCTG CAGAAGAAAG GAATTGCAGA 4620

GATACATCAG AAGGAGTCAT TGTTACAACG CAAAAGGGAC CAAGTTTTAA CAGCACAGGT 4680

GCCAGTGAAA CCTTTGGAAG TGTAACGGTG CCTAACATTA ACTTTGTCAC AACTGAAAAG 4740

CTACCCTATA ATACCAAGAA AAGATATGAA ACACAGATTA TTTCTCGGAT TCACCCAGTC 4800

GTAAGCAACA TGTTTCATAA ACACTTGGAT GTTGAAGTGA TTGCGGTGGA TTTACCAGGA 4860

AACATGATGA AGAATTTTGC CCATTTGGAG TGGTGTGAGG ATGAAGAGTC CTTTGAAGAG 4920

AGCAGAAAGG AATTAATCGG CAAATTGCCA AAGCAGCGAA AGTATTTGGA GGATATCTGC 4980

GATGAAATCC ACGAGCTGAA GATAGAAAAA CGGGTGCCCA TAGTGATCGT TTACAGCTAC 5040

AGGGATGACG TTCACCGTTT CATCTTCTGA 5070

Domain Profile

S: 1     feeikvlGkGgfgvVlkaknkldkkeyaikriklnkakkelekverevkaLaklehpniv  60

         fee+++lGkG+fg+V+k+knkld+++ya kri++n  ++++++++ ev++L++l+h+niv

Q: 616   FEELALLGKGAFGAVIKVKNKLDGCYYALKRIAVNPTSRQFRRIKGEVTLLSRLNHENIV  675

         899*********************************************************

S: 61    rYfaawleekeesl..............................................  74

         rY++aw+e+ e s

Q: 676   RYYNAWIERYELSPsdaketpdvanvrgrgpamhlsrlsgiaglddveanapppvtastr  735

         ********999777999*******************************************

S: 75    .....................................................tdsseve  81

                                                              +++ +v

Q: 736   tvasgsvewsmsyehsvsarcgpsttggspsdssdeddeddvvfgrsfvpsgsDSDCDVV  795

         ********9999999999999999999999999999999999999999998852245555

S: 82    aeaeleesesseesdtk......................llyiqmelceketLkdwider  119

          e + e+ +s+e++d++                      +l+iqme+ce++tL+d+id+

Q: 796   FENSGEKNQSEESHDSSlsdkelsknrapvcqptptvvhHLFIQMEYCERSTLRDTIDKG  855

         555555555555555557778888899999******************************

S: 120   kllesrselvmrlfkqllegleylHskgliHrdLkpsniFldsddqvKigDFgLatalae  179

          l  ++++++ rlf+++l+gl+y+H++g+iHrdLkp+niFlds+d vKigDFgLat+

Q: 856   -LHMETDRMW-RLFREILDGLAYIHEQGMIHRDLKPVNIFLDSSDSVKIGDFGLATDHRL  913

         .999******.**********************************************887

S: 180   alkedvkqdaqske...........akhtgqvgtklymsPeql..eksqYnkkvDifsLG  226

           +e++k d ++++           +  tgq+gt+ly+sPe+l   k+ Yn+kvD++sLG

Q: 914   VATESSKIDVSTANielptenmdvtGGLTGQIGTALYVSPEVLgnIKAVYNQKVDLYSLG  973

         777666665555556677777666669****************9889*************

S: 227   lilfeLly.pfstemervetltelrd..gkipedfdd.kvpkekkllqkllsrdpkeRps  282

         +i+fe+ y p+ t++erv +l++lr   +++pedf+    ++++ ++++ll++d+ +Rp+

Q: 974   IIFFEMTYhPMTTASERVAVLQKLRLptIQFPEDFHPqTLKQQAFIIRWLLNHDAGQRPT  1033

         ************************9888*******87688999999**************

S: 283   asellksel  291

         a+ellkse

Q: 1034  AQELLKSEQ  1042

         ******986

Domain Sequence
(FASTA)

FEELALLGKG AFGAVIKVKN KLDGCYYALK RIAVNPTSRQ FRRIKGEVTL LSRLNHENIV 60

RYYNAWIERY ELSPSDAKET PDVANVRGRG PAMHLSRLSG IAGLDDVEAN APPPVTASTR 120

TVASGSVEWS MSYEHSVSAR CGPSTTGGSP SDSSDEDDED DVVFGRSFVP SGSDSDCDVV 180

FENSGEKNQS EESHDSSLSD KELSKNRAPV CQPTPTVVHH LFIQMEYCER STLRDTIDKG 240

LHMETDRMWR LFREILDGLA YIHEQGMIHR DLKPVNIFLD SSDSVKIGDF GLATDHRLVA 300

TESSKIDVST ANIELPTENM DVTGGLTGQI GTALYVSPEV LGNIKAVYNQ KVDLYSLGII 360

FFEMTYHPMT TASERVAVLQ KLRLPTIQFP EDFHPQTLKQ QAFIIRWLLN HDAGQRPTAQ 420

ELLKSEQ 427

Keyword

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>