EKS-POA-00234

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-POA-00234

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	386.8	4.1E-116	60	311	252

Status

Unreviewed

Ensembl Protein

ENSPPYP00000000210

UniProt Accession

H2N3N7;

Protein Name

Protein Synonyms/Alias

Gene Name

MARK1

Gene Synonyms/Alias

MARK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000000206	ENSPPYP00000000210	ENSPPYT00000000225

Organism

Pongo abelii

Functional Description

Protein Length

795

Protein Sequence
(FASTA)

MSARTPLPTV NERDTENHTS VDGYTEPHIQ PTKSSSRQNI PRCRNSITSA TDEQPHIGNY 60

RLQKTIGKGN FAKVKLARHV LTGREVAVKI IDKTQLNPTS LQKLFREVRI MKILNHPNIV 120

KLFEVIETEK TLYLVMEYAS GGEVFDYLVA HGRMKEKEAR AKFRQIVSAV QYCHQKYIVH 180

RDLKAENLLL DGDMNIKIAD FGFSNEFTVG NKLDTFCGSP PYAAPELFQG KKYDGPEVDV 240

WSLGVILYTL VSGSLPFDGQ NLKELRERVL RGKYRIPFYM STDCENLLKK LLVLNPIKRG 300

SLEQIMKDRW MNVGHEEEEL KPYTEPDPDF NDTKRIDIMV TMGFARDEIN DALINQKYDE 360

VMATYILLGR KPPEFEGGES LSSGNLCQRS RPSSDLNNST LQSPAHLKVQ RSISANQKQR 420

RFSDHAGPSI PPAVSYTKRP QANSVESEQK EEWDKDVARK LGSTTVGSKS EMTASPLVGP 480

ERKKSSTIPS NNVYSGGSMA RRNTYVCERT TDRYAALQNG KDSSLTEMSV SSISSAGSSV 540

ASAVPSARPR HQKSMSTSGH PIKVTLPTIK DGSEAYRPGT TQRVPAASPS AHSISTATPD 600

RTRFPRGSSS RSTFHGEQLR ERRSAAYNGP PASPSHETGA FAHARRGTST GIISKITSKF 660

VRRDPSEGEA SGRTDTSRST SGEPKERDKE EGKDSKPRSL RFTWSMKTTS SMDPNDMMRE 720

IRKVLDANNC DYEQKERFLL FCVHGDARQD SLVQWEMEVC KLPRLSLNGV RFKRISGTSI 780

AFKNIASKIA NELKL 795

Nucleotide Sequence
(FASTA)

ATGTCGGCCC GGACGCCATT GCCGACGGTG AACGAGCGGG ACACGGAAAA TCATACATCT 60

GTGGATGGAT ATACTGAACC ACACATCCAG CCTACCAAGT CGAGTAGCAG ACAGAACATC 120

CCCCGGTGTA GAAACTCCAT TACGTCAGCA ACAGATGAAC AGCCTCACAT TGGAAATTAC 180

CGTTTACAAA AAACAATAGG GAAGGGAAAT TTTGCCAAAG TCAAATTGGC AAGACACGTT 240

CTAACTGGTA GAGAGGTTGC TGTGAAAATA ATAGACAAAA CTCAGCTAAA TCCTACCAGT 300

CTACAAAAGT TATTTCGAGA AGTACGAATA ATGAAGATAC TGAATCATCC TAATATAGTA 360

AAATTGTTTG AAGTTATTGA AACAGAGAAG ACTCTCTATT TAGTCATGGA ATACGCGAGT 420

GGGGGTGAAG TATTTGATTA CTTAGTTGCC CATGGAAGAA TGAAAGAGAA AGAGGCCCGT 480

GCAAAATTTA GGCAGATTGT ATCTGCTGTA CAGTACTGTC ATCAAAAGTA CATTGTTCAC 540

CGTGATCTTA AGGCTGAAAA CCTTCTCCTT GATGGTGATA TGAATATTAA AATTGCTGAC 600

TTTGGTTTTA GTAATGAATT TACAGTTGGG AACAAATTGG ACACATTTTG TGGAAGCCCA 660

CCCTATGCTG CTCCCGAGCT TTTCCAAGGA AAGAAGTATG ACGGGCCTGA AGTGGATGTG 720

TGGAGTCTGG GCGTCATTCT CTATACATTA GTCAGTGGCT CCTTGCCTTT CGATGGCCAG 780

AATTTAAAGG AACTGCGAGA GCGAGTTTTA CGAGGGAAGT ACCGTATTCC CTTCTATATG 840

TCCACAGACT GTGAAAATCT TCTGAAGAAA TTATTAGTCC TGAATCCAAT AAAGAGAGGC 900

AGCTTGGAAC AAATAATGAA AGATCGATGG ATGAATGTTG GTCATGAAGA AGAAGAACTA 960

AAGCCATATA CTGAGCCTGA TCCAGATTTC AATGACACAA AAAGAATAGA CATTATGGTC 1020

ACCATGGGCT TTGCACGAGA TGAAATAAAT GATGCCTTAA TAAATCAGAA GTATGATGAA 1080

GTTATGGCTA CTTATATTCT TCTAGGTAGA AAACCACCTG AATTTGAAGG TGGTGAATCG 1140

TTATCCAGTG GAAACTTGTG TCAGAGGTCC CGGCCCAGTA GTGACTTAAA TAACAGCACT 1200

CTTCAGTCCC CTGCTCACCT GAAGGTCCAG AGAAGTATCT CAGCAAATCA GAAGCAGCGG 1260

CGTTTCAGTG ATCATGCTGG TCCATCCATT CCTCCTGCTG TATCATATAC CAAAAGACCT 1320

CAGGCTAACA GCGTGGAAAG TGAACAGAAA GAGGAGTGGG ACAAAGATGT GGCTCGAAAA 1380

CTTGGCAGCA CAACAGTTGG ATCAAAAAGC GAGATGACTG CAAGCCCTCT TGTAGGGCCA 1440

GAGAGGAAAA AATCTTCAAC TATTCCAAGT AACAATGTGT ATTCTGGAGG TAGCATGGCA 1500

AGAAGGAATA CATATGTCTG TGAAAGGACC ACAGATCGAT ACGCAGCATT GCAGAATGGA 1560

AAAGACAGCA GCCTTACGGA GATGTCTGTG AGTAGCATAT CTTCTGCAGG CTCTTCGGTG 1620

GCCTCTGCTG TCCCCTCAGC ACGACCCCGC CACCAGAAGT CCATGTCCAC TTCTGGTCAT 1680

CCTATTAAAG TCACACTGCC AACCATTAAA GACGGCTCTG AAGCTTACCG GCCTGGTACA 1740

ACCCAGAGAG TGCCTGCTGC TTCCCCATCT GCTCACAGTA TTAGTACTGC GACTCCAGAC 1800

CGGACCCGTT TTCCCCGAGG GAGCTCAAGC CGAAGCACTT TCCATGGTGA ACAGCTCCGG 1860

GAGCGACGCA GCGCTGCTTA TAATGGGCCA CCTGCTTCAC CATCCCATGA AACGGGTGCA 1920

TTTGCACATG CCAGAAGGGG AACGTCAACT GGTATAATAA GCAAAATCAC ATCCAAATTT 1980

GTTCGCAGGG ATCCAAGTGA AGGCGAAGCC AGTGGCAGAA CCGACACCTC AAGAAGTACA 2040

TCAGGGGAAC CAAAAGAAAG AGACAAGGAA GAGGGTAAAG ATTCTAAGCC GCGTTCTTTG 2100

CGGTTCACAT GGAGTATGAA GACCACTAGT TCAATGGACC CTAATGACAT GATGAGAGAA 2160

ATCCGAAAAG TGTTAGATGC AAATAACTGT GATTATGAGC AAAAAGAGAG ATTTTTGCTT 2220

TTCTGTGTCC ATGGAGATGC TAGACAGGAT AGCCTCGTGC AGTGGGAGAT GGAAGTCTGC 2280

AAGTTGCCAC GACTGTCACT TAATGGGGTT CGCTTCAAGC GAATATCTGG GACATCTATT 2340

GCCTTTAAAA ACATTGCATC AAAAATAGCA AATGAGCTTA AGCTGTAA 2388

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y+l+kt+G+g+f+kVkla+h +t+++vavKii+k++l+ +sl+k++rE++i+k+l+hpni

Q: 60    YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNI  119

         99**********************************************************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         +kl+eviet+k+lylv+eyasgge+fdy++++gr+kekear+ f+q+vsav+Y+h+k iv

Q: 120   VKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIV  179

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvD  180

         HrDlK+eNllld ++nikiaDFG++n+f+ g++l+tfcGsppYaaPel++gkkY+gp+vD

Q: 180   HRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVD  239

         ************************************************************

S: 181   vWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekR  240

         vWslGv+Ly+lv+g+lPfd++nlkel+e++l+gk++ip+++s+++e+Ll+klLv +p kR

Q: 240   VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKR  299

         ************************************************************

S: 241   atieeilkhewl  252

          ++e+i+k++w+

Q: 300   GSLEQIMKDRWM  311

         ***********8

Domain Sequence
(FASTA)

YRLQKTIGKG NFAKVKLARH VLTGREVAVK IIDKTQLNPT SLQKLFREVR IMKILNHPNI 60

VKLFEVIETE KTLYLVMEYA SGGEVFDYLV AHGRMKEKEA RAKFRQIVSA VQYCHQKYIV 120

HRDLKAENLL LDGDMNIKIA DFGFSNEFTV GNKLDTFCGS PPYAAPELFQ GKKYDGPEVD 180

VWSLGVILYT LVSGSLPFDG QNLKELRERV LRGKYRIPFY MSTDCENLLK KLLVLNPIKR 240

GSLEQIMKDR WM 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0070300	; F:phosphatidic acid binding
GO:0005546	; F:phosphatidylinositol-4,5-bisphosphate binding
GO:0001786	; F:phosphatidylserine binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

pon:100456064

;

InterPros

IPR001772	; Kinase-assoc_KA1.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF02149	; KA1; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220	; S_TKc; 1.
SM00165	; UBA; 1.

Prosites

PS50032	; KA1; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013