EKS-POA-00231

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-POA-00231

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Abl	552.2	1.6E-166	267	518	252

Status

Unreviewed

Ensembl Protein

ENSPPYP00000000534

UniProt Accession

H2N4J6;

Protein Name

Protein Synonyms/Alias

Gene Name

ABL2

Gene Synonyms/Alias

ABL2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000000464	ENSPPYP00000000534	ENSPPYT00000000555

Organism

Pongo abelii

Functional Description

Protein Length

1161

Protein Sequence
(FASTA)

MGQQVGRVGE APGLQQPQPR GIRGSSAARP SGRRRDPAGR TTETGFNIFT QHEALHRPYG 60

CDVEPQALNE AIRWSSKENL LGATESDPNL FVALYDFVAS GDNTLSITKG EKLRVLGYNQ 120

NGEWSEVRSK NGQGWVPSNY ITPVNSLEKH SWYHGPVSRS AAEYLLSSLI NGSFLVRESE 180

SSPGQLSISL RYEGRVYHYR INTTTDGKVY VTAESRFSTL AELVHHHSTV ADGLVTTLHY 240

PAPKCNKPTV YGVSPIHDKW EMERTDITMK HKLGGGQYGE VYVGVWKKYS LTVAVKTLKE 300

DTMEVEEFLK EAAVMKEIKH PNLVQLLGVC TLEPPFYIVT EYMPYGNLLD YLRECNREEV 360

TAVVLLYMAT QISSAMEYLE KKNFIHRDLA ARNCLVGENH VVKVADFGLS RLMTGDTYTA 420

HAGAKFPIKW TAPESLAYNT FSIKSDVWAF GVLLWEIATY GMSPYPGIDL SQVYDLLEKG 480

YRMEQPEGCP PKVYELMRAC WKWSPADRPS FAETHQAFET MFHDSSISEE VAEELGRAAS 540

SSSVVPYLPR LPILPSKTRT LKKQVENKEN IEGAQDATEN SASSLAPGFI RGAQASSGSP 600

ALPRKQRDKS PSSLLEDAKE TCFTRDRKGG FFSSFMKKRN APTPPKRSSS FREMENQPHK 660

KYELTGNFSS VASLQHADGF SFTPAQQEAN LVPPKCYGGS FAQRNLCNDD GGGGGGSGTA 720

GGGWSGITGF FTPRLIKKTL GLRAGKPTAS DDTSKPFPRS NSTSSMSSGL PEQDRMAMTL 780

PRNCQRSKLH LERTVSTSSQ PEENVDRAND MLPKKSEESA APSRERPKAK LLPRGAAALP 840

LRTPSGDLAI TEKDPPGVGV AGVAAAPKGK EKNGGARLGM AGVPEDGEQP GWPSPAKAAP 900

VLPTTHNHKV PVLISPTLKH TPADVQLIGT DSQGNKFKLL SEHQVTSSGD KDRPRRVKPK 960

CAPPPPPVMR LLQHPSICSD PTEEPTALTA GQSTSETQEG GKKAALGAVP ISGKAGRPVM 1020

PPPQVPLPTS SISPAKMANG TAGTKVALRK TKQAAEKISA DKISKEALLE CADLLSSAIT 1080

EPVPNSQLVD TGHQLLDYCS GYVDCIPQTR NKFAFREAVS KLELSLQELQ VSSAAAGVPG 1140

TNPVLNNLLS CVQEISDVVQ R 1161

Nucleotide Sequence
(FASTA)

ATGGGGCAGC AGGTGGGCCG CGTCGGGGAA GCTCCGGGGC TCCAGCAGCC TCAGCCCCGC 60

GGGATCCGGG GCAGCAGTGC AGCCAGGCCC TCCGGCCGCA GGCGGGACCC GGCGGGGCGC 120

ACCACAGAGA CTGGCTTCAA TATCTTCACC CAGCATGAAG CTTTGCATCG TCCCTATGGT 180

TGTGATGTTG AACCCCAGGC ACTAAATGAG GCTATCAGGT GGAGCTCCAA GGAGAACTTG 240

CTCGGAGCCA CCGAGAGTGA CCCTAATCTC TTCGTTGCAC TTTATGATTT TGTAGCAAGT 300

GGTGATAACA CACTCAGCAT CACTAAAGGT GAAAAGCTAC GAGTCCTTGG TTACAACCAG 360

AATGGCGAGT GGAGTGAAGT TCGCTCTAAG AACGGGCAGG GCTGGGTGCC AAGCAACTAC 420

ATCACCCCAG TGAACAGTCT GGAAAAACAC TCCTGGTACC ATGGACCTGT GTCACGCAGT 480

GCAGCTGAGT ATCTGCTCAG CAGTCTAATC AATGGCAGCT TCCTGGTACG AGAAAGTGAG 540

AGTAGCCCTG GGCAGCTGTC CATCTCGCTC AGGTACGAGG GACGTGTGTA TCACTACAGG 600

ATCAATACCA CCACAGATGG CAAGGTGTAT GTGACTGCTG AGAGCCGCTT CAGCACCTTG 660

GCAGAGCTTG TACACCATCA CTCCACAGTG GCTGATGGGC TGGTGACAAC ATTACACTAC 720

CCAGCACCCA AGTGTAATAA GCCTACAGTC TATGGTGTGT CCCCCATCCA CGACAAATGG 780

GAAATGGAGC GAACAGATAT TACCATGAAG CACAAACTTG GGGGCGGTCA GTATGGAGAG 840

GTTTACGTTG GCGTCTGGAA GAAATACAGC CTTACAGTTG CTGTGAAAAC ATTGAAGGAA 900

GATACCATGG AGGTAGAAGA ATTCCTGAAA GAAGCTGCGG TAATGAAGGA AATCAAGCAT 960

CCTAATCTGG TACAACTTTT AGGTGTGTGT ACTTTGGAGC CACCATTTTA CATTGTGACT 1020

GAATACATGC CATACGGGAA TTTGCTGGAT TACCTCCGAG AATGCAACCG AGAAGAGGTG 1080

ACTGCAGTTG TGCTGCTCTA CATGGCCACT CAGATTTCTT CTGCAATGGA GTACTTAGAG 1140

AAGAAGAATT TCATCCATAG AGATCTTGCA GCTCGTAACT GCCTAGTGGG AGAAAACCAT 1200

GTGGTAAAAG TGGCTGACTT TGGCTTAAGT AGATTGATGA CTGGAGACAC TTATACTGCT 1260

CATGCTGGAG CCAAATTTCC TATTAAGTGG ACAGCACCAG AGAGTCTTGC CTACAATACC 1320

TTCTCAATTA AATCTGACGT CTGGGCTTTT GGGGTACTGT TGTGGGAAAT CGCTACCTAT 1380

GGAATGTCAC CATATCCAGG TATTGACCTG TCTCAGGTCT ACGACCTCCT AGAAAAAGGA 1440

TATCGAATGG AACAGCCTGA GGGATGCCCC CCTAAGGTTT ATGAACTTAT GAGAGCATGC 1500

TGGAAGTGGA GCCCTGCCGA TAGGCCCTCT TTTGCTGAAA CACACCAAGC TTTTGAAACC 1560

ATGTTCCATG ACTCCAGCAT TTCTGAAGAG GTAGCTGAGG AGCTTGGGAG AGCTGCCTCC 1620

TCATCATCTG TTGTTCCATA CCTGCCCCGG CTACCTATAC TTCCTTCCAA GACTCGGACA 1680

CTGAAGAAAC AGGTGGAGAA CAAGGAGAAC ATTGAAGGGG CACAAGATGC CACAGAAAAT 1740

TCTGCTTCCA GTTTAGCACC AGGGTTCATC AGAGGTGCGC AGGCCTCCAG TGGATCCCCA 1800

GCACTGCCTC GAAAGCAAAG AGACAAGTCA CCCAGCAGCC TCTTGGAAGA TGCCAAAGAG 1860

ACATGCTTCA CCAGGGATAG GAAGGGGGGC TTCTTCAGCT CCTTCATGAA AAAGAGAAAT 1920

GCTCCTACAC CCCCTAAACG CAGCAGCTCC TTCCGAGAAA TGGAGAATCA GCCCCATAAG 1980

AAATACGAAC TCACGGGTAA CTTCTCATCT GTTGCTTCTC TACAGCATGC TGATGGGTTC 2040

TCTTTCACTC CTGCCCAGCA AGAGGCGAAT CTGGTGCCAC CCAAGTGCTA TGGGGGGAGC 2100

TTTGCACAGA GGAACCTCTG TAATGACGAC GGTGGTGGGG GTGGGGGCAG TGGCACTGCT 2160

GGGGGTGGGT GGTCTGGCAT CACAGGCTTC TTTACACCAC GCTTAATCAA AAAGACACTG 2220

GGCTTACGAG CAGGTAAACC CACAGCCAGT GATGACACTT CCAAGCCTTT TCCAAGGTCA 2280

AACTCTACAT CTTCCATGTC CTCAGGGCTT CCAGAGCAGG ATAGGATGGC AATGACCCTT 2340

CCCAGGAACT GCCAGAGGTC CAAACTCCAC CTGGAAAGGA CAGTGTCCAC CTCTTCTCAG 2400

CCAGAAGAGA ATGTGGACAG GGCCAATGAC ATGCTTCCAA AAAAATCAGA GGAAAGTGCT 2460

GCTCCAAGCA GGGAGAGACC AAAAGCCAAG TTATTGCCCA GAGGAGCCGC AGCTCTTCCT 2520

CTCAGAACAC CCTCTGGGGA TCTAGCCATT ACAGAGAAGG ACCCTCCAGG GGTGGGAGTG 2580

GCTGGAGTGG CAGCTGCCCC CAAGGGCAAA GAGAAGAATG GTGGGGCACG ACTTGGGATG 2640

GCTGGAGTTC CAGAGGATGG AGAGCAGCCG GGCTGGCCTT CTCCAGCCAA GGCTGCCCCT 2700

GTCCTCCCAA CCACTCACAA CCACAAAGTG CCAGTCCTTA TCTCACCCAC CCTGAAACAC 2760

ACTCCAGCTG ATGTGCAGCT CATTGGCACA GACTCTCAGG GGAATAAATT CAAGCTCTTA 2820

TCTGAGCATC AGGTCACATC CTCTGGAGAC AAGGACCGAC CCCGACGGGT AAAACCAAAG 2880

TGTGCCCCAC CCCCACCACC AGTGATGAGA CTACTGCAGC ATCCGTCCAT CTGCTCAGAC 2940

CCTACAGAAG AGCCGACTGC CCTAACTGCA GGACAGTCCA CGTCAGAAAC ACAGGAAGGA 3000

GGAAAGAAGG CAGCTCTGGG CGCAGTGCCC ATCAGTGGGA AAGCTGGGAG GCCAGTGATG 3060

CCTCCACCTC AAGTGCCTCT GCCCACATCT TCCATCTCGC CAGCCAAAAT GGCCAACGGC 3120

ACAGCAGGTA CTAAAGTGGC TCTGAGAAAA ACCAAACAGG CCGCTGAGAA AATCTCAGCA 3180

GACAAAATCA GCAAAGAGGC CCTGCTGGAA TGTGCTGACC TACTGTCCAG TGCAATCACG 3240

GAACCTGTGC CCAACAGCCA GCTGGTAGAC ACTGGACACC AGCTGCTTGA CTACTGCTCA 3300

GGCTATGTGG ACTGCATCCC TCAAACTCGC AACAAATTTG CCTTCCGAGA GGCTGTGAGC 3360

AAACTGGAAC TCAGCCTGCA GGAGCTACAG GTTTCTTCAG CAGCTGCTGG TGTGCCCGGG 3420

ACAAACCCTG TCCTTAATAA CTTATTGTCA TGTGTACAGG AAATCAGTGA TGTGGTGCAG 3480

AGGTAG 3486

Domain Profile

S: 1     iimkhklgggqygevyegvwkkysltvavktlkedtmeveeflkeaavmkelkhpnlvql  60

         i+mkhklgggqygevy+gvwkkysltvavktlkedtmeveeflkeaavmke+khpnlvql

Q: 267   ITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQL  326

         89**********************************************************

S: 61    lgvctreppfyiitefmsygnlldylreadreeveavvllymatqissameylekknfih  120

         lgvct eppfyi+te+m+ygnlldylre++reev+avvllymatqissameylekknfih

Q: 327   LGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIH  386

         ************************************************************

S: 121   rdlaarnclvgenklvkvadfglsrlmkedtytahagakfpikwtapeslaynkfsiksd  180

         rdlaarnclvgen++vkvadfglsrlm++dtytahagakfpikwtapeslayn+fsiksd

Q: 387   RDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSD  446

         ************************************************************

S: 181   vwafgvllweiatygmspypgidlsqvyellekgyrmerpegcppkvyelmracwkwsps  240

         vwafgvllweiatygmspypgidlsqvy+llekgyrme+pegcppkvyelmracwkwsp+

Q: 447   VWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPA  506

         ************************************************************

S: 241   drpsfaeihqal  252

         drpsfae+hqa+

Q: 507   DRPSFAETHQAF  518

         *********986

Domain Sequence
(FASTA)

ITMKHKLGGG QYGEVYVGVW KKYSLTVAVK TLKEDTMEVE EFLKEAAVMK EIKHPNLVQL 60

LGVCTLEPPF YIVTEYMPYG NLLDYLRECN REEVTAVVLL YMATQISSAM EYLEKKNFIH 120

RDLAARNCLV GENHVVKVAD FGLSRLMTGD TYTAHAGAKF PIKWTAPESL AYNTFSIKSD 180

VWAFGVLLWE IATYGMSPYP GIDLSQVYDL LEKGYRMEQP EGCPPKVYEL MRACWKWSPA 240

DRPSFAETHQ AF 252

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity

KEGG

InterPros

IPR015015	; F-actin_binding.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF08919	; F_actin_bind; 1.
PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00808	; FABD; 1.
SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013