EPS-PEM-00022

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-PEM-00022

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	143.6	5.2E-42	295	548	254

Status

Unreviewed

Ensembl Protein

ENSPMAP00000009339

Gene Name

PHLPP1

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPMAG00000008482	ENSPMAP00000009339	ENSPMAT00000009378

Organism

Petromyzon marinus

Protein Length

841

Protein Sequence
(FASTA)

LSTVSIHPAP VQLTYADISR NKLESVPEWI PDATSLEILN ISHNEISELP IRLMCAEGLK 60

RLLAGHNQLR RLPERLERVH TETLDVQHNL LTELPTALFL KAPSLRSLNA SANRLESLPP 120

SVLGEGESVS TLQELYLANN QLVDKCVPHL TGHQHLRVLH LTYNLLTTFP ASKLAKLTEL 180

EELNLSGNRL RTVPTTILGC KRLHTLCAHS NAINVFPEVF QLPETQLVDL SCNELTEVPL 240

PESLPPKLQE LDLMGNPRLA LDLAALDMLS HITCLKIDPR PTLPPGDAAE SPIWSHGCAE 300

TLGQRKKLCV SSLASGAFGE DAREALYGVF DGERNVEVPR LLQCTMGDVL SEEMQRAPAS 360

SSEDHMLYTF LGTHKKLGTA GQKLGASAVL CHLRRDLPEA GNGGGGRLTL TAGNVGSCRV 420

LLCRAGCTVS LTPDFTLTEC REERERLRGI NAIITEDNKV GGVTNVTRLL GCSFLYPSVL 480

PRPHTRALRL TPDDELLLLC SRSLAAFLPP TEAVEAIRDV ADPLAAAKKL TTLAQGYGCH 540

DNLGVVVVRL SVALEDAGCC TCDAVSAETA VNNGSGGSSS GAFSELSSEV SSEVAGSEVS 600

SEVGSTASDE QPPSLGLVEC ILKLSERRCS LHPSASARTF QRQMSAATFS SAYSDPGLDS 660

SDDEDAMGGG GQRLEVEADV HPLCALAGPS SRSLKTLSVT SSETSDEGIV ISLRADASVA 720

CSEKPPGAHE PRSSSAAATA SGTLGRGRRN GSVVTPDCGQ GLMEVIVASD AAPARPKRSA 780

YFVSEPAPGP DPDDELIVPP ELEEEVREQI RQYQQQQKLQ DQQKVTEQQK VEQQQQMKQP 840

L 841

Nucleotide Sequence
(FASTA)

CTCTCCACAG TCAGCATACA CCCTGCGCCT GTACAGCTCA CGTACGCTGA CATATCGAGG 60

AATAAGTTGG AGAGCGTTCC CGAATGGATT CCTGATGCAA CCAGCCTGGA AATTCTCAAT 120

ATCAGCCACA ATGAAATCAG CGAATTACCG ATCAGGCTGA TGTGTGCCGA GGGCTTGAAG 180

AGACTCCTTG CTGGCCACAA CCAACTGCGT CGGCTGCCTG AGCGGCTGGA GAGAGTGCAC 240

ACGGAGACAC TGGACGTGCA GCACAACCTG CTCACGGAGC TGCCCACGGC GCTCTTCCTC 300

AAGGCGCCCA GCCTACGCTC TCTGAACGCG TCGGCCAACC GCCTGGAGTC GCTGCCGCCG 360

TCAGTGCTAG GCGAGGGGGA GAGCGTGAGC ACGCTGCAGG AGCTCTACCT TGCCAACAAC 420

CAGCTGGTGG ACAAGTGTGT CCCTCATCTG ACCGGGCACC AGCACTTGCG TGTCCTACAC 480

CTGACCTACA ACCTGCTCAC CACATTCCCT GCAAGTAAAC TGGCCAAGCT GACGGAGCTG 540

GAGGAGCTGA ACCTGAGCGG GAACCGCCTG CGCACAGTGC CCACCACCAT CCTGGGCTGC 600

AAGAGGCTGC ACACGCTCTG TGCTCACTCC AACGCTATCA ATGTCTTCCC GGAGGTCTTT 660

CAGCTGCCCG AAACGCAGCT CGTGGATCTC AGCTGCAACG AGCTGACAGA GGTGCCGCTG 720

CCCGAGAGCC TGCCCCCCAA GCTGCAGGAG CTCGACCTCA TGGGCAACCC TCGGCTGGCG 780

CTCGACCTCG CCGCGCTCGA CATGCTCAGC CACATCACCT GCCTGAAGAT TGATCCCCGT 840

CCGACCTTGC CGCCCGGAGA TGCGGCAGAG TCACCAATTT GGAGCCACGG CTGCGCCGAG 900

ACTTTAGGGC AAAGGAAAAA GCTGTGCGTG TCGTCACTGG CGTCGGGCGC TTTCGGCGAG 960

GACGCTCGAG AGGCCCTCTA CGGGGTCTTC GACGGCGAGC GCAACGTGGA GGTGCCACGG 1020

CTGCTGCAGT GCACCATGGG GGACGTGCTG AGCGAGGAGA TGCAGCGAGC TCCCGCCTCG 1080

TCCAGCGAGG ACCACATGCT CTACACCTTC CTGGGGACTC ACAAGAAGCT TGGCACGGCG 1140

GGGCAGAAGC TGGGCGCCTC GGCGGTGCTG TGCCACCTCC GCAGGGATCT CCCTGAAGCC 1200

GGCAATGGAG GCGGCGGGCG TCTCACGCTA ACGGCCGGCA ACGTTGGGAG CTGCCGCGTG 1260

CTGCTGTGCC GCGCCGGCTG CACCGTGTCC CTGACTCCCG ACTTCACACT CACCGAGTGC 1320

CGGGAGGAGC GCGAAAGGCT ACGTGGCATC AACGCCATCA TTACGGAGGA CAACAAGGTG 1380

GGTGGGGTGA CGAACGTGAC GCGGCTGCTG GGCTGCTCCT TCCTCTACCC GTCGGTGCTG 1440

CCCCGGCCCC ACACGCGTGC CCTGCGCCTC ACGCCTGACG ACGAGCTCCT GCTCCTGTGC 1500

AGCCGCTCCC TCGCCGCCTT TCTCCCGCCC ACCGAGGCTG TGGAGGCGAT CCGGGACGTC 1560

GCCGACCCGC TGGCCGCCGC CAAGAAGCTC ACTACGCTCG CCCAGGGCTA TGGCTGCCAC 1620

GACAACCTGG GAGTGGTGGT GGTGAGGCTC AGCGTCGCCT TGGAGGATGC AGGCTGCTGC 1680

ACCTGTGATG CTGTCTCTGC TGAAACGGCC GTGAACAATG GCAGCGGAGG GAGCAGCAGT 1740

GGAGCGTTCT CGGAACTGAG CAGCGAGGTG AGCAGCGAAG TCGCGGGGTC AGAGGTCAGC 1800

AGCGAGGTTG GCTCCACCGC TTCTGACGAG CAGCCGCCGT CTCTGGGCCT TGTGGAGTGC 1860

ATTCTCAAGC TCTCCGAGCG TCGATGCAGC CTCCACCCGA GCGCCTCTGC GCGCACCTTC 1920

CAGCGGCAGA TGTCGGCCGC CACCTTCTCA AGCGCGTACT CCGATCCGGG CCTGGACAGC 1980

AGCGACGACG AGGACGCGAT GGGCGGCGGG GGACAGCGGC TGGAGGTGGA GGCCGACGTG 2040

CACCCGCTGT GCGCCTTAGC CGGGCCCTCG TCGCGATCGC TCAAGACCCT GTCGGTGACG 2100

TCCTCCGAGA CGAGCGACGA GGGGATCGTC ATCTCGCTCC GCGCTGACGC CTCCGTGGCG 2160

TGCTCCGAGA AGCCGCCCGG CGCCCACGAG CCCAGGTCGA GCAGTGCGGC GGCAACGGCC 2220

TCCGGCACCC TGGGGCGCGG GCGCCGCAAC GGCTCCGTGG TGACGCCCGA TTGTGGCCAG 2280

GGCCTCATGG AGGTGATCGT GGCGAGCGAC GCGGCCCCCG CACGCCCCAA GCGCTCCGCC 2340

TACTTCGTGT CGGAGCCGGC ACCAGGGCCG GACCCGGACG ATGAACTCAT CGTCCCGCCG 2400

GAGCTGGAGG AGGAAGTAAG GGAACAGATC CGGCAATACC AGCAGCAGCA GAAGCTGCAA 2460

GATCAGCAGA AAGTTACCGA GCAACAGAAA GTTGAGCAGC AGCAGCAGAT GAAGCAGCCG 2520

CTG 2523

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         ++g+++  g+r++++ ++ +s+ f+++  +    a++gv+DG+++ ev + +++++ ++l

Q: 295   SHGCAETLGQRKKLCVSSLASGAFGEDARE----ALYGVFDGERNVEVPRLLQCTMGDVL  350

         6899**********************9776....79************************

S: 62    aeelesseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikds......  115

          ee++         ++ + ++Fl t+++l       ++ +k G++av+++++ +

Q: 351   SEEMQ--RAPASSSEDHMLYTFLGTHKKL------GTAGQKLGASAVLCHLRRDlpeagn  402

         ***99..5666677789************......99***************88888999

S: 116   ......klyvanvGdSravLcrngkavelssdHk.psredEleRieeaggsvilkdgaRv  168

               +l+  nvG +r++Lcr g  v+l+ d++ +++ +E+eR++   + +++++  +v

Q: 403   ggggrlTLTAGNVGSCRVLLCRAGCTVSLTPDFTlTECREERERLRGINAIITEDN--KV  460

         9999999999**************88*******934667**********9999998..**

S: 169   lGvLavsRalGdlylkpyvtpePevtshrltsedefliLasDGlwdvvsneeavslvrdv  228

          Gv++v+R lG+ +l+p v p+P++   rlt++de l L s  l   +++ eav+++rdv

Q: 461   GGVTNVTRLLGCSFLYPSVLPRPHTRALRLTPDDELLLLCSRSLAAFLPPTEAVEAIRDV  520

         ************************************************************

S: 229   lekkeaeqeaakkLvklalargskdnvsaivv  260

          +    + +aakkL++la+ +g++dn+ ++vv

Q: 521   AD----PLAAAKKLTTLAQGYGCHDNLGVVVV  548

         **....*********************99987

Domain Sequence
(FASTA)

SHGCAETLGQ RKKLCVSSLA SGAFGEDARE ALYGVFDGER NVEVPRLLQC TMGDVLSEEM 60

QRAPASSSED HMLYTFLGTH KKLGTAGQKL GASAVLCHLR RDLPEAGNGG GGRLTLTAGN 120

VGSCRVLLCR AGCTVSLTPD FTLTECREER ERLRGINAII TEDNKVGGVT NVTRLLGCSF 180

LYPSVLPRPH TRALRLTPDD ELLLLCSRSL AAFLPPTEAV EAIRDVADPL AAAKKLTTLA 240

QGYGCHDNLG VVVV 254

Keyword

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>